"Mutational signature in colorectal cancer caused by genotoxic pks+ E. coli" Hans Clevers presents this paper as published in the February 27, 2020 issue of Nature. Link to Video on UCTV: https://t.co/gZzefCUXVC https://t.co/2gpOE7v8bG
Mutational signature in colorectal cancer caused by genotoxic pks E. coli.
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Feb 2020 – Jul 2025Where it's discussed
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What people are saying
The discussions frequently reference notable aspects of the research, such as mentions of the implications of pks+ E. coli on DNA mutations and the significant findings shared by researchers like Hans Clevers in lectures. Phrases like "genuine breakthrough" and "important implications" used by various participants underscore the excitement surrounding the publication, indicating a strong consensus on its relevance and impact within the scientific community.
Many discussions show strong alignment with the publication's findings, highlighting the connections between pks+ E. coli and colorectal cancer.
Participants exhibit high interest in the implications of the research, evidenced by numerous references to relevant lectures and previous studies.
While some discussions are more surface level, several posts engage deeply with the research methodology and implications for cancer understanding.
There is a shared belief that the discoveries in this paper significantly contribute to our understanding of cancer biology and potential future therapies.
Abstract in brief
- Various species of intestinal bacteria, particularly Escherichia coli with the pks pathogenicity island, may contribute to colorectal cancer by producing colibactin, which can damage DNA.
- In a study, human intestinal organoids were exposed to genotoxic pks E. coli over five months, revealing a specific mutational signature through whole-genome sequencing.
- This unique mutational signature was also found in a subset of human cancer genomes, suggesting a direct link between bacterial exposure and cancer mutations.
Top posts
Most liked on X and BlueskyNewly published in @nature: A common type of bacteria found in our guts could contribute to bowel cancer, according to #CRUKGrandChallenge research from @_Hubrecht & @UniversityLeeds with the help of @GenomicsEngland https://t.co/GJ1DnnX2Ti https://t.co/H6d7XQIifb
Mutational signature in colorectal cancer caused by genotoxic pks + E. coli. Some species of E. coli produce colibactin, which may disrupt DNA in colonic cells and lead to cancer. One of those species may include E. coli Nissle 1917, a probiotic. https://t.co/reGy7rKUPE
Mutational signature in colorectal cancer caused by genotoxic pks + E. coli | Nature https://t.co/KQ1Jp8bSXm
Mutational signature in colorectal cancer caused by genotoxic pks+ E. coli..... a genuine breakthrough @nature @HansClevers https://t.co/bXBxe9n1Hz
Very interesting: a direct role of bacteria in the occurrence of oncogenic mutations Mutational signature in colorectal cancer caused by genotoxic pks + E. coli | Nature https://t.co/VdAA4fcKU4
All mentions
Gut Microbiome's Role in Cancer Modulation and New Hallmarks
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RT @StephanHacker2: @HansClevers in his @LED3hub lecture also presented very interesting insights into the use of colon organoids to study…
@HansClevers in his @LED3hub lecture also presented very interesting insights into the use of colon organoids to study the genotixicity of colibactin produced by pks+ E. coli and how it contributes to colorectal cancer development. https://t.co/ChN7KQ5n7y
RT @CancerGrand: The study builds on the team's 2020 @Nature paper (in collab with @HansClevers @JensPuschhof @Cayetanopm) which showed how…
The study builds on the team's 2020 @Nature paper (in collab with @HansClevers @JensPuschhof @Cayetanopm) which showed how pks+ E coli, a toxin-producing bacterium found in the gut, causes a #mutationalsignature linked to #colorectalcancer https://t.co/YAHkHW0MhQ 2/n
Lectures continue in #mckusickshortcourse catching up on amazing lecture by @HansClevers on increased mutations in PKS+ E. Coli exposed organoids. This is a mutagenic bacteria which is being taken over the counter by people!!! https://t.co/7TsGL0Vpch
RT @OpenResLeeds: Mutational signature in colorectal cancer caused by genotoxic pks⁺ E. coli https://t.co/BJAOCuv9YR #wrro #openaccess http…
Mutational signature in colorectal cancer caused by genotoxic pks⁺ E. coli https://t.co/BJAOCuv9YR #wrro #openaccess https://t.co/I7wBFvzZ7T
RT @HansClevers: "Mutational signature in colorectal cancer caused by genotoxic pks+ E. coli" Hans Clevers presents this paper as publishe…
RT @HansClevers: "Mutational signature in colorectal cancer caused by genotoxic pks+ E. coli" Hans Clevers presents this paper as publishe…
RT @HansClevers: "Mutational signature in colorectal cancer caused by genotoxic pks+ E. coli" Hans Clevers presents this paper as publishe…
RT @HansClevers: "Mutational signature in colorectal cancer caused by genotoxic pks+ E. coli" Hans Clevers presents this paper as publishe…
RT @HansClevers: "Mutational signature in colorectal cancer caused by genotoxic pks+ E. coli" Hans Clevers presents this paper as publishe…
RT @HansClevers: "Mutational signature in colorectal cancer caused by genotoxic pks+ E. coli" Hans Clevers presents this paper as publishe…
RT @HansClevers: "Mutational signature in colorectal cancer caused by genotoxic pks+ E. coli" Hans Clevers presents this paper as publishe…
RT @HansClevers: "Mutational signature in colorectal cancer caused by genotoxic pks+ E. coli" Hans Clevers presents this paper as publishe…
RT @HansClevers: "Mutational signature in colorectal cancer caused by genotoxic pks+ E. coli" Hans Clevers presents this paper as publishe…
RT @HansClevers: "Mutational signature in colorectal cancer caused by genotoxic pks+ E. coli" Hans Clevers presents this paper as publishe…
RT @HansClevers: "Mutational signature in colorectal cancer caused by genotoxic pks+ E. coli" Hans Clevers presents this paper as publishe…
"Mutational signature in colorectal cancer caused by genotoxic pks+ E. coli" Hans Clevers presents this paper as published in the February 27, 2020 issue of Nature. Link to Video on UCTV: https://t.co/gZzefCUXVC https://t.co/2gpOE7v8bG
RT @OrdoFibonacci: Mutational Signature in Colorectal Cancer caused by Genotoxic pks+ E. coli https://t.co/8UNeGPROVp via @YouTube
Mutational Signature in Colorectal Cancer caused by Genotoxic pks+ E. coli https://t.co/8UNeGPROVp via @YouTube
RT @Psychobiotic: Mutational signature in colorectal cancer caused by genotoxic pks + E. coli. Some species of E. coli produce colibactin,…
RT @OpenResLeeds: Mutational signature in colorectal cancer caused by genotoxic pks+ E. coli https://t.co/BJAOCuv9YR Released from #wrro t…
Mutational signature in colorectal cancer caused by genotoxic pks+ E. coli https://t.co/BJAOCuv9YR Released from #wrro today #openaccess @MedicineDean @LeedsMedHealth https://t.co/NKec6IABSB
RT @PKS_papers: Mutational signature in colorectal cancer caused by genotoxic pks+ E. coli. https://t.co/Mxzxlz9QYr
Mutational signature in colorectal cancer caused by genotoxic pks + E. coli | Nature https://t.co/0Wc5xVajbG
3. Mutational signature in colorectal cancer caused by genotoxic pks+ E. coli https://t.co/aNE6uMMR0s
RT @peixitu_m: Mutational signature in colorectal cancer caused by genotoxic pks+ E. coli https://t.co/BJjLU5AgoS
Mutational signature in colorectal cancer caused by genotoxic pks+ E. coli https://t.co/BJjLU5AgoS
Mutational signature in colorectal cancer caused by genotoxic pks + E. coli | Nature https://t.co/f2zMRqPrwH
Mutational signature in colorectal cancer caused by genotoxic pks + E. coli https://t.co/naZ8kRCDh7 https://t.co/16KWPM6Zox
Mutational signature in colorectal cancer caused by genotoxic pks+ E. coli. https://t.co/JXOHUgroFh https://t.co/HzxVyANJzK
A link between a type of gut bacterium and colorectal cancer (CRC) has been reported. #Science #Cancer #gut #microbioma
Mutational signature in colorectal cancer caused by genotoxic pks+ E. coli from @HansClevers https://t.co/sQIZoOqbUH
Mutational signature in colorectal cancer caused by genotoxic pks+ E. coli - https://t.co/GVWgeFR6oX https://t.co/JwKSZ1ulga
Mutational signature in colorectal cancer caused by genotoxic pks+ E. coli https://t.co/8NykiwGnDm https://t.co/3hnjcEu0tJ
We as #nymus3d are happy to share our latest animation produced for #cleverslab to help communicate their latest publication in #naturejournal, "Mutational signature in colorectal cancer caused by genotoxic pks+ E. coli" https://t.co/1pYYj2jnmD. https://t.co/jHkENiklz4
RT @Psychobiotic: Mutational signature in colorectal cancer caused by genotoxic pks + E. coli. Some species of E. coli produce colibactin,…
RT @IsbergRalph: Another reason to fear a subset of commensal E coli. . Mutational signature in colorectal cancer caused by genotoxic pks…
RT @NatRevClinOncol: Mutational signature in colorectal cancer caused by genotoxic pks+ E. coli: https://t.co/1nEASBO197 #CRCSM
RT @IsbergRalph: Another reason to fear a subset of commensal E coli. . Mutational signature in colorectal cancer caused by genotoxic pks…
RT @IsbergRalph: Another reason to fear a subset of commensal E coli. . Mutational signature in colorectal cancer caused by genotoxic pks…
Mutational signature in colorectal cancer caused by genotoxic pks+ E. coli: https://t.co/1nEASBO197 #CRCSM
Another reason to fear a subset of commensal E coli. . Mutational signature in colorectal cancer caused by genotoxic pks + E. coli | Nature https://t.co/jjxmnL47jR
RT @Psychobiotic: Mutational signature in colorectal cancer caused by genotoxic pks + E. coli. Some species of E. coli produce colibactin,…
RT @Psychobiotic: Mutational signature in colorectal cancer caused by genotoxic pks + E. coli. Some species of E. coli produce colibactin,…
RT @EDurandINSERM: Mutational signature in colorectal cancer caused by genotoxic pks+ E. coli https://t.co/8NykiwGnDm
RT @PubTrend: Trending on PubMed: Mutational signature in colorectal cancer caused by genotoxic pks+ E. coli. https://t.co/4kc6jDCP7m
Trending on PubMed: Mutational signature in colorectal cancer caused by genotoxic pks+ E. coli. https://t.co/4kc6jDCP7m
Mutational signature in colorectal cancer caused by genotoxic pks + E. coli | Nature @HansClevers https://t.co/WcBW2aPEKt
RT @bernatolle: Very interesting: a direct role of bacteria in the occurrence of oncogenic mutations Mutational signature in colorectal c…
Mutational signature in colorectal cancer caused by genotoxic pks+ E. coli: 3 E. Coli causing DNA mutations ? https://t.co/bbTukc2qgo
RT @JeremyFarrar: Mutational signature in colorectal cancer caused by genotoxic pks + E. coli | Nature https://t.co/KQ1Jp8bSXm
Mutational signature in colorectal cancer caused by genotoxic pks+ E. coli https://t.co/8NykiwGnDm
RT @Psychobiotic: Mutational signature in colorectal cancer caused by genotoxic pks + E. coli. Some species of E. coli produce colibactin,…
RT @Psychobiotic: Mutational signature in colorectal cancer caused by genotoxic pks + E. coli. Some species of E. coli produce colibactin,…
RT @nlbigas: Very interesting: Mutational signature in colorectal cancer caused by genotoxic pks+ E. coli https://t.co/kvt1ldDVwk https://t…
RT @Psychobiotic: Mutational signature in colorectal cancer caused by genotoxic pks + E. coli. Some species of E. coli produce colibactin,…
RT @bernatolle: Very interesting: a direct role of bacteria in the occurrence of oncogenic mutations Mutational signature in colorectal c…
RT @Psychobiotic: Mutational signature in colorectal cancer caused by genotoxic pks + E. coli. Some species of E. coli produce colibactin,…
Very interesting: a direct role of bacteria in the occurrence of oncogenic mutations Mutational signature in colorectal cancer caused by genotoxic pks + E. coli | Nature https://t.co/VdAA4fcKU4
RT @Psychobiotic: Mutational signature in colorectal cancer caused by genotoxic pks + E. coli. Some species of E. coli produce colibactin,…
RT @Psychobiotic: Mutational signature in colorectal cancer caused by genotoxic pks + E. coli. Some species of E. coli produce colibactin,…
Mutational signature in colorectal cancer caused by genotoxic pks+ E. coli https://t.co/mEgbotOIxy
コリバクチンを産生する大腸菌が腸管細胞に特異的なDNA損傷を引き起こし、大腸がんの発生に寄与する。 英国の患者の20人に1人で、コリバクチン由来のDNA損傷のパターンを発見。 腸内細菌の毒素による腫瘍発生の1つ。 https://t.co/coYrT4baPY
RT @Psychobiotic: Mutational signature in colorectal cancer caused by genotoxic pks + E. coli. Some species of E. coli produce colibactin,…
Mutational signature in colorectal cancer caused by genotoxic pks + E. coli. Some species of E. coli produce colibactin, which may disrupt DNA in colonic cells and lead to cancer. One of those species may include E. coli Nissle 1917, a probiotic. https://t.co/reGy7rKUPE
#Escherichia coli can carry the pathogenicity island pks (encodes a set of enzymes that synthesize colibactin) Exposure to E. coli pkc+ induces distinct mutational signature in organoid model- same signature detected in 5,876 human cancer genomes https://t.co/btfLqbCvaR
RT @kevinjmonahan: Mutational signature in colorectal cancer caused by genotoxic pks+ E. coli..... a genuine breakthrough @nature @HansC…
Mutational signature in colorectal cancer caused by genotoxic pks + E. coli | Nature https://t.co/KnqIPGM4B8
RT @BarbMarte: Hot off the press: a mutational signature in colorectal cancer caused by genotoxic pks+ E. coli. The same signature is also…
Mutational signature in colorectal cancer caused by genotoxic pks+ E. coli..... a genuine breakthrough @nature @HansClevers https://t.co/bXBxe9n1Hz
RT @organoidscience: Two very interesting #organoid papers out today! First highlight is a @nature paper from @TheCleversLab! Mutational…
Mutational signature in colorectal cancer caused by genotoxic pks + E. coli https://t.co/MUrQJsSap6
RT @nlbigas: Very interesting: Mutational signature in colorectal cancer caused by genotoxic pks+ E. coli https://t.co/kvt1ldDVwk https://t…
RT @GDLeahy: Some gut bacteria may have carcinogenic properties. Mutational signature in colorectal cancer caused by genotoxic pks+ E. coli…
RT @JensPuschhof: Bacteria cause mutations in colorectal cancer. Simple message, short paper, great time working with @Cayetanopm and Axel…
RT @nlbigas: Very interesting: Mutational signature in colorectal cancer caused by genotoxic pks+ E. coli https://t.co/kvt1ldDVwk https://t…
RT @BarbMarte: Hot off the press: a mutational signature in colorectal cancer caused by genotoxic pks+ E. coli. The same signature is also…
RT @BatlleLab: Relevant finding from @TheCleversLab with important implications. Mutational signature in colorectal cancer caused by geno…
N/ Mutational signature in colorectal cancer caused by genotoxic pks+ E. coli. https://t.co/RZDf2DdDs1
Mutational signature in colorectal cancer caused by genotoxic pks+ E. coli. https://t.co/nKI8ZViagX
RT @JensPuschhof: Bacteria cause mutations in colorectal cancer. Simple message, short paper, great time working with @Cayetanopm and Axel…
Mutational signature in colorectal cancer caused by genotoxic pks + E. coli | Nature دراسه حديثه عن علاقة الـ E.coli بسرطان الأمعاء/القولون.. https://t.co/50Dn1dge2W
RT @JensPuschhof: Bacteria cause mutations in colorectal cancer. Simple message, short paper, great time working with @Cayetanopm and Axel…
@HansClevers @Cayetanopm @TheCleversLab El enlace al artículo original @nature: Mutational signature in colorectal cancer caused by genotoxic pks+ E. coli https://t.co/xK3au7tkeu y el video explicativo: https://t.co/FD69zF16BG
RT @nlbigas: Very interesting: Mutational signature in colorectal cancer caused by genotoxic pks+ E. coli https://t.co/kvt1ldDVwk https://t…
Mutational signature in colorectal cancer caused by genotoxic pks<sup>+</sup> e. coli. - Pleguezuelos-Manzano C et al. - https://t.co/07cVbWNd8n #microbiome
RT @nlbigas: Very interesting: Mutational signature in colorectal cancer caused by genotoxic pks+ E. coli https://t.co/kvt1ldDVwk https://t…
Mutational signature in colorectal cancer caused by genotoxic pks + E. coli | Nature
RT @BarbMarte: Hot off the press: a mutational signature in colorectal cancer caused by genotoxic pks+ E. coli. The same signature is also…
Mutational signature in colorectal cancer caused by genotoxic pks + E. coli | Nature https://t.co/TALhupMYdm
Mutational signature in colorectal cancer caused by genotoxic pks + E. coli | Nature https://t.co/goO0MP9VPU
RT @BarbMarte: Hot off the press: a mutational signature in colorectal cancer caused by genotoxic pks+ E. coli. The same signature is also…
RT @TheBottomDoc: Mutational signature in colorectal cancer caused by genotoxic pks + E. coli | Nature https://t.co/LOewHriVea
RT @JeremyFarrar: Mutational signature in colorectal cancer caused by genotoxic pks + E. coli | Nature https://t.co/KQ1Jp8bSXm
RT @JeremyFarrar: Mutational signature in colorectal cancer caused by genotoxic pks + E. coli | Nature https://t.co/KQ1Jp8bSXm
RT @nlbigas: Very interesting: Mutational signature in colorectal cancer caused by genotoxic pks+ E. coli https://t.co/kvt1ldDVwk https://t…
RT @nlbigas: Very interesting: Mutational signature in colorectal cancer caused by genotoxic pks+ E. coli https://t.co/kvt1ldDVwk https://t…
RT @nlbigas: Very interesting: Mutational signature in colorectal cancer caused by genotoxic pks+ E. coli https://t.co/kvt1ldDVwk https://t…
RT @BarbMarte: Hot off the press: a mutational signature in colorectal cancer caused by genotoxic pks+ E. coli. The same signature is also…
Some gut bacteria may have carcinogenic properties. Mutational signature in colorectal cancer caused by genotoxic pks+ E. coli: https://t.co/QFuvUosQqw @NanciGuestRDPhD @NutritionNerd @DavyBrenda @CynthiaLDavis1
RT @BarbMarte: Hot off the press: a mutational signature in colorectal cancer caused by genotoxic pks+ E. coli. The same signature is also…
RT @BarbMarte: Hot off the press: a mutational signature in colorectal cancer caused by genotoxic pks+ E. coli. The same signature is also…
RT @JeremyFarrar: Mutational signature in colorectal cancer caused by genotoxic pks + E. coli | Nature https://t.co/KQ1Jp8bSXm
RT @BarbMarte: Hot off the press: a mutational signature in colorectal cancer caused by genotoxic pks+ E. coli. The same signature is also…
RT @JensPuschhof: Bacteria cause mutations in colorectal cancer. Simple message, short paper, great time working with @Cayetanopm and Axel…
Mutational signature in colorectal cancer caused by genotoxic pks + E. coli | Nature https://t.co/KQ1Jp8bSXm
RT @jyasuda1: これやね。 Mutational signature in colorectal cancer caused by genotoxic pks + E. coli | Nature https://t.co/S54REdX5BG
RT @nlbigas: Very interesting: Mutational signature in colorectal cancer caused by genotoxic pks+ E. coli https://t.co/kvt1ldDVwk https://t…
RT @jyasuda1: これやね。 Mutational signature in colorectal cancer caused by genotoxic pks + E. coli | Nature https://t.co/S54REdX5BG
RT @CRUKresearch: Newly published in @nature: A common type of bacteria found in our guts could contribute to bowel cancer, according to #…
RT @CRUKresearch: Newly published in @nature: A common type of bacteria found in our guts could contribute to bowel cancer, according to #…
RT @CRUKresearch: Newly published in @nature: A common type of bacteria found in our guts could contribute to bowel cancer, according to #…
RT @JensPuschhof: Bacteria cause mutations in colorectal cancer. Simple message, short paper, great time working with @Cayetanopm and Axel…
RT @JensPuschhof: Bacteria cause mutations in colorectal cancer. Simple message, short paper, great time working with @Cayetanopm and Axel…
RT @JensPuschhof: Bacteria cause mutations in colorectal cancer. Simple message, short paper, great time working with @Cayetanopm and Axel…
RT @JensPuschhof: Bacteria cause mutations in colorectal cancer. Simple message, short paper, great time working with @Cayetanopm and Axel…
RT @CRUKresearch: Newly published in @nature: A common type of bacteria found in our guts could contribute to bowel cancer, according to #…
RT @JensPuschhof: Bacteria cause mutations in colorectal cancer. Simple message, short paper, great time working with @Cayetanopm and Axel…
RT @CRUKresearch: Newly published in @nature: A common type of bacteria found in our guts could contribute to bowel cancer, according to #…
RT @CRUKresearch: Newly published in @nature: A common type of bacteria found in our guts could contribute to bowel cancer, according to #…
RT @CRUKresearch: Newly published in @nature: A common type of bacteria found in our guts could contribute to bowel cancer, according to #…
RT @JensPuschhof: Bacteria cause mutations in colorectal cancer. Simple message, short paper, great time working with @Cayetanopm and Axel…
RT @CRUKresearch: Newly published in @nature: A common type of bacteria found in our guts could contribute to bowel cancer, according to #…
Newly published in @nature: A common type of bacteria found in our guts could contribute to bowel cancer, according to #CRUKGrandChallenge research from @_Hubrecht & @UniversityLeeds with the help of @GenomicsEngland https://t.co/GJ1DnnX2Ti https://t.co/H6d7XQIifb
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