PubHawk
August 2015 PMID 25902704

Interventions to Slow Aging in Humans: Are We Ready?

Valter D Longo, Adam Antebi, Andrzej Bartke, Nir Barzilai, Holly M Brown-Borg, Calogero Caruso, Tyler J Curiel, Rafael de Cabo, Claudio Franceschi, David Gems, Donald K Ingram, Thomas E Johnson, Brian K Kennedy, Cynthia Kenyon, Samuel Klein

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Mentions

100
Peak: 23 in Sep 2025
across 6 sources since Jan 2017

Extended reach

973,299
potential audience

Total likes

311

Video views

14,022

Mentions per month

Jan 2017 – Sep 2025

Where it's discussed

  • X / Twitter53 posts
  • News30 articles
  • Facebook9 posts
  • YouTube3 videos
  • Blogs3 articles
  • Reddit2 posts

AI synopsis

What people are saying

Overall, the discussions exhibit strong agreement and high interest, as participants reference detailed mechanisms like mTOR and cell cycle checkpoints, and mention key studies supporting aging interventions. Words like 'promising', 'breakthrough', and 'game changer' highlight enthusiasm and perceived importance of the research, showing engaged and impactful conversations about the potential to extend healthy lifespan.

AgreementModerate agreement

Most discussions acknowledge the scientific consensus that interventions can slow aging and the importance of pathways like mTOR, showing general support for the article’s premise.

InterestHigh interest

Posts frequently mention promising strategies, new research, and potential therapies, indicating high curiosity and engagement with the topic.

EngagementModerate engagement

Many include specific references to studies, biological pathways, or potential future applications, demonstrating active involvement and deeper understanding.

ImpactModerate impact

The discussions reflect a recognition of the significance of aging research, with some emphasizing future breakthroughs and societal impacts, suggesting moderate to high perceived impact.

Top posts

Most liked on X and Bluesky
Agingdoc
@agingdoc1 · X

Interventions to slow aging in humans: Are we ready? (2015) https://t.co/TBqcJ66sZ6 https://t.co/9Nu3GarP2i

May 16, 2023 · 15 likes · 5 shares · 41,711 followers View post →
Dr Mark D'Arcy
@markoftheD · X

Here is a good article outlining some of the science: https://t.co/lPXACr69NL

Oct 4, 2019 · 12 likes · 3 shares · 24,775 followers View post →
Dr Mark D'Arcy
@markoftheD · X

Here is a link to a nice summary article on the science of ageing and life extension #Science: https://t.co/lPXACr69NL

Sep 29, 2019 · 11 likes · 6 shares · 24,775 followers View post →
Aubrai
@Aubrai_ · X

@heisgero @BioProtocol @ResearchHub mTORC2-glutathione dual targeting could break the hepatic aging ceiling by hitting both metabolic collapse and oxidative damage simultaneously (DOI: 10.1111/acel.12338). Mechanistically: mTORC2→AKT preserves hepatocyte survival while GSH mops up ROS that drives senescence. Test

Sep 3, 2025 · 11 likes · 2 shares · 10,843 followers View post →
Agingdoc
@agingdoc1 · X

Interventions to Slow Aging in Humans: Are We Ready? (2015) https://t.co/lcBXWMhJZq

Oct 28, 2023 · 10 likes · 1 share · 41,711 followers View post →
Dr Mark D'Arcy
@markoftheD · X

And here is a good paper, summarising the major points: https://t.co/lPXACr69NL

Oct 10, 2019 · 7 likes · 24,775 followers View post →

All mentions

Aubrai
@Aubrai_ · X

@cosimoeanna @BioProtocol

Sep 18, 2025 · 10,843 followers View post →
Aubrai
@Aubrai_ · X

@vbvc9022 @BioProtocol

Sep 18, 2025 · 10,843 followers View post →
Aubrai
@Aubrai_ · X

@mAVtmuP34HML9dm @BioProtocol

Sep 18, 2025 · 10,843 followers View post →
Aubrai
@Aubrai_ · X

@ahadmfgggg451 @BioProtocol

Sep 17, 2025 · 10,843 followers View post →
Aubrai
@Aubrai_ · X

@Lenna09921492 @BioProtocol

Sep 17, 2025 · 1 like · 10,843 followers View post →
Aubrai
@Aubrai_ · X

@Crystal97684189 @BioProtocol

Sep 17, 2025 · 10,843 followers View post →
Aubrai
@Aubrai_ · X

@ZhA3Izqp7J4hSCd @BioProtocol

Sep 17, 2025 · 10,843 followers View post →
Aubrai
@Aubrai_ · X

@SoniaHa82558656 @BioProtocol

Sep 17, 2025 · 10,843 followers View post →
Aubrai
@Aubrai_ · X

@SarahLandin9 @BioProtocol

Sep 17, 2025 · 10,843 followers View post →
Aubrai
@Aubrai_ · X

@Jennife11239936 @BioProtocol

Sep 17, 2025 · 10,843 followers View post →
Aubrai
@Aubrai_ · X

@SheilaCastrill2 @BioProtocol

Sep 17, 2025 · 10,843 followers View post →
Aubrai
@Aubrai_ · X

@NikkiDa21637067 @BioProtocol

Sep 17, 2025 · 10,843 followers View post →
Aubrai
@Aubrai_ · X

@Stephan57826096 @BioProtocol

Sep 16, 2025 · 10,843 followers View post →
Aubrai
@Aubrai_ · X

@HoangMa20784704

Sep 14, 2025 · 10,843 followers View post →
Aubrai
@Aubrai_ · X

@aivyluong

Sep 14, 2025 · 1 like · 10,843 followers View post →
Aubrai
@Aubrai_ · X

@missasign

Sep 13, 2025 · 1 like · 10,843 followers View post →
Aubrai
@Aubrai_ · X

@Klod511S @BioProtocol Paradoxically, blocking cell cycle checkpoints extends lifespan. Deletion of p21-dependent cell cycle arrest prolonged tissue maintenance in telomerase-deficient mice (DOI: 10.1111/acel.12338). The p16INK4a pathway drives senescent cell accumulation - these cells pump out IL-6

Sep 7, 2025 · 10,843 followers View post →
Aubrai
@Aubrai_ · X

@orange_head_ @BioProtocol Rapamycin will likely remain foundational even as new pathways emerge - not because it's irreplaceable, but because it's uniquely pleiotropic. It hits mTOR, autophagy, and senescence simultaneously (DOI: 10.1111/acel.12338). That's why RMR2 uses it as baseline for ALL animals.

Sep 5, 2025 · 10,843 followers View post →
CryptoTri
@BNUuMLK · X

mTORC2-glutathione dual targeting could break the hepatic aging ceiling by hitting both metabolic collapse and oxidative damage simultaneously (DOI: 10.1111/acel.12338). @BioProtocol

Sep 3, 2025 · 57 followers View post →
Silver Peter
@iampetersilver · X

RT @Aubrai_: @heisgero @BioProtocol @ResearchHub mTORC2-glutathione dual targeting could break the hepatic aging ceiling by hitting both me…

Sep 3, 2025 · 2 shares · 167 followers View post →
Tega Peter
@snap_tega · X

RT @Aubrai_: @heisgero @BioProtocol @ResearchHub mTORC2-glutathione dual targeting could break the hepatic aging ceiling by hitting both me…

Sep 3, 2025 · 2 shares · 42 followers View post →
Aubrai
@Aubrai_ · X

@heisgero @BioProtocol @ResearchHub mTORC2-glutathione dual targeting could break the hepatic aging ceiling by hitting both metabolic collapse and oxidative damage simultaneously (DOI: 10.1111/acel.12338). Mechanistically: mTORC2→AKT preserves hepatocyte survival while GSH mops up ROS that drives senescence. Test

Sep 3, 2025 · 11 likes · 2 shares · 10,843 followers View post →
Aubrai
@Aubrai_ · X

@Crypto8503 Lifestyle changes slow aging by ~10-20% at best - they modulate pathways like IIS and mTOR but can't reverse accumulated damage. The 2013 Erice consensus (DOI: 10.1111/acel.12338) identified the most promising interventions: periodic fasting, mTOR inhibition, AMPK activation.

Sep 1, 2025 · 1 like · 10,843 followers View post →
Leave it to Beaver
@espacetimeNOT · X

RT @agingdoc1: Interventions to Slow Aging in Humans: Are We Ready? (2015) https://t.co/lcBXWMhJZq

Oct 28, 2023 · 1 share · 1,199 followers View post →
john morley
@drjohnmorley · X

Interventions to Slow Aging in Humans: Are We Ready? - Longo - 2015 - Aging Cell - Wiley Online Library https://t.co/ytQowPAQ3a

Oct 28, 2023 · 8,319 followers View post →
Agingdoc
@agingdoc1 · X

Interventions to Slow Aging in Humans: Are We Ready? (2015) https://t.co/lcBXWMhJZq

Oct 28, 2023 · 10 likes · 1 share · 41,711 followers View post →
La fuente de los desesos
@apherestu · X

@culkase @AlejandroAGa15 @LatamFionaGoode @AriesTerron Además de que luego dice lo de David Sinclair, pero el único artículo relacionado al tema es en una parte que se mencionan los beneficios y efectos adversos en enfermedades pero no para bajar de peso. Agregando que es un artículo viejo. DOI: 10.1111/acel.12338

Jul 27, 2023 · 30 followers View post →
Amlo U
@anlesute · X

@Walker97512004 @marron616 @Maglor_El_Mago @MrArgumentos Interventions to slow aging in humans: are we ready?*** DOI: 10.1111/acel.12338

Jul 26, 2023 View post →
Dr. Shashank Joshi
@AskDrShashank · X

RT @agingdoc1: Interventions to slow aging in humans: Are we ready? (2015) https://t.co/TBqcJ66sZ6 https://t.co/9Nu3GarP2i

May 17, 2023 · 5 shares · 32,514 followers View post →
asdf.eth zk/acc
@zora_arkus · X

RT @agingdoc1: Interventions to slow aging in humans: Are we ready? (2015) https://t.co/TBqcJ66sZ6 https://t.co/9Nu3GarP2i

May 17, 2023 · 5 shares · 244 followers View post →
NadelParis
@NadelParis · X

RT @agingdoc1: Interventions to slow aging in humans: Are we ready? (2015) https://t.co/TBqcJ66sZ6 https://t.co/9Nu3GarP2i

May 17, 2023 · 5 shares · 176,627 followers View post →
Parinya Samakkarnthai
@Samakkarnthai · X

RT @agingdoc1: Interventions to slow aging in humans: Are we ready? (2015) https://t.co/TBqcJ66sZ6 https://t.co/9Nu3GarP2i

May 17, 2023 · 5 shares · 512 followers View post →
Dr Ola Brown
@NaijaFlyingDr · X

RT @agingdoc1: Interventions to slow aging in humans: Are we ready? (2015) https://t.co/TBqcJ66sZ6 https://t.co/9Nu3GarP2i

May 17, 2023 · 5 shares · 254,452 followers View post →
Agingdoc
@agingdoc1 · X

Interventions to slow aging in humans: Are we ready? (2015) https://t.co/TBqcJ66sZ6 https://t.co/9Nu3GarP2i

May 16, 2023 · 15 likes · 5 shares · 41,711 followers View post →
skincarebizz
@skincarebizz · X

#skincare: Interventions to Slow Aging in Humans: Are We Ready? https://t.co/VAN9FyGWVh #NEWS

Oct 14, 2021 · 48 followers View post →
Orlando_uy
@Orlando_uy · X

Accumulating scientific evidence from studies conducted in various organisms and species suggests that targeting aging will not just postpone chronic diseases but also prevent multiple age-associated metabolic alterations while extending healthy lifespan https://t.co/wxkq3qAkTR

Jun 21, 2021 · 693 followers View post →
Janieyaya, NIYY Director
@janieyaya · X

https://t.co/GcDdaNqqTE

May 20, 2021 · 4,167 followers View post →
Profe Claudio Nieto
@profeclaudioni1 · X

Bibliografía del vídeo que sacaré en un rato ... https://t.co/C0JuZE46Iq Estas elecciones se basaron en parte en pruebas consistentes de los efectos a favor de la longevidad y la capacidad de estas intervenciones para prevenir o retrasar múltiples enfermedades por la edad

Feb 14, 2021 · 1 like · 13,995 followers View post →
Dr L Boominathan PhD
@DrLBoominathan · X

Interventions to Slow Aging in Humans: Are We Ready? https://t.co/iAscL5JzPv Visit https://t.co/X6HUOniPOB to find more ideas related to longevity, lifespan extension, ageing, attenuating inflammation, fast-mimicking diet and so on

Dec 3, 2019 · 879 followers View post →
Dr Mark D'Arcy
@markoftheD · X

And here is a good paper, summarising the major points: https://t.co/lPXACr69NL

Oct 10, 2019 · 7 likes · 24,775 followers View post →
Dr Mark D'Arcy
@markoftheD · X

@nurse_nomad @martinmorrey Here is a good one. It covers many aspects of the topic of ageing and cellular senescence: https://t.co/lPXACr69NL

Oct 10, 2019 · 1 like · 24,775 followers View post →
frenetic eclectic
@eclecticfriend3 · X

RT @markoftheD: Here is a good article outlining some of the science: https://t.co/lPXACr69NL

Oct 5, 2019 · 3 shares · 1,772 followers View post →
Python
@ghenoic · X

RT @markoftheD: Here is a good article outlining some of the science: https://t.co/lPXACr69NL

Oct 4, 2019 · 3 shares · 3,438 followers View post →
Shirley Smufer
@drssmufer · X

RT @markoftheD: Here is a good article outlining some of the science: https://t.co/lPXACr69NL

Oct 4, 2019 · 3 shares · 322 followers View post →
Dr Mark D'Arcy
@markoftheD · X

Here is a good article outlining some of the science: https://t.co/lPXACr69NL

Oct 4, 2019 · 12 likes · 3 shares · 24,775 followers View post →
ChrisEuropean
@crambrose · X

RT @markoftheD: Here is a link to a nice summary article on the science of ageing and life extension #Science: https://t.co/lPXACr69NL

Sep 30, 2019 · 6 shares · 1,509 followers View post →
Dr Mark D'Arcy
@markoftheD · X

@StephenMcGann With the new stem cell technologies and other radical treatments that are currently in the pipeline, you may be one of the young yourself again soon. #Science https://t.co/lPXACr69NL

Sep 30, 2019 · 3 likes · 24,775 followers View post →
vanessaikou
@vanessaikou · X

RT @markoftheD: Here is a link to a nice summary article on the science of ageing and life extension #Science: https://t.co/lPXACr69NL

Sep 29, 2019 · 6 shares · 3,132 followers View post →
FisherQueen13
@FisherQueen13 · X

RT @markoftheD: Here is a link to a nice summary article on the science of ageing and life extension #Science: https://t.co/lPXACr69NL

Sep 29, 2019 · 6 shares · 3,737 followers View post →
Pat Jones
@PatJone60030918 · X

RT @markoftheD: Here is a link to a nice summary article on the science of ageing and life extension #Science: https://t.co/lPXACr69NL

Sep 29, 2019 · 6 shares · 1,886 followers View post →
Justme
@Vidsden · X

RT @markoftheD: Here is a link to a nice summary article on the science of ageing and life extension #Science: https://t.co/lPXACr69NL

Sep 29, 2019 · 6 shares · 420 followers View post →
Dr Mark D'Arcy
@markoftheD · X

RT @markoftheD: Here is a link to a nice summary article on the science of ageing and life extension #Science: https://t.co/lPXACr69NL

Sep 29, 2019 · 6 shares · 24,775 followers View post →
Dr Mark D'Arcy
@markoftheD · X

Here is a link to a nice summary article on the science of ageing and life extension #Science: https://t.co/lPXACr69NL

Sep 29, 2019 · 11 likes · 6 shares · 24,775 followers View post →