Must read!!! Apolipoprotein B Particles and Cardiovascular Disease (by A. Sniderman & Co) A Narrative Review @pabeda1 @SABOURETCardio @Drlipid @lipiddoc doi:10.1001/jamacardio.2019.3780 https://t.co/xaAemRSPnh
Apolipoprotein B Particles and Cardiovascular Disease: A Narrative Review.
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Oct 2019 – Oct 2025Where it's discussed
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What people are saying
The group's comments demonstrate strong agreement with the article's conclusions, with many posts emphasizing that all apoB particles are equally atherogenic, supported by direct quotes and references to authoritative reviews. Their tone reflects genuine interest and deep engagement, aiming to inform and influence health-related decisions and perceptions of lipid management.
Most discussions strongly align with the article's assertion that all apoB particles are equally atherogenic, supported by phrases like 'All LDL is atherogenic' and references to Sniderman's review confirming this view.
The posts actively explore detailed aspects of lipid biology, emphasizing the importance of apoB and particle size, indicating high curiosity and concern about the subject.
Several posts cite specific studies, share summaries, and urge testing or reading the article, showing deep involvement and reflection on the material.
The discussions highlight a consensus that understanding apoB's role could significantly influence cardiovascular risk assessment and treatment strategies, stressing the article's high relevance.
Abstract in brief
- Apolipoprotein B (apoB) particles are a better indicator of atherosclerosis risk than traditional cholesterol measures because each atherogenic lipoprotein particle contains one apoB molecule, and the number of these particles determines how much cholesterol is deposited in the arterial wall.
- Cholesterol only enters the arterial wall via apoB particles, and smaller, cholesterol-depleted apoB particles are more likely to be trapped within arterial walls compared to larger, cholesterol-rich ones, influencing the extent of atherosclerosis.
- Overall, all apoB-containing particles are similarly atherogenic, and measuring apoB provides a clearer, more straightforward assessment of cardiovascular risk than conventional lipid markers like LDL cholesterol.]
Top posts
Most liked on X and Bluesky#apoB clarifies and unifies—and therefore simplifies—the role of the atherogenic lipoproteins in causing CV disease https://t.co/Qe3SYj64Jt
"ApoB unifies, amplifies, and simplifies the information from the conventional lipid markers as to the atherogenic risk attributable to the apoB lipoproteins." https://t.co/OOCyCuw1ZY @Drlipid @drpablocorral @lipiddoc @cwojcik @ProfKausikRay @ErinMichos @MartinTibuakuu
#apoB clarifies and unifies—and therefore simplifies—the role of the atherogenic lipoproteins in causing CV disease https://t.co/3RwGAHvVA7
Apolipoprotein B Particles and Cardiovascular Disease: A Narrative Review @JAMACardio https://t.co/jscWW8Znpj
Ending notes: If someone is asking you or trying to convenience you that high cholesterol is fine, they are pushing you towards a cardiac arrest. https://t.co/wrX0kgFzDz https://t.co/FXW9GMHgCL
All mentions
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@SamaHoole As below - all apoB particles are equally atherogenic Being comforted by having more large fluffy LDL is seriously misguided - they are not cute fluffy toys
Other agents: ❌ Bile acid sequestrants: work (~15–20%) but poorly tolerated ❌ Fibrates: limited ApoB effect unless TGs are very high ❌ Niacin: no reduction in risk of death, MACE, or stroke
Alirocumab & evolocumab are monoclonal antibodies which act as PCSK9 inhibitors to prevent LDL receptor degradation. ✅ More recycling ✅ More clearance ✅ Additional 50–60% ApoB drop
Compounding 5 Actions to unlock your Healthiest, Longest Life https://t.co/rmjkJ0j1Ls via @YouTube
@daveyx2 @MohammedAlo Found it! Apolipoprotein B Particles and Cardiovascular Disease: A Narrative Review. Allan D. Sniderman https://t.co/dpVfO0GMe1
@MasalaFry69 @DrFrankLipman This article describes the pathway: JAMA Cardiol. 2019 Dec 1;4(12):1287–1295. doi: 10.1001/jamacardio.2019.3780 Apolipoprotein B Particles and Cardiovascular Disease: A Narrative Review.
@DudzLightLime @AlexJLeaf @MattCalkinsMD @lipo_fan @Clint_OMeley @Lipoprotein @MattBMartin @realDaveFeldman @DoctorTro @NutritionMadeS3 @nicknorwitz @AdrianSotoMota Size matters insofar as it affects particle number. For a given cholesterol amount, if you have smaller particles, you’ll need more of them to carry the cholesterol…Higher risk https://t.co/5f5Tr4XUGl
Apolipoprotein B Particles and Cardiovascular Disease: A Narrative Review | @scoopit https://t.co/OmjroxwrQE
https://t.co/DmsUaeh2hF
Compounding 5 Actions to unlock your Healthiest, Longest Life https://t.co/efKBrAXs9v via @YouTube
https://t.co/EmKgaZR9Z8
Recomiendo mucho este artículo para darle una repasada el tema https://t.co/mffJpBK694
Compounding 5 Actions to unlock your Healthiest, Longest Life https://t.co/2Tqiipa004 via @YouTube
Compounding 5 Actions to unlock your Healthiest, Longest Life https://t.co/IqJtmJvCMP
@jivanmuktii ALL LDL Particles Are Atherogenic, Not Just Small Dense or Oxidized This is a great article to read that is a great review of atherosclerosis and the role LDL plays in atherogenisis. https://t.co/ndMUMDxAkb Conclusion: The net result is, with the exceptions of the abnormal
@HueckerM Re the overwhelming data supporting apoB - see https://t.co/dBg9UUdEcK and https://t.co/NF2suBIdYj and https://t.co/SJsKfSv6EU and https://t.co/8qKqhnVAIw
https://t.co/IpjQLDLgjo
@freedominguez See https://t.co/dBg9UUdEcK and https://t.co/NF2suBIdYj or watch this https://t.co/kdHkSkemRK
@claytooine @NutritionMadeS3 @onesecanshul To learn about apoB, ask your doc to read any current lipid textbook or any of the current guidelines or share this open access paper with him https://t.co/dBg9UUdEcK
@JohnAdamsDOI ALL LDL Particles Are Atherogenic, Not Just Small Dense or Oxidized This is a great article to read that is a great review of atherosclerosis and the role LDL plays in atherogenisis. https://t.co/ndMUMDxAkb Conclusion: The net result is, with the exceptions of the abnormal
@CaryKelly11 https://t.co/vGoEimSYdH
@REV_Insulin_Res @TheBhupiThakur In short yes. This is a great review from Sniderman https://t.co/vGoEimSqo9
@shelly_187 @ivan_martineau https://t.co/vGoEimSqo9 here's a narrative review from world authority on ApoB, Allan Sniderman & colleagues.
@TotalCytopath @DrNadolsky ALL LDL Particles Are Atherogenic, Not Just Small Dense or Oxidized This is a great article to read that is a great review of atherosclerosis and the role LDL plays in atherogenisis. https://t.co/ndMUMDxAkb Conclusion: The net result is, with the exceptions of the abnormal
@MeowMeowPetrus https://t.co/NF2suBIdYj and https://t.co/dBg9UUdEcK https://t.co/7wPT1b5bmd
@KetoCarnivore @JohnnyScott234 @exfatloss @jerryteixeira @gri999999 @garytaubes @SBakerMD https://t.co/B1DNIgm6k6 I’m not not of the opinion this is the only thing that matters or even if it’s the most important. I do think it’s manageable through diet so do consider it with my choices regardless of my current status.
टिप्पणियो को खतम करते हुए । अगर कोई आपसे पूछता है , या आपको यह मनाने की कोशिश करता है , कि उच्च कोलेस्ट्रॉल ठीक है , वह आपको दिल के दोहरे की तरफ धकेल रहा है । https://t.co/wrX0kgFzDz
Apparently the number of apoB particles AND the amount of cholesterol in the apoB particle contribute to AS. Size (apparently) does matter. https://t.co/tRSZHutWKi
RT @chiragbarjatyaa: Ending notes: If someone is asking you or trying to convenience you that high cholesterol is fine, they are pushing y…
Ending notes: If someone is asking you or trying to convenience you that high cholesterol is fine, they are pushing you towards a cardiac arrest. https://t.co/wrX0kgFzDz https://t.co/FXW9GMHgCL
RT @MohammedAlo: @TuckerGoodrich oxLDL is not reliable. Labs are just making a killing selling labs that are unreliable. We've studied this…
@TuckerGoodrich oxLDL is not reliable. Labs are just making a killing selling labs that are unreliable. We've studied this extensively. Maybe back in 2008 we used to think that. But not in 2023. https://t.co/ndMUMDxAkb
@smaart_bugger @malcolmken All #LDL / #ApoB particles are atherogenic regardless of size. https://t.co/ndMUMDxAkb
@MohammedAlo @Drlipid Allan Sniderman would say net risk is the same. Smaller particles more likely to penetrate but deposit less cholesterol each time. https://t.co/5f5Tr4XUGl
RT @MohammedAlo: @Drlipid @society_eas https://t.co/xdWtTEw4tJ "The net result is, with the exceptions of the abnormal chylomicron remnant…
@DudzLightLime https://t.co/xdWtTEw4tJ "The net result is, with the exceptions of the abnormal chylomicron remnants in type III hyperlipoproteinemia and lipoprotein (a), all apoB particles are equally atherogenic."
@KenDBerryMD @Drlipid @society_eas All LDL is atherogenic. https://t.co/xdWtTEw4tJ "The net result is, with the exceptions of the abnormal chylomicron remnants in type III hyperlipoproteinemia and lipoprotein (a), all apoB particles are equally atherogenic."
@Drlipid @society_eas https://t.co/xdWtTEw4tJ "The net result is, with the exceptions of the abnormal chylomicron remnants in type III hyperlipoproteinemia and lipoprotein (a), all apoB particles are equally atherogenic."
@gildone84 All LDL is atherogenic https://t.co/xdWtTEw4tJ
@MasalaFry69 Correct, the biomarker ApoB is not causal of disease. However, measuring your ApoB levels can help you and your healthcare provider further evaluate the status of your heart health. https://t.co/nsCKqNX2Ig
RT @InsideTracker: @ZahcM Here are three peer-reviewed scientific articles that describe this concept. https://t.co/nsCKqNX2Ig https://t.co…
@ZahcM Here are three peer-reviewed scientific articles that describe this concept. https://t.co/nsCKqNX2Ig https://t.co/OeiLbPQ7t4 https://t.co/6Jl2gQMMqS We’re interested to hear more about your scientific perspective on the standard lipid panels and the marker ApoB!
@Nope53640754 @bodyofwine https://t.co/IckCUICaFO
RT @drpablocorral: Must read!!! Apolipoprotein B Particles and Cardiovascular Disease (by A. Sniderman & Co) A Narrative Review @pabeda1 @S…
@PaulRBerg Regarding apoB: Hundreds of studies: epidemiological, clinical trials Mendelian randomization trials - see https://t.co/dBg9UTW2Oa and https://t.co/8qKqhnDZjW and https://t.co/u4YoqetsAw and https://t.co/iNQwGLHljv
RT @fipco: Why might small LDL particles have risk greater than implied by cholesterol mass? Review by Sniderman et al. from 2019 https://t…
Why might small LDL particles have risk greater than implied by cholesterol mass? Review by Sniderman et al. from 2019 https://t.co/Amk1OYkrzD https://t.co/w3uL6uFbzh
@Lpa_Doc Would be interested to hear @Drlipid and Allan Sniderman comment on this. But here’s Sniderman’s review on this: https://t.co/JXaLOCYClq
@Conigman I think you should get your ApoB tested at any time. Periodically. CVD is a major risk factor of T2D. ApoB covered here in detail https://t.co/5f5Tr4XUGl Non-HDL is essentially the same information
Apolipoprotein B Particles and Cardiovascular Disease: A Narrative Review - PubMed @Mangan150 https://t.co/ibBjEy9t5N
“all apoB particles are equally atherogenic” Agree or disagree? https://t.co/5f5Tr4XUGl
@John_G_Willis @ScepticalDoctor @bulkbiker @coalhoof @Alecsplaining @MattMadore576 @kevinnbass I'll just post these to brush up your understanding and clear up some misconceptions. https://t.co/UEmtA0zoq3 https://t.co/zCJ1DIKZU0 https://t.co/bgHpwrsfG8 https://t.co/EPKT5mDggg https://t.co/7bo22LtT1D https://t.co/mM0dMK1X1z Now I can go back to ignoring you
RT @prabhud19: Apolipoprotein B Particles and Cardiovascular Disease: A Narrative Review. https://t.co/VI3PMK8g0F @pmanokar this is for you
Apolipoprotein B Particles and Cardiovascular Disease: A Narrative Review. https://t.co/VI3PMK8g0F @pmanokar this is for you
RT @drpablocorral: Must read!!! Apolipoprotein B Particles and Cardiovascular Disease (by A. Sniderman & Co) A Narrative Review @pabeda1 @S…
Is it more important to focus on large LDL-C❓ 'The net effect is that all LDL-C particles pose relatively equal risk' Study link supporting this
RT @Drlipid: @ethanjweiss @PierreEliasMD @Lpa_Doc @lipiddoc https://t.co/hr6qJrK4nB and https://t.co/dBg9UUdEcK
@ethanjweiss @PierreEliasMD @Lpa_Doc @lipiddoc https://t.co/hr6qJrK4nB and https://t.co/dBg9UUdEcK
RT @drpablocorral: Must read!!! Apolipoprotein B Particles and Cardiovascular Disease (by A. Sniderman & Co) A Narrative Review @pabeda1 @S…
RT @Drlipid: Nice review but - to clarify - VLDL-apoB NEVER EVER APPROACHES LDL-apoB except in Type III patients https://t.co/dBg9UUdEc…
RT @Drlipid: Nice review but - to clarify - VLDL-apoB NEVER EVER APPROACHES LDL-apoB except in Type III patients https://t.co/dBg9UUdEc…
RT @Drlipid: Nice review but - to clarify - VLDL-apoB NEVER EVER APPROACHES LDL-apoB except in Type III patients https://t.co/dBg9UUdEc…
Nice review but - to clarify - VLDL-apoB NEVER EVER APPROACHES LDL-apoB except in Type III patients https://t.co/dBg9UUdEcK Graphic from https://t.co/Yg0BhHxB4z https://t.co/gTVfCBZe67 https://t.co/a9WhKh33Yv
For more information, check out this great review by Sniderman and colleagues regarding the association of ApoB and CVD risk! https://t.co/zR4DznTvcI
RT @JAMACardio: #apoB clarifies and unifies—and therefore simplifies—the role of the atherogenic lipoproteins in causing CV disease https:/…
RT @JAMACardio: #apoB clarifies and unifies—and therefore simplifies—the role of the atherogenic lipoproteins in causing CV disease https:/…
RT @JAMACardio: #apoB clarifies and unifies—and therefore simplifies—the role of the atherogenic lipoproteins in causing CV disease https:/…
RT @JAMACardio: #apoB clarifies and unifies—and therefore simplifies—the role of the atherogenic lipoproteins in causing CV disease https:/…
https://t.co/suuiYL1Og6
RT @JAMACardio: #apoB clarifies and unifies—and therefore simplifies—the role of the atherogenic lipoproteins in causing CV disease https:/…
RT @JAMACardio: #apoB clarifies and unifies—and therefore simplifies—the role of the atherogenic lipoproteins in causing CV disease https:/…
RT @JAMACardio: #apoB clarifies and unifies—and therefore simplifies—the role of the atherogenic lipoproteins in causing CV disease https:/…
RT @JAMACardio: #apoB clarifies and unifies—and therefore simplifies—the role of the atherogenic lipoproteins in causing CV disease https:/…
RT @JAMACardio: #apoB clarifies and unifies—and therefore simplifies—the role of the atherogenic lipoproteins in causing CV disease https:/…
RT @JAMACardio: #apoB clarifies and unifies—and therefore simplifies—the role of the atherogenic lipoproteins in causing CV disease https:/…
RT @JAMACardio: #apoB clarifies and unifies—and therefore simplifies—the role of the atherogenic lipoproteins in causing CV disease https:/…
Apolipoprotein B Particles and Cardiovascular Disease: A Narrative Review | Cardiology | JAMA Cardiology | JAMA Network https://t.co/FjIbQSKTa0
RT @JAMACardio: #apoB clarifies and unifies—and therefore simplifies—the role of the atherogenic lipoproteins in causing CV disease https:/…
RT @JAMACardio: #apoB clarifies and unifies—and therefore simplifies—the role of the atherogenic lipoproteins in causing CV disease https:/…
RT @JAMACardio: #apoB clarifies and unifies—and therefore simplifies—the role of the atherogenic lipoproteins in causing CV disease https:/…
RT @JAMACardio: #apoB clarifies and unifies—and therefore simplifies—the role of the atherogenic lipoproteins in causing CV disease https:/…
RT @JAMACardio: #apoB clarifies and unifies—and therefore simplifies—the role of the atherogenic lipoproteins in causing CV disease https:/…
RT @JAMACardio: #apoB clarifies and unifies—and therefore simplifies—the role of the atherogenic lipoproteins in causing CV disease https:/…
RT @JAMACardio: #apoB clarifies and unifies—and therefore simplifies—the role of the atherogenic lipoproteins in causing CV disease https:/…
RT @JAMACardio: #apoB clarifies and unifies—and therefore simplifies—the role of the atherogenic lipoproteins in causing CV disease https:/…
RT @JAMACardio: #apoB clarifies and unifies—and therefore simplifies—the role of the atherogenic lipoproteins in causing CV disease https:/…
RT @JAMACardio: #apoB clarifies and unifies—and therefore simplifies—the role of the atherogenic lipoproteins in causing CV disease https:/…
#apoB clarifies and unifies—and therefore simplifies—the role of the atherogenic lipoproteins in causing CV disease https://t.co/Qe3SYj64Jt
Apolipoprotein B Particles and Cardiovascular Disease: A Narrative Review https://t.co/O6vxncnBjK
RT @ehlJAMA: @adamcifu More than extrapolation being problematic- the entire thesis about lowering LDL may be off base explaining why this…
RT @ehlJAMA: @adamcifu More than extrapolation being problematic- the entire thesis about lowering LDL may be off base explaining why this…
@adamcifu More than extrapolation being problematic- the entire thesis about lowering LDL may be off base explaining why this study had such a small effect. It may be Apo B is more important than LDL. See https://t.co/OSzH47zsWT
RT @pnatarajanmd: Apolipoprotein B Particles and Cardiovascular Disease: A Narrative Review @JAMACardio https://t.co/jscWW8Znpj
RT @pnatarajanmd: Apolipoprotein B Particles and Cardiovascular Disease: A Narrative Review @JAMACardio https://t.co/jscWW8Znpj
RT @pnatarajanmd: Apolipoprotein B Particles and Cardiovascular Disease: A Narrative Review @JAMACardio https://t.co/jscWW8Znpj
RT @pnatarajanmd: Apolipoprotein B Particles and Cardiovascular Disease: A Narrative Review @JAMACardio https://t.co/jscWW8Znpj
RT @pnatarajanmd: Apolipoprotein B Particles and Cardiovascular Disease: A Narrative Review @JAMACardio https://t.co/jscWW8Znpj
RT @pnatarajanmd: Apolipoprotein B Particles and Cardiovascular Disease: A Narrative Review @JAMACardio https://t.co/jscWW8Znpj
RT @pnatarajanmd: Apolipoprotein B Particles and Cardiovascular Disease: A Narrative Review @JAMACardio https://t.co/jscWW8Znpj
RT @pnatarajanmd: Apolipoprotein B Particles and Cardiovascular Disease: A Narrative Review @JAMACardio https://t.co/jscWW8Znpj
RT @drpablocorral: Must read!!! Apolipoprotein B Particles and Cardiovascular Disease (by A. Sniderman & Co) A Narrative Review @pabeda1 @S…
Apolipoprotein B Particles and Cardiovascular Disease https://t.co/LW83w5f3Ck
RT @drpablocorral: Must read!!! Apolipoprotein B Particles and Cardiovascular Disease (by A. Sniderman & Co) A Narrative Review @pabeda1 @S…
#apoB clarifies and unifies—and therefore simplifies—the role of the atherogenic lipoproteins in causing CV disease https://t.co/3RwGAHvVA7
Apolipoprotein B Particles and Cardiovascular Disease https://t.co/WCN6aRW0ML
RT @drjkahn: Good Stuff! Apolipoprotein B Particles and Cardiovascular Disease: A Narrative Review. - PubMed - NCBI https://t.co/dFlJaASM…
Good Stuff! Apolipoprotein B Particles and Cardiovascular Disease: A Narrative Review. - PubMed - NCBI https://t.co/dFlJaASMdc @lipoproteinaFDN
Apolipoprotein B Particles and Cardiovascular Disease https://t.co/YgO3NpOEFO
Apolipoprotein B Particles and Cardiovascular Disease https://t.co/rjEXSz0DcQ
RT @drpablocorral: Must read!!! Apolipoprotein B Particles and Cardiovascular Disease (by A. Sniderman & Co) A Narrative Review @pabeda1 @S…
RT @drpablocorral: Must read!!! Apolipoprotein B Particles and Cardiovascular Disease (by A. Sniderman & Co) A Narrative Review @pabeda1 @S…
https://t.co/zzlQ5evILu
RT @drpablocorral: Must read!!! Apolipoprotein B Particles and Cardiovascular Disease (by A. Sniderman & Co) A Narrative Review @pabeda1 @S…
RT @drpablocorral: Must read!!! Apolipoprotein B Particles and Cardiovascular Disease (by A. Sniderman & Co) A Narrative Review @pabeda1 @S…
RT @drpablocorral: Must read!!! Apolipoprotein B Particles and Cardiovascular Disease (by A. Sniderman & Co) A Narrative Review @pabeda1 @S…
RT @drpablocorral: Must read!!! Apolipoprotein B Particles and Cardiovascular Disease (by A. Sniderman & Co) A Narrative Review @pabeda1 @S…
RT @drpablocorral: Must read!!! Apolipoprotein B Particles and Cardiovascular Disease (by A. Sniderman & Co) A Narrative Review @pabeda1 @S…
RT @drpablocorral: Must read!!! Apolipoprotein B Particles and Cardiovascular Disease (by A. Sniderman & Co) A Narrative Review @pabeda1 @S…
RT @drpablocorral: Must read!!! Apolipoprotein B Particles and Cardiovascular Disease (by A. Sniderman & Co) A Narrative Review @pabeda1 @S…
RT @pnatarajanmd: Apolipoprotein B Particles and Cardiovascular Disease: A Narrative Review @JAMACardio https://t.co/jscWW8Znpj
Apolipoprotein B Particles and Cardiovascular Disease: A Narrative Review @JAMACardio https://t.co/jscWW8Znpj
RT @drpablocorral: Must read!!! Apolipoprotein B Particles and Cardiovascular Disease (by A. Sniderman & Co) A Narrative Review @pabeda1 @S…
RT @drpablocorral: Must read!!! Apolipoprotein B Particles and Cardiovascular Disease (by A. Sniderman & Co) A Narrative Review @pabeda1 @S…
RT @JPSwcpmc: "ApoB unifies, amplifies, and simplifies the information from the conventional lipid markers as to the atherogenic risk attri…
RT @JPSwcpmc: "ApoB unifies, amplifies, and simplifies the information from the conventional lipid markers as to the atherogenic risk attri…
"ApoB unifies, amplifies, and simplifies the information from the conventional lipid markers as to the atherogenic risk attributable to the apoB lipoproteins." https://t.co/OOCyCuw1ZY @Drlipid @drpablocorral @lipiddoc @cwojcik @ProfKausikRay @ErinMichos @MartinTibuakuu
RT @drpablocorral: Must read!!! Apolipoprotein B Particles and Cardiovascular Disease (by A. Sniderman & Co) A Narrative Review @pabeda1 @S…
RT @drpablocorral: Must read!!! Apolipoprotein B Particles and Cardiovascular Disease (by A. Sniderman & Co) A Narrative Review @pabeda1 @S…
RT @drpablocorral: Must read!!! Apolipoprotein B Particles and Cardiovascular Disease (by A. Sniderman & Co) A Narrative Review @pabeda1 @S…
RT @drpablocorral: Must read!!! Apolipoprotein B Particles and Cardiovascular Disease (by A. Sniderman & Co) A Narrative Review @pabeda1 @S…
Must read!!! Apolipoprotein B Particles and Cardiovascular Disease (by A. Sniderman & Co) A Narrative Review @pabeda1 @SABOURETCardio @Drlipid @lipiddoc doi:10.1001/jamacardio.2019.3780 https://t.co/xaAemRSPnh
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