Defining ADHD symptom persistence in adulthood: optimizing sensitivity and specificity.
Margaret H Sibley, James M Swanson, L Eugene Arnold, Lily T Hechtman, Elizabeth B Owens, Annamarie Stehli, Howard Abikoff, Stephen P Hinshaw, Brooke S G Molina, John T Mitchell, Peter S Jensen, Andrea L Howard, Kimberley D Lakes, William E Pelham,
June 2017 J Child Psychol PsychiatryAbstract
Objective: Longitudinal studies of children diagnosed with ADHD report widely ranging ADHD persistence rates in adulthood (5-75%). This study documents how information source (parent vs. self-report), method (rating scale vs. interview), and symptom threshold (DSM vs. norm-based) influence reported ADHD persistence rates in adulthood.
Method: Five hundred seventy-nine children were diagnosed with DSM-IV ADHD-Combined Type at baseline (ages 7.0-9.9 years) 289 classmates served as a local normative comparison group (LNCG), 476 and 241 of whom respectively were evaluated in adulthood (Mean Age = 24.7). Parent and self-reports of symptoms and impairment on rating scales and structured interviews were used to investigate ADHD persistence in adulthood.
Results: Persistence rates were higher when using parent rather than self-reports, structured interviews rather than rating scales (for self-report but not parent report), and a norm-based (NB) threshold of 4 symptoms rather than DSM criteria. Receiver-Operating Characteristics (ROC) analyses revealed that sensitivity and specificity were optimized by combining parent and self-reports on a rating scale and applying a NB threshold.
Conclusion: The interview format optimizes young adult self-reporting when parent reports are not available. However, the combination of parent and self-reports from rating scales, using an 'or' rule and a NB threshold optimized the balance between sensitivity and specificity. With this definition, 60% of the ADHD group demonstrated symptom persistence and 41% met both symptom and impairment criteria in adulthood.
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| Download Source 2 | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5809153 | PMC |
| Download Source 3 | http://dx.doi.org/10.1111/jcpp.12620 | DOI Listing |