Association of Triglyceride-Lowering LPL Variants and LDL-C-Lowering LDLR Variants With Risk of Coronary Heart Disease.

Brian A Ference, John J P Kastelein, Kausik K Ray, Henry N Ginsberg, M John Chapman, Chris J Packard, Ulrich Laufs, Clare Oliver-Williams, Angela M Wood, Adam S Butterworth, Emanuele Di Angelantonio, John Danesh, Stephen J Nicholls, Deepak L Bhatt, Marc S Sabatine

January 2019 JAMA

Synopsis of Social media discussions

The discussions frequently emphasize the role of ApoB in cardiovascular risk, with users referencing specific studies and genetic evidence, such as the association of gene variants with heart disease. The tone ranges from supportive to skeptical, citing detailed research and expressing interest in how these findings might influence clinical practices, with expressions like 'strong evidence' and 'interesting support' suggesting an overall recognition of the research's importance.

A
Agreement
 Moderate agreement

Most discussions support the idea that triglyceride and LDL cholesterol reductions, especially via genetic traits related to ApoB, have similar effects on reducing heart disease risk, indicating a moderate to high level of consensus.

I
Interest
 High level of interest

The posts demonstrate strong curiosity, with multiple discussions referencing detailed studies, gene variants, and mechanisms, showing high relevance and engagement with the topic.

E
Engagement
 High engagement

Many users delve into technical aspects such as the roles of ApoB, genetic analyses, and the influence of diet or insulin on lipids, reflecting deep engagement beyond surface-level discussion.

I
Impact
 Moderate level of impact

While the debates highlight robust evidence regarding the importance of ApoB and lipid management, some skepticism about the clinical application or interpretation indicates moderate perceived impact, though there’s acknowledgment of the significance of g

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YouTube

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15 Posts

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29 Posts

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Metrics

Video Views

948

Total Likes

72

Extended Reach

109,067

Social Features

50

Timeline: Posts about article

Top Social Media Posts

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  • Austin Dudzinski, PharmD, BCACP
    @DudzLightLime (Twitter)

    @jpegan10 @lipo_fan @JoshJwageman @drhungo He generally cites these studies to support that position: “Therefore, the clinical benefit of lowering triglyceride and LDL-C levels may be proportional to the absolute change in ApoB.” https://t.co/oSLHBxL28g “The association of genetically predicted TG with CAD persisted
    view full post

    February 6, 2025

    1

  • Nick
    @upRootNutrition (Twitter)

    @CarnivoreMeme @jpegan10 @TapaDaBoy @ethanjweiss @realDaveFeldman Take your pick. But in the case of people like Dave and Nick, the genetics are probably related to insulin. Insulin is an independent mediator of LDL receptor activity. Low carb diets just make their lipids high, most likely. https://t.co/PPxuvO0lBU
    view full post

    January 18, 2025

    1

  • Rafael Zubirán
    @RZubiranS (Twitter)

    @cultistslayer @AldonSnow48246 @Drlipid @nationallipid @society_eas @TheFHFoundation @fhpatienteurope @drpablocorral If publishing yesterday isn't enough, let me know. 10.1056/NEJMoa2304146 And data on ApoB on Athero: 10.1001/jama.2018.20045 Does lowering Apo B works? Sure it does 10.1001/jamacardio.2021.5083
    view full post

    July 24, 2023

  • Linda
    @wordfinga (Twitter)

    RT @pabeda1: @SABOURETCardio @DrMarthaGulati @robmentz @vbluml @AndrewJSauer @iamritu @khurramn1 @ErinMichos @dranulala @SantosGallegoMD @S…
    view full post

    November 5, 2022

    1

  • Sergio Kaiser MD, PhD, FACC, FESC
    @pabeda1 (Twitter)

    @SABOURETCardio @DrMarthaGulati @robmentz @vbluml @AndrewJSauer @iamritu @khurramn1 @ErinMichos @dranulala @SantosGallegoMD @ShelleyZieroth @dramitkhera @AnnMarieNavar Actually I'm looking forward to knowing how they will expalin the failure. I wasn't surprised by the frustrating results since I read that MR study published 3 years ago by @ProfKausikRay and Brian Ference in @JAMA_current (doi:10.1001/jama.2018.20045)
    view full post

    November 5, 2022

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  • Nick
    @upRootNutrition (Twitter)

    3/8 Extremely thorough Mendelian randomization analyses find a dose-dependent relationship between ApoB and CHD across approximately two dozen genetic variants across many independent pathways. Neither ApoA-1 nor pleiotropy can reasonably explain this. https://t.co/PPxuvO0lBU https://t.co/wJ3NJBKv5P
    view full post

    September 24, 2022

    11

  • fipco
    @fipco (Twitter)

    @JohnKastelein @Lpa_Doc “[need TG⬇️ >200mg/dL to show benefit comparable to 1mmol⬇️LDL-C]” He did say that here (1) in a 2016 interview & elsewhere. I thought his later work emphasized ⬇️ apoB containing lipoproteins. Ex:(2) (1) https://t.co/XT1EBafmc4 (2) https://t.co/88hQJ5hZJ3
    view full post

    April 9, 2022

    3

  • fipco
    @fipco (Twitter)

    Pemafibrate lowers TG 40%-50%, but very small change in apoB. Outcome consistent with genetic studies by Ference and others. https://t.co/zjoJmHCT2L https://t.co/88hQJ5hZJ3 https://t.co/iYVWBaajyK
    view full post

    April 8, 2022

    2

  • Bhopender Thakur
    @TheBhupiThakur (Twitter)

    RT @The_Nutrivore: This was across 14 different data-sets. https://t.co/PPxuvOhoDU
    view full post

    April 29, 2021

    1

  • Nick
    @upRootNutrition (Twitter)

    This was across 14 different data-sets. https://t.co/PPxuvOhoDU
    view full post

    April 28, 2021

    5

    1

  • Bhopender Thakur
    @TheBhupiThakur (Twitter)

    RT @The_Nutrivore: @ondrej_sibl @RChrisCC @zerohedge https://t.co/PPxuvOhoDU https://t.co/EE9l693PHh The association between CVD and LDL-C…
    view full post

    March 3, 2021

    2

  • Bhopender Thakur
    @TheBhupiThakur (Twitter)

    RT @The_Nutrivore: @ScepticalDoctor @professionaldog @enjoylife3D @NickEggleton @FoodFirst_Ty Show me evidence that dietary cholesterol inc…
    view full post

    March 1, 2021

    2

  • Bhopender Thakur
    @TheBhupiThakur (Twitter)

    RT @The_Nutrivore: @ondrej_sibl @RChrisCC @zerohedge https://t.co/PPxuvOhoDU https://t.co/EE9l693PHh The association between CVD and LDL-C…
    view full post

    February 16, 2021

    2

  • Nick
    @upRootNutrition (Twitter)

    @ondrej_sibl @RChrisCC @zerohedge https://t.co/PPxuvOhoDU https://t.co/EE9l693PHh The association between CVD and LDL-C is null after adjusting for ApoB. https://t.co/EULPjoPsPJ
    view full post

    January 18, 2021

    2

    2

  • Bhopender Thakur
    @TheBhupiThakur (Twitter)

    RT @The_Nutrivore: Ultimately this is why I am skeptical of the LDL residence time stuff. Whether or not the gene variants affecting LDL co…
    view full post

    December 24, 2020

    1

  • Bhopender Thakur
    @TheBhupiThakur (Twitter)

    RT @The_Nutrivore: @ScepticalDoctor @professionaldog @enjoylife3D @NickEggleton @FoodFirst_Ty Show me evidence that dietary cholesterol inc…
    view full post

    December 6, 2020

    2

  • Nick
    @upRootNutrition (Twitter)

    Ultimately this is why I am skeptical of the LDL residence time stuff. Whether or not the gene variants affecting LDL concentration are increasing secretion or reducing clearance, it's the total concentration that the risk is tracking. https://t.co/PPxuvOhoDU https://t.co/RmkmqmYydM https://t.co/gUuP2JYfv7
    view full post

    October 24, 2020

    12

    1

  • Ariel Kraselnik
    @AKraselnik (Twitter)

    @DaveKeto @skinnygaz https://t.co/v3AUyPGbIE IMO this is a pretty solid proof that ApoB is what matters the most. Impact of lower TG and/or LDL is proportional to ApoB reduction.
    view full post

    October 6, 2020

  • Nick
    @upRootNutrition (Twitter)

    @ScepticalDoctor @professionaldog @enjoylife3D @NickEggleton @FoodFirst_Ty Show me evidence that dietary cholesterol increases ApoB as a general effect. We know it increases the cholesterol content of lipoproteins, sure. But the cholesterol content of lipoproteins isn't nearly as relevant as ApoB for CVD risk. https://t.co/PPxuvOhoDU
    view full post

    June 5, 2020

    1

    2

  • RagamuffinGirl
    @FuelledByFat (Twitter)

    RT @PreKureOfficial: Here's something that helps explain this - genes that lower TGs, and genes that lower LDL, are equally protective agai…
    view full post

    June 26, 2019

    1

  • PREKURE
    @PREKUREOfficial (Twitter)

    Here's something that helps explain this - genes that lower TGs, and genes that lower LDL, are equally protective against IHD, But genes that lower LDL-C also lower TGs, while genes that lower TGs raise LDL-C. This makes LDL-C a Janus-faced marker. 7/n https://t.co/t7URzQ8TyX
    view full post

    June 25, 2019

    1

    1

  • IMA
    @internetmedassn (Twitter)

    Association of Triglyceride-Lowering LPL Variants and LDL-C-Lowering LDLR Variants With Risk of Coronary Heart Disease. https://t.co/gjlnuer8Yw
    view full post

    March 23, 2019

  • POPLINE
    @POPLINE_org (Twitter)

    RT @EurekaMag: Association of Triglyceride-Lowering LPL Variants and LDL-C-Lowering LDLR Variants With Risk of Coronary Heart Disease https…
    view full post

    March 17, 2019

    2

  • Science Alerts
    @Science_Alerts (Twitter)

    RT @EurekaMag: Association of Triglyceride-Lowering LPL Variants and LDL-C-Lowering LDLR Variants With Risk of Coronary Heart Disease https…
    view full post

    March 17, 2019

    2

  • EurekaMag
    @EurekaMag (Twitter)

    Association of Triglyceride-Lowering LPL Variants and LDL-C-Lowering LDLR Variants With Risk of Coronary Heart Disease https://t.co/T8Bkg0BRMz #eurekamag
    view full post

    March 17, 2019

    2

  • Paul D. Thompson, MD
    @PaulDThompsonMD (Twitter)

    Here is my take on this interesting study supporting the importance of Apo B in CVD risk. Association of Triglyceride-Lowering LPL Variants and LDL-C-Lowering LDLR Variants With Risk of Coronary Heart Disease https://t.co/A69vcesqaO via @practiceupdate
    view full post

    February 7, 2019

    3

  • Bouvet Island 3Y0Z
    @Bouvet_3Y0Z (Twitter)

    Association of Triglyceride-Lowering LPL Variants and LDL-C-Lowering LDLR Variants With Risk of Coronary Heart Disease https://t.co/gevmZ1FUbU via @practiceupdate
    view full post

    February 7, 2019

  • KALLEL AMANI
    @KALLELAMANI (Twitter)

    Association of Triglyceride-Lowering LPL Variants and LDL-C-Lowering LDLR Variants With CHD Risk https://t.co/O9yjZD7L6D
    view full post

    January 29, 2019

  • هشام سعد
    @h_elerm (Twitter)

    Association of Triglyceride-Lowering LPL Variants and LDL-C-Lowering LDLR Variants With CHD Risk https://t.co/DVsUAfqch5
    view full post

    January 29, 2019

Abstract Synopsis

  • The study investigates whether lowering triglycerides or LDL cholesterol has a similar impact on reducing the risk of coronary heart disease by examining genetic variants in the LPL (triglyceride-lowering) and LDLR (LDL-lowering) genes.
  • Results showed that genetic variants in LPL and LDLR affected levels of triglycerides, LDL cholesterol, and ApoB-containing lipoproteins differently, but both were linked to a similarly reduced risk of coronary heart disease.
  • This suggests that reducing triglycerides through genetic means may lower heart disease risk as effectively as lowering LDL cholesterol, despite their differing effects on specific lipid levels.