https://t.co/1JQh21BHMU https://t.co/VHVazqe1Ne https://t.co/XrmUqdYB48
Placebo Effect in the Treatment of Depression and Anxiety.
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Nov 2019 – Oct 2025Where it's discussed
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X / Twitter102 posts
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News72 articles
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Blogs15 articles
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YouTube3 videos
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What people are saying
The overall tone emphasizes the substantial placebo response in depression and anxiety treatments, with examples such as Kirsch’s meta-analyses and FDA data reanalysis. Words like 'misinformation,' 'negligible benefit,' and 'game of gaslighting' showcase a critical tone aimed at questioning traditional treatment approaches, indicating a shift toward skepticism of pharmacological efficacy and influence on medical standards.
Many discussions highlight that much of the perceived benefits of antidepressants are due to placebo effects, with some posts directly citing Kirsch's research, indicating a general consensus of skepticism.
The posts show high interest, referencing detailed meta-analyses, FDA reanalyses, and discussions about clinical trials, reflecting engagement with complex scientific data.
Conversations delve into detailed critique of research methodologies, clinical guidelines, and implications for practice, demonstrating deep engagement with the subject matter.
The discussions challenge established medical practices and prescribing guidelines, suggesting significant influence on perspectives about mental health treatments and the validity of pharmacological benefits.
Top posts
Most liked on X and Bluesky@Coucou_CFC @ReadReadj @Martin_Ploederl @HengartnerMP @joannamoncrieff @EikoFried @PGtzsche1 @Mad_In_America @BigPhilHickey "antidepressants are no better in treating anxiety disorders than they are in treating depression" See: https://t.co/XmaNCRBNEp & https://t.co/8Eey7JBGI5
@JakeGoodmanMD I appreciate your effort and courage to destigmatize mental health.However, there are safer options than psychiatric drugs with comparable efficacy.Pls be mindful that you endorse the former over the latter with this post. https://t.co/y1bNGC5rE8 https://t.co/rRIGL7tO3J Take care
@IdaHockerstrand @c_dahlstrom Det finns dock gott om studier som visar att allt möjligt har goda effekter vid depression och ångest. Merparten av effekten är placebo. Fördelen med dyra stenar är att de inte har så mycket kända bieffekter. https://t.co/XYxsV6jXgD
When you look at two studies that have done this you can see in the group that has not been given ADs before so harder to unblind there is no difference in response between pbo and AD, https://t.co/5TiqSrGy8x (17/n)
@melina_manolas @benzosarebad https://t.co/Z5JC0Hu3sl
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@LurksOnX https://t.co/0s5nRIyCfw In dem Review ist die Studie von Cipriani et al. 2018 enthalten. Das ist ja der Sinn von solchen übergreifenden Analysen - dass man sich eben nicht jedes Paper einzeln anschauen muss, sondern dass der Wissensstand zu einer Fragestellung sinnvoll
https://t.co/1JQh21BHMU https://t.co/VHVazqe1Ne https://t.co/XrmUqdYB48
@DaveLeghorn @drjanaway https://t.co/TqNV2qM4yG
@MiguelBarbero7 @BeatrizTalegon Toma agua la tus barbas… https://t.co/NVT77LvKg9 https://t.co/EoPJHwrJ1I
@melina_manolas @benzosarebad https://t.co/Z5JC0Hu3sl
1/ How then shall we treat depression? One suggestion that has been made to me informally is to prescribe antidepressants as active placebos.. https://t.co/rJ8UXipSRe
@CaulfieldTim @jonathanstea @crackedscience @DocMCohen @DrvanTilburg @BlakeMMurdoch @StanKutcher @RyanMarino @DrShazmaMithani @CFPC_e @ABFamDocs Same can be said for pharmaceutical interventions. Regardless, no one ever died from a placebo effect. https://t.co/LTGq08x8qU
@nypost Placebo oftentimes is the only necessary factor https://t.co/XeHcqXv08N
@Grantshotfirst People aren't happy? Nah, it's not capitalist ruling class to blame for outsourcing jobs, importing foreign workers, and conducting society-wide culture war against people, nope, it must be depression and anxiety, or maybe they are just schizo. https://t.co/vUJDRgcp05
@sdcrosby @taalumot I'll do you one better and provide a link to a meta-analysis: https://t.co/Zq7oKowoJH
@makemebethless @noplaceforsheep I believe dangers of some antidepressants outweigh benefits My daughter began self-harming after going on one so her Psychiatrists answer was up the dose I read more info about the drug & she shouldn't have even been given that med as she was under 25yrs https://t.co/uyBpflU4hZ.
@mess0Falife https://t.co/Vo6mJXjpS9 “Antidepressant medications have little or no pharmacological effects on depression or anxiety, but they do elicit a substantial placebo effect”
Placebo Effect in the Treatment of Depression and Anxiety https://t.co/yPNX2y86Nf
Alsoooo placebo effect https://t.co/24JFspn2el https://t.co/lbL8WZd7Wm https://t.co/QStm1IoIlo
@Medicalemesis @f_hieronymus @PloederlM @ueafam @johndrummond33 Kirsch's article seems to say the drug effect is almost gone with people who have used the drug before: https://t.co/vr1Mijkbik Anyway good night from me - thanks for the discussion
When you look at two studies that have done this you can see in the group that has not been given ADs before so harder to unblind there is no difference in response between pbo and AD, https://t.co/5TiqSrGy8x (17/n)
@guzmannutrition @hubermanlab although highly controversial, it appears most (if not all) of the effect is due to a placebo response. SSRI mechanism of action is still largely unknown - they have many non-selective effects - on GABA, glutamate, K+ channels. https://t.co/zBCFrJ70Sl
@Sams_Antics @sbkaufman Kirsch’s work still holds up in regards to this https://t.co/wkscCdQZns
https://t.co/F4FWntqpq6
RT @cfs_research: @CyruxiME @MarekSJF @david_colquhoun There are a number of different aspects to the placebo effect. That Cochrane review…
@CyruxiME @MarekSJF @david_colquhoun There are a number of different aspects to the placebo effect. That Cochrane review is from 2010, and there hadn't been any 3-arm RCTs comparing antidepressants and a non-placebo control group, but there has been one since then: https://t.co/X3WSjQqdoR
https://t.co/6e5PDlpXbj
@MissyKiku @Asher_Wolf @RACGP "However, analyses of the published and the unpublished clinical trial data are consistent in showing that most (if not all) of the benefits of antidepressants in the treatment of depression and anxiety are due to the placebo response" https://t.co/AB3JUI4pPs
@AlaaBabidan @YaRrr89i @BandarAlsaqry ". Antidepressant medications have little or no pharmacological effects on depression or anxiety, but they do elicit a substantial placebo effect" https://t.co/REdIN72tPP.
@Gh4nder @_jonasschnelli_ It’s true. In many cases people become chronic from drug access. https://t.co/UzjMjG1IvY
Frontiers | Placebo Effect in the Treatment of Depression and Anxiety | Psychiatry—mind-blowing https://t.co/omDBvZiUXN
Placebo Effect in the Treatment of Depression and Anxiety https://t.co/IJmTezRNuV
@giganteholandes @hackeusss Inclusive uma metananálise realizada pelo Dr Irving Kirsch por exemplo, demonstrou que não há muita diferença na eficácia com utilização de antidepressivos e placebos, sendo que na utilização da medicação, há diversos efeitos colaterais. https://t.co/lxHA0CrGev
https://t.co/ppKaiXK4is
@ProfRobHoward @scibip Source: https://t.co/AB3JUI4pPs
@thehealthb0t https://t.co/oke6IOggzQ
@DrJessTaylor It seems that anti depressants despite massive hype for several decades don't really work. CBT was the next 'cure' https://t.co/oke6IOggzQ
RT @cleanslateblog: Improvement of an emotional condition upon taking a drug doesn’t prove that the drug “works” https://t.co/OLh3wJ4A7l
Improvement of an emotional condition upon taking a drug doesn’t prove that the drug “works” https://t.co/OLh3wJ4A7l
@winged @Andromeda10101 @JakeGoodmanMD People “don’t do well” on SSRIs because they are primarily placebo effect. Fact. Also, adverse reactions= body is signaling neurotoxicity. Please look beyond the pharma party line. https://t.co/TG0pmlTzDe https://t.co/AUFMYSApkS
@JakeGoodmanMD I appreciate your effort and courage to destigmatize mental health.However, there are safer options than psychiatric drugs with comparable efficacy.Pls be mindful that you endorse the former over the latter with this post. https://t.co/y1bNGC5rE8 https://t.co/rRIGL7tO3J Take care
@ProfRobHoward @PloederlM Why you claiming people said there no differences between drug and placebo @ProfRobHoward That's not what Kirsch said He said on re-analysis of the data, the difference was often *clinically insignificant* What is the scale? It's cut off your graph https://t.co/4ZyruuMPk6
@markrdavis @SameiHuda @Keith_Laws Ate you deliberately misinterpreting the science @markrdavis Or do you just not understand it? If mechanism of anti-depressants is placebo, not drug FX It is not truth teller reduced drug efficacy,but the doctors who described a drug for it's placebo fx https://t.co/8lLGHNVKT0
@SameiHuda @SameiHuda this is consistent with placebo/active placebo mechanism you claimed was misinterpretion of placebo data But your own tweet endorses primary mechanism placebo Please explicitly state your interpretation on placebo mechanism of anti-depressants https://t.co/8lLGHNVKT0
النسب في الدراسات مرعبة! https://t.co/H3Q28cLlVe
RT @FalteringlyOn: @DickieRAnderson @DrDJWilde @jill_d35 @benzosarebad @peterkinderman @swinton57 @Dr_Ellie What did these RCTs show? Well,…
@DickieRAnderson @FalteringlyOn @DrDJWilde @TheCenterGroun1 Patients should not have to think to ask the question "what was the effect size of drug over placebo in RCTs" What patient knows to ask that? This evidence should be part of prescribing guidance to physicians Physician education is important https://t.co/8lLGHNVKT0
@DickieRAnderson @DrDJWilde @jill_d35 @benzosarebad @peterkinderman @swinton57 @Dr_Ellie What did these RCTs show? Well, for the list of complaints clustered as "depression" or "anxiety" They showed that the drug was unable to achieve a clinically significant benefit over placebo. This means, statistically, there is a high likelihood that https://t.co/4ZyruuMPk6
@benzosarebad @atomicaceso @EveSimmns @Dr_Ellie @DickieRAnderson @erumnomani @BarneyCalman @ProfRobHoward @AshCurryOcd @Rozewicz @SameiHuda @jonathanstea @Tiny__Biologist And Kirsch Why isn't he getting Top billing? Hellllo? Placebo FX? Possibility of active placebo FX? Placebo FX so high drug FX often nit clinically significant? How does that not get explained or factored into GP guidance?? https://t.co/4ZyruuMPk6
@atpolgar @DuthieAlyne @T_A_Psupport @AnnaKin06551830 Why would you call them "sedatives"? Do you have any evidence of "sedative" action over placebo? Would not calling them by what evidence most strongly demonstrates Mean calling them substituting a drug for benefits most like caused in the main by placebo? https://t.co/4ZyruuMPk6
@Wigglyworm8 Also, stop misinforming when the statistical evidence overwhelmingly demonstrates that the bulk of "benefit" in drug naive clients is placebo, with minimal drug effects, often failing to be "clinically significant", and these too may be "active placebo" https://t.co/4ZyruuMPk6
@benzosarebad @_roseyesha @_roseyesha it's not true that a small proportion, or any proportion benefit from the *drug effects* substantially according to statistical evidence Burying this information is part of the game This is the mental health sector It's game is gaslighting https://t.co/4ZyruuMPk6
@benzosarebad @SophiePorritt @Dr_Ellie @BarneyCalman @EveSimmns @DrRosena @KnightAyton @thismorning @Rylan @JonAshworth @jimmycarr @SadiqKhan @RealDeniseWelch Dr Ellie is spreading absolute falsehood, in saying that it is "worth the risk" to take a pill that the random controlled trials have made clear provides minimal, clinically insignificant benefit over placebo instead of open label placebo https://t.co/4ZyruuMPk6
@ReadReadj @AlisonSmith29 @thismorning @AllisonSmith29 2/ Neither "side" is discussing the evidence of benefits in Random Controlled Trials. As Kirch's excellent research explains antidepressants have a very high placebo effect. Placebo inot "fake" a strong, potent effect putatively operant conditioning 2/ https://t.co/4ZyruuMPk6
@ReadReadj @AlisonSmith29 @thismorning @AllisonSmith29 @ReadReadj Both the people advocating informed consent and those, unprincipled, professionals spreading misinformation are concerning me. 1. Informed consent is accurate explaination benefit/risk/harm profile based on evidence. 1/ https://t.co/4ZyruuMPk6
@shvogt @HengartnerMP @johndrummond33 But without any data It's not possible to know & Knowing makes a huge difference Kirsch covers the placebo/active placebo effect really well Another study looked at the impact of biological vs contextual beliefs about "depression" https://t.co/4ZyruuMPk6
@_eleven13_ @Alacoque6 @psychgeist52 @thismorning @rcpsych This is what bothers me about the open letter: why doesn't it emphasize the placebo vs drug DX in RCTs? As well as clarification on how much worse these are in children? Without this key piece of info The main message is lost https://t.co/4ZyruuMPk6
@dranniehickox @Rozewicz @psychgeist52 @joannamoncrieff @thismorning @Dr_Ellie Mental health paradigm is shaming. The whole idea is to blame people for their crises & turmoil. Crises never arise out of nothing facts are woman misinformed blatantly on the evidence. If data say drug FX not clinically significant https://t.co/4ZyruuMPk6 1/
@shazamichelle @DuthieAlyne It's a *great* video @CEP_UK what I don't understand why start new people at all? How cost/benefit If no "clinically significant" benefit over placebo? Shouldn't GP guidance be stop to prescribing in drug naive clients When no clinically significant RCT? https://t.co/4ZyruuMPk6
@Dr_Ellie Did not NICE agree to warn on withdrawal/dependence? Are you not bound to give proper information based on evidence, including many SSRIs don't have clinically significant "benefits" over placebo? NICE don't back "chemical imbalance", surely https://t.co/4ZyruuMPk6
@Rozewicz @psychgeist52 @joannamoncrieff @thismorning @Dr_Ellie But they aren't effective over placebo, not clinically significant effectiveness for many So statistically it's likely people could have been "saved" by placebo, without the dangerous, sometimes lethal withdrawal Without harmful damage to molecular biology https://t.co/4ZyruuMPk6
@Rozewicz @joannamoncrieff @thismorning @psychgeist52 @Dr_Ellie Yet SSRIs are not Evidence based & most do not achieve "clinically significant" benefit over placebo no meaningful drug benefit over placebo You do know that? Informed consent is law Why no crackown in person misinforming on TV? Shouldn't that be illegal? https://t.co/4ZyruuMPk6
@FirstSteptweets @PatMcGorry @DrNicoleLee @NicoClark_ Pied piper and his band of flutes have so much influence,the scientists above sent on a wild goose chase after causal evidence of harms when alleged "benefits" Don't even have strong correlation in adults, none in children. Unapproved in children https://t.co/4ZyruuMPk6
@TheCenterGroun1 @dranniehickox @_eleven13_ @DrDJWilde @RxSafety_org @JDaviesPhD @ReadReadj @markrdavis When there isn't even strong correlation on "benefit" For adults. There isn't even statistical correlation in manufacturer RCTs for children That is why the drugs are not approved Prescription is off label https://t.co/4ZyruuMPk6
@SoundWellMusic @BecauseIMatter @psychetrick Becausesame lobbiests described inarticle & all other charities and practioners who spread narrative of benefits that aren't evidenced are very, very persuasive & influential. Despite correlation on benefits being statistical, not clinically significant https://t.co/4ZyruuMPk6
Irving Kirsch did it again! :) Placebo Effect in the Treatment of Depression and Anxiety https://t.co/WPKLzyhkw7 I love this man!
@sphams Indeed, and thank you for sharing, Steve, as many have said. I took Mirtazapine some years ago, but was recently shown this (peer-reviewed) article, which makes me wonder about SSRIs generally. Interested to hear the thoughts/opinions of others. https://t.co/zjorUQ65lD
@regnans @notgoingquieter @DrNic16 When there isn't even strong correlation evidence on alleged "benefit" For adults For children they couldn't even get a statistical trial They are unapproved for children hence "off label" So you're a bit of Johnny come lately to real issues with respect https://t.co/4ZyruuMPk6
@adamfare1996 There is not evidence of drug effects of SSRI of clinically significant benefit cause for concern Is it not? In adults In children, not even regulatory approval They could not even meet the arguably inappropriately low standards
@gikkos1 including lack of sham controlled trials or analysis of nonspecific effects being the cause of alleged 'benefits' of ECT. Antidepressants also don't have strong drug effects and weak drug effects they do have may be due to active placebo. https://t.co/4ZyruuMPk6
@johno0910 @RebeccadiGirola @SabraLane @leighsales media engagement led by self proclaimed "MH leaders" not engaged on placebo FX & withdrawal FX of SSRIs Akathesia gets no attention in Aus. correlation on youth suicide ignored for no "causal link" despite poor/dubious correlative data in "benefits" https://t.co/4ZyruuMPk6
RT @FalteringlyOn: @dan__brummitt Did you see these? Very similar. In agreement. Written by Doctors. The first one was result of probe laun…
@dan__brummitt Did you see these? Very similar. In agreement. Written by Doctors. The first one was result of probe launched by Australian Health minister Openly discusses misinformation spread by 2 prominent Psychiatrists https://t.co/8a1Lo7nFi1 https://t.co/4ZyruuMPk6 https://t.co/WBIchXfihO
@dan__brummitt @_d_a_n_i_e_l__b @thebeatles https://t.co/4ZyruuMPk6
@engagedpractx @SimonKatterl @psychepi plus there's Kirsch's work on FDA trial reanalysis in adules i wish someone would take a look at evidence review in context of this - &put easy read explainer for ppl w/ cognitive disability. how does this compare to 2009 evidence review methodologies? https://t.co/4ZyruuMPk6
@Samoskal What concerns me, is that Kirsch's reanalysis of FDA data that was obtained later shows that SSRI is mostly placebo Even in adults So what's going on with youth? How well do even evidence of moderate benefits hold up in light of this info? https://t.co/4ZyruuMPk6
@ShoreyThe3rd @PatMcGorry @KitanaValentine @suicideresearch @jeff_kennett @60Mins @DRC_AU It's actually wild, prominent Australian psychiatrists tried to discredit FDA blackbox warning on SSRIs &TGA didn't echo the warning. Claims it was cost/benefit ratio in favour of SSRIs makes no sense in light of minimal/negligible clinical FX over placebo https://t.co/4ZyruuMPk6
Also this article by Dr. Irving Kirsch a professor at Harvard Medical School is really good talking about double blinds broken in clinical trials for SSRIs & the placebo effect. https://t.co/e1uIZLLtUJ
@eactnowuk @davecurtis314 @ProfLAppleby @ProfRobHoward The serotonin hypothesis of depression is far from proven. It’s most likely a spurious correlation related to a survival adaption to mast cell overactivation. The dopamine hypothesis has a lot more supporting evidence. https://t.co/AB3JUHMgBk
@SameiHuda @DrEvgenyLegedin @PureDemocracyNZ @askdheeraj @joannamoncrieff While I think there is strong evidence pointing towards mast cell activation and dopamine having multi dimensional role in depressive pathogenesis, I am skeptical re: the serotonin hypothesis - upon which the whole antidepressant industry is based off. https://t.co/AB3JUHMgBk
https://t.co/AB3JUHMgBk https://t.co/FlHPOnSpTY
https://t.co/fgBU2AjMxd
Now combine that with the concern that SSRIs are no more effective than placebo (https://t.co/YQoFomGgEA) https://t.co/4ihEfD7QcK
Placebo Effect in the Treatment of Depression and Anxiety https://t.co/2qdXQtpF9Z
Embarrassing question to researchers/clinicians: what's with this hypothesis that most (if not all) of the benefits of antidepressants (for depression and anxiety) are due to the placebo response? Is this a fringe view? I want to cover placebo in lecture.. https://t.co/8YLBTv2sQV
RT @joannamoncrieff: In this paper, Irving Kirsch reports results of FDA's own meta-analysis of antidepressant studies which finds miniscul…
@awaisaftab @David27221696 That sounds right -although 'actual’ ADs don’t always significantly outperform placebo either. I’d be interested to see the trial papers you’ve in mind. I just read Kirsch 2019 which was interesting. https://t.co/VYPn5sA5OZ
@JodiMcKayMP @chiccomarx As long as that doesn’t automatically mean that they’re prescribed with anti-depressants, as they’ve been found to be less effective than a sugar pill, but with tragic side effects. “Placebo Effect in the Treatment of Depression and Anxiety” https://t.co/w64YuLZg44
@Herne_TheHunter @psychunseen @DrSathyaPrakas1 @AllenFrancesMD @awaisaftab @askdheeraj @EsquireRN @evolutionarypsy @J_F_Hayes @dawso007 @DrJefferyHayden @MaryFernando_ @jonathanstea @tylerblack32 @amybarnhorst @sameerjauhar @SameiHuda @ProfRobHoward @DrHowardLiu @DrvanTilburg @wendyburn @CoyneoftheRealm @cadoganhealthc1 It is not “my” argument – it is what research clearly shows. Also see the following (much newer) article that specifically discusses the placebo effect in psychiatry: https://t.co/Yotwg9lJtB
@elyasgarad Hi all, during these stressful times it’s important to seek help when needed however, please read the following research papers before taking Any Anti-Depresant pharmachalogical agents. You’re life may well depend on it! https://t.co/w64YuLZg44; https://t.co/wIT8zZ9rUe
@IdaHockerstrand @c_dahlstrom Det finns dock gott om studier som visar att allt möjligt har goda effekter vid depression och ångest. Merparten av effekten är placebo. Fördelen med dyra stenar är att de inte har så mycket kända bieffekter. https://t.co/XYxsV6jXgD
RT @joannamoncrieff: In this paper, Irving Kirsch reports results of FDA's own meta-analysis of antidepressant studies which finds miniscul…
RT @CEP_UK: @Coucou_CFC @ReadReadj @Martin_Ploederl @HengartnerMP @joannamoncrieff @EikoFried @PGtzsche1 @Mad_In_America @BigPhilHickey "an…
RT @CEP_UK: @Coucou_CFC @ReadReadj @Martin_Ploederl @HengartnerMP @joannamoncrieff @EikoFried @PGtzsche1 @Mad_In_America @BigPhilHickey "an…
@Coucou_CFC @ReadReadj @Martin_Ploederl @HengartnerMP @joannamoncrieff @EikoFried @PGtzsche1 @Mad_In_America @BigPhilHickey "antidepressants are no better in treating anxiety disorders than they are in treating depression" See: https://t.co/XmaNCRBNEp & https://t.co/8Eey7JBGI5
RT @joannamoncrieff: In this paper, Irving Kirsch reports results of FDA's own meta-analysis of antidepressant studies which finds miniscul…
RT @joannamoncrieff: In this paper, Irving Kirsch reports results of FDA's own meta-analysis of antidepressant studies which finds miniscul…
RT @joannamoncrieff: In this paper, Irving Kirsch reports results of FDA's own meta-analysis of antidepressant studies which finds miniscul…
RT @joannamoncrieff: In this paper, Irving Kirsch reports results of FDA's own meta-analysis of antidepressant studies which finds miniscul…
RT @joannamoncrieff: In this paper, Irving Kirsch reports results of FDA's own meta-analysis of antidepressant studies which finds miniscul…
RT @joannamoncrieff: In this paper, Irving Kirsch reports results of FDA's own meta-analysis of antidepressant studies which finds miniscul…
RT @joannamoncrieff: In this paper, Irving Kirsch reports results of FDA's own meta-analysis of antidepressant studies which finds miniscul…
RT @joannamoncrieff: In this paper, Irving Kirsch reports results of FDA's own meta-analysis of antidepressant studies which finds miniscul…
RT @joannamoncrieff: In this paper, Irving Kirsch reports results of FDA's own meta-analysis of antidepressant studies which finds miniscul…
RT @joannamoncrieff: In this paper, Irving Kirsch reports results of FDA's own meta-analysis of antidepressant studies which finds miniscul…
https://t.co/RsjZDymkXC
A veces conviene recordar que los efectos clínicos positivos de los antidepresivos y el placebo no se diferencian apenas. Mientras que los efectos secundarios... pues sí. https://t.co/RCYT9bZaOZ
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