Modulating Androgen Receptor-Driven Transcription in Prostate Cancer with Selective CDK9 Inhibitors.

André Richters, Shelby K Doyle, David B Freeman, Christina Lee, Becky S Leifer, Sajjeev Jagannathan, Florian Kabinger, Jošt Vrabič Koren, Nicholas B Struntz, Julie Urgiles, Ryan A Stagg, Brice H Curtin, Deep Chatterjee, Sebastian Mathea, Peter J Mikochik

February 2021 Cell Chem Biol

Synopsis of Social media discussions

The overall tone demonstrates strong support and excitement, with phrases like 'great work' and 'collaborative research' emphasizing its relevance. Examples such as references to the discovery of a 'potent, ultra-selective CDK9 inhibitor' and appreciation for applying 'novel drug discovery techniques' highlight the perceived importance and innovative nature of the study, with words and tone reflecting optimism and acknowledgment of its potential impact in oncology.

A
Agreement
 Moderate agreement

Most discussions express support and recognition for the significance of the research findings.

I
Interest
 High level of interest

The discussions show a high level of interest, with multiple mentions of collaboration, novelty, and potential implications.

E
Engagement
 Moderate level of engagement

Replies include appreciation for the researchers' work, mentions of the techniques used, and comments on the importance of the findings, indicating a moderate level of engagement.

I
Impact
 Moderate level of impact

The recognition of this research as a promising approach to treating resistant prostate cancer suggests a meaningful impact in the field.

Social Mentions

YouTube

3 Videos

Facebook

2 Posts

Twitter

7 Posts

Blogs

2 Articles

News

18 Articles

Metrics

Video Views

674

Total Likes

33

Extended Reach

171,872

Social Features

32

Timeline: Posts about article

Top Social Media Posts

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  • Drosophilosopher
    @HammedBadmos (Twitter)

    RT @CellPressNews: Modulating Androgen Receptor-driven Transcription in Prostate Cancer with Selective #CDK9 #Inhibitors @CellChemBiol from…
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    May 22, 2021

    2

  • Science in Boston
    @ScienceinBoston (Twitter)

    RT @CellPressNews: Modulating Androgen Receptor-driven Transcription in Prostate Cancer with Selective #CDK9 #Inhibitors @CellChemBiol from…
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    May 21, 2021

    2

  • Cell Press
    @CellPressNews (Twitter)

    Modulating Androgen Receptor-driven Transcription in Prostate Cancer with Selective #CDK9 #Inhibitors @CellChemBiol from Angel Koehler's lab @kochinstitute at @MIT. #AACR21 https://t.co/A02iFfqot0
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    May 21, 2021

    8

    2

  • Science in Boston
    @ScienceinBoston (Twitter)

    . @AndreRichters and @shelbykatdoyle in the Koehler lab at the @kochinstitute have discovered a potent, ultra-selective CDK9 inhibitor that modulates androgen receptor-transcription in #ProstateCancer. https://t.co/QTWo7qJyYn https://t.co/D8H27ozOW9
    view full post

    November 2, 2020

    5

    1

  • Newcastle University Centre for Cancer
    @NU_Cancer (Twitter)

    Well done to Ian Hickson for his published work "Modulating Androgen Receptor-Driven Transcription in Prostate Cancer with Selective CDK9 Inhibitors" collaborating with Angela Koehler's lab at the Koch University. @NU_Cancer https://t.co/eqwhiiNklw
    view full post

    October 29, 2020

    4

  • Paperbirds_Oncology
    @PaperbirdsO (Twitter)

    New article: Modulating Androgen Receptor-Driven Transcription in Prostate Cancer with Selective CDK9 Inhibitors. https://t.co/EKyOOjWexB #prostatecancer #oncology https://t.co/gy2RAqQESK
    view full post

    October 22, 2020

  • Ian Hickson
    @IanHickson2 (Twitter)

    Great to see this work published today. Collaborative research, applying novel drug discovery techniques to an old foe and finding new targets! Great work everyone: Angela Koehler's lab @AndreRichters @kochinstitute @shelbykatdoyle @KronosBio @MIT https://t.co/LHhsMSJKc7
    view full post

    October 22, 2020

    3

Abstract Synopsis

  • The study identifies a selective CDK9 inhibitor, KB0742, which effectively reduces androgen receptor-driven transcription and tumor growth in castration-resistant prostate cancer (CRPC) models.
  • KB0742 was discovered through a microarray assay targeting AR variants, and it works by inhibiting CDK9, a key factor for oncogenic transcription involving AR, MYC, and others.
  • Oral administration of KB0742 in vivo shows significant tumor suppression, highlighting CDK9 inhibition as a promising approach to treat resistant prostate cancers dependent on androgen receptor activity.]