J Hepatol May 2018 PMID 29408694

Fructose and sugar: A major mediator of non-alcoholic fatty liver disease.

Thomas Jensen, Manal F Abdelmalek, Shelby Sullivan, Kristen J Nadeau, Melanie Green, Carlos Roncal, Takahiko Nakagawa, Masanari Kuwabara, Yuka Sato, Duk-Hee Kang, Dean R Tolan, Laura G Sanchez-Lozada, Hugo R Rosen, Miguel A Lanaspa, Anna Mae Diehl

Mentions

122
Peak: 15 in May 2024
across 6 sources since Jan 2019

Extended reach

1,339,861
potential audience

Total likes

3,837

Video views

291,638

Mentions per month

Jan 2019 – Jan 2026

Where it's discussed

  • X / Twitter50 posts
  • News50 articles
  • Facebook14 posts
  • YouTube5 videos
  • Blogs2 articles
  • Bluesky1 posts

AI synopsis

What people are saying

Overall, the discussions reflect strong agreement and interest, with posters referencing scientific articles and health recommendations, such as noting that added sugars overload the liver and link to fatty liver disease, which indicates both curiosity and significant perceived impact of the research.

AgreementStrong agreement

The majority of discussions support the article’s claims about the negative effects of fructose and sugar on liver health, emphasizing the role of sugar in NAFLD.

InterestHigh interest

Many posts reference specific scientific studies and health implications, showing high curiosity about the topic.

EngagementHigh engagement

Posts include detailed explanations, references to studies, and calls for moderation, indicating deep involvement in the subject.

ImpactHigh impact

The discussions highlight significant concern about sugar intake and its health consequences, demonstrating awareness of the issue’s importance.

Abstract in brief

  • Nonalcoholic fatty liver disease (NAFLD) is closely linked to metabolic syndrome, and its rise is associated with increased obesity and diabetes, with high sugar diets playing a key role.
  • Fructose from sugar and high-fructose corn syrup contributes to fat buildup in the liver by boosting fat creation (lipogenesis) and reducing fat breakdown, primarily through its metabolism involving fructokinase C, which leads to uric acid production.
  • Limiting sugary drinks and fructose intake may help reduce liver fat, but more large-scale studies are needed to determine if decreasing sugar consumption or blocking uric acid production can prevent NAFLD and its serious liver complications.]

Top posts

Most liked on X and Bluesky
P.D. Mangan Health & Freedom Maximalist
@Mangan150 · X

Fructose and sugar: A major mediator of non-alcoholic fatty liver disease NAFLD is another disease, like type 2 diabetes, that shouldn't exist https://t.co/3mOloAHmJn

May 10, 2024 · 62 likes · 10 shares · 291,059 followers View post →
P.D. Mangan Health & Freedom Maximalist
@Mangan150 · X

Fructose and sugar: A major mediator of non-alcoholic fatty liver disease Sugary drinks appear to be a major factor. https://t.co/RBwJGRtfPM

May 4, 2021 · 26 likes · 6 shares · 291,059 followers View post →
Francis Deng, MD
@francisdeng · X

@DrHarryThomas @marklewismd "Fructose and sugar: A major mediator of non-alcoholic fatty liver disease" J Hepatol 2018 https://t.co/gtMXql8R2T https://t.co/qm6q2Njd7K

May 7, 2020 · 6 likes · 2 shares · 16,844 followers View post →
TheLiverDoc™
@theliverdr · X

@Raghu_Techguy @leftyaright @ShahabJafri55 I love playing with little illiterate Twitter puppies like you. "Sugarcane is high in a type of natural sugar called sucrose." https://t.co/xVQheXKwub https://t.co/eJegcy1CsB

May 26, 2023 · 5 likes · 312,988 followers View post →
Thomas Dunson
@DavidL_Hunt · X

@AustinAyotte @davidasinclair @CalvinAyre https://t.co/bpH70ucdsp

Dec 16, 2021 · 4 likes · 158 followers View post →
Agingdoc
@agingdoc1 · X

Fructose and sugar: A major mediator of non-alcoholic fatty liver disease (2018) https://t.co/n6MXeLs8Wj

May 10, 2024 · 3 likes · 2 shares · 41,221 followers View post →

All mentions

David Collier
@davidacollier.bsky.social · Bluesky

HFCS contains a slightly higher ratio of fructose to glucose than cane sugar. Since fructose is metabolised directly by the liver, unlike sucrose, it can lead to fat accumulation. A slightly higher level of fructose seems enough to increase the risk of this. pubmed.ncbi.nlm.nih.gov/29408694/

Jul 30, 2025 · 1 share View post →
Inimicus Ignorantiae
@LegalEzra · X

RT @Maina_Poultry: @LegalEzra @inglorious_bat @SeweS_ @joeruturi @WamathaiKamara @Double_____O Yes. Anything that might depress liver funct…

Jul 29, 2025 · 1 share · 3,537 followers View post →
Chief Jogoo Castrator and Mĩera Inseminator (PhD)
@Maina_Poultry · X

@LegalEzra @inglorious_bat @SeweS_ @joeruturi @WamathaiKamara @Double_____O Yes. Anything that might depress liver function should be taken with extreme moderation. Kwanza you may look fit and all healthy but the sugar messed your liver now it looks like moderately fried eggs! Read more here: https://t.co/ALR7fRcB8y https://t.co/CscOQataDS

Jul 29, 2025 · 1 like · 1 share · 7,844 followers View post →
Claus Carlsen
@ClausCarlsen1 · X

@mikeoniron @Thermobolic Easy to find the information. Pubmed has a +2000 articles and studies just in the last decade. Here's one: https://t.co/bfxpaj1uer Here's another video in popularised language: https://t.co/hhutGOrU5D

Oct 31, 2024 · 1 like · 15,702 followers View post →
David Childress
@David91027655 · X

Fructose and sugar: A major mediator of non-alcoholic fatty liver disease https://t.co/O7lJ8BfsjW

Jun 11, 2024 · 3 likes · 2,458 followers View post →
Claus Carlsen
@ClausCarlsen1 · X

@Mqsley @mdredpillawake @mikeoniron Oh look: https://t.co/bfxpaj1uer

May 12, 2024 · 2 likes · 15,702 followers View post →
Bensther DF
@BenstherDf · X

RT @Mangan150: Fructose and sugar: A major mediator of non-alcoholic fatty liver disease NAFLD is another disease, like type 2 diabetes, t…

May 11, 2024 · 10 shares · 145 followers View post →
Mind Your Science!
@MindYourSci · X

RT @agingdoc1: Fructose and sugar: A major mediator of non-alcoholic fatty liver disease (2018) https://t.co/n6MXeLs8Wj

May 11, 2024 · 2 shares · 133 followers View post →
Tony Scott
@DIY_Tardis · X

RT @Mangan150: Fructose and sugar: A major mediator of non-alcoholic fatty liver disease NAFLD is another disease, like type 2 diabetes, t…

May 10, 2024 · 10 shares · 1,629 followers View post →
Bow Hunter
@HunterGirlSoul · X

RT @Mangan150: Fructose and sugar: A major mediator of non-alcoholic fatty liver disease NAFLD is another disease, like type 2 diabetes, t…

May 10, 2024 · 10 shares · 1,903 followers View post →
Kmidjr
@kmidjr68 · X

RT @Mangan150: Fructose and sugar: A major mediator of non-alcoholic fatty liver disease NAFLD is another disease, like type 2 diabetes, t…

May 10, 2024 · 10 shares · 1,752 followers View post →
Igor Lekic
@IgorLekicc · X

RT @agingdoc1: Fructose and sugar: A major mediator of non-alcoholic fatty liver disease (2018) https://t.co/n6MXeLs8Wj

May 10, 2024 · 2 shares · 67 followers View post →
Agingdoc
@agingdoc1 · X

Fructose and sugar: A major mediator of non-alcoholic fatty liver disease (2018) https://t.co/n6MXeLs8Wj

May 10, 2024 · 3 likes · 2 shares · 41,221 followers View post →
Markus Lehtonen
@MarkusLehtone14 · X

RT @Mangan150: Fructose and sugar: A major mediator of non-alcoholic fatty liver disease NAFLD is another disease, like type 2 diabetes, t…

May 10, 2024 · 10 shares · 91 followers View post →
PC ⛓
@PC65049955 · X

RT @Mangan150: Fructose and sugar: A major mediator of non-alcoholic fatty liver disease NAFLD is another disease, like type 2 diabetes, t…

May 10, 2024 · 10 shares · 1,476 followers View post →
Kim Mello
@KMello314 · X

RT @Mangan150: Fructose and sugar: A major mediator of non-alcoholic fatty liver disease NAFLD is another disease, like type 2 diabetes, t…

May 10, 2024 · 10 shares · 515 followers View post →
Vivia Sthel
@vivia_sthel · X

RT @Mangan150: Fructose and sugar: A major mediator of non-alcoholic fatty liver disease NAFLD is another disease, like type 2 diabetes, t…

May 10, 2024 · 10 shares · 202 followers View post →
Mahito L'apostolos
@OMaMihai · X

RT @Mangan150: Fructose and sugar: A major mediator of non-alcoholic fatty liver disease NAFLD is another disease, like type 2 diabetes, t…

May 10, 2024 · 10 shares · 304 followers View post →
P.D. Mangan Health & Freedom Maximalist
@Mangan150 · X

Fructose and sugar: A major mediator of non-alcoholic fatty liver disease NAFLD is another disease, like type 2 diabetes, that shouldn't exist https://t.co/3mOloAHmJn

May 10, 2024 · 62 likes · 10 shares · 291,059 followers View post →
KetoKweenCooks
@KetoKweenCooks · X

@PatsyDiabetes @ZenQueen_zen @DikemanDave Sugar drives The Metabolic Syndrome. You can engage in a play on words, but sugar is a major driver of multiple metabolic disorders including but not limited to fatty liver disease, T2D, CVD, obesity, autoimmune diseases, PCOS & some cancer’s for starters. https://t.co/QhnbS52h2t

Nov 18, 2023 · 2 likes · 148 followers View post →
Bryan Krantz
@bakrantz · X

@JamesStanard @KenDBerryMD Fructose and NAFLD https://t.co/FNH1sUP4Bg

Nov 11, 2023 · 765 followers View post →
TheLiverDoc™
@theliverdr · X

@Raghu_Techguy @leftyaright @ShahabJafri55 I love playing with little illiterate Twitter puppies like you. "Sugarcane is high in a type of natural sugar called sucrose." https://t.co/xVQheXKwub https://t.co/eJegcy1CsB

May 26, 2023 · 5 likes · 312,988 followers View post →
ごりおし職人
@GORIOSIshokunin · X

お腹の脂肪が落ちない人の残念な3つの特徴 https://t.co/46f0h6UJrH @YouTubeより

May 19, 2023 · 33 followers View post →
KTR_FUKUOKA
@KTR_FUKUOKA · X

【衝撃の事実】身体を変えたいなら「和菓子」は食べるな https://t.co/iUftbw7iSe やっぱり芋か米

May 1, 2023 · 1 like · 630 followers View post →
fabrice☭AntifaSince2005
@fabricedelamort · X

https://t.co/vnQQqV9ENc これ!! こういうお話を待ってた!! というか最近の #和菓子 って「糖質控えめ脂肪分マシマシ」になってますよね これ前言ったように「必ずしも糖質ばかり摂っとけば体に良いわけではない」ことが #アメリカ で歴史的にわかってるから

Apr 30, 2023 · 1 like · 2,405 followers View post →
タカサン
@bubublackvezel · X

【衝撃の事実】身体を変えたいなら「和菓子」は食べるな https://t.co/84emfdhunr @YouTube

Apr 29, 2023 · 232 followers View post →
シオン
@IRON_BULE · X

【衝撃の事実】身体を変えたいなら「和菓子」は食べるな https://t.co/Gl4edQ5uDX @YouTubeより

Apr 29, 2023 · 581 followers View post →
トレマニ
@training_mania5 · X

お腹の脂肪が落ちない人の残念な3つの特徴 https://t.co/J73R0jsJJP @YouTubeより

Mar 29, 2023 · 2 followers View post →
Rue Merlot
@EtRueMerlot · X

@MDNOShaughnessy Sugar definitely can kill your liver- high sugar diets are basically the reason we had to invent the new category of Non-Alcoholic Fatty Liver Disease https://t.co/FeUMWmJfzK

Jan 20, 2023 · 1 like · 195 followers View post →
Theresa Furey May
@Theresa_May_PhD · X

@gorlando5 @NanaVotesDem @DrFrankLipman Don’t know what you were search but took <1 min, https://t.co/QyaDzY0zz7

Oct 21, 2022 · 1,188 followers View post →
MJ Evers
@evers_mj · X

RT @CatheeAli: @FrontiersIn Thoughts? @RobertLustigMD https://t.co/LhtuE3Eryb.

Sep 19, 2022 · 1 share · 308 followers View post →
Dr Cathee Ali
@CatheeAli · X

@FrontiersIn Thoughts? @RobertLustigMD https://t.co/LhtuE3Eryb.

Sep 15, 2022 · 3 likes · 1 share · 543 followers View post →
الـLee
@alithej · X

@moheb1414 در سال ٢٠٠٥ مصرف فروكتوز در صنعت غذاى امريكا بخاطر تاثيرش رو كبد محدود شد، قندى كه قند اصليه ميوه هست و قبل ٢٠٠٥ چون فكر ميكردن رژيمى هست استفاده زيادى داشت، چيزى كه الان ايران درگيرشه https://t.co/IxYZNOVkTP https://t.co/LxUoyKV8DQ https://t.co/zhGaL8m59s

Jan 28, 2022 · 2,010 followers View post →
DrRPalmquist
@DrPalmquist · X

Fructose and sugar: A major mediator of non-alcoholic fatty liver disease - Journal of Hepatology https://t.co/egHPeunATg

Dec 24, 2021 · 1 like · 3,161 followers View post →
Thomas Dunson
@DavidL_Hunt · X

@AustinAyotte @davidasinclair @CalvinAyre https://t.co/bpH70ucdsp

Dec 16, 2021 · 4 likes · 158 followers View post →
André Calero Valdez
@Sumidu · X

@DoDoDoBtch @daspiefkelein @Dr_Emergencydoc Zucker besteht zu 50% aus Fruktose und muss daher über die Leber verstoffwechselt werden und führt zu Leberverfettung https://t.co/4sbw60MsME. Die WHO empfiehlt maximal 5% der Kalorien über Zucker zu decken (https://t.co/JfuvfuI4S9). Die WHO ist sicherlich eher konservativ.

Nov 3, 2021 · 617 followers View post →
naimsufi
@naeeemmm · X

references: 1) https://t.co/NE2FcHq13i 2) https://t.co/lpvL8C3V6M 3) https://t.co/DtS1CRsIRe 4) https://t.co/KEYYhkR3gP 5) https://t.co/bapDeRxCZL 6) https://t.co/nuvkQULntD 7) https://t.co/niqTupXnGn

Jul 24, 2021 · 1 like · 1 share · 2,191 followers View post →
Sure Tips Lord
@Sure_Tips_Lord · X

Large amounts of added sugar in the form of fructose overload your liver, leading to non-alcoholic fatty liver disease (NAFLD), a condition characterized by excessive fat buildup in the liver (Source (https://t.co/QsnbXvxvZz)).

May 7, 2021 · 166 followers View post →
I don't know much
@paquibena · X

RT @Mangan150: Fructose and sugar: A major mediator of non-alcoholic fatty liver disease Sugary drinks appear to be a major factor. http…

May 5, 2021 · 6 shares · 266 followers View post →
MK
@KhameemrK · X

RT @Mangan150: Fructose and sugar: A major mediator of non-alcoholic fatty liver disease Sugary drinks appear to be a major factor. http…

May 4, 2021 · 6 shares · 1,055 followers View post →
H Nairobian
@HNairobian · X

RT @Mangan150: Fructose and sugar: A major mediator of non-alcoholic fatty liver disease Sugary drinks appear to be a major factor. http…

May 4, 2021 · 6 shares · 33 followers View post →
MR
@moonjr4x1 · X

RT @Mangan150: Fructose and sugar: A major mediator of non-alcoholic fatty liver disease Sugary drinks appear to be a major factor. http…

May 4, 2021 · 6 shares · 306 followers View post →
P.D. Mangan Health & Freedom Maximalist
@Mangan150 · X

Fructose and sugar: A major mediator of non-alcoholic fatty liver disease Sugary drinks appear to be a major factor. https://t.co/RBwJGRtfPM

May 4, 2021 · 26 likes · 6 shares · 291,059 followers View post →
Mishka
@BoredMishka · X

@NowhereTOR22 @BioLayne https://t.co/ZshzXq4tjv https://t.co/6m85VWyW95 https://t.co/oU41JpFoWD

Apr 21, 2021 · 23 followers View post →
Pribadi
@kakakamri · X

RT @francisdeng: @DrHarryThomas @marklewismd "Fructose and sugar: A major mediator of non-alcoholic fatty liver disease" J Hepatol 2018 htt…

May 7, 2020 · 2 shares · 856 followers View post →
Steven Bollipo
@stevenbollipo · X

RT @francisdeng: @DrHarryThomas @marklewismd "Fructose and sugar: A major mediator of non-alcoholic fatty liver disease" J Hepatol 2018 htt…

May 7, 2020 · 2 shares · 16,622 followers View post →
Francis Deng, MD
@francisdeng · X

@DrHarryThomas @marklewismd "Fructose and sugar: A major mediator of non-alcoholic fatty liver disease" J Hepatol 2018 https://t.co/gtMXql8R2T https://t.co/qm6q2Njd7K

May 7, 2020 · 6 likes · 2 shares · 16,844 followers View post →
DrRPalmquist
@DrPalmquist · X

Fructose and Sugar: A Major Mediator of Non-Alcoholic Fatty Liver Disease - PubMed https://t.co/rEufiJNmzy

Mar 22, 2020 · 3,161 followers View post →
HealthPimp | Healthcare Marketing & Design
@Healthpimp1 · X

https://t.co/hUji6rsdOK - Fructose and sugar: A major mediator of non-alcoholic fatty liver disease. - submitted by /u/Waterrat [link] [comments] - Follow us for more! https://t.co/dcNrOhF5YP

Dec 14, 2019 · 23 followers View post →
Mira Behn
@tbdnonymous · X

@Forbes If you are a health-conscious person who found this article interesting, you may also want to read this peer reviewed paper released last year: Fructose and sugar: A major mediator of non-alcoholic fatty liver disease. https://t.co/Jz3ZIchbKa

Jun 18, 2019 · 1 like · 2,582 followers View post →
Diabetes Research WA
@TheDRFWA · X

Fructose and sugar: A major mediator of non-alcoholic fatty liver disease. - PubMed - NCBI https://t.co/SV7ExYztVw

Jan 29, 2019 · 1,038 followers View post →