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The overall discourse emphasizes the importance of the gene mutation, with comments mentioning 7-year increased lifespan, lower diabetes risk, and the role of PAI-1 in aging, demonstrating strong agreement and high interest. The tone is scientific yet accessible, reflecting curiosity about genetic aging mechanisms and their implications for health and longevity.
Most discussions support the findings, highlighting the connection between the mutation and increased lifespan.
Posts demonstrate high curiosity about the mutation's effects and implications for aging.
Many individuals reference specific details like lifespan extension and genetic factors, showing active engagement.
The widespread recognition of genetic influences on aging suggests significant potential for future research and therapies.
People with a genetic mutation leading to lower clotting activity live on average 7 years longer than others. Low clotting activity -> longer life and better health https://t.co/jgakXpHyQv
People with a genetic mutation that gives them lower PAI-1 levels have longer leukocyte telomere length, lower fasting insulin levels, less diabetes, and live on average 7 years longer. That's how important PAI-1 is. https://t.co/Sbs0UyeGhz
@DiogoSnows @calleymeans @kirillzubovsky I had a similar question. I found that their current lifespan is similar to American Caucasians, however they used to live longer up until the non-Amish caught up around the middle of the 20th century. Also of note, they have a high rate of this mutation: https://t.co/Kq9k0vGkrm
A null mutation in the gene that encodes PAI-1 is associated with *7 years* longer lifespan. This is in an Amish community. They also have no diabetes. https://t.co/jgakXpHyQv
A null mutation in SERPINE1 protects against biological aging in humans (2017) https://t.co/2zDavvL4na @ScienceAdvances https://t.co/DXwjRehIYr
@jakescottMD Good thread. I appreciate that you still noted they have good longevity. Another factor you didn't mention is that the limited gene pool of the initial Amish population led to a widespread gene mutation that likely lengthens their life. https://t.co/BkVEpkAcu6
The video explores the recent clinical trial results of ET-02 as a potential breakthrough for hair loss treatment, highlighting scientific insights and the therapeutic implications of targeting PAI1 in aging and related…
A null mutation in the SERPINE1 gene protects against biological aging in humans. Studies in humans and mice suggest that inhibiting or deleting PAI1 can prevent aging-related issues and extend lifespan.
@jakescottMD Good thread. I appreciate that you still noted they have good longevity. Another factor you didn't mention is that the limited gene pool of the initial Amish population led to a widespread gene mutation that likely lengthens their life. https://t.co/BkVEpkAcu6
@mike_lustgarten https://t.co/Sbs0UyeGhz
@thomson_free https://t.co/d2LuEry2y9
@FitFastCoach The study: https://t.co/2YldEOVc5E
@bhan_ban @ChampoDr Vrai pour les Amish qui ont une mutation spécifique du gène Serpine1. Pas tous les amish https://t.co/WjiaDuAb4G
People with a genetic mutation that gives them lower PAI-1 levels have longer leukocyte telomere length, lower fasting insulin levels, less diabetes, and live on average 7 years longer. That's how important PAI-1 is. https://t.co/Sbs0UyeGhz
RT @Mangan150: A null mutation in the gene that encodes PAI-1 is associated with *7 years* longer lifespan. This is in an Amish community.…
@DiogoSnows @calleymeans @kirillzubovsky I had a similar question. I found that their current lifespan is similar to American Caucasians, however they used to live longer up until the non-Amish caught up around the middle of the 20th century. Also of note, they have a high rate of this mutation: https://t.co/Kq9k0vGkrm
@pangyre thankfully my flash drive was handy; amish slower mutation rate likely due to enviro. other articles noting said mutations; https://t.co/CCgoTPqz11 / https://t.co/1yu21ghHca / https://t.co/XOUF5VgHSx / / https://t.co/2YCfJzRaNo
RT @agingdoc1: A null mutation in SERPINE1 protects against biological aging in humans (2017) https://t.co/2zDavvL4na @ScienceAdvances ht…
A null mutation in SERPINE1 protects against biological aging in humans (2017) https://t.co/2zDavvL4na @ScienceAdvances https://t.co/DXwjRehIYr
@no_vacruniado Seguro? Tu sabes lo que es el síndrome de Angelman? Sabes lo que es la mutación Serpine1? Toma un Informe de los Amish "De los que no existen" Más tarado y no naces. https://t.co/yXTzo1z51R
@stkirsch @JayBarlowBot @Liz_Wheeler No. A genetic mutation gives some of them an advantage - see https://t.co/4Kd2sTVsFX. However, the overall life expectancy of the Amish community is the same as the general population - see https://t.co/AbumkoIJ3i
RT @spokespun: @stadtwildnis @SocratesPoly @WheatPM there are some exceptions, like there's one Amish community in Indiana that carries a g…
@stadtwildnis @SocratesPoly @WheatPM there are some exceptions, like there's one Amish community in Indiana that carries a genetic mutation that actually does allow them live longer (also due to inbreeding). but across the country, on average, they live shorter lives. https://t.co/BPk4HaCMO6
RT @benjileibo: @HairDAO_ It's the PAI1 superpower https://t.co/tCdaGrw5Ur
@HairDAO_ It's the PAI1 superpower https://t.co/tCdaGrw5Ur
RT @Mangan150: People with a genetic mutation leading to lower clotting activity live on average 7 years longer than others. Low clotting…
RT @Mangan150: People with a genetic mutation leading to lower clotting activity live on average 7 years longer than others. Low clotting…
RT @Mangan150: People with a genetic mutation leading to lower clotting activity live on average 7 years longer than others. Low clotting…
People with a genetic mutation leading to lower clotting activity live on average 7 years longer than others. Low clotting activity -> longer life and better health https://t.co/jgakXpHyQv
A null mutation in the gene that encodes PAI-1 is associated with *7 years* longer lifespan. This is in an Amish community. They also have no diabetes. https://t.co/jgakXpHyQv
Science Advances 3 [ 2017 ] , doi: 10.1126/sciadv.aao1617). 47. N. Wade, "Japon Bilim Adamları Kulak Kiri Genini Tanımladı", New York Times , 29 Ocak, 2006 ...
DOI: 10.1126/sciadv.aao1617 · PREVIOUS ARTICLE. Rapid, directed transport of DC-SIGN clusters in the plasma membrane. Previous · NEXT ARTICLE. Measuring ...
https://www.science.org/doi/10.1126/sciadv.aao1617 · https://news.feinberg.northwestern.edu/2017/11/amish-longevity-may-be-due-to-genetic ...
A null mutation in SERPINE1 protects against biological aging in humans. Science Advances, 15 Nov 2017 DOI: 10.1126/sciadv.aao1617. Source- ...
Source: Science Advances 15 Nov 2017 DOI: 10.1126/sciadv.aao1617 A null mutation in SERPINE1 protects against biological aging in humans.
... 10.1126/sciadv.aao1617. 打赏. First slide 引领行业 | 聚焦麦特绘谱代谢组学整体解决方案>> · First slide 「大小鼠繁育与健康管理」指导海报，点击 ...
Published online November 15 2017 doi:10.1126/sciadv.aao1617. Feel free to share this Neuroscience News. Join our Newsletter. Thank you for ...
Original Study DOI: 10.1126/sciadv.aao1617. Related. Tech use may benefit older adults' well-being · Can the secret of these whales' long lives ...
... 10.1126/sciadv.aao1617). (Science Advances/ Northwestern University, 16.11.2017 – DAL). 16. November 2017. Keine Meldungen mehr verpassen – mit ...
DOI: 10.1126/sciadv.aao1617. Link: http://advances.sciencemag.org/content/3/11/eaao1617. Abstract. Plasminogen activator inhibitor–1 (PAI-1) ...
“There are numerous groups that may benefit from a drug blocking PAI-1,” says Vaughan. Science Advances DOI: 10.1126/sciadv.aao1617. Read ...
Khan et al. ,. A null mutation in SERPINE1 protects against biological aging in humans.Sci. Adv.3,eaao1617(2017).DOI:10.1126/sciadv.aao1617 ...
10.1126/sciadv.aao1617. Keywords. /Life sciences/Biochemistry/Biomolecules/Nucleic acids/DNA/Chromosomes/Chromosome structure/Telomeres ...
10.1126/sciadv.aao1617. Keywords. /Life sciences/Biochemistry/Biomolecules/Nucleic acids/DNA/Chromosomes/Chromosome structure/Telomeres ...
A null mutation in SERPINE1 protects against biological aging in humans. Science Advances, 15 Nov 2017 DOI: 10.1126/sciadv.aao1617. Cite This ...
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