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Cell Rep December 2019 PMID 31875561

Human Primordial Germ Cells Are Specified from Lineage-Primed Progenitors.

Di Chen, Na Sun, Lei Hou, Rachel Kim, Jared Faith, Marianna Aslanyan, Yu Tao, Yi Zheng, Jianping Fu, Wanlu Liu, Manolis Kellis, Amander Clark

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Mentions

42
Peak: 10 in Dec 2019
across 5 sources since Dec 2019

Extended reach

28,619
potential audience

Total likes

29

Video views

122

Mentions per month

Dec 2019 – Sep 2021

Where it's discussed

  • News18 articles
  • X / Twitter15 posts
  • Blogs5 articles
  • YouTube2 videos
  • Facebook2 posts

AI synopsis

What people are saying

The overall tone reflects strong support and intrigue, with posters highlighting the study's role in advancing stem cell and germ cell research, exemplified by phrases like 'fascinating', 'breakthrough', and 'important for future studies'. Comments celebrating collaborations and method improvements also indicate active engagement and recognition of the study's impact on scientific progress.

AgreementModerate agreement

Most discussions express support or appreciation for the significance of the research, highlighting its contribution to understanding germ cell development.

InterestHigh interest

Posts show high enthusiasm and curiosity, with many referencing the importance of the findings and potential applications.

EngagementModerate engagement

The discussions include acknowledgments of the collaboration, commendations for the researchers, and mentions of related methods, indicating active engagement.

ImpactModerate impact

Several posts suggest this research advances the field noticeably, such as references to its role in in vitro gametogenesis and reproducibility, hinting at moderate to high significance.

Abstract in brief

  • Human primordial germ cells (hPGCs) are specified around day 12 postfertilization, beginning the process of germline formation in vitro from pluripotent stem cells.
  • The study shows that the formation of hPGCLCs involves resetting pluripotency to a transitional state, which shares features of both naive and primed pluripotency, followed by differentiation into lineage-primed TFAP2A progenitors.
  • The transcription factor TFAP2C plays a crucial role in this process by acting upstream of PRDM1 to regulate SOX17 expression, which protects developing germ cells from adopting somatic cell fates, crucial for successful in vitro gametogenesis.]
Read the full abstract

Top posts

Most liked on X and Bluesky
clarklabucla
@clarklabucla1 · X

Congratulations to Di, Na and Lei for their latest paper Human Primordial Germ Cells Are Specified from Lineage-Primed Progenitors https://t.co/CEGwz0xPTN We are especially grateful for the fantastic collaboration with the Kellis Lat at MIT!

Dec 24, 2019 · 10 likes · 4 shares · 681 followers View post →
Pedro Madrigal
@compBiology · X

Human Primordial Germ Cells Are Specified from Lineage-Primed Progenitors https://t.co/kgBeffXRrd

Jan 19, 2020 · 10 likes · 2 shares · 558 followers View post →
Luciano Martelotto
@LGMartelotto · X

Dec 27, 2019 · 4 likes · 10,147 followers View post →
Single Cell papers
@scell_papers · X

Human Primordial Germ Cells Are Specified from Lineage-Primed Progenitors. https://t.co/vX4UOzMLod

Dec 26, 2019 · 3 likes · 11,517 followers View post →
Min Dai
@artofbiology · X

RT @clarklabucla1: Congratulations to Di, Na and Lei for their latest paper Human Primordial Germ Cells Are Specified from Lineage-Primed P…

Dec 27, 2019 · 4 shares · 1,223 followers View post →
Pete Shuster
@stratoman1 · X

Neuromics Antibodies-Staining in 3-D https://t.co/pDaNv66Rem via @YouTube

Dec 31, 2019 · 1,030 followers View post →

All mentions

RRID Robot
@RobotRrid · X

RRIDs were included in the Cell Reports paper "Human Primordial Germ Cells Are Specified from Lin…" (https://t.co/XwFGdlnWAw). RRIDs like this improve reproducibility in scientific research. #methodsmatter #ReproducibleResearch

Sep 1, 2021 · 161 followers View post →
kimiissue
@kimiissue · X

RT @iaminnowhere: ขอเลย #สมรสเท่าเทียม ไปนิด คนที่บอกว่าเพศเดียวกันมีลูกที่แชร์พันธุกรรมกันไม่ได้ จะไม่จริงอีกต่อไป 1.https://t.co/5ynawrKo…

Jul 6, 2020 · 1 share · 196 followers View post →
My name is Alice
@iaminnowhere · X

ขอเลย #สมรสเท่าเทียม ไปนิด คนที่บอกว่าเพศเดียวกันมีลูกที่แชร์พันธุกรรมกันไม่ได้ จะไม่จริงอีกต่อไป 1.https://t.co/5ynawrKobz 2.https://t.co/yYwEMHZcIh 2 งานวิจัยนี้คือความก้าวหน้าในการใช้ stem cell เอามาสร้างสืบพันธุ์ต้นกำเนิดได้ และมันทำใน stem cell 'มนุษย์' ดังนั้นอีกไม่นานแน่ ๆ

Jul 6, 2020 · 1 share · 282 followers View post →
Grace Bower
@gracecbower · X

RT @clarklabucla1: Congratulations to Di, Na and Lei for their latest paper Human Primordial Germ Cells Are Specified from Lineage-Primed P…

Jan 31, 2020 · 4 shares · 75 followers View post →
Aristos Achaion.
@articlesncoins · X

RT @compBiology: Human Primordial Germ Cells Are Specified from Lineage-Primed Progenitors https://t.co/kgBeffXRrd

Jan 21, 2020 · 2 shares · 135 followers View post →
Functional Embryo Genomics lab
@funcembryomics · X

RT @compBiology: Human Primordial Germ Cells Are Specified from Lineage-Primed Progenitors https://t.co/kgBeffXRrd

Jan 20, 2020 · 2 shares · 1,007 followers View post →
Pedro Madrigal
@compBiology · X

Human Primordial Germ Cells Are Specified from Lineage-Primed Progenitors https://t.co/kgBeffXRrd

Jan 19, 2020 · 10 likes · 2 shares · 558 followers View post →
Pete Shuster
@stratoman1 · X

Neuromics Antibodies-Staining in 3-D https://t.co/pDaNv66Rem via @YouTube

Dec 31, 2019 · 1,030 followers View post →
Min Dai
@artofbiology · X

RT @clarklabucla1: Congratulations to Di, Na and Lei for their latest paper Human Primordial Germ Cells Are Specified from Lineage-Primed P…

Dec 27, 2019 · 4 shares · 1,223 followers View post →
Luciano Martelotto
@LGMartelotto · X

Dec 27, 2019 · 4 likes · 10,147 followers View post →
Single Cell papers
@scell_papers · X

Human Primordial Germ Cells Are Specified from Lineage-Primed Progenitors. https://t.co/vX4UOzMLod

Dec 26, 2019 · 3 likes · 11,517 followers View post →
Invitro Diagnostics News & Research
@IVDiagnostics · X

Human Primordial Germ Cells Are Specified from LineagePrimed Progenitors.: InÂvitro gametogenesis is the process of making germline cells from human pluripotent stem cells. The foundation of this model is the quality of the first progenitors called… https://t.co/azuCGfZVqh #IVDs

Dec 26, 2019 · 1 share · 410 followers View post →
single cell papers
@sc_papers · X

Human Primordial Germ Cells Are Specified from Lineage-Primed Progenitors. https://t.co/HNWoQvYcOA

Dec 26, 2019 · 305 followers View post →
Lachezar Nikolov
@Luke_Nikolov · X

RT @clarklabucla1: Congratulations to Di, Na and Lei for their latest paper Human Primordial Germ Cells Are Specified from Lineage-Primed P…

Dec 25, 2019 · 4 shares · 721 followers View post →
clarklabucla
@clarklabucla1 · X

Congratulations to Di, Na and Lei for their latest paper Human Primordial Germ Cells Are Specified from Lineage-Primed Progenitors https://t.co/CEGwz0xPTN We are especially grateful for the fantastic collaboration with the Kellis Lat at MIT!

Dec 24, 2019 · 10 likes · 4 shares · 681 followers View post →