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The discussions collectively emphasize the strong connection between tobacco smoking and mutational signatures in various cancers, particularly lung cancer, highlighting molecules like DNA-damaging agents and specific signatures like Signature 4. The tone shifts from supportive affirmations to detailed references of the research's mechanistic insights, indicating high interest and perceived impact.
Most discussions strongly affirm the link between smoking and increased mutational signatures in cancer, emphasizing DNA damage and mutation accumulation.
Posters demonstrate high interest, focusing on the specific mechanisms and examples, such as lung cancer's unique mutational signatures and the role of DNA damage.
While many posters share supportive statements, some, like those referencing detailed studies or the impact of specific signatures, show deeper engagement.
The discussions reflect a recognition of the significant influence of the findings, with mentions of implications for understanding cancer mechanisms and the role of smoking.
Yup, v true. C 'Smoking causes hundreds of genetic mutations' https://t.co/XHas1Factg via @NHSuk . The full @SerenaNikZainal et al study is available here ⬇️ 'Mutational signatures associated with tobacco smoking in human cancer' https://t.co/RV4pqgEiqf https://t.co/D8NPoQVglc
Mutational signatures associated with tobacco smoking in human cancer https://t.co/g5TRf1gjtE
e.g lung cancers have a very specific mutational signature compared to others (because of smoking being a DNA damaging agent triggering a specific DNA repair mechanism) https://t.co/RX4Sf83vJz 5/
がんゲノム解析で、喫煙者の肺癌には、Signature 4というC>A転移が多い変異パターンが見られる https://t.co/9nGU9jt0GA Mutational signatures associated with tobacco smoking in human cancer SCIENCE 4 Nov 2016 Vol 354, Issue 6312 pp. 618-622
@MaartenvSmeden @go_bayes It creates DNA damage https://t.co/oBon8BImD7 DNA damage causes cancer
RT @pash22: Yup, v true. C 'Smoking causes hundreds of genetic mutations' https://t.co/XHas1Factg via @NHSuk . The full @SerenaNikZainal et…
Tobacco smoking is linked to increased mutations in at least 17 types of human cancer, with different mutational signatures contributing to cancer development depending on the tissue. The primary mechanism involves…
This video discusses perspectives on tobacco smoking as a mutagenic mechanism related to environmental exposure and cancer. It explores key findings from the study on global trends in early-onset cancer, emphasizing the…
This video discusses how tobacco smoking contributes to mutagenic mechanisms in cancer development, emphasizing the increased mutation load and diverse mutational signatures across different human cancers, highlighting…
がんゲノム解析で、喫煙者の肺癌には、Signature 4というC>A転移が多い変異パターンが見られる https://t.co/9nGU9jt0GA Mutational signatures associated with tobacco smoking in human cancer SCIENCE 4 Nov 2016 Vol 354, Issue 6312 pp. 618-622
RT @PhilippMarkolin: e.g lung cancers have a very specific mutational signature compared to others (because of smoking being a DNA damaging…
e.g lung cancers have a very specific mutational signature compared to others (because of smoking being a DNA damaging agent triggering a specific DNA repair mechanism) https://t.co/RX4Sf83vJz 5/
Smoking tobacco is a major contributor to tumor mutation burden in lung cancer. https://t.co/OK0ZAcFjbQ https://t.co/6VyWppLeHa https://t.co/7oRm1J92KL https://t.co/6LOawbLDBl
@MaartenvSmeden @go_bayes It creates DNA damage https://t.co/oBon8BImD7 DNA damage causes cancer
RT @pash22: Yup, v true. C 'Smoking causes hundreds of genetic mutations' https://t.co/XHas1Factg via @NHSuk . The full @SerenaNikZainal et…
RT @pash22: Yup, v true. C 'Smoking causes hundreds of genetic mutations' https://t.co/XHas1Factg via @NHSuk . The full @SerenaNikZainal et…
Yup, v true. C 'Smoking causes hundreds of genetic mutations' https://t.co/XHas1Factg via @NHSuk . The full @SerenaNikZainal et al study is available here ⬇️ 'Mutational signatures associated with tobacco smoking in human cancer' https://t.co/RV4pqgEiqf https://t.co/D8NPoQVglc
RT @Wdekanter: Mutational signatures associated with tobacco smoking in human cancer https://t.co/g5TRf1gjtE
Mutational signatures associated with tobacco smoking in human cancer https://t.co/UmObI0966D
Mutational signatures associated with tobacco smoking in human cancer https://t.co/g5TRf1gjtE
Mutational signatures associated with tobacco smoking in human cancer. - PubMed - NCBI https://t.co/VLxcRBx5Tb
Mutational signatures associated with tobacco smoking in human cancer: http://science.sciencemag.org/content/354/6312/618