Science. 4 May 2020. Vol 369, Issue 6501. pp. 330-333. DOI: 10.1126/science.abb9983 · PREVIOUS ARTICLE. A programmable fate decision landscape underlies single ...
@ThingsHiddenn @AnneliseBocquet
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The collective discussions emphasize the importance of the detailed analysis, mentioning how the mapping of glycan sites informs vaccine development and immune evasion strategies. Phrases like 'brilliant work,' 'significant threat,' and 'less densely glycosylated' reflect both admiration and the real-world impact of these findings, demonstrating high interest and engagement with the scientific content and its implications.
Most discussions support the significance of the glycan analysis, indicating strong consensus on its importance for understanding virus immunoevasion and vaccine development.
These posts demonstrate high curiosity and focus on the detailed glycosylation mapping, showing active scientific engagement.
The discussions reference technical aspects like mass spectrometry, glycan types, and mutation sites, indicating deep involvement and analysis.
Many posts highlight the potential implications for vaccine design and immune response, signaling recognition of high impact on public health and scientific research.
@ThingsHiddenn @AnneliseBocquet
The spikes are coated with polysaccharide molecules to camouflage them, evading surveillance of the host immune system during entry https://t.co/TzsoUtbpsj https://t.co/Z2LEgsepjl
Site specific glycan analysis of the SARS-COV-2 sp!ke protein https://t.co/bHt3SpIab6
Site-specific glycan analysis of the SARS-CoV-2 spike. Detailed glycosylation analysis of a natively folded trimeric spike of SARS-CoV-2 offers a route for comparing immunogen integrity of glycoprotein-based vaccine candidates. https://t.co/V1uKZMVt2o
Site-specific glycan analysis of the SARS-CoV-2 spike. Brilliant #glycotime work from @CrispinMax Now in @ScienceMagazine https://t.co/8VVDuCJMVW, previously and still at @biorxivpreprint https://t.co/fTpGzcdzu5
Site-specific glycan analysis of the SARS-CoV-2 spike | Great paper, but not a fan of term ‘biological replicates’. Replicates are not biological https://t.co/t3LRc0RkIr
One year after the emergence of SARS-CoV-2, scientists rapidly developed effective vaccines. This video explores how basic research in a specialized lab directly contributed to these lifesaving vaccines, linking…
The science behind how taking a leek helps your immune system kill SARS-CoV-2. Research shows eating leeks may enhance innate immunity to recognize and destroy the virus, supported by studies on plant lectins and immune…
Eating a leek a week may boost your immune system by increasing Mannose Binding Lectin levels, aiding in the fight against SARS-CoV-2. This video reviews scientific research on how leeks support innate immunity and…
RT @Leo238umi: #glycans-① - N-linked glycosylation sequons; N- X- S/T, where X≠P - As yet there have been no observed mutations to N-lin…
@LongDesertTrain @FabrizioChiodo Master correspondibg paper.... Watanabe Y, Allen JD, Wrapp D, McLellan JS, Crispin M. Site-specific glycan analysis of the SARS-CoV-2 spike. Science. 2020;369:330–333.
@breakfast_dogs @Daoyu15 If I remeber correctly the nearest glycan was on N657, not even close to 680-683 where the S1-S2 junction was located. https://t.co/xjLTHFoAUw
@gemoscatelli @Jikkyleaks @jwtmdmba @LmBubba @NestCommander @CharlesRixey @BillyBostickson @still_a_nerd @Doctor_I_am_The @pizzapicklespur @NameIsSpartacus @weve_read @BrokenTruthTV @HamEggsnSam @Parsifaler Oligomannose type glycosylation, comparison with HIV and Lassavirus and SARS1 https://t.co/eR6yDyKKBn https://t.co/SRcz1svUAU
#Sars https://t.co/CoeTLFTUI3
I am an expert on the following topics that can be applied to SARS-CoV-2: complete blood count, glycoproteins, immunopathology, RT-qPCR, and oncology. https://t.co/f6n3PPbK56
@Jikkyleaks @carl_jurassic @MicrobiomDigest @JesslovesMJK @SabinehazanMD See the mass spec in the supplemental figures. The sugars can be removed for mass spec and be run on a SDS PAGE gel like in Figure 1. https://t.co/AQmRpRwm80
@Kevin_McKernan @Jikkyleaks @NateWeymouth @MicrobiomDigest @JesslovesMJK Normally highly glycosylated proteins are smeary on gels due to micro heterogeneity … and Spike has something like 20 Asn-Xaa-Thr/Ser sites … https://t.co/bKjhIn1I2u
@denis89196880 @kazeokanjiro_00 @mp4e81 @LaBombetta76 @C1cc10b3770 @DrPaoloMezzana @il_pat @topindex2022 @VladimiroZacch1 @marco_borrano @riggio_carla @AkiliWazi @SimonaAnomis8 @Yosemitebaffo @Arturoarthuren @BildarteDesy @Twitter @RemindMe_OfThis https://t.co/Uzd721a0uM
@tony_vandongen @bH2Omiamigo @BioAnon_1vy_ @breakfast_dogs @BiotechObserver @ShakeTheCensor Yes. And N74 (homology region 1) and N149 (homology region 2) are known to be glycosylated. https://t.co/SeAmvpdGT7 https://t.co/Qpl1Dk6p1p https://t.co/mvRpfkOSHk
@KazimBridges GP120 (S2) / GP41 (S1) https://t.co/71PgwWiX2Z https://t.co/1bajw5xnzb https://t.co/ISad0iPSNd https://t.co/cZMHnDPTiY GP41 und GP120 vermieden? ziemlich interessante Forschung...
RT @foofu: @ThingsHiddenn @AnneliseBocquet
RT @foofu: @ThingsHiddenn @AnneliseBocquet
RT @foofu: @ThingsHiddenn @AnneliseBocquet
RT @foofu: @ThingsHiddenn @AnneliseBocquet
@ThingsHiddenn @AnneliseBocquet
ま、我々が知らないだけで、それらは「誰でも疑問に思う点」だろし研究論文は出ているのかもしれないがな(笑)
"(How convenient that the authors a) Osterhaus ignored and b) GP41 and GP120 avoided and kept it in general)" https://t.co/ZhSpIsY6F9 #OriginsOfCovid / #COVID19 / #Omicron / #centaurus / #Covid_19 https://t.co/SatqQzvmmV
@TAH_Sci @whippletom @andrew_lilico Sorry, can't agree that people didn't provide evidence at the time. I'm as far away from the coalface of pandemic vaccinology as they come but there was published evidence available as early as May 2020 that SARS2 is going to be a vaccineable disease. 1/ https://t.co/Q8xi0pvVVl
@jhas5 Diagram of N-linked glycosylation sites. The two engineered inserts are shows attached by dashed lines as they are attached in flexible loops. Referred to as N74 and N149 in this article on glycosylation in SARS-COV-2: https://t.co/WMSnD99umV https://t.co/wB6054PBBf
@OA_19 @makhno8 @bastien_tell https://t.co/V42jFD8B97
RT @deNutrients: Site specific glycan analysis of the SARS-COV-2 sp!ke protein https://t.co/bHt3SpIab6
RT @deNutrients: Site specific glycan analysis of the SARS-COV-2 sp!ke protein https://t.co/bHt3SpIab6
Site specific glycan analysis of the SARS-COV-2 sp!ke protein https://t.co/bHt3SpIab6
RT @GlycobiologyUK: Site-specific glycan analysis of the SARS-CoV-2 spike. https://t.co/Apzxg9ees1 https://t.co/6TSgkEgToD
Site-specific glycan analysis of the SARS-CoV-2 spike | Science https://t.co/Qg2QOkk87F
RT @nob_mai: @torusengoku @Cur4E7Iox5S0mOR RBDは糖鎖修飾部位が2カ所しかないので、ここをエピトープにした抗体ができやすいと思われます 10.1126/science.abb9983
@torusengoku @Cur4E7Iox5S0mOR RBDは糖鎖修飾部位が2カ所しかないので、ここをエピトープにした抗体ができやすいと思われます 10.1126/science.abb9983
@rebeccabw @_iboys @JudgeClayJ Site-specific glycan analysis of the SARS-CoV-2 spike https://t.co/z2qRzVob3i
There weren't any direct links on the page so https://t.co/duhJUWy2T9 https://t.co/hLn0lFiJPb
The spikes are coated with polysaccharide molecules to camouflage them, evading surveillance of the host immune system during entry https://t.co/TzsoUtbpsj https://t.co/Z2LEgsepjl
Site-specific glycan analysis of the SARS-CoV-2 spike
Site-specific glycan analysis of the SARS-CoV-2 spike | https://t.co/hkPmCZIv3F https://t.co/MQiNF31hwr
Site-specific glycan analysis of the SARS-CoV-2 spike https://t.co/QMTZUpmhAU The emergence of the betacoronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19), represents a considerable threat to gl... https://t.co/Crj5PbgDB4
Site-specific glycan analysis of the SARS-CoV-2 spike. Detailed glycosylation analysis of a natively folded trimeric spike of SARS-CoV-2 offers a route for comparing immunogen integrity of glycoprotein-based vaccine candidates. https://t.co/V1uKZMVt2o
@PiereBiophysics @quipupe @INS_Peru https://t.co/YVYca42PmT https://t.co/AwkkglCcQS
Site-specific glycan analysis of the SARS-CoV-2 spike | Science https://t.co/g8k411pqaM
#glycans-① - N-linked glycosylation sequons; N- X- S/T, where X≠P - As yet there have been no observed mutations to N-linked #glycosylation sites in #SARSCoV2- S. Thanks to Site-specific glycan analysis of the SARS-CoV-2 spike https://t.co/6Zehku9YdT
Site-specific glycan analysis of the SARS-CoV-2 spike | Science https://t.co/Mg1YHfAana
Site-specific glycan analysis of the SARS-CoV-2 spike https://t.co/QFMjdpVAsw
Site-specific glycan analysis of the SARS-CoV-2 spike https://t.co/zRUp8wjURU
Site-specific glycan analysis of the SARS-CoV-2 spike | Science https://t.co/HAKn6mAots
RT @GlycobiologyUK: Site-specific glycan analysis of the SARS-CoV-2 spike. https://t.co/Apzxg9ees1 https://t.co/6TSgkEgToD
RT @GlycobiologyUK: Site-specific glycan analysis of the SARS-CoV-2 spike. https://t.co/Apzxg9ees1 https://t.co/6TSgkEgToD
Site-specific glycan analysis of the SARS-CoV-2 spike https://t.co/EWrzXGwdyB
Site-specific glycan analysis of the SARS-CoV-2 spike https://t.co/QW2Stbtyqz
RT @GlycobiologyUK: Site-specific glycan analysis of the SARS-CoV-2 spike. https://t.co/Apzxg9ees1 https://t.co/6TSgkEgToD
Site-specific glycan analysis of the SARS-CoV-2 spike https://t.co/eqQQUKLN3V
Site-specific glycan analysis of the SARS-CoV-2 spike https://t.co/dZotH5ENd6
Site-specific glycan analysis of the SARS-CoV-2 spike https://t.co/fVKK5UtVZs
AbstractThe emergence of the betacoronavirus, SARS-CoV-2, the causative agent of COVID-19, represents a significant threat to global human health. https://t.co/zjNXzkEf8P https://t.co/Pd7HUddLtH
RT @GlycobiologyUK: Site-specific glycan analysis of the SARS-CoV-2 spike. https://t.co/Apzxg9ees1 https://t.co/6TSgkEgToD
S/ Site-specific glycan analysis of the SARS-CoV-2 spike. https://t.co/ZPWgOZbleg
RT @GlycobiologyUK: Site-specific glycan analysis of the SARS-CoV-2 spike. https://t.co/Apzxg9ees1 https://t.co/6TSgkEgToD
RT @GlycobiologyUK: Site-specific glycan analysis of the SARS-CoV-2 spike. https://t.co/Apzxg9ees1 https://t.co/6TSgkEgToD
RT @GlycobiologyUK: Site-specific glycan analysis of the SARS-CoV-2 spike. https://t.co/Apzxg9ees1 https://t.co/6TSgkEgToD
Site-specific glycan analysis of the SARS-CoV-2 spike https://t.co/eR7o67G0up
RT @GlycobiologyUK: Site-specific glycan analysis of the SARS-CoV-2 spike. https://t.co/Apzxg9ees1 https://t.co/6TSgkEgToD
Site-specific glycan analysis of the SARS-CoV-2 spike https://t.co/vw85XveMRz
RT @bnschlz: Site-specific glycan analysis of the SARS-CoV-2 spike. Brilliant #glycotime work from @CrispinMax Now in @ScienceMagazine http…
Site-specific glycan analysis of the SARS-CoV-2 spike. Brilliant #glycotime work from @CrispinMax Now in @ScienceMagazine https://t.co/8VVDuCJMVW, previously and still at @biorxivpreprint https://t.co/fTpGzcdzu5
RT @GlycobiologyUK: Site-specific glycan analysis of the SARS-CoV-2 spike. https://t.co/Apzxg9ees1 https://t.co/6TSgkEgToD
Site-specific glycan analysis of the SARS-CoV-2 spike | Great paper, but not a fan of term ‘biological replicates’. Replicates are not biological https://t.co/t3LRc0RkIr
Top #tweeted story in #structbio: Site-specific glycan analysis of the SARS-CoV-2 spike | Science https://t.co/WaQO2A8nCL, see more https://t.co/ThsI8L7UXY
RT @GlycobiologyUK: Site-specific glycan analysis of the SARS-CoV-2 spike. https://t.co/Apzxg9ees1 https://t.co/6TSgkEgToD
RT @Fm7: Site-specific glycan analysis of the SARS-CoV-2 spike https://t.co/cj0bZNfVC7
RT @Fm7: Site-specific glycan analysis of the SARS-CoV-2 spike https://t.co/cj0bZNfVC7
RT @Fm7: Site-specific glycan analysis of the SARS-CoV-2 spike https://t.co/cj0bZNfVC7
Site-specific glycan analysis of the SARS-CoV-2 spike https://t.co/cj0bZNfVC7
RT @GlycobiologyUK: Site-specific glycan analysis of the SARS-CoV-2 spike. https://t.co/Apzxg9ees1 https://t.co/6TSgkEgToD
RT @GlycobiologyUK: Site-specific glycan analysis of the SARS-CoV-2 spike. https://t.co/Apzxg9ees1 https://t.co/6TSgkEgToD
Site-specific glycan analysis of the SARS-CoV-2 spike https://t.co/HfjyJHuKzs
RT @GlycobiologyUK: Site-specific glycan analysis of the SARS-CoV-2 spike. https://t.co/Apzxg9ees1 https://t.co/6TSgkEgToD
RT @GlycobiologyUK: Site-specific glycan analysis of the SARS-CoV-2 spike. https://t.co/Apzxg9ees1 https://t.co/6TSgkEgToD
.@CrispinMax reports in @sciencemagazine today that SARS-CoV-2 S protein is less densely glycosylated than some other viral glycoproteins, possessing a sparse “glycan shield,” which may be beneficial for the elicitation of potent neutralizing antibodies. https://t.co/UAOAFFCSrS
RT @GlycobiologyUK: Site-specific glycan analysis of the SARS-CoV-2 spike. https://t.co/Apzxg9ees1 https://t.co/6TSgkEgToD
RT @GlycobiologyUK: Site-specific glycan analysis of the SARS-CoV-2 spike. https://t.co/Apzxg9ees1 https://t.co/6TSgkEgToD
RT @GlycobiologyUK: Site-specific glycan analysis of the SARS-CoV-2 spike. https://t.co/Apzxg9ees1 https://t.co/6TSgkEgToD
RT @GlycobiologyUK: Site-specific glycan analysis of the SARS-CoV-2 spike. https://t.co/Apzxg9ees1 https://t.co/6TSgkEgToD
RT @GlycobiologyUK: Site-specific glycan analysis of the SARS-CoV-2 spike. https://t.co/Apzxg9ees1 https://t.co/6TSgkEgToD
Site-specific glycan analysis of the SARS-CoV-2 spike https://t.co/zRUp8wjURU
RT @GlycobiologyUK: Site-specific glycan analysis of the SARS-CoV-2 spike. https://t.co/Apzxg9ees1 https://t.co/6TSgkEgToD
RT @GlycobiologyUK: Site-specific glycan analysis of the SARS-CoV-2 spike. https://t.co/Apzxg9ees1 https://t.co/6TSgkEgToD
RT @GlycobiologyUK: Site-specific glycan analysis of the SARS-CoV-2 spike. https://t.co/Apzxg9ees1 https://t.co/6TSgkEgToD
Site-specific glycan analysis of the SARS-CoV-2 spike | Science https://t.co/F12VZ7D0lK
RT @GlycobiologyUK: Site-specific glycan analysis of the SARS-CoV-2 spike. https://t.co/Apzxg9ees1 https://t.co/6TSgkEgToD
RT @GlycobiologyUK: Site-specific glycan analysis of the SARS-CoV-2 spike. https://t.co/Apzxg9ees1 https://t.co/6TSgkEgToD
RT @GlycobiologyUK: Site-specific glycan analysis of the SARS-CoV-2 spike. https://t.co/Apzxg9ees1 https://t.co/6TSgkEgToD
RT @GlycobiologyUK: Site-specific glycan analysis of the SARS-CoV-2 spike. https://t.co/Apzxg9ees1 https://t.co/6TSgkEgToD
Site-specific glycan analysis of the SARS-CoV-2 spike | Science #covid #covid19 #corona #coronavirus #sars https://t.co/gmEvTOuwZY
RT @Rndubois: Site-specific glycan analysis of the #SARS-CoV-2 #spike protein: https://t.co/sXjQllLjtk
Site-specific glycan analysis of the SARS-CoV-2 spike https://t.co/IhgChZdUOR
Site-specific glycan analysis of the #SARS-CoV-2 #spike protein: https://t.co/sXjQllLjtk
Science. 4 May 2020. Vol 369, Issue 6501. pp. 330-333. DOI: 10.1126/science.abb9983 · PREVIOUS ARTICLE. A programmable fate decision landscape underlies single ...
AnywhereScienceScience AdvancesScience ImmunologyScience RoboticsScience SignalingScience ... Report | Science Date: 4-May-2020 DOI: 10.1126/science.abb9983.
Science. 2020;369(6501):330-333. doi: 10.1126/science.abb9983. 3. Zhao P, Praissman JL, Grant OC, et al. Virus-Receptor Interactions of ...
Science 369, 330–333 (2020). doi:10.1126/science.abb9983 Medline. 30. Z. Ke, J. Oton, K. Qu, M. Cortese, V. Zila, L. McKeane, T. Nakane, J ...
Published online 4 May 2020. 10.1126/science.abb9983. Watanabe et al., Science 369, 330–333 (2020). 17 July 2020. 4 of 4. RESEARCH | REPORT.
Watanabe et al., Science. 10.1126/science.abb9983 (2020). REPORTS. First release: 4 May 2020 www.sciencemag.org. (Page numbers not final at ...