Association Between Triglyceride Lowering and Reduction of Cardiovascular Risk Across Multiple Lipid-Lowering Therapeutic Classes: A Systematic Review and Meta-Regression Analysis of Randomized Controlled Trials.

Nicholas A Marston, Robert P Giugliano, KyungAh Im, Michael G Silverman, Michelle L O'Donoghue, Stephen D Wiviott, Brian A Ference, Marc S Sabatine

October 2019

Synopsis of Social media discussions

Many discussions highlight key studies and their implications, such as the effectiveness of high-dose EPA noted in the REDUCE-IT trial and the comparative futility found in the STRENGTH trial. The tone in these discussions is analytical and intensive, using phrases like 'the benefits of marine-derived omega-3 fatty acids appear to exceed their lipid-lowering effects,' which indicates a serious consideration of the potential clinical impacts this research could have.

A
Agreement
 Moderate agreement

The majority of discussions support the article's findings regarding triglyceride lowering and cardiovascular risk reduction, showing a positive consensus.

I
Interest
 High level of interest

Posts reflect high interest as participants discuss and analyze various studies and findings related to the publication.

E
Engagement
 High engagement

Many discussions delve into detailed comparisons of studies like REDUCE-IT and STRENGTH, indicating a thorough engagement with the content.

I
Impact
 High level of impact

Participants express a belief that the findings will significantly influence clinical practices regarding triglyceride management.

Social Mentions

YouTube

2 Videos

Facebook

2 Posts

Twitter

87 Posts

News

119 Articles

Metrics

Video Views

147,170

Total Likes

3,693

Extended Reach

631,284

Social Features

210

Timeline: Posts about article

Top Social Media Posts

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  • くに
    @daipc0203 (Twitter)

    RT @Fizz_DI: TG低下治療のメタ解析（24件の研究、n=197,270）。 ・心血管イベント EPAの追加：RR=0.93 [95%CI: 0.91-0.95] DHAの追加：RR=0.96 [95%CI: 0.89-1.03] Circulation.14…
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    September 26, 2025

    1

  • Fizz-DI＠比較と使い分け-KOJIMA Yushi
    @Fizz_DI (Twitter)

    TG低下治療のメタ解析（24件の研究、n=197,270）。 ・心血管イベント EPAの追加：RR=0.93 [95%CI: 0.91-0.95] DHAの追加：RR=0.96 [95%CI: 0.89-1.03] Circulation.140(16):1308-1317,(2019) PMID:31530008 https://t.co/XLpCQihc80
    view full post

    September 26, 2025

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  • Vass Vassiliou
    @vass_vassiliou (Twitter)

    @WALangProf @PeroneFrancesco @escardio @EAPCPresident @m_piepoli @AboyansV @hansen_phd @ESC_Journals @ESC_Camille @ESC_Lavinia @gbiondizoccai @El_Cavarretta @MichaelPapadak2 @FlavioDascenzi And the correct link!! https://t.co/H7BIwhJFAC.
    view full post

    February 24, 2024

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  • Das
    @shivadas29 (Twitter)

    https://t.co/f9XRhkSo6k https://t.co/39utlykkJC
    view full post

    May 22, 2021

  • Bhopender Thakur
    @TheBhupiThakur (Twitter)

    RT @NutritionMadeS3: Which is more important, LDL-C or triglycerides? 1) LDL-C changes have 4X more impact on CV risk BUT... 2) both LDL-…
    view full post

    May 14, 2021

    3

  • Bhopender Thakur
    @TheBhupiThakur (Twitter)

    RT @NutritionMadeS3: Which is more important, LDL-C or triglycerides? 1) LDL-C changes have 4X more impact on CV risk BUT... 2) both LDL-…
    view full post

    February 8, 2021

    3

  • Hidetaka Hamasaki
    @hhamasaki78 (Twitter)

    Association Between Triglyceride Lowering and Reduction of Cardiovascular Risk Across Multiple Lipid-Lowering Therapeutic Classes | Circulation https://t.co/vdBOy99zJp
    view full post

    August 29, 2020

  • Gil Carvalho MD PhD
    @NutritionMadeS3 (Twitter)

    Which is more important, LDL-C or triglycerides? 1) LDL-C changes have 4X more impact on CV risk BUT... 2) both LDL-C and TGs are surrogates of atherogenic apoB lipoproteins 3) you want BOTH under control! ignoring either one = playing Russian roulette https://t.co/4am8RVRBS4 https://t.co/nrqFkr7GFL
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    August 28, 2020

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  • Kamol
    @KamolMU (Twitter)

    RT @marstonMD: STRENGTH trial stopped early for futility. Unlike REDUCE-IT (4 g EPA), STRENGTH used a combo of EPA and DHA (2 g each). Our…
    view full post

    January 25, 2020

    8

  • Nishant Shah, MD
    @Nishant_ShahMD (Twitter)

    RT @marstonMD: STRENGTH trial stopped early for futility. Unlike REDUCE-IT (4 g EPA), STRENGTH used a combo of EPA and DHA (2 g each). Our…
    view full post

    January 14, 2020

    8

  • Stephen Juraschek MD, PhD, FAHA, AHSCP-CHS
    @spjuraschek (Twitter)

    RT @marstonMD: STRENGTH trial stopped early for futility. Unlike REDUCE-IT (4 g EPA), STRENGTH used a combo of EPA and DHA (2 g each). Our…
    view full post

    January 14, 2020

    8

  • SAMIT GHOSAL
    @SAMITGHOSAL (Twitter)

    RT @marstonMD: STRENGTH trial stopped early for futility. Unlike REDUCE-IT (4 g EPA), STRENGTH used a combo of EPA and DHA (2 g each). Our…
    view full post

    January 14, 2020

    8

  • Fusion Prog Guy @ fusionprogguy.bsky.social
    @FusionProgGuy (Twitter)

    RT @marstonMD: STRENGTH trial stopped early for futility. Unlike REDUCE-IT (4 g EPA), STRENGTH used a combo of EPA and DHA (2 g each). Our…
    view full post

    January 13, 2020

    8

  • Danielle Belardo, MD
    @DBelardoMD (Twitter)

    RT @marstonMD: STRENGTH trial stopped early for futility. Unlike REDUCE-IT (4 g EPA), STRENGTH used a combo of EPA and DHA (2 g each). Our…
    view full post

    January 13, 2020

    8

  • Edward K. Duran
    @EKDuranMD (Twitter)

    RT @marstonMD: STRENGTH trial stopped early for futility. Unlike REDUCE-IT (4 g EPA), STRENGTH used a combo of EPA and DHA (2 g each). Our…
    view full post

    January 13, 2020

    8

  • Nicholas Marston
    @marstonMD (Twitter)

    STRENGTH trial stopped early for futility. Unlike REDUCE-IT (4 g EPA), STRENGTH used a combo of EPA and DHA (2 g each). Our meta-analysis in @CircAHA this fall showed that the benefit of omega-3 fatty acids appeared to be in EPA only. @TIMIStudyGroup https://t.co/3qgAwRBbGq https://t.co/vs5vZ2S3Xy
    view full post

    January 13, 2020

    39

    8

  • Antonio Manteca
    @amango30 (Twitter)

    RT @RevistaMFSamfyc: Asociación entre el descenso de triglicéridos y la reducción de riesgo cardiovascular a través de varias clases de ter…
    view full post

    November 5, 2019

    1

  • Stefania Arciello
    @StefaniaArciell (Twitter)

    Association Between Triglyceride Lowering and Reduction of Cardiovascular Risk Across Multiple Lipid-Lowering Therapeutic Classes | Circulation https://t.co/NS2qWbT253
    view full post

    October 26, 2019

  • CNCFCardio
    @CNCFCardio (Twitter)

    RT @SABOURETCardio: Association Between Triglyceride Lowering and Reduction of Cardiovascular Risk Across Multiple Lipid-Lowering Therapeut…
    view full post

    October 20, 2019

    4

  • Arthur Win
    @artIMArt17 (Twitter)

    Association between triglyceride lowering and reduction of cardiovascular risk across multiple lipid-lowering therapeutic classes https://t.co/BxGzZ7V1wF
    view full post

    October 20, 2019

  • Erwin Téllez MD-Interventional Cardiologist
    @erwintellez (Twitter)

    RT @TIMIStudyGroup: Published this week in @CircAHA: TG lowering is associated with lower risk of CV events, but to a lesser extent than LD…
    view full post

    October 18, 2019

    1

  • TIMI Study Group
    @TIMIStudyGroup (Twitter)

    Published this week in @CircAHA: TG lowering is associated with lower risk of CV events, but to a lesser extent than LDL-C lowering. CV benefits of high dose EPA appear to exceed their lipid-lowering effects. @marstonMD https://t.co/Ge0E6xdwjK @DrM_ODonoghue @swiviott https://t.co/ZLDHZ04a13
    view full post

    October 18, 2019

    9

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  • yolimar meza
    @meza0208 (Twitter)

    RT @gonzaeperez: TRIGLICERIDOS Y REDUCCIÓN DEL RIESGO CARDIOVASCULAR No todo es #LDL El colesterol No-HDL es un valor que debemos mirar en…
    view full post

    October 17, 2019

    24

  • leo uzych
    @LeoUzych (Twitter)

    Association Between #Triglyceride Lowering and Reduction of #Cardiovascular Risk Across Multiple #Lipid-Lowering Therapeutic Classes | #Circulation https://t.co/3MxLRYgQfL
    view full post

    October 17, 2019

  • Jorge Montoya
    @JorgeMontoyaMD (Twitter)

    RT @gonzaeperez: TRIGLICERIDOS Y REDUCCIÓN DEL RIESGO CARDIOVASCULAR No todo es #LDL El colesterol No-HDL es un valor que debemos mirar en…
    view full post

    October 17, 2019

    24

  • Corine Aboa-Eboulé
    @corinne8154 (Twitter)

    RT @SABOURETCardio: Association Between Triglyceride Lowering and Reduction of Cardiovascular Risk Across Multiple Lipid-Lowering Therapeut…
    view full post

    October 17, 2019

    4

  • Euri Rivas
    @euri_rivas (Twitter)

    RT @gonzaeperez: TRIGLICERIDOS Y REDUCCIÓN DEL RIESGO CARDIOVASCULAR No todo es #LDL El colesterol No-HDL es un valor que debemos mirar en…
    view full post

    October 17, 2019

    24

  • SIAC
    @SIAC_cardio (Twitter)

    RT @gonzaeperez: TRIGLICERIDOS Y REDUCCIÓN DEL RIESGO CARDIOVASCULAR No todo es #LDL El colesterol No-HDL es un valor que debemos mirar en…
    view full post

    October 17, 2019

    24

  • Matilda
    @Karenina101010 (Twitter)

    RT @gonzaeperez: TRIGLICERIDOS Y REDUCCIÓN DEL RIESGO CARDIOVASCULAR No todo es #LDL El colesterol No-HDL es un valor que debemos mirar en…
    view full post

    October 17, 2019

    24

  • John Pernik
    @JohnPernik (Twitter)

    RT @gonzaeperez: TRIGLICERIDOS Y REDUCCIÓN DEL RIESGO CARDIOVASCULAR No todo es #LDL El colesterol No-HDL es un valor que debemos mirar en…
    view full post

    October 17, 2019

    24

  • Alejandra Fernández
    @AleFer_endo (Twitter)

    RT @gonzaeperez: TRIGLICERIDOS Y REDUCCIÓN DEL RIESGO CARDIOVASCULAR No todo es #LDL El colesterol No-HDL es un valor que debemos mirar en…
    view full post

    October 17, 2019

    24

  • Juan Carlos Cárdenas
    @juanc_c (Twitter)

    RT @gonzaeperez: TRIGLICERIDOS Y REDUCCIÓN DEL RIESGO CARDIOVASCULAR No todo es #LDL El colesterol No-HDL es un valor que debemos mirar en…
    view full post

    October 17, 2019

    24

  • gilmary marcano
    @gilmarym (Twitter)

    RT @gonzaeperez: TRIGLICERIDOS Y REDUCCIÓN DEL RIESGO CARDIOVASCULAR No todo es #LDL El colesterol No-HDL es un valor que debemos mirar en…
    view full post

    October 17, 2019

    24

  • Dr Daniel Valencia Torres
    @Doc_Valencia (Twitter)

    RT @gonzaeperez: TRIGLICERIDOS Y REDUCCIÓN DEL RIESGO CARDIOVASCULAR No todo es #LDL El colesterol No-HDL es un valor que debemos mirar en…
    view full post

    October 17, 2019

    24

  • Saad Ahmad, MD
    @SaadAhmadMD (Twitter)

    RT @SABOURETCardio: Association Between Triglyceride Lowering and Reduction of Cardiovascular Risk Across Multiple Lipid-Lowering Therapeut…
    view full post

    October 16, 2019

    4

  • Henry Gaviria
    @henrygav5 (Twitter)

    RT @gonzaeperez: TRIGLICERIDOS Y REDUCCIÓN DEL RIESGO CARDIOVASCULAR No todo es #LDL El colesterol No-HDL es un valor que debemos mirar en…
    view full post

    October 16, 2019

    24

  • Angela Romero Zarante, MD
    @ANGELARZ28 (Twitter)

    RT @gonzaeperez: TRIGLICERIDOS Y REDUCCIÓN DEL RIESGO CARDIOVASCULAR No todo es #LDL El colesterol No-HDL es un valor que debemos mirar en…
    view full post

    October 16, 2019

    24

  • Chile717
    @Chile7171 (Twitter)

    RT @gonzaeperez: TRIGLICERIDOS Y REDUCCIÓN DEL RIESGO CARDIOVASCULAR No todo es #LDL El colesterol No-HDL es un valor que debemos mirar en…
    view full post

    October 16, 2019

    24

  • Sherry-Ann Brown, MD, PhD, FACC, FAHA
    @drbrowncares (Twitter)

    RT @SABOURETCardio: Association Between Triglyceride Lowering and Reduction of Cardiovascular Risk Across Multiple Lipid-Lowering Therapeut…
    view full post

    October 16, 2019

    4

  • Daniel Velarde
    @dvelarde85 (Twitter)

    RT @gonzaeperez: TRIGLICERIDOS Y REDUCCIÓN DEL RIESGO CARDIOVASCULAR No todo es #LDL El colesterol No-HDL es un valor que debemos mirar en…
    view full post

    October 16, 2019

    24

  • Fernando Rodriguez
    @recetario1 (Twitter)

    RT @gonzaeperez: TRIGLICERIDOS Y REDUCCIÓN DEL RIESGO CARDIOVASCULAR No todo es #LDL El colesterol No-HDL es un valor que debemos mirar en…
    view full post

    October 16, 2019

    24

  • Shinya Goto
    @sgoto4 (Twitter)

    RT @CircAHA: Systematic review & meta-regression analysis of the association between #triglyceride lowering & reduction of #CV risk across…
    view full post

    October 16, 2019

    24

  • Manuel Gaxiola
    @cardiogax (Twitter)

    RT @gonzaeperez: TRIGLICERIDOS Y REDUCCIÓN DEL RIESGO CARDIOVASCULAR No todo es #LDL El colesterol No-HDL es un valor que debemos mirar en…
    view full post

    October 16, 2019

    24

  • Héctor Meckler
    @mecklerh (Twitter)

    RT @gonzaeperez: TRIGLICERIDOS Y REDUCCIÓN DEL RIESGO CARDIOVASCULAR No todo es #LDL El colesterol No-HDL es un valor que debemos mirar en…
    view full post

    October 16, 2019

    24

  • SABOURETCardiologist
    @SABOURETCardio (Twitter)

    Association Between Triglyceride Lowering and Reduction of Cardiovascular Risk Across Multiple Lipid-Lowering Therapeutic Classes | Circulation Will TG come back to the party ?
    view full post

    October 16, 2019

    17

    4

  • Aditya Doni Pradana
    @adityadoni (Twitter)

    RT @CircAHA: Systematic review & meta-regression analysis of the association between #triglyceride lowering & reduction of #CV risk across…
    view full post

    October 16, 2019

    24

  • Fernando de la Guía
    @Cardio_delaGuia (Twitter)

    RT @gonzaeperez: TRIGLICERIDOS Y REDUCCIÓN DEL RIESGO CARDIOVASCULAR No todo es #LDL El colesterol No-HDL es un valor que debemos mirar en…
    view full post

    October 16, 2019

    24

  • Gonzalo Perez
    @gonzaeperez (Twitter)

    TRIGLICERIDOS Y REDUCCIÓN DEL RIESGO CARDIOVASCULAR No todo es #LDL El colesterol No-HDL es un valor que debemos mirar en nuestros pacientes Vía @CircAHA #Trigliceridos #Colesterol #CardioTwitter https://t.co/4ipKByaULi https://t.co/i4VffODqxJ
    view full post

    October 16, 2019

    54

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  • СГАМ
    @CGAM2016 (Twitter)

    RT @CircAHA: Systematic review & meta-regression analysis of the association between #triglyceride lowering & reduction of #CV risk across…
    view full post

    October 16, 2019

    24

  • Salva García Morillo PhD. MD.
    @UCAMIraras (Twitter)

    RT @CircAHA: Systematic review & meta-regression analysis of the association between #triglyceride lowering & reduction of #CV risk across…
    view full post

    October 16, 2019

    24

  • Jose Jiménez. MD, PhD
    @josjmnzt (Twitter)

    RT @CircAHA: Systematic review & meta-regression analysis of the association between #triglyceride lowering & reduction of #CV risk across…
    view full post

    October 16, 2019

    24

  • FJGomezDelgado
    @gomezdelgadoFJ (Twitter)

    RT @CircAHA: Systematic review & meta-regression analysis of the association between #triglyceride lowering & reduction of #CV risk across…
    view full post

    October 16, 2019

    24

  • Joseph hill
    @josephahill (Twitter)

    RT @CircAHA: Systematic review & meta-regression analysis of the association between #triglyceride lowering & reduction of #CV risk across…
    view full post

    October 16, 2019

    24

  • SFDiabète
    @SFDiabete (Twitter)

    RT @CircAHA: Systematic review & meta-regression analysis of the association between #triglyceride lowering & reduction of #CV risk across…
    view full post

    October 16, 2019

    24

  • Carlos Maiorana
    @MaioranaCarlos (Twitter)

    RT @CircAHA: Systematic review & meta-regression analysis of the association between #triglyceride lowering & reduction of #CV risk across…
    view full post

    October 16, 2019

    24

  • Brett Gordon
    @BrettGordonAEP (Twitter)

    RT @CircAHA: Systematic review & meta-regression analysis of the association between #triglyceride lowering & reduction of #CV risk across…
    view full post

    October 16, 2019

    24

  • Renato Junior
    @RenatoJ41685542 (Twitter)

    RT @CircAHA: Systematic review & meta-regression analysis of the association between #triglyceride lowering & reduction of #CV risk across…
    view full post

    October 16, 2019

    24

  • SystematicReviewBot
    @EvidenceRobot (Twitter)

    RT @CircAHA: Systematic review & meta-regression analysis of the association between #triglyceride lowering & reduction of #CV risk across…
    view full post

    October 16, 2019

    24

  • Circulation
    @CircAHA (Twitter)

    Systematic review & meta-regression analysis of the association between #triglyceride lowering & reduction of #CV risk across multiple #lipid lowering therapeutic classes: Learn more: https://t.co/c1Kzkv82jj #AHAJournals @marstonMD https://t.co/S1b6Keg3qy
    view full post

    October 16, 2019

    31

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  • Dr Jean Pierre Laroche #vacciné 6.0
    @Echoraljpangio (Twitter)

    Association Between Triglyceride Lowering and Reduction of Cardiovascular Risk Across Multiple Lipid-Lowering Therapeutic Classes | Circulation https://t.co/lDbNCtgqVi
    view full post

    October 15, 2019

  • Larry Diamond
    @natureboyrr (Twitter)

    RT @Nutradvance: New sys review: "Triglyceride lowering is associated with lower risk of major CV events, even after adjusting for LDL-C lo…
    view full post

    September 27, 2019

    4

  • Lindt
    @Lindt52240991 (Twitter)

    RT @Nutradvance: New sys review: "Triglyceride lowering is associated with lower risk of major CV events, even after adjusting for LDL-C lo…
    view full post

    September 27, 2019

    4

  • DiscoStew
    @DiscoStew66 (Twitter)

    RT @Nutradvance: New sys review: "Triglyceride lowering is associated with lower risk of major CV events, even after adjusting for LDL-C lo…
    view full post

    September 27, 2019

    4

  • Globiance Live Chat & Support
    @globiance_Desk (Twitter)

    RT @Nutradvance: New sys review: "Triglyceride lowering is associated with lower risk of major CV events, even after adjusting for LDL-C lo…
    view full post

    September 27, 2019

    4

  • Michael Joseph
    @Nutradvance (Twitter)

    New sys review: "Triglyceride lowering is associated with lower risk of major CV events, even after adjusting for LDL-C lowering" EPA omega-3 possibly protective: "Each 1 gram/d of EPA associated with a 7% relative risk reduction in major vascular events" https://t.co/qJFpSgZqRG
    view full post

    September 27, 2019

    8

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  • Evan Beloff
    @evanbeloff (Twitter)

    “In randomized controlled trials, triglyceride lowering is associated with lower risk of major vascular events...Furthermore, the benefits of marine-derived omega-3 fatty acids, particularly high-dose EPA, appear to exceed their lipid-lowering effects” https://t.co/ITnkC5pprx
    view full post

    September 23, 2019

  • TIMI Study Group
    @TIMIStudyGroup (Twitter)

    2/2: The CV benefit of high-dose EPA may exceed lipid-lowering effect. @marstonMD @circAHA https://t.co/awVPfGAlcx
    view full post

    September 23, 2019

    2

  • Dawna Mughal PhD RDN
    @DawnaMughalPhD (Twitter)

    Association Between Triglyceride Lowering and Reduction of Cardiovascular Risk Across Multiple Lipid-Lowering Therapeutic Classes: A Systematic Rev... - PubMed - NCBI https://t.co/hxOatTNb57
    view full post

    September 22, 2019

    1

  • Rafael Radaeli
    @rfradaeli (Twitter)

    RT @marstonMD: Is triglyceride lowering associated with CV risk reduction? Does high-dose EPA have CV benefit that exceeds what is expected…
    view full post

    September 20, 2019

    9

  • Patrick Holmes
    @drpatrickholmes (Twitter)

    RT @marstonMD: Is triglyceride lowering associated with CV risk reduction? Does high-dose EPA have CV benefit that exceeds what is expected…
    view full post

    September 20, 2019

    9

  • phillip
    @phillip09255792 (Twitter)

    RT @marstonMD: Is triglyceride lowering associated with CV risk reduction? Does high-dose EPA have CV benefit that exceeds what is expected…
    view full post

    September 20, 2019

    9

  • Antoine Rimbert
    @AntoineRimbert (Twitter)

    RT @marstonMD: Is triglyceride lowering associated with CV risk reduction? Does high-dose EPA have CV benefit that exceeds what is expected…
    view full post

    September 20, 2019

    9

  • Dan Murphy
    @DanMurp64755192 (Twitter)

    Association Between Triglyceride Lowering and Reduction of Cardiovascular Risk Across Multiple Lipid-Lowering Therapeutic Classes: A Systematic Review and Meta-Regression Analysis of Randomized Controlled Trials | Circulation https://t.co/ik1xSTs2EL
    view full post

    September 19, 2019

  • Thomas Zelniker
    @ThomasZelniker (Twitter)

    RT @marstonMD: Is triglyceride lowering associated with CV risk reduction? Does high-dose EPA have CV benefit that exceeds what is expected…
    view full post

    September 19, 2019

    9

  • Brigham & Women's CV Fellows
    @BrighamFellows (Twitter)

    RT @marstonMD: Is triglyceride lowering associated with CV risk reduction? Does high-dose EPA have CV benefit that exceeds what is expected…
    view full post

    September 19, 2019

    9

  • George Thanassoulis
    @ThanassoulisMD (Twitter)

    RT @marstonMD: Is triglyceride lowering associated with CV risk reduction? Does high-dose EPA have CV benefit that exceeds what is expected…
    view full post

    September 19, 2019

    9

  • Muthu Vaduganathan
    @mvaduganathan (Twitter)

    RT @marstonMD: Is triglyceride lowering associated with CV risk reduction? Does high-dose EPA have CV benefit that exceeds what is expected…
    view full post

    September 19, 2019

    9

  • Pradeep Natarajan
    @pnatarajanmd (Twitter)

    RT @marstonMD: Is triglyceride lowering associated with CV risk reduction? Does high-dose EPA have CV benefit that exceeds what is expected…
    view full post

    September 19, 2019

    9

  • Nicholas Marston
    @marstonMD (Twitter)

    Is triglyceride lowering associated with CV risk reduction? Does high-dose EPA have CV benefit that exceeds what is expected by lipid-lowering alone? Our 49 trial meta-regression sheds light on these questions @circAHA @TIMIStudyGroup @BrighamFellows https://t.co/QXR1nXlg9p https://t.co/ZV0WOFWbAt
    view full post

    September 19, 2019

    38

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  • BearDownAZ
    @BearDownAZ_2019 (Twitter)

    Fair and balanced review article on CVD risk reduction in TG-lowering trials with emphasis on omega-3s. Last couple of paragraphs were superb. Acknowledged both the awesomeness on icosapent ethyl in REDUCE-IT as well as the concerns and unknowns. https://t.co/bgb1EIxKym https://t.co/sZXTPdzcTU
    view full post

    September 19, 2019

  • TerraPharma
    @TerraPharma1 (Twitter)

    Association Between TG Lowering and Reduction of CV Risk Across Multiple Lipid-Lowering Therapeutic Classes "Furthermore, benefits of marine-derived omega-3 fatty acids, particularly high-dose EPA, appear to exceed their lipid-lowering effects" $AMRN https://t.co/6RzCgdZnJc
    view full post

    September 19, 2019

    19

  • SystematicReviewBot
    @EvidenceRobot (Twitter)

    RT @mbotana: Association Between Triglyceride Lowering and Reduction of Cardiovascular Risk Across Multiple Lipid-Lowering Therapeutic Clas…
    view full post

    September 19, 2019

    1

  • Manuel Botana
    @mbotana (Twitter)

    Association Between Triglyceride Lowering and Reduction of Cardiovascular Risk Across Multiple Lipid-Lowering Therapeutic Classes: A Systematic Review and Meta-Regression Analysis of Randomized Controlled Trials | Circulation https://t.co/KQAc2cDCou
    view full post

    September 19, 2019

    7

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  • SBR
    @SBRInvestor (Twitter)

    @DrMarthaGulati @NadeenFaza @HMethodistCV @NorthwesternU @WilliamZoghbi @DipanJShah @almallahmo @DeBakeyCVedu @ChamsiPash @ACCinTouch @escardio @Heart_SCCT @SCAI @AHAScience @nstonedoc https://t.co/QR7B4tHbQR
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Abstract Synopsis

  • The study analyzed randomized controlled trials to assess the relationship between lowering triglycerides and reducing cardiovascular risk, focusing on therapies like fibrates, niacin, and omega-3 fatty acids alongside statins.
  • It included data from 374,358 participants, highlighting that while triglyceride-lowering therapies showed varying results in reducing major vascular events, reductions in non-high-density lipoprotein cholesterol (non-HDL-C) and low-density lipoprotein cholesterol (LDL-C) were associated with reduced cardiovascular risks.
  • The REDUCE-IT trial, which examined the effects of icosapent ethyl, was noted as a significant outlier in showing a strong impact on reducing cardiovascular events.