Ribosome Stoichiometry: From Form to Function.

Edward Emmott, Marko Jovanovic, Nikolai Slavov

February 2019 Trends Biochem Sci

Synopsis of Social media discussions

The participants collectively show strong interest and agreement by discussing the potential of specialized ribosomes to regulate protein synthesis, with mentions of advanced techniques like mass spectrometry and sequencing. The tone is inquisitive and optimistic, emphasizing the transformative potential of the research and its role in unlocking new cellular insights.

A
Agreement
 Moderate agreement

Most discussions express support and recognition of the importance of understanding ribosome diversity, indicating general agreement with the article's premise.

I
Interest
 High level of interest

Posts show high interest by highlighting methods, implications, and significance of research on specialized ribosomes.

E
Engagement
 Moderate level of engagement

Comments include mentions of sequencing techniques and future research directions, reflecting active engagement.

I
Impact
 Moderate level of impact

The posts suggest that this research could influence future studies and understanding of cellular translation mechanisms, indicating moderate impact.

Social Mentions

YouTube

2 Videos

Facebook

2 Posts

Twitter

6 Posts

Metrics

Video Views

1,796

Total Likes

35

Extended Reach

14,429

Social Features

10

Timeline: Posts about article

Top Social Media Posts

Posts referencing the article

Ribosome Composition and Its Role in Protein Synthesis Regulation

Ribosome Composition and Its Role in Protein Synthesis Regulation

This talk provides a historical overview and summarizes findings on ribosomal protein variability across different conditions, highlighting how changes in ribosome composition may regulate protein synthesis and cellular function.

Nikolai Slavov

September 14, 2016

1,185 views

Quantifying Proteoforms Using HIquant in Proteomics Research

Quantifying Proteoforms Using HIquant in Proteomics Research

Presentation by Nikolai Slavov at the Broad Institute Computational Seminar. The HIquant algorithm was developed to accurately quantify proteoform stoichiometries by avoiding peptide-specific biases in mass spectrometry data, aiding in understanding protein diversity and function.

Nikolai Slavov

November 24, 2018

611 views

  • Dave Grawoig, Ph.D.
    @grawoig (Twitter)

    RT @ribosomopathy: Ribosome Stoichiometry: From Form to Function. https://t.co/KjfUS0Lg3J
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    April 13, 2019

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  • Victor Zegarra
    @zegarrv (Twitter)

    RT @ribosomopathy: Ribosome Stoichiometry: From Form to Function. https://t.co/KjfUS0Lg3J
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    April 13, 2019

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  • CHARETTE LAB
    @ribosome_asmbly (Twitter)

    RT @ribosomopathy: Ribosome Stoichiometry: From Form to Function. https://t.co/KjfUS0Lg3J
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    April 13, 2019

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  • ribosomopathy_papers
    @ribosomopathy (Twitter)

    Ribosome Stoichiometry: From Form to Function. https://t.co/KjfUS0Lg3J
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    April 13, 2019

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  • CHARETTE LAB
    @ribosome_asmbly (Twitter)

    RT @edemmott: In this companion to our 'Ribosome Stoichiometry: From Form to Function' article, we outline some of the sequencing and #Mass…
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    February 19, 2019

    1

  • Ed Emmott
    @edemmott (Twitter)

    In this companion to our 'Ribosome Stoichiometry: From Form to Function' article, we outline some of the sequencing and #MassSpec approaches to characterize specialized ribosomes and their impact on translation. You can find our earlier article here: https://t.co/daiM2GHEZd
    view full post

    February 18, 2019

    5

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Abstract Synopsis

  • Recent research using advanced techniques like mass spectrometry has revealed that eukaryotic ribosomes can have different compositions of ribosomal proteins (RPs), which may regulate how proteins are synthesized.
  • These variations in RP stoichiometry, along with numerous protein modifications, create many distinct proteoforms that could act as a "ribosome code" to fine-tune translation and enhance cellular function.
  • The article discusses the potential benefits of specialized ribosomes, the methods to study their composition and function, and suggests directions for future research to better understand how ribosome diversity influences protein production.]