PubHawk
Nat Chem June 2018 PMID 29686376

I-motif DNA structures are formed in the nuclei of human cells.

Mahdi Zeraati, David B Langley, Peter Schofield, Aaron L Moye, Romain Rouet, William E Hughes, Tracy M Bryan, Marcel E Dinger, Daniel Christ

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Mentions

140
Peak: 3 in Apr 2025
across 6 sources since Apr 2018

Extended reach

172,739
potential audience

Total likes

3,253

Video views

124,719

Mentions per month

Apr 2018 – Apr 2025

Where it's discussed

  • News72 articles
  • Facebook29 posts
  • Blogs23 articles
  • X / Twitter9 posts
  • Reddit5 posts
  • YouTube2 videos

AI synopsis

What people are saying

Several social discussions emphasize the potential regulatory importance of i-motif DNA structures, illustrated by phrases like 'important for proteins in the cell to recognise their DNA sequence' and 'transformative potential for gene regulation.' The tone varies from scientific curiosity to excitement about novel DNA conformations, reflecting a shared recognition of the study's significance.

AgreementModerate agreement

Most discussions acknowledge the significance of the findings, especially in highlighting regulatory roles and the formation of i-motif structures in cell nuclei.

InterestHigh interest

Posts show high enthusiasm and curiosity, with many referencing detailed aspects like antibody detection and structural features.

EngagementModerate engagement

Comments include references to the implications for DNA recognition and gene regulation, indicating active involvement and thoughtfulness.

ImpactModerate impact

There is a shared belief that discovering these structures could influence future research in genetics and cell biology, suggesting moderate to high potential impact.

Abstract in brief

  • Imotif DNA structures form in the nuclei of human cells, especially in cytosine-rich regions, and are believed to play regulatory roles, but direct evidence has been limited.
  • Researchers developed an antibody fragment called iMab that specifically detects imotif structures in living human cells, showing their formation depends on the cell cycle and pH.
  • The study finds that imotif structures appear in critical genomic areas like promoters and telomeres, suggesting they are important for regulating gene activity.]
Read the full abstract

Top posts

Most liked on X and Bluesky
Lifeboat Foundation
@LifeboatHQ · X

I-motif DNA structures are formed in the nuclei of human cells https://t.co/6iwfE1ZLM5

Apr 18, 2025 · 2 likes · 2 shares · 31,351 followers View post →
GenScript
@GenScript · X

An i-motif is a DNA structure formed by stacking intercalated hemiprotonated C-neutral C base pairs formed in the nuclei of human cells. #DNAFunFacts #DNAStructure #iMotif DOI: https://t.co/NHoK58kxra, Photo credit: Zeraati, M., Langley, D.B., Schofield, P. et al https://t.co/NeMx0iop0R

Oct 28, 2020 · 8,590 followers View post →
tin⁷ -very ia-
@monohopeagustd_ · X

@hopeARMY4ever @jooniestk @BTS_twt "it’s called i-motif and has been described as “a four-stranded knot of DNA”. "these alternative DNA conformations might be important for proteins in the cell to recognise their cognate DNA sequence and exert their regulatory functions," Zeraati et al. https://t.co/logLBw4Kz1 https://t.co/nIJ1zhMbrK

May 10, 2020 · 4,582 followers View post →
Naomi Attar
@naomiattar · X

I-motif DNA structures are formed in the nuclei of human cells https://t.co/viO4CRUghk

Mar 1, 2019 · 1,243 followers View post →
DNA nanotech papers
@dnananopapers · X

I-motif DNA structures are formed in the nuclei of human cells. https://t.co/ZJcewvfljQ

May 6, 2019 · 994 followers View post →
BreakthroughMedicine&AdvancedResearchTools
@JayChance12 · X

RT @LifeboatHQ: I-motif DNA structures are formed in the nuclei of human cells https://t.co/6iwfE1ZLM5

Apr 19, 2025 · 2 shares · 634 followers View post →

All mentions

CivilisatioTransform
@CapabilitYes · X

RT @LifeboatHQ: I-motif DNA structures are formed in the nuclei of human cells https://t.co/6iwfE1ZLM5

Apr 19, 2025 · 2 shares · 240 followers View post →
BreakthroughMedicine&AdvancedResearchTools
@JayChance12 · X

RT @LifeboatHQ: I-motif DNA structures are formed in the nuclei of human cells https://t.co/6iwfE1ZLM5

Apr 19, 2025 · 2 shares · 634 followers View post →
Lifeboat Foundation
@LifeboatHQ · X

I-motif DNA structures are formed in the nuclei of human cells https://t.co/6iwfE1ZLM5

Apr 18, 2025 · 2 likes · 2 shares · 31,351 followers View post →
Pub.Reading
@PubReading · X

Listen to PubReading [44] - I-motif DNA structures are formed in the nuclei of human cells - M. Zeraati, D. Christ et al. https://t.co/cHef3b7qo6 @rss @Mahdi__Zeraati #UNSWBABS #IMotif #Nuclei #iMab #PubReading

Oct 26, 2021 · 95 followers View post →
GenScript
@GenScript · X

An i-motif is a DNA structure formed by stacking intercalated hemiprotonated C-neutral C base pairs formed in the nuclei of human cells. #DNAFunFacts #DNAStructure #iMotif DOI: https://t.co/NHoK58kxra, Photo credit: Zeraati, M., Langley, D.B., Schofield, P. et al https://t.co/NeMx0iop0R

Oct 28, 2020 · 8,590 followers View post →
tin⁷ -very ia-
@monohopeagustd_ · X

@hopeARMY4ever @jooniestk @BTS_twt "it’s called i-motif and has been described as “a four-stranded knot of DNA”. "these alternative DNA conformations might be important for proteins in the cell to recognise their cognate DNA sequence and exert their regulatory functions," Zeraati et al. https://t.co/logLBw4Kz1 https://t.co/nIJ1zhMbrK

May 10, 2020 · 4,582 followers View post →
DNA nanotech papers
@dnananopapers · X

I-motif DNA structures are formed in the nuclei of human cells. https://t.co/ZJcewvfljQ

May 6, 2019 · 994 followers View post →
taqpolimeraz
@taqpolimeraz · X

I-motif DNA structures are formed in the nuclei of human cells https://t.co/XhRnMTdVSJ https://t.co/mJAcBTSPNa

Mar 19, 2019 · 279 followers View post →
Naomi Attar
@naomiattar · X

I-motif DNA structures are formed in the nuclei of human cells https://t.co/viO4CRUghk

Mar 1, 2019 · 1,243 followers View post →