N Engl J Med September 2017 PMID 28845751

Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease.

Paul M Ridker, Brendan M Everett, Tom Thuren, Jean G MacFadyen, William H Chang, Christie Ballantyne, Francisco Fonseca, Jose Nicolau, Wolfgang Koenig, Stefan D Anker, John J P Kastelein, Jan H Cornel, Prem Pais, Daniel Pella, Jacques Genest

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Mentions

377
Peak: 26 in Apr 2023
across 6 sources since Jan 2019

Extended reach

2,145,348
potential audience

Total likes

22,318

Video views

961,767

Mentions per month

Jan 2019 – Sep 2025

Where it's discussed

  • News148 articles
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  • Reddit3 posts

AI synopsis

What people are saying

Overall, the discussions express strong agreement with the article's emphasis on inflammation as a key factor in cardiovascular risk, supported by technical references to the CANTOS trial and biological pathways. The tone is analytical and involved, with examples like references to IL-1β, CRP levels, and the implications of targeting inflammation, highlighting their perceived high impact on treatment approaches and research directions.

AgreementStrong agreement

Most discussions highlight the significance of targeting inflammation, especially with Canakinumab, aligning with the research findings.

InterestHigh interest

The conversations demonstrate high engagement, referencing multiple trials, biological pathways, and potential clinical implications.

EngagementHigh engagement

Posts delve into detailed mechanisms like IL-1β, CRP, and immune pathways, indicating deep understanding and involvement.

ImpactHigh impact

Many discussions consider how these findings may influence future treatments and clinical practice, emphasizing the importance of inflammation in cardiovascular disease.

Abstract in brief

  • The study tested whether reducing inflammation with canakinumab can lower the risk of cardiovascular events in patients with a history of myocardial infarction, without affecting lipid levels.
  • Canakinumab significantly decreased inflammation markers (C-reactive protein levels), especially at the 150mg dose, and showed a reduction in the primary cardiovascular endpoints compared to placebo, with the 150mg dose achieving statistical significance.
  • The results suggest that targeting inflammation, particularly with the 150mg dose, may help reduce the risk of future cardiovascular events in high-risk patients, supporting the idea that inflammation plays a role in atherothrombosis.]

Top posts

Most liked on X and Bluesky
Viva Longevity!
@VivaLongevity · X

I think @NutritionMadeS3 is the king of cutting through the fog of misinformation on the Internet wrt heart disease risk. https://t.co/Jho8iojnLB

Apr 4, 2023 · 62 likes · 2 shares · 4,736 followers View post →
Gil Carvalho MD PhD
@NutritionMadeS3 · X

- is cholesterol associated with LESS death? - does HDL-cholesterol offset risk? - is oxidized LDL in blood (oxLDL) the "real" cause of heart disease? - LDL size - insulin resistance & CVD - inflammation & CVD - statin side effects etc https://t.co/HcC8FdaUiJ

Apr 3, 2023 · 44 likes · 2 shares · 27,737 followers View post →
Roger Seheult, MD
@RogerSeheult · X

Really like this channel. I recommend this video if you want insight on diet and nutrition: https://t.co/9iKzxnX2ai

May 4, 2023 · 31 likes · 26,605 followers View post →
Bryce Hanna
@photobiogenesis · X

More and more studies suggest that reducing inflammation is an important exis of heart disease prevention, similar to lipid markers https://t.co/xo4m522fLg

Sep 14, 2021 · 24 likes · 5 shares · 34,227 followers View post →
Hans-Joachim Anders
@hjanders_hans · X

Another trial showing benefits from targeting chronic inflammation in cardiovascular disease. Colchicine is certainly cheaper than canakinumab #CANTOS https://t.co/zlNtt37N6s https://t.co/uETaokaQcY

Nov 16, 2019 · 17 likes · 6 shares · 2,972 followers View post →
Gil Carvalho MD PhD
@NutritionMadeS3 · X

full video: https://t.co/4rEtxW92ey

May 8, 2023 · 10 likes · 4 shares · 27,737 followers View post →

All mentions

bili
@bimiki · X

@bioinvestor24 It’s not a new concept for Novartis! Remember the Cantos trial? Antiinflammatory therapy with canakinumab (anti IL-1β) for CVRR? https://t.co/6ve1uVqcmq

Sep 9, 2025 · 1 like · 139 followers View post →
TR2020
@tr1010 · X

@VigilantFox This coming Aug. 7. Should be interesting.https://t.co/5XjKHyAipp

Aug 5, 2025 · 249 followers View post →
Gil Carvalho MD PhD
@NutritionMadeS3 · X

full video: https://t.co/4rEtxW92ey

Jul 16, 2025 · 7 likes · 27,737 followers View post →
د/عبدالله القرني Abdullah Algarni
@abaidalgarni · X

@Banitoto Interesting landmark study. https://t.co/QzM0TOIiVc

Dec 22, 2024 · 3 likes · 1 share · 2,014 followers View post →
Dr.shahzad ahmad
@DrShahzadAhmad · X

@InPsx https://t.co/xqZ2Ui9ESz have a look at the video for more clarity

Nov 15, 2024 · 1 like · 241 followers View post →
Joe
@Sylvester9786 · X

@delectblydelinq @Sisilmultisari @LDLSkeptic @KenDBerryMD When health influencers say that "cholesterol is healthy" they are ignoring hundreds of credible randomized controlled trials and studies showing that cholesterol in not "healthy." But people believe what they want to believe and ignore the evidence: https://t.co/C4DOXlXFUE

Oct 10, 2024 · 2 followers View post →
Sarel H
@SJHHard · X

https://t.co/STRlkc1QLc

Oct 5, 2024 · 4 followers View post →
Marios Georgakis
@MariosGeorgakis · X

Background: Inflammation governs the progression of atherosclerotic lesions. On top of experimental, genetic and epidemiological data, #CANTOS (2017) showed that targeting inflammation among patients with atherosclerosis leads to decreases in CV risk https://t.co/03yokFz0t7 https://t.co/Qc1DjMOkDf

May 19, 2024 · 4,293 followers View post →
Gunnar Henrik Heine
@gunnar_heine · X

@PWoywodt @AnnetteBruchfe1 @monicafontana13 @ynptweets @ERAkidney https://t.co/h7ifAPAMlz

May 10, 2024 · 2,326 followers View post →
Cotic
@Cotic · X

https://t.co/u4stZ88GFC

Jan 8, 2024 · 826 followers View post →
Richard Buka
@richardbuka · X

15/ There’s ++ interest in targeting thromboinflammation - shouldn’t affect haemostasis. CANTOS study (https://t.co/Esx1Q3L1h1) randomised pts with prev MI + CRP >2 to anti IL-1β, anakinra or placebo. Led to ⬆️recurrent cardiovasc events but ⬆️fatal infection – no effect on OS. https://t.co/5TVf38axuA

Jan 6, 2024 · 4 likes · 1,421 followers View post →
Richard Buka
@richardbuka · X

13/ There’s ++ interest in targeting thromboinflammation - shouldn’t affect haemostasis. CANTOS study (https://t.co/1799RCmWkH) randomised pts with prev MI + CRP >2 to anti IL-1β, anakinra or placebo. Led to ⬆️ recurrent cardiovasc events but ⬆️fatal infection – no effect on OS.

Jan 6, 2024 · 1,421 followers View post →
Danijel
@MiocanDanijel · X

RT @FoolproofMaster: @Drlipid @theproof Whilst others with nearly 3 million youtube subscribers are confusing LDL particles with cells...…

Dec 5, 2023 · 1 share · 1,118 followers View post →
レ点
@m0370 · X

カナキヌマブは抗腫瘍効果よりも心血管系疾患のCANTOS試験のほうが有名かもしれない。抗炎症効果で心筋梗塞既往があってCRP陽性を示す人の心血管・脳卒中イベントを減らしたらしい。ググると冠動脈疾患のデータの方がたくさん出てくる。/NEJM https://t.co/R4X8Di5H7W

Dec 4, 2023 · 1 like · 28,755 followers View post →
Gil Carvalho MD PhD
@NutritionMadeS3 · X

@drewlocke @theproof https://t.co/lKIlRy9LZU and https://t.co/HcC8FdaUiJ

Nov 20, 2023 · 3 likes · 27,737 followers View post →
Andrew Fortuna ®NT MSc (mBANT)
@andrewfortunaNT · X

Cardiovascular disease (CVD) is an inflammatory issue not a high cholesterol one. An RCT showed by ↓ inflammation w/o lowering blood lipids, less to sig ↓ in CVD events. Reduce inflammation with diet & lifestyle, not the consequence with drugs #Gibraltar https://t.co/sDM6xRDtb8

Nov 7, 2023 · 23 followers View post →
Abdulmalik M. AlEissa, BCPS
@A1aleissa · X

Canakinumab demonstrated 15% lower risk of cardiovascular events than placebo. but unfortunately this antibody showed slightly higher incidence of fatal infections. (CANTOS trial)

Oct 20, 2023 · 52 followers View post →
:wq
@edxe47 · X

@NutritionMadeS3 @DrNadolsky @TarbuckSam @BioLayne Haven’t watched this, but you also briefly touched it in your Sten Ekberg fact-check video. https://t.co/2XXeksFzkB

Sep 21, 2023 · 131 followers View post →
Silly Grandma☮️☪️
@sillygrandma99 · X

#statins & high #cholesterol EDUCATIONAL VIDEO Long but important with references https://t.co/xRrLWTdGgS

Sep 17, 2023 · 5,114 followers View post →
Silly Grandma☮️☪️
@sillygrandma99 · X

How NON-medical doctors nurses, laymen social media "experts"& lawyers like JFK Jr OFTEN misinterpret medical studies& give wrongful "advice" #cholesterol #lipids #HeartDisease #statins #PublicHealth #CAD It's actually complicated&most won't listen 2 this https://t.co/RUF8eafKOu

Sep 17, 2023 · 5,114 followers View post →
yar zuk
@yarzuk · X

Dr Sten Ekberg gets fact-checked by MD PhD Doctor https://t.co/ONk6LuS6HO via @YouTube

Sep 4, 2023 · 624 followers View post →
Gunnar Henrik Heine
@gunnar_heine · X

RT @gunnar_heine: An academic giant at HOMe: Few days before ⁦#ESCCongress 23 it is an honor and pleasure to host Dr Peter Libby together w…

Aug 18, 2023 · 3 shares · 2,326 followers View post →
Florian Custodis
@floriancustodis · X

RT @gunnar_heine: An academic giant at HOMe: Few days before ⁦#ESCCongress 23 it is an honor and pleasure to host Dr Peter Libby together w…

Aug 17, 2023 · 3 shares · 751 followers View post →
marcus_saemann
@MarcusSaemann · X

RT @gunnar_heine: An academic giant at HOMe: Few days before ⁦#ESCCongress 23 it is an honor and pleasure to host Dr Peter Libby together w…

Aug 17, 2023 · 3 shares · 679 followers View post →
Gunnar Henrik Heine
@gunnar_heine · X

An academic giant at HOMe: Few days before ⁦#ESCCongress 23 it is an honor and pleasure to host Dr Peter Libby together with ⁦@floriancustodis⁩ ⁦@StephanSchirme2⁩ ⁦@MarcusSaemann⁩ ⁦@dgfn_ev⁩ ⁦@oegnephro⁩ ⁦@com_SFNDT⁩ https://t.co/Tkk7XxzSoN

Aug 17, 2023 · 5 likes · 3 shares · 2,326 followers View post →
Gil Carvalho MD PhD
@NutritionMadeS3 · X

@AndeanFlora @drlipid has great content on this. statins can affect cholesterol production in the brain & good specialists consider it also see our content for effects on cognition which are often misstated on social media https://t.co/HcC8FdaUiJ (at 1h11min)

Aug 16, 2023 · 27,737 followers View post →
Beverly G. Tchang, MD
@BevTchangMD · X

@MichaelJBlaha

Jul 22, 2023 · 1 like · 6,105 followers View post →
Jonas Schnelli
@_jonasschnelli_ · X

@STC_BTC Dude. Don’t follow Dr. Ekberg. Facts check him: https://t.co/EWiyczm9dS

Jul 21, 2023 · 3 likes · 49,473 followers View post →
Pablo Corral MD
@drpablocorral · X

@Lpa_Doc @OxPL_apoB The word "Lp(a)" is not mentioned throughout the CANTOS protocol

Jul 16, 2023 · 3 likes · 11,204 followers View post →
Michael Joseph
@Nutradvance · X

RT @NutritionMadeS3: @Nutradvance @_advg_ we recently went over this exact FAQ of inflammation in CVD https://t.co/4rEtxW92ey inflammation…

Jul 9, 2023 · 1 share · 11,788 followers View post →
Gil Carvalho MD PhD
@NutritionMadeS3 · X

@Nutradvance @_advg_ we recently went over this exact FAQ of inflammation in CVD https://t.co/4rEtxW92ey inflammation is obviously involved but the common idea that "hypercholesterolemia is ok as long as inflammatory markers are low" is almost certainly a misconception

Jul 9, 2023 · 8 likes · 1 share · 27,737 followers View post →
Gil Carvalho MD PhD
@NutritionMadeS3 · X

@JohnnyScott234 with statins it's possible. mixed evidence but for secondary prevention (history of hem stroke) there's a possibility covered here (toward the end) https://t.co/HcC8FdaUiJ

Jun 26, 2023 · 27,737 followers View post →
Gil Carvalho MD PhD
@NutritionMadeS3 · X

@steross245 @Conigman @shiv_twitts we also covered it here in the 1st 10mins https://t.co/HcC8FdaUiJ Peter Attia also had a recent article explaining this. it´s possibly the #1 FAQ about cholesterol on social media

Jun 1, 2023 · 3 likes · 27,737 followers View post →
HEALTH IS A DAILY DISCIPLINE
@DebbieMaybery · X

RT @NutritionMadeS3: full video: https://t.co/4rEtxW92ey

May 22, 2023 · 4 shares · 1,946 followers View post →
agressive strawberry
@cordx666 · X

@WFPB_Longevity @SentientBlobBob Ik u r joking but still posting this: https://t.co/NrHnyASDKr https://t.co/aC1zX2mGXR

May 12, 2023 · 3 followers View post →
Jeffrey A. Hirschfield, MD
@DrHirschfield · X

From our colleague Gil Carvalho MD, Ph.D https://t.co/9qj6ZDoisb

May 11, 2023 · 11,979 followers View post →
Will Brink
@WillBrink · X

@drpablocorral 1/"Antiinflammatory therapy targeting the interleukin-1β innate immunity pathway with canakinumab at a dose of 150 mg every 3 months led to a significantly lower rate of recurrent cardiovascular events than placebo, independent of lipid-level lowering." https://t.co/k4UlvQAo90

May 11, 2023 · 1 like · 3,620 followers View post →
Marcin Lignowski MSc
@_RadicalHealth_ · X

@lipo_fan @ChristofferBN @NutritionMadeS3 @WillBrink @Drlipid @joerogan @ZDoggMD So targeting inflammation does lower the rate of recurrent CVD but (of course) it doesn't prevent it completely. Btw. have a look at the participants' characteristics. They have low LDL but high TG. https://t.co/g93CHLIq84 https://t.co/WiCPTFZ97o

May 11, 2023 · 25 followers View post →
Will Brink
@WillBrink · X

@Drlipid People get tunnel vision, even those with the sci/med background to know better. Focusing on inflammation to the exclusion of apoB is poor science. Still, inflammation appears a therapeutic target: https://t.co/k4UlvQAo90

May 11, 2023 · 1 like · 3,620 followers View post →
Elliot
@Loh · X

RT @NutritionMadeS3: full video: https://t.co/4rEtxW92ey

May 11, 2023 · 4 shares · 6,709 followers View post →
Will Brink
@WillBrink · X

@galaxysplain @Drlipid @PrimaryCarePAC @NutritionMadeS3 @joerogan @ZDoggMD "...targeting the interleukin-1β innate immunity pathway with canakinumab at a dose of 150 mg every 3 months led to a significantly lower rate of recurrent cardiovascular events than placebo, independent of lipid-level lowering" https://t.co/k4UlvQAo90

May 11, 2023 · 3,620 followers View post →
Will Brink
@WillBrink · X

@Drlipid @_RadicalHealth_ @NutritionMadeS3 @joerogan @ZDoggMD For those interested: https://t.co/k4UlvQAo90

May 11, 2023 · 3,620 followers View post →
Jeffrey A. Hirschfield, MD
@DrHirschfield · X

Gil Carvalho explains environmental factors to decrease personal risk for ascvd. Lowering Apo-B over a prolonged therapeutic duration is ideal. Optimally, the lower the Apo-B the better and of course this depends on baseline risk factors! https://t.co/9qj6ZDoisb

May 9, 2023 · 11,979 followers View post →
Elisa Haas, MD
@ElisaAHaas · X

RT @NutritionMadeS3: full video: https://t.co/4rEtxW92ey

May 8, 2023 · 4 shares · 444 followers View post →
Revel Peters
@urbanlamb · X

RT @NutritionMadeS3: full video: https://t.co/4rEtxW92ey

May 8, 2023 · 4 shares · 105 followers View post →
Gil Carvalho MD PhD
@NutritionMadeS3 · X

full video: https://t.co/4rEtxW92ey

May 8, 2023 · 10 likes · 4 shares · 27,737 followers View post →
Roger Seheult, MD
@RogerSeheult · X

Really like this channel. I recommend this video if you want insight on diet and nutrition: https://t.co/9iKzxnX2ai

May 4, 2023 · 31 likes · 26,605 followers View post →
Gil Carvalho MD PhD
@NutritionMadeS3 · X

@ChristofferBN @ThelastStyleb16 @MohammedAlo @BradStanfieldMD @MichaelAlbertMD @DBelardoMD we reviewed the evidence on statins and stroke (of the 2 kinds) here: https://t.co/HcC8FdaUiJ (toward the end) this is specific to statins, not having lower cholesterol levels genetically or via lifestyle

May 4, 2023 · 27,737 followers View post →
Gary T. Sottile
@GPZO · X

Dr Sten Ekberg gets fact-checked by MD PhD Doctor https://t.co/RlsUlJmrye via @YouTube

Apr 29, 2023 · 1,058 followers View post →
Tony Scott
@DIY_Tardis · X

RT @simondankel: Landmark CANTOS trial: "Antiinflammatory therapy targeting interleukin-1β innate immunity pathway with canakinumab [...] l…

Apr 22, 2023 · 2 shares · 1,628 followers View post →
DiscoStew
@DiscoStew66 · X

RT @simondankel: Landmark CANTOS trial: "Antiinflammatory therapy targeting interleukin-1β innate immunity pathway with canakinumab [...] l…

Apr 22, 2023 · 2 shares · 10,588 followers View post →
Simon Dankel
@simondankel · X

Landmark CANTOS trial: "Antiinflammatory therapy targeting interleukin-1β innate immunity pathway with canakinumab [...] led to a significantly lower rate of recurrent cardiovascular events than placebo, independent of lipid-level lowering" #paradigmshift https://t.co/sVlYuftNeS https://t.co/NJgUDTUzZ3

Apr 22, 2023 · 1 like · 2 shares · 763 followers View post →
Viva Longevity!
@VivaLongevity · X

@ivanprieto8 Yes, my episode was only 23 minutes, so I referenced this one from @NutritionMadeS3 , which is 82 minutes and covers all the things: https://t.co/Jho8iojnLB

Apr 18, 2023 · 2 likes · 4,736 followers View post →
Errare humanum ... eat!
@PeterDMayr · X

@MasalaFry69 @marelit @BigJonHookEm @OptumisticAg https://t.co/WhyeCUAaJP Apo(a) too https://t.co/fLVTYtvF3V https://t.co/uyV6ILhX7o

Apr 15, 2023 · 594 followers View post →
Earthling
@_earthling74 · X

@NutritionMadeS3 u make a lot of good videos, but I have to give u a special shoutout for this one. I can think of few others out there that do a better job at exposing the difference btwn good quality scientific analysis and, well, bs. Thnx as always. https://t.co/bxASm7sZoj

Apr 14, 2023 · 1 like · 428 followers View post →
CEsco
@ca_esco · X

Dr Sten Ekberg gets fact-checked by MD PhD Doctor https://t.co/J0iqUfeO9K via @YouTube

Apr 10, 2023 · 41 followers View post →
jimbovelure
@L7Weenie32 · X

@josiahgarber @holmanm @NutritionMadeS3 1:11:50 https://t.co/UvCRGuuvZr

Apr 6, 2023 · 547 followers View post →
Yamin
@AhmedYaminn · X

RT @agingdoc1: Gil’s @NutritionMadeS3 (@YouTube @YouTubeCreators) respond to @drstenekberg‘s video

Apr 6, 2023 · 1 share · 2,530 followers View post →
RAO
@corpliazon · X

RT @NutritionMadeS3: - is cholesterol associated with LESS death? - does HDL-cholesterol offset risk? - is oxidized LDL in blood (oxLDL…

Apr 6, 2023 · 2 shares · 1,228 followers View post →
Ray Strode ❤️
@halfhealthiness · X

Great information about ASCVD risk factors and prevention in this video by @NutritionMadeS3 https://t.co/drRiwVaY2F

Apr 5, 2023 · 1 like · 10 followers View post →
Agingdoc
@agingdoc1 · X

Gil’s @NutritionMadeS3 (@YouTube @YouTubeCreators) respond to @drstenekberg‘s video

Apr 5, 2023 · 5 likes · 1 share · 40,891 followers View post →
Neale Blackwood
@ExcelYourself · X

RT @PlantChompers: I think @NutritionMadeS3 is the king of cutting through the fog of misinformation on the Internet wrt heart disease risk…

Apr 4, 2023 · 2 shares · 1,409 followers View post →
Robin
@rowforfun · X

RT @PlantChompers: I think @NutritionMadeS3 is the king of cutting through the fog of misinformation on the Internet wrt heart disease risk…

Apr 4, 2023 · 2 shares · 1,165 followers View post →
Viva Longevity!
@VivaLongevity · X

I think @NutritionMadeS3 is the king of cutting through the fog of misinformation on the Internet wrt heart disease risk. https://t.co/Jho8iojnLB

Apr 4, 2023 · 62 likes · 2 shares · 4,736 followers View post →
brandon kim
@w9life · X

@Mangan150 https://t.co/7H3OQO05eU this is the video... I refering to....

Apr 4, 2023 · 278 followers View post →
Foolproof Mastery
@FoolproofMaster · X

@Drlipid @theproof Whilst others with nearly 3 million youtube subscribers are confusing LDL particles with cells... @NutritionMadeS3 is doing a great job at clarifying so much confusion... Claim timestamped. Just click the video. https://t.co/B9TAYzWd3q

Apr 4, 2023 · 4 likes · 1 share · 1,175 followers View post →
Brian Turner
@briankturner101 · X

RT @NutritionMadeS3: - is cholesterol associated with LESS death? - does HDL-cholesterol offset risk? - is oxidized LDL in blood (oxLDL…

Apr 4, 2023 · 2 shares · 1,466 followers View post →
Fusion Prog Guy @ fusionprogguy.bsky.social
@FusionProgGuy · X

For the love of science, stop listening to Dr. Eric Berg. While you're at it, also ignore Dr. Ken Berry. They both ignore the strongest evidence and provide misleading information on the causes of heart disease. Please listen to scientists and experts. https://t.co/0380IAJEYT

Apr 4, 2023 · 1,560 followers View post →
Summer M
@SummerMinvest · X

@ppoppopower 그사람 틀린 말할때도 많어! 형부한테 이거 보여드려 (근데 브로콜리는 좋은거 맞음 ㅋㅋㅋㅋㅋ) https://t.co/p2uPzvKS2S

Apr 3, 2023 · 12,067 followers View post →
San Franchrisco
@SkyZer0_ · X

@NutritionMadeS3's reaction video

Apr 3, 2023 · 1 like · 210 followers View post →
Light-Yagami
@LightYa33625392 · X

Dr Sten Ekberg gets fact-checked by MD PhD Doctor https://t.co/MLDF3oSdsK via @YouTube

Apr 3, 2023 · 24 followers View post →
Methi
@MasalaFry69 · X

@holmanm Check this propganda out Marion: https://t.co/95VTSAjW0z

Apr 3, 2023 · 6,674 followers View post →
Gil Carvalho MD PhD
@NutritionMadeS3 · X

- is cholesterol associated with LESS death? - does HDL-cholesterol offset risk? - is oxidized LDL in blood (oxLDL) the "real" cause of heart disease? - LDL size - insulin resistance & CVD - inflammation & CVD - statin side effects etc https://t.co/HcC8FdaUiJ

Apr 3, 2023 · 44 likes · 2 shares · 27,737 followers View post →
Agingdoc
@agingdoc1 · X

Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease (2017) #CANTOS https://t.co/OGWZQ8dFml https://t.co/dPLJ7gxZwT

Mar 17, 2023 · 4 likes · 41,232 followers View post →
João Carlos Silva
@Silva_J_Carlos · X

@frondynamics @leiatheinvestor Todo estudo envolve financiamento. Inclusive os que não dão certo. Por exemplo esse daqui: Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease. Esse estudo deu foi patrocinado pela indústria, deu ruim, mesmo assim foi publicado.

Jan 16, 2023 · 318 followers View post →
名古屋大学大学院医学系研究科 循環器内科学
@Cardio_Nagoya · X

https://t.co/jZIpHzAJLk https://t.co/OSvH0jKM5S https://t.co/xXFKnfHH5t

Dec 17, 2022 · 370 followers View post →
Mark Lambie
@markrlambie · X

@SBdoc33 @PD_Perls @ImprovePd Justification for CANTOS https://t.co/lQETldHdrJ and subsequent colchicine trials came from https://t.co/zBHI6a1irz

Nov 24, 2022 · 480 followers View post →
Ronaldo Correa Fabiano
@Ronaldo_CFF · X

9/ For a median follow-up of 3.7 years, Canakinumab reduced recurrent major adverse cardiovascular events w/ unaffected LDL levels. https://t.co/ain7dYx3Wu

Oct 30, 2022 · 3 likes · 835 followers View post →
DiscoStew
@DiscoStew66 · X

Reducing CVD events without reducing LDL

Aug 11, 2022 · 3 likes · 10,588 followers View post →
DiscoStew
@DiscoStew66 · X

@DrPaulMason @LDLSkeptic @BenBikmanPhD “The CANTOS trial [has] taken a drug that doesn’t affect cholesterol levels but………also reduce rates of cardiovascular events,...” https://t.co/Rj3SqB5QEI https://t.co/LnM3lXqlFd

Aug 11, 2022 · 5 likes · 10,588 followers View post →
Matthew Herper
@matthewherper · X

@JeremySussman @hmkyale @djc795 interleukin-1β. https://t.co/cMIaLWTaPF

Jul 18, 2022 · 1 like · 109,765 followers View post →
Matthew Herper
@matthewherper · X

@BiotechObserver A drug that lowered interleukin-1 beta lowered CV events. So that seems like a relevant marker. https://t.co/7HaY7z0o8y

Jul 1, 2022 · 109,765 followers View post →
Gabriel Cara-Fuentes
@carafuentes_g · X

RT @FPoppelaars: Today, I discussed the CANTOS trial @NEJM with my scientific colleagues @SciFiMed: https://t.co/HdylkTuWtp I noticed that…

May 6, 2022 · 2 shares · 973 followers View post →
Vojtech Petr
@VojtechPetr · X

RT @FPoppelaars: Today, I discussed the CANTOS trial @NEJM with my scientific colleagues @SciFiMed: https://t.co/HdylkTuWtp I noticed that…

May 6, 2022 · 2 shares · 295 followers View post →
Felix Poppelaars
@FPoppelaars · X

Today, I discussed the CANTOS trial @NEJM with my scientific colleagues @SciFiMed: https://t.co/HdylkTuWtp I noticed that they did not share my enthusiasm for this LANDMARK paper, so i'll try again on #MedTwitter! Check out the

May 6, 2022 · 10 likes · 2 shares · 550 followers View post →
Charlotte H
@C_A_Lott · X

RT @ck_eternity_: More and more studies suggest that reducing inflammation is an important exis of heart disease prevention, similar to lip…

Sep 14, 2021 · 5 shares · 924 followers View post →
Derma Essentials
@DermaEssentials · X

RT @ck_eternity_: More and more studies suggest that reducing inflammation is an important exis of heart disease prevention, similar to lip…

Sep 14, 2021 · 5 shares · 1,087 followers View post →
Sophia Koltavary
@holypaprika23 · X

RT @ck_eternity_: More and more studies suggest that reducing inflammation is an important exis of heart disease prevention, similar to lip…

Sep 14, 2021 · 5 shares · 221 followers View post →
Bryce Hanna
@photobiogenesis · X

More and more studies suggest that reducing inflammation is an important exis of heart disease prevention, similar to lipid markers https://t.co/xo4m522fLg

Sep 14, 2021 · 24 likes · 5 shares · 34,227 followers View post →
Vitas Gerulaitis
@VGerulaitis · X

RT @healthmisinfo: More directly, CANTOS, which tested whether directly reducing inflammation in the body would help prevent and treat hear…

Aug 24, 2021 · 1 share · 153 followers View post →
Public Health Initiative Against Misinformation
@healthmisinfo · X

More directly, CANTOS, which tested whether directly reducing inflammation in the body would help prevent and treat heart disease, resoundingly showed that yes indeed, inflammation does play an important role in the development of cardiovascular disease. https://t.co/s5tWrukaaZ

Aug 23, 2021 · 1 like · 1 share · 4,152 followers View post →
Mike Putman
@EBRheum · X

2/ There’s an interesting backstory here - this trial comes in the wake of the largely unsuccessful CANTOS (https://t.co/93hYXblNf4) & CIRT trials (https://t.co/wgXWmGNIrx) for IL1 and MTX, respectively

May 22, 2021 · 2 likes · 9,141 followers View post →
Professor M Z Khalil
@mzkhalil · X

Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease | NEJM $200,000 for IL-1 inhibitor post MI with modest benefits at the price of this increased infections. https://t.co/otJkKCCsEb https://t.co/OCEOZMWLP8

Mar 6, 2021 · 2,854 followers View post →
David R. Perkins
@DavidRobertPer1 · X

Interesting clinical trial (CANTOS) looking at immunotherapy with canakinumab (150 mg q3months) in a reduction in cardiovascular events. https://t.co/n3SmM8vDmQ

Feb 26, 2021 · 1 like · 15 followers View post →
Vicent Tomás, Diabetes conCiencia
@diabconciencia · X

⚠️Reducción de los eventos cardiovasculares mediante un antiinflamatorio SIN variación en los niveles de LDL-c. https://t.co/vkg7uWrfeK

Feb 11, 2021 · 4,983 followers View post →
Uxue
@Iluntze_ · X

@ToniElFisico https://t.co/T3AuGjf3wP ahí va

Jan 27, 2021 · 353 followers View post →
John Mandrola, MD
@drjohnm · X

@Hokkis @JACCJournals They published it in the main paper — https://t.co/ZxDtuuy1uz https://t.co/mxNPZpbj30

Oct 7, 2020 · 1 like · 68,447 followers View post →
Brian Scott Edwards
@brianedwardsmd · X

@DrNadolsky @ZKForTre @DaveKeto @gerdosi @The_Nutrivore @Gearoidmuar @erreyedoc @johnzahorik @FatEmperor @LukeEdwards504 @julie_eye @DrDeborahMD @Drlipid @DrPaulMason @nationallipid @DoctorTro @PeterAttiaMD @kevinnbass @mdavidsonmd @SethJBaumMD @Lipoprotein @lipiddoc @LipidCNS @DaveDixonPharmD @NeilFlochMD @drpablocorral @DrTomFrieden @NYTHealth @JoanneKenen @JamesTodaroMD "Canakinumab was associated with a higher incidence of fatal infection than was placebo." Long way to go. https://t.co/mccfhuwUi5

Sep 17, 2020 · 1,895 followers View post →
Dr. Spencer Nadolsky
@DrNadolsky · X

@ZKForTre @DaveKeto @gerdosi @The_Nutrivore @Gearoidmuar @erreyedoc @brianedwardsmd @johnzahorik @FatEmperor @LukeEdwards504 @julie_eye @DrDeborahMD @Drlipid @DrPaulMason @nationallipid @DoctorTro @PeterAttiaMD @kevinnbass @mdavidsonmd @SethJBaumMD @Lipoprotein @lipiddoc @LipidCNS @DaveDixonPharmD @NeilFlochMD @drpablocorral @DrTomFrieden @NYTHealth @JoanneKenen @JamesTodaroMD I think I’m gathering what the discussion is. A lot of good info about the topic in these two recent trials https://t.co/oHdluIcIvI https://t.co/HsMXVhzlmW

Sep 17, 2020 · 2 likes · 58,870 followers View post →
Tucker Goodrich
@TuckerGoodrich · X

Er... "Antiinflammatory therapy targeting the interleukin-1β innate immunity pathway... led to a significantly lower rate of recurrent cardiovascular events than placebo, independent of lipid-level lowering..." https://t.co/CXTycJSmRJ @FatEmperor @DaveKeto @siobhan_huggins

Sep 11, 2020 · 2 likes · 28,258 followers View post →
David Brenes-Castro
@DavidBrenesMD · X

10/14 anti-inflammatory rx demonstrated favorable effects w/ Canakinumab induced IL1B inhibition in the CANTOS trial; but not w/ Methotrexate in the CIRT trial https://t.co/nKjAwE3XAC https://t.co/2XAgRJWqA8

Sep 7, 2020 · 3 likes · 140 followers View post →
Maria Sokolova, MD PhD
@msokolova_rheum · X

Everybody seems to love #canakinumab Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease | NEJM https://t.co/9wMRHv8UD7

Aug 13, 2020 · 785 followers View post →
caroleth + the machine
@florencista · X

@beatricinha2 https://t.co/HIV2fDiAUt

Jun 16, 2020 · 290 followers View post →
Omar Al-Qudsi
@Oqudsi · X

@ogi_gajic @DrSamuelBrown @timothygirard @DrJMLuther @DMAronoff @toddrice_ICU @medevidenceblog Ridker has studied IL6 blocking. Statins have the same effect as a novel IL6 blocker. Less harmful than steroids as well. https://t.co/QkLvDSoSRv

Mar 19, 2020 · 1 like · 160 followers View post →
Juan Senior
@jsenior64 · X

Hasta que llegó el estudio CANTOS con Canakinumab y demostró efectos benéficos, sin embargo aumentaba la incidencia de infecciones fatales con respecto al placebo. https://t.co/l8baLpJwUW

Feb 9, 2020 · 11,065 followers View post →
Ujjwal Rastogi, MD
@UjjwalRastogiMD · X

RT @AkhmetzhanG: @ArturoGiacaman @PCRonline @Julio_Farjat @DavidLBrownMD @EuroInterventio @NEJM @Dr_DanMD @INC_CathLab @aayshacader @yeh_ja…

Dec 7, 2019 · 2 shares · 3,289 followers View post →
James Yeh
@yeh_james3 · X

RT @AkhmetzhanG: @ArturoGiacaman @PCRonline @Julio_Farjat @DavidLBrownMD @EuroInterventio @NEJM @Dr_DanMD @INC_CathLab @aayshacader @yeh_ja…

Dec 7, 2019 · 2 shares · 5,304 followers View post →
Akhmetzhan Galimzhanov
@AkhmetzhanG · X

@ArturoGiacaman @PCRonline @Julio_Farjat @DavidLBrownMD @EuroInterventio @NEJM @Dr_DanMD @INC_CathLab @aayshacader @yeh_james3 @RandyKoh24 @UjjwalRastogiMD Hi, Arturo! Agree further research would be of importance. Stratification of pts based on inflammatory biomarkers (such as CRP https://t.co/XbmifrADto) could help identify responders to colchicine. Or colchicine could have noninflammatory mechanism (but! https://t.co/sNjoJd0OgF)

Dec 7, 2019 · 7 likes · 2 shares · 808 followers View post →
Özant Helvaci
@drozant1 · X

@M_Elraggal

Nov 17, 2019 · 1 like · 574 followers View post →
Hasham Sarwar MD
@hashamsarwar · X

https://t.co/8DJuOYSbBy This trial from 2017. Antiinflammatory therapy targeting the interleukin-1β innate immunity pathway with canakinumab at a dose of 150 mg every 3 months led to lower rate of recurrent cardiovascular events than placebo, independent of lipid-level lowering.

Nov 16, 2019 · 1,365 followers View post →
Mostapha Habib Allah
@NephroMostapha · X

RT @hjanders_hans: Another trial showing benefits from targeting chronic inflammation in cardiovascular disease. Colchicine is certainly c…

Nov 16, 2019 · 6 shares · 1,540 followers View post →
Edoardo Melilli
@EdoardoMelilli · X

RT @hjanders_hans: Another trial showing benefits from targeting chronic inflammation in cardiovascular disease. Colchicine is certainly c…

Nov 16, 2019 · 6 shares · 3,262 followers View post →
Özant Helvaci
@drozant1 · X

RT @hjanders_hans: Another trial showing benefits from targeting chronic inflammation in cardiovascular disease. Colchicine is certainly c…

Nov 16, 2019 · 6 shares · 574 followers View post →
Clark H
@Clarksterh · X

@matthewherper As I’m sure you’re aware, have been other big MACE RCTs w anti-inflammatories that show similar efficacy (eg see CANTOS). And Sek showed Mendelian Rand data that inflammation genes are important in MI risk. But it doesn’t seem to change clinical practice? https://t.co/eeL1al13WU

Nov 16, 2019 · 1,371 followers View post →
Susan Bernstein
@VelvetBarstool · X

RT @hjanders_hans: Another trial showing benefits from targeting chronic inflammation in cardiovascular disease. Colchicine is certainly c…

Nov 16, 2019 · 6 shares · 1,893 followers View post →
Jochen Reiser MD PhD
@JochenReiser · X

RT @hjanders_hans: Another trial showing benefits from targeting chronic inflammation in cardiovascular disease. Colchicine is certainly c…

Nov 16, 2019 · 6 shares · 4,613 followers View post →
Annette Bruchfeld
@AnnetteBruchfe1 · X

RT @hjanders_hans: Another trial showing benefits from targeting chronic inflammation in cardiovascular disease. Colchicine is certainly c…

Nov 16, 2019 · 6 shares · 2,291 followers View post →
Hans-Joachim Anders
@hjanders_hans · X

Another trial showing benefits from targeting chronic inflammation in cardiovascular disease. Colchicine is certainly cheaper than canakinumab #CANTOS https://t.co/zlNtt37N6s https://t.co/uETaokaQcY

Nov 16, 2019 · 17 likes · 6 shares · 2,972 followers View post →
Alpha Diallo
@AlphaGuinea · X

RT @CarlosdelRio7: Canakinunab is the correct answer based on CANTOS trial published in @NEJM https://t.co/1qx6qj42Yl

Oct 20, 2019 · 1 share · 19 followers View post →
Carlos del Rio
@CarlosdelRio7 · X

Canakinunab is the correct answer based on CANTOS trial published in @NEJM https://t.co/1qx6qj42Yl

Oct 19, 2019 · 3 likes · 1 share · 55,713 followers View post →
Paul Sufka, MD
@psufka · X

@Mangan150 The CANTOS study (using anti-IL-1) supports the role of inflammation in CVD https://t.co/JlIGuuHGX2

Jul 6, 2019 · 2 likes · 8,340 followers View post →
Paul Sufka, MD
@psufka · X

@EBRheum You mean IL-1 worked for CVD.... CANTOS. https://t.co/JlIGuuq65u

Jul 5, 2019 · 3 likes · 8,340 followers View post →
Paul Sufka, MD
@psufka · X

(A quick aside: blockage of this innate immune response is likely why the following studies showed positive results: - CANTOS - using IL-1 https://t.co/JlIGuuq65u - LoDoCo - using colchicine https://t.co/bdUIOqezRI ) /7

Mar 20, 2019 · 2 likes · 8,340 followers View post →
แมว(ไม่ว่างแล้ว)ในจักรวาล
@RaviponSH · X

https://t.co/T22cv8agjJ

Mar 7, 2019 · 206 followers View post →
movedoc
@movedoc · X

Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease | NEJM https://t.co/bTNEOwbu6n

Jan 3, 2019 · 485 followers View post →