June 2019 PMID 31081635

DO-MS: Data-Driven Optimization of Mass Spectrometry Methods.

R Gray Huffman, Albert Chen, Harrison Specht, Nikolai Slavov

Mentions

69
Peak: 21 in Jan 2019
across 3 sources since Jan 2019

Extended reach

543,137
potential audience

Total likes

341

Video views

32,501

Mentions per month

Jan 2019 – Sep 2021

Where it's discussed

  • X / Twitter62 posts
  • YouTube5 videos
  • Facebook2 posts

AI synopsis

What people are saying

Overall, the discussions reveal strong agreement and interest, with many posts praising DO-MS for its diagnostic capabilities and practical uses, such as identifying bottlenecks and optimizing sample prep, evidenced by phrases like 'diagnose problems' and 'great overview,' which reflect deep engagement and appreciation of its impact on proteomics research.

AgreementModerate agreement

Most discussions express strong support or recognition of the publication's importance, especially with praise for the software platform and its applications.

InterestHigh interest

The majority of posts show high interest, discussing specific tools like DO-MS, and the potential for diagnostics and optimization in mass spectrometry.

EngagementModerate engagement

Posts frequently reference detailed features of DO-MS, share guidelines, and suggest real-world applications, indicating active engagement.

ImpactModerate impact

The discussions highlight the significant influence of the publication and its tools on current research practices and community standards.

Abstract in brief

  • DOMS is a software platform designed to diagnose and optimize mass spectrometry methods, specifically in ultra-sensitive liquid chromatography and tandem mass spectrometry like single-cell proteomics.
  • It helps identify problems in the complex links between different stages of the analysis process and suggests improvements, leading to better data quality.
  • By using DOMS to optimize parameters such as ion sampling at peak apexes, researchers achieved a 370% increase in ion efficiency for MS2 analysis, making the process more effective.]

Top posts

Most liked on X and Bluesky
Prof. Nikolai Slavov
@slavov_n · X

DO-MS is now online at @JProteomeRes https://t.co/RfjJHYDvo2 This was a great team effort by @GrayHuffman, @atchen_ , @harrisonspecht Try it and let us know what you think. https://t.co/YiuKX2rHKv

May 13, 2019 · 19 likes · 5 shares · 19,980 followers View post →
Prof. Nikolai Slavov
@slavov_n · X

Congratulation to @harrisonspecht for being selected a rising start by @JProteomeRes https://t.co/iVnJZFazgg Well deserved Harrison! Check out some of his @JProteomeRes papers: https://t.co/LKOq5CA3rP https://t.co/RfjJHYV6fA https://t.co/peylTwJdyY

Jan 14, 2021 · 19 likes · 3 shares · 19,980 followers View post →
Prof. Nikolai Slavov
@slavov_n · X

Another benchmarking study of the isobaric carrier in @naturemethods https://t.co/fYFGviN3Ch. The main conclusions align with previously discussed & demonstrated effects https://t.co/LKOq5CisAh https://t.co/RfjJHYDvo2 https://t.co/K78qaokhUY

Dec 10, 2020 · 15 likes · 1 share · 19,980 followers View post →
ProtiFi LLC
@ProtifiLlc · X

DO-MS: Data-Driven Optimization of Mass Spectrometry Methods https://t.co/gPEamna2EB

Jan 7, 2019 · 14 likes · 7 shares · 3,121 followers View post →
Prof. Nikolai Slavov
@slavov_n · X

If you would like to use DO-MS https://t.co/RfjJHYV6fA, check out this guide by @atchen_: https://t.co/XfzdolJl1i https://t.co/mYfnjjL574

May 28, 2019 · 8 likes · 6 shares · 19,980 followers View post →
Prof. Nikolai Slavov
@slavov_n · X

The basics essential to know before starting research. They are simple & very important! More important than the more complex science that will get mixed up and misrepresented if we don't know and follow these basic guidelines! https://t.co/Ax2mt2oDnK https://t.co/RfjJHYDvo2 https://t.co/3vl6LkrcAr

Aug 26, 2020 · 8 likes · 1 share · 19,980 followers View post →

All mentions

Prof. Nikolai Slavov
@slavov_n · X

@VDBiology As you know, we use DIA & DIA-NN and find them very useful, though I still have a response to your last question: I would like DIA-NN to output features for DO-MS (https://t.co/RfjJHYV6fA) that help us easily diagnose and optimize sample prep and MS analysis.

Sep 23, 2021 · 3 likes · 19,980 followers View post →
Prof. Nikolai Slavov
@slavov_n · X

@JohnRYatesIII Indeed, many of the invitations are from journals that I would not submit to, but some are from appropriate journals to which I would submit the paper. For example, I was invited to submit this paper https://t.co/RfjJHYDvo2 to Bioinformatics, which would have been a good venue.

Jun 10, 2021 · 2 likes · 19,980 followers View post →
Northeastern University Bioengineering
@NUBioE1 · X

RT @slavov_n: Congratulation to @harrisonspecht for being selected a rising start by @JProteomeRes https://t.co/iVnJZFazgg Well deserved H…

Feb 1, 2021 · 3 shares · 613 followers View post →
Sara Fonseca Costa
@essepf · X

RT @slavov_n: Congratulation to @harrisonspecht for being selected a rising start by @JProteomeRes https://t.co/iVnJZFazgg Well deserved H…

Jan 14, 2021 · 3 shares · 253 followers View post →
Ed Emmott
@edemmott · X

RT @slavov_n: Congratulation to @harrisonspecht for being selected a rising start by @JProteomeRes https://t.co/iVnJZFazgg Well deserved H…

Jan 14, 2021 · 3 shares · 3,727 followers View post →
Journal of Proteome Research
@JProteomeRes · X

RT @slavov_n: Congratulation to @harrisonspecht for being selected a rising start by @JProteomeRes https://t.co/iVnJZFazgg Well deserved H…

Jan 14, 2021 · 3 shares · 3,825 followers View post →
Prof. Nikolai Slavov
@slavov_n · X

Congratulation to @harrisonspecht for being selected a rising start by @JProteomeRes https://t.co/iVnJZFazgg Well deserved Harrison! Check out some of his @JProteomeRes papers: https://t.co/LKOq5CA3rP https://t.co/RfjJHYV6fA https://t.co/peylTwJdyY

Jan 14, 2021 · 19 likes · 3 shares · 19,980 followers View post →
lbgbox
@lbgbox · X

RT @slavov_n: Another benchmarking study of the isobaric carrier in @naturemethods https://t.co/fYFGviN3Ch. The main conclusions align wi…

Dec 11, 2020 · 1 share · 51 followers View post →
Prof. Nikolai Slavov
@slavov_n · X

Another benchmarking study of the isobaric carrier in @naturemethods https://t.co/fYFGviN3Ch. The main conclusions align with previously discussed & demonstrated effects https://t.co/LKOq5CisAh https://t.co/RfjJHYDvo2 https://t.co/K78qaokhUY

Dec 10, 2020 · 15 likes · 1 share · 19,980 followers View post →
Amit Kumar Yadav
@theoneamit · X

RT @slavov_n: The basics essential to know before starting research. They are simple & very important! More important than the more comple…

Aug 26, 2020 · 1 share · 1,428 followers View post →
Prof. Nikolai Slavov
@slavov_n · X

The basics essential to know before starting research. They are simple & very important! More important than the more complex science that will get mixed up and misrepresented if we don't know and follow these basic guidelines! https://t.co/Ax2mt2oDnK https://t.co/RfjJHYDvo2 https://t.co/3vl6LkrcAr

Aug 26, 2020 · 8 likes · 1 share · 19,980 followers View post →
Andrew Leduc
@_AndrewLeduc · X

RT @slavov_n: @CMichaelRose @slavovLab @harrisonspecht @SCP_meeting This is exactly the effect that we described previously https://t.co/Rf…

Aug 25, 2020 · 1 share · 619 followers View post →
Prof. Nikolai Slavov
@slavov_n · X

@CMichaelRose @slavovLab @harrisonspecht @SCP_meeting This is exactly the effect that we described previously https://t.co/RfjJHYV6fA https://t.co/ILK0E1OvxE

Aug 25, 2020 · 1 share · 19,980 followers View post →
Slavov Laboratory
@slavovLab · X

Guidelines: 1. The size of the isobaric carrier should reflect the project priorities. 2. Evaluate whether the isobaric carrier affects peptide sampling, e.g., by using DO-MS https://t.co/H6YHASYKhZ & https://t.co/wBMtxNbqYD

Aug 24, 2020 · 2,831 followers View post →
Prof. Nikolai Slavov
@slavov_n · X

@ChasingMicrobes @astacus I think it depends on the case. I would certainly look at the search engine output, and run it through our usual pipelines, such as DO-MS https://t.co/RfjJHYDvo2 This takes only a few minutes and gives a great overview of the data. Can be more informative than reading the paper.

May 18, 2020 · 1 like · 19,980 followers View post →
Prof. Nikolai Slavov
@slavov_n · X

@BiswapriyaMisra @kabalak @dtabb73 I agree with @dtabb73 -- QC & precise diagnosis of bottlenecks is a big part of the solution. We do it with DO-MS https://t.co/RfjJHYDvo2 Another part is using robust options, e.g., manual loading on 10 um ID nLC may afford high peak performance but not high average performance.

Apr 28, 2020 · 2 likes · 19,980 followers View post →
Andrea Petretto
@Angrist_Fusion · X

RT @slavovLab: @maxquant Thanks to @maxquant, DO-MS https://t.co/RfjJHYDvo2 makes it possible to specifically diagnose problems typically…

Oct 25, 2019 · 2 shares · 580 followers View post →
Prof. Nikolai Slavov
@slavov_n · X

@maxquant Thanks to @maxquant, DO-MS https://t.co/RfjJHYDvo2 makes it possible to specifically diagnose problems typically manifested by nonspecific symptoms. https://t.co/grDDTt44W1

Oct 25, 2019 · 2 likes · 2 shares · 19,980 followers View post →
Pastel BioScience
@PastelBio · X

RT @kermitmurray: [ASAP] DO-MS: Data-Driven Optimization of Mass Spectrometry Methods https://t.co/sxsfd8J5pu

Jun 1, 2019 · 1 share · 5,376 followers View post →
Kermit Murray
@kermitmurray · X

[ASAP] DO-MS: Data-Driven Optimization of Mass Spectrometry Methods https://t.co/sxsfd8J5pu

Jun 1, 2019 · 2 likes · 1 share · 1,967 followers View post →
Chris Trivedi
@Chris_Trivedi · X

RT @slavovLab: If you would like to use DO-MS https://t.co/RfjJHYV6fA, check out this guide by @atchen_: https://t.co/XfzdolJl1i https://t.…

May 30, 2019 · 6 shares · 778 followers View post →
Aditya Bandla
@adityabandla · X

RT @slavovLab: If you would like to use DO-MS https://t.co/RfjJHYV6fA, check out this guide by @atchen_: https://t.co/XfzdolJl1i https://t.…

May 30, 2019 · 6 shares · 495 followers View post →
Prof. Nikolai Slavov
@slavov_n · X

RT @slavovLab: If you would like to use DO-MS https://t.co/RfjJHYV6fA, check out this guide by @atchen_: https://t.co/XfzdolJl1i https://t.…

May 30, 2019 · 6 shares · 19,980 followers View post →
Pastel BioScience
@PastelBio · X

DO-MS: Data-Driven Optimization of Mass Spectrometry Methods | https://t.co/YvYHxOinyI #proteomics https://t.co/El4L2If2Eo

May 29, 2019 · 1 like · 5,376 followers View post →
Edu Chicano (@educhicano@bsky.social)
@educhicano · X

"[ASAP] DO-MS: Data-Driven Optimization of Mass Spectrometry Methods" https://t.co/josMfuhA9J #proteomics

May 29, 2019 · 1,347 followers View post →
Pastel BioScience
@PastelBio_prot · X

[ASAP] DO-MS: Data-Driven Optimization of Mass Spectrometry Methods https://t.co/Ze5PO9uxW3

May 29, 2019 · 215 followers View post →
Andrea Petretto
@Angrist_Fusion · X

RT @slavovLab: If you would like to use DO-MS https://t.co/RfjJHYV6fA, check out this guide by @atchen_: https://t.co/XfzdolJl1i https://t.…

May 29, 2019 · 6 shares · 580 followers View post →
BioMassSpec
@realBioMassSpec · X

DO-MS: Data-Driven Optimization of Mass Spectrometry Methods | Journal of Proteome Research https://t.co/XMQoZn1dcq

May 29, 2019 · 5,993 followers View post →
Ed Emmott
@edemmott · X

RT @slavovLab: If you would like to use DO-MS https://t.co/RfjJHYV6fA, check out this guide by @atchen_: https://t.co/XfzdolJl1i https://t.…

May 28, 2019 · 6 shares · 3,727 followers View post →
Prof. Nikolai Slavov
@slavov_n · X

If you would like to use DO-MS https://t.co/RfjJHYV6fA, check out this guide by @atchen_: https://t.co/XfzdolJl1i https://t.co/mYfnjjL574

May 28, 2019 · 8 likes · 6 shares · 19,980 followers View post →
Dr. Biswapriya Misra
@BiswapriyaMisra · X

RT @slavovLab: DO-MS is now online at @JProteomeRes https://t.co/RfjJHYDvo2 This was a great team effort by @GrayHuffman, @atchen_ , @harri…

May 25, 2019 · 5 shares · 5,765 followers View post →
Pastel BioScience
@PastelBio · X

DO-MS: Data-Driven Optimization of Mass Spectrometry Methods | https://t.co/YvYHxOinyI #proteomics @slavovLab https://t.co/rJJPxZojBP

May 20, 2019 · 5,376 followers View post →
Pastel BioScience
@PastelBio · X

RT @realBioMassSpec: DO-MS: Data-Driven Optimization of Mass Spectrometry Methods https://t.co/y6UuEuuqcF

May 15, 2019 · 2 shares · 5,376 followers View post →
Joris Meurs
@JorisMeurs · X

RT @slavovLab: DO-MS is now online at @JProteomeRes https://t.co/RfjJHYDvo2 This was a great team effort by @GrayHuffman, @atchen_ , @harri…

May 14, 2019 · 5 shares · 146 followers View post →
Eduardo Armienta
@eduardoarmienta · X

RT @realBioMassSpec: DO-MS: Data-Driven Optimization of Mass Spectrometry Methods https://t.co/y6UuEuuqcF

May 13, 2019 · 2 shares · 1,208 followers View post →
Journal of Proteome Research
@JProteomeRes · X

RT @slavovLab: DO-MS is now online at @JProteomeRes https://t.co/RfjJHYDvo2 This was a great team effort by @GrayHuffman, @atchen_ , @harri…

May 13, 2019 · 5 shares · 3,825 followers View post →
Albert Chen
@atchen_ · X

RT @slavovLab: DO-MS is now online at @JProteomeRes https://t.co/RfjJHYDvo2 This was a great team effort by @GrayHuffman, @atchen_ , @harri…

May 13, 2019 · 5 shares · 83 followers View post →
BioMassSpec
@realBioMassSpec · X

DO-MS: Data-Driven Optimization of Mass Spectrometry Methods https://t.co/y6UuEuuqcF

May 13, 2019 · 5 likes · 2 shares · 5,993 followers View post →
ProteomicsScience
@HFazelinia · X

RT @slavovLab: DO-MS is now online at @JProteomeRes https://t.co/RfjJHYDvo2 This was a great team effort by @GrayHuffman, @atchen_ , @harri…

May 13, 2019 · 5 shares · 901 followers View post →
Ed Emmott
@edemmott · X

RT @slavovLab: DO-MS is now online at @JProteomeRes https://t.co/RfjJHYDvo2 This was a great team effort by @GrayHuffman, @atchen_ , @harri…

May 13, 2019 · 5 shares · 3,727 followers View post →
Prof. Nikolai Slavov
@slavov_n · X

DO-MS is now online at @JProteomeRes https://t.co/RfjJHYDvo2 This was a great team effort by @GrayHuffman, @atchen_ , @harrisonspecht Try it and let us know what you think. https://t.co/YiuKX2rHKv

May 13, 2019 · 19 likes · 5 shares · 19,980 followers View post →
Ahmed Mohamed
@dataRtest · X

RT @PastelBio: DO-MS: Data-Driven Optimization of Mass Spectrometry Methods | https://t.co/rz3Qez9EaO #proteomics @slavovLab https://t.co/9…

Jan 22, 2019 · 3 shares · 113 followers View post →
BioMassSpec
@realBioMassSpec · X

RT @PastelBio: DO-MS: Data-Driven Optimization of Mass Spectrometry Methods | https://t.co/rz3Qez9EaO #proteomics @slavovLab https://t.co/9…

Jan 22, 2019 · 3 shares · 5,993 followers View post →
Dunc Smith ///
@duncoafc · X

RT @PastelBio: DO-MS: Data-Driven Optimization of Mass Spectrometry Methods | https://t.co/rz3Qez9EaO #proteomics @slavovLab https://t.co/9…

Jan 22, 2019 · 3 shares · 959 followers View post →
Pastel BioScience
@PastelBio · X

DO-MS: Data-Driven Optimization of Mass Spectrometry Methods | https://t.co/rz3Qez9EaO #proteomics @slavovLab https://t.co/9uKggGAU6d

Jan 22, 2019 · 5 likes · 3 shares · 5,376 followers View post →
BioNews
@SingleCellNews · X

RT @PastelBio: DO-MS: Data-Driven Optimization of Mass Spectrometry Methods | https://t.co/rz3Qez9EaO #proteomics @slavovLab https://t.co/q…

Jan 12, 2019 · 1 share · 28 followers View post →
Srikanth S. Manda
@srithegreat143 · X

RT @ProtifiLlc: DO-MS: Data-Driven Optimization of Mass Spectrometry Methods https://t.co/gPEamna2EB

Jan 8, 2019 · 7 shares · 173 followers View post →
Adrian Jinich
@champiDicty · X

RT @ProtifiLlc: DO-MS: Data-Driven Optimization of Mass Spectrometry Methods https://t.co/gPEamna2EB

Jan 7, 2019 · 7 shares · 1,329 followers View post →
Gary Siuzdak
@kadzuis · X

RT @ProtifiLlc: DO-MS: Data-Driven Optimization of Mass Spectrometry Methods https://t.co/gPEamna2EB

Jan 7, 2019 · 7 shares · 6,305 followers View post →
annibal_ms
@AnnibalMs · X

RT @ProtifiLlc: DO-MS: Data-Driven Optimization of Mass Spectrometry Methods https://t.co/gPEamna2EB

Jan 7, 2019 · 7 shares · 304 followers View post →
ProteomicsScience
@HFazelinia · X

RT @ProtifiLlc: DO-MS: Data-Driven Optimization of Mass Spectrometry Methods https://t.co/gPEamna2EB

Jan 7, 2019 · 7 shares · 901 followers View post →
Vladislav Petyuk
@vapetyuk · X

RT @ProtifiLlc: DO-MS: Data-Driven Optimization of Mass Spectrometry Methods https://t.co/gPEamna2EB

Jan 7, 2019 · 7 shares · 148 followers View post →
ProtiFi LLC
@ProtifiLlc · X

DO-MS: Data-Driven Optimization of Mass Spectrometry Methods https://t.co/gPEamna2EB

Jan 7, 2019 · 14 likes · 7 shares · 3,121 followers View post →
Mark Borris Aldonza (@precursorcell.bsky.social
@PrecursorCell · X

RT @biorxiv_bioinfo: DO-MS: Data-Driven Optimization of Mass Spectrometry Methods https://t.co/cJ8FJ5KHln #biorxiv_bioinfo

Jan 7, 2019 · 3 shares · 1,384 followers View post →
BioMassSpec
@realBioMassSpec · X

RT @biorxiv_bioinfo: DO-MS: Data-Driven Optimization of Mass Spectrometry Methods https://t.co/cJ8FJ5KHln #biorxiv_bioinfo

Jan 7, 2019 · 3 shares · 5,993 followers View post →
Pastel BioScience
@PastelBio · X

DO-MS: Data-Driven Optimization of Mass Spectrometry Methods | https://t.co/rz3Qez9EaO #proteomics @slavovLab https://t.co/quDuceaIVh

Jan 7, 2019 · 3 likes · 1 share · 5,376 followers View post →
SeqComplete
@SeqComplete · X

#BioIT #BioInformatics DO-MS: Data-Driven Optimization of Mass Spectrometry Methods [NEW RESULTS] https://t.co/23pB3x3lGD

Jan 7, 2019 · 4,412 followers View post →
Kamal (卡馬爾) (@kamalmdm.bsky.social)
@KamalMdM · X

DO-MS: Data-Driven Optimization of Mass Spectrometry Methods https://t.co/gipW1JSb0y

Jan 6, 2019 · 1 like · 414 followers View post →
bxv_bioinf
@bxv_bioinf · X

DO-MS: Data-Driven Optimization of Mass Spectrometry Methods https://t.co/Mhb13vdvzq

Jan 6, 2019 · 491 followers View post →
Helio Rocha
@_elioRocha · X

#bioRxiv DO-MS: Data-Driven Optimization of Mass Spectrometry Methods #bioinfo https://t.co/QTEQUcIfYV

Jan 6, 2019 · 609 followers View post →
bioRxiv Bioinfo
@biorxiv_bioinfo · X

DO-MS: Data-Driven Optimization of Mass Spectrometry Methods https://t.co/cJ8FJ5KHln #biorxiv_bioinfo

Jan 6, 2019 · 6 likes · 3 shares · 18,049 followers View post →
bioRxiv
@biorxivpreprint · X

DO-MS: Data-Driven Optimization of Mass Spectrometry Methods https://t.co/SmyE5kgN4a #bioRxiv

Jan 6, 2019 · 2 likes · 136,867 followers View post →