Cell Rep November 2015 PMID 26565899

Differential Stoichiometry among Core Ribosomal Proteins.

Nikolai Slavov, Stefan Semrau, Edoardo Airoldi, Bogdan Budnik, Alexander van Oudenaarden

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Peak: 1 in Nov 2018

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The overall tone conveys acknowledgment of the study’s importance, with phrases like 'published as' and hashtags indicating relevance, while the limited depth suggests moderate enthusiasm and engagement in ongoing scientific conversations.

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Abstract in brief

The study investigates whether core ribosomal proteins (RPs) in ribosomes vary in their amounts, challenging the idea that ribosomes always have a fixed protein composition.
Using mass spectrometry, the researchers measured RP levels in mouse embryonic stem cells and yeast, finding that RP composition changes based on growth conditions and the number of ribosomes attached to mRNA.
The results suggest that ribosomes with different protein makeups may have distinct functions and that the presence of specific RPs in polysomes is linked to cell fitness, indicating functional diversity in ribosomes.]

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All mentions

Quantifying Proteoforms Using HIquant in Proteomics Research

Presentation by Nikolai Slavov at the Broad Institute Computational Seminar. The HIquant algorithm was developed to accurately quantify proteoform stoichiometries by avoiding peptide-specific biases in mass spectrometry…

Nikolai Slavov · Nov 24, 2018 611 views

備忘録

@bibourokuabc · X

RT @biorxiv_pubd: Differential stoichiometry among core ribosomal proteins published as: https://t.co/1XWTMmw7NS @cellreports #biorxiv

Jan 1, 2020 · 1 share · 229 followers View post →

bioRxiv Published

@biorxiv_pubd · X

Differential stoichiometry among core ribosomal proteins published as: https://t.co/1XWTMmw7NS @cellreports #biorxiv

Dec 31, 2019 · 1 like · 1 share · 2,908 followers View post →