Front Immunol November 2020 PMID 33123154

Increased Plasma Heparanase Activity in COVID-19 Patients.

Baranca Buijsers, Cansu Yanginlar, Aline de Nooijer, Inge Grondman, Marissa L Maciej-Hulme, Inge Jonkman, Nico A F Janssen, Nils Rother, Mark de Graaf, Peter Pickkers, Matthijs Kox, Leo A B Joosten, Tom Nijenhuis, Mihai G Netea, Luuk Hilbrands

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Mentions

Peak: 4 in Jun 2020

across 3 sources since Jun 2020

Extended reach

1,038,307

potential audience

Total likes

37,332

Video views

1,009,203

Mentions per month

Jun 2020 – Aug 2024

Where it's discussed

X / Twitter7 posts
News3 articles
YouTube2 videos

AI synopsis

What people are saying

The social discussions reflect a high level of interest and engagement, with comments exploring the mechanisms like blood vessel leakage and the therapeutic potential of HBPM, supported by references to related hypotheses. Words such as 'interesting' and 'plaisant' convey curiosity and tentative support, indicating that the research prompts thoughtful consideration of COVID-19's pathology and possible interventions.

AgreementModerate agreement

Most discussions find the findings plausible and supportive of further research, especially with comments praising the hypothesis about heparanase's role in COVID-19 severity.

InterestHigh interest

Participants show high curiosity, engaging with detailed mechanisms such as blood vessel leakage and the effects of heparanase, indicating a strong interest in the research.

EngagementModerate engagement

Responses include referencing other studies, hypothesizing about treatments like HBPM, and debating the biological processes, demonstrating a thoughtful level of engagement.

ImpactModerate impact

While the discussions acknowledge the potential implications for understanding severe COVID-19 complications and treatment options, they remain somewhat speculative, so the perceived impact is moderate.

Abstract in brief

The study suggests that COVID-19 patients have higher levels of heparanase activity and heparan sulfate in their blood, which are linked to worse disease severity and the need for intensive care.
Heparanase is an enzyme that damages the endothelial glycocalyx, leading to blood vessel leakage and inflammation, which are common issues in severe COVID-19 cases.
Since low molecular weight heparins (LMWH) can inhibit heparanase activity, using LMWH as a treatment for COVID-19 patients might help reduce vascular damage and improve outcomes, making it a potential therapeutic option to explore.]

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All mentions

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tune

@keisuke4713 · X

MMPは心筋炎~拡張型心筋症へ進行:ECM remodelling,抗

Aug 17, 2024 · 1 like · 3,734 followers View post →

vieil_garde_PH

@vieil_garde_ph · X

Feb 13, 2021 · 2 likes · 1,643 followers View post →

vieil_garde_PH

@vieil_garde_ph · X

Oct 13, 2020 · 1 like · 1,643 followers View post →

Cansu

@CansuYJ · X

RT @medrxivpreprint: Increased plasma heparanase activity in COVID-19 patients https://t.co/FUobVuHJpk #medRxiv

Jun 25, 2020 · 1 share · 49 followers View post →

Cansu

@CansuYJ · X

RT @COVID19arXiv:

Jun 16, 2020 · 1 share · 49 followers View post →

COVID-19_arXiv

@COVID19arXiv · X

Jun 15, 2020 · 1 like · 1 share · 4,519 followers View post →

medRxiv

@medrxivpreprint · X

Increased plasma heparanase activity in COVID-19 patients https://t.co/FUobVuHJpk #medRxiv

Jun 15, 2020 · 3 likes · 1 share · 17,460 followers View post →