Br J Pharmacol February 2021 PMID 33125711

Unfractionated heparin inhibits live wild type SARS-CoV-2 cell infectivity at therapeutically relevant concentrations.

Julia A Tree, Jeremy E Turnbull, Karen R Buttigieg, Michael J Elmore, Naomi Coombes, John Hogwood, Courtney J Mycroft-West, Marcelo A Lima, Mark A Skidmore, Richard Karlsson, Yen-Hsi Chen, Zhang Yang, Cosma Mirella Spalluto, Karl J Staples, Edwin A Yates

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Mentions

109

Peak: 37 in Mar 2022

across 4 sources since Oct 2020

Extended reach

328,273

potential audience

Total likes

313

Video views

782

Mentions per month

Oct 2020 – Feb 2023

Where it's discussed

X / Twitter81 posts
News24 articles
YouTube2 videos
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AI synopsis

What people are saying

Several discussions highlight the effectiveness of unfractionated heparin in inhibiting SARS-CoV-2, with phrases like 'strongly supports further clinical investigation' and 'compelling use as a preventive measure' showcasing the excitement and urgency regarding its potential application. The tone is largely optimistic, emphasizing the drug's new role in COVID-19 treatment, which contributes to the positive sentiment reflected in the overall analysis.

AgreementStrong agreement

Most discussions express strong support for the findings of the publication, indicating consensus on the effectiveness of UFH.

InterestHigh interest

There is a high level of interest in the research, with many users actively sharing and discussing the potential applications of UFH.

EngagementModerate engagement

While some posts provide detailed descriptions of the study, others offer a general overview, indicating moderate engagement.

ImpactHigh impact

Users perceive that the findings could significantly influence treatment options for COVID-19, showing a belief in a high potential for impact.

Abstract in brief

Unfractionated heparin (UFH) demonstrates significant antiviral effects against live SARS-CoV-2, showing potential as a COVID-19 treatment.
Different heparin types, including low molecular weight heparins (LMWH), were tested, revealing UFH's effectiveness at concentrations between 25 and 41 µg/ml compared to LMWH's much weaker effect.
The study indicates UFH's mechanism involves binding to the spike protein's receptor-binding domain, preventing its interaction with the human ACE2 receptor, highlighting the need for further clinical investigation.

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Heparin's Antiviral Effect Against SARS-CoV-2 Infection

Research shows that unfractionated heparin significantly inhibits SARS-CoV-2 cell infectivity at concentrations between 25 and 41 µg/ml. This video explores the potential of heparin as a treatment for COVID-19 by…

Scholar Horizon · Feb 10, 2021 542 views

Heparin's Role in Reducing SARS-CoV-2 Infectivity

This video discusses the potential of unfractionated heparin (UFH) as a treatment for COVID-19. Research indicates that UFH effectively inhibits SARS-CoV-2 infectivity at therapeutic concentrations, signaling the need…

Scholar Horizon · Feb 19, 2021 240 views

Rene Sugar

@renesugar · X

Unfractionated heparin inhibits live wild type #SARSCoV2 cell infectivity at therapeutically relevant concentrations #LongCovid https://t.co/sAdw2m21mc "UFH acts to directly inhibit binding of spike protein to the human ACE2 protein receptor."

Feb 21, 2023 · 3,970 followers View post →

Rene Sugar

@renesugar · X

RT @BeateJaegerMD: We should consider the use of unfractionated heparin (UFH) as a preventive measure to stop progression of SARS-CoV-2. UF…

Feb 20, 2023 · 81 shares · 3,970 followers View post →

Ntisec

@ntisec · X

RT @BeateJaegerMD: We should consider the use of unfractionated heparin (UFH) as a preventive measure to stop progression of SARS-CoV-2. UF…

Dec 31, 2022 · 81 shares · 4,362 followers View post →

K3vin

@Tr_K3vin · X

RT @BeateJaegerMD: We should consider the use of unfractionated heparin (UFH) as a preventive measure to stop progression of SARS-CoV-2. UF…

Nov 23, 2022 · 81 shares · 1,125 followers View post →

Friesein

@Friesein · X

RT @renesugar: https://t.co/gj4JBfMEtF "UFH has significantly stronger #SARSCoV2 antiviral activity compared to LMWHs. UFH acts to directl…

Nov 7, 2022 · 1 share · 12,512 followers View post →

El Ray !

@elray67 · X

RT @renesugar: Unfractionated heparin inhibits live wild type #SARSCoV2 cell infectivity at therapeutically relevant concentrations #LongCo…

Nov 7, 2022 · 1 share · 570 followers View post →

Rene Sugar

@renesugar · X

https://t.co/gj4JBfMEtF "UFH has significantly stronger #SARSCoV2 antiviral activity compared to LMWHs. UFH acts to directly inhibit binding of spike protein to the human ACE2 protein receptor."

Nov 7, 2022 · 2 likes · 1 share · 3,970 followers View post →

Rene Sugar

@renesugar · X

Unfractionated heparin inhibits live wild type #SARSCoV2 cell infectivity at therapeutically relevant concentrations #LongCovid https://t.co/gj4JBfMEtF

Nov 7, 2022 · 2 likes · 1 share · 3,970 followers View post →

Rene Sugar

@renesugar · X

RT @BeateJaegerMD: We should consider the use of unfractionated heparin (UFH) as a preventive measure to stop progression of SARS-CoV-2. UF…

Nov 7, 2022 · 81 shares · 3,970 followers View post →

Pharm. D

@pharresearcher · X

RT @BeateJaegerMD: We should consider the use of unfractionated heparin (UFH) as a preventive measure to stop progression of SARS-CoV-2. UF…

Nov 2, 2022 · 81 shares · 170 followers View post →

Peter Tell

@PeterTell3 · X

RT @BeateJaegerMD: We should consider the use of unfractionated heparin (UFH) as a preventive measure to stop progression of SARS-CoV-2. UF…

Oct 20, 2022 · 81 shares · 260 followers View post →

abigail stern- artist

@abigailstern1 · X

RT @BeateJaegerMD: We should consider the use of unfractionated heparin (UFH) as a preventive measure to stop progression of SARS-CoV-2. UF…

Jul 24, 2022 · 81 shares · 19,578 followers View post →

FlotteBiene86

@FlotteBiene86 · X

RT @BeateJaegerMD: We should consider the use of unfractionated heparin (UFH) as a preventive measure to stop progression of SARS-CoV-2. UF…

Jul 6, 2022 · 81 shares · 742 followers View post →

Louise

@WillowLymeInfo · X

RT @BeateJaegerMD: We should consider the use of unfractionated heparin (UFH) as a preventive measure to stop progression of SARS-CoV-2. UF…

Jun 27, 2022 · 81 shares · 812 followers View post →

Debbie Seymour

@debbie_seymour · X

RT @BeateJaegerMD: We should consider the use of unfractionated heparin (UFH) as a preventive measure to stop progression of SARS-CoV-2. UF…

Jun 27, 2022 · 81 shares · 1,740 followers View post →

Sir Cordelia Appleby

@CordeliaAppleb1 · X

RT @BeateJaegerMD: We should consider the use of unfractionated heparin (UFH) as a preventive measure to stop progression of SARS-CoV-2. UF…

Jun 27, 2022 · 81 shares · 13,092 followers View post →

Brian Kiely

@BrianKiely2 · X

RT @BeateJaegerMD: We should consider the use of unfractionated heparin (UFH) as a preventive measure to stop progression of SARS-CoV-2. UF…

Jun 26, 2022 · 81 shares · 4,175 followers View post →

LadyDee

@rodee55 · X

RT @BeateJaegerMD: We should consider the use of unfractionated heparin (UFH) as a preventive measure to stop progression of SARS-CoV-2. UF…

Jun 26, 2022 · 81 shares · 1,991 followers View post →

Evaluator Speculator

@MarwarWarrior · X

RT @BeateJaegerMD: We should consider the use of unfractionated heparin (UFH) as a preventive measure to stop progression of SARS-CoV-2. UF…

Jun 12, 2022 · 81 shares · 213 followers View post →

Carlos Oya

@estariade · X

RT @BeateJaegerMD: We should consider the use of unfractionated heparin (UFH) as a preventive measure to stop progression of SARS-CoV-2. UF…

Jun 12, 2022 · 81 shares · 2,709 followers View post →

dadlani

@dadlani · X

RT @BeateJaegerMD: We should consider the use of unfractionated heparin (UFH) as a preventive measure to stop progression of SARS-CoV-2. UF…

Jun 11, 2022 · 81 shares · 1,144 followers View post →

YES

@ejoooj12 · X

RT @BeateJaegerMD: We should consider the use of unfractionated heparin (UFH) as a preventive measure to stop progression of SARS-CoV-2. UF…

Jun 11, 2022 · 81 shares · 332 followers View post →

Mullberry

@Millibars923 · X

RT @BeateJaegerMD: We should consider the use of unfractionated heparin (UFH) as a preventive measure to stop progression of SARS-CoV-2. UF…

Jun 8, 2022 · 81 shares · 494 followers View post →

Elizabeth Milo

@akaemilo · X

RT @BeateJaegerMD: We should consider the use of unfractionated heparin (UFH) as a preventive measure to stop progression of SARS-CoV-2. UF…

Jun 8, 2022 · 81 shares · 729 followers View post →

howard Angela

@howardAngela14 · X

RT @BeateJaegerMD: We should consider the use of unfractionated heparin (UFH) as a preventive measure to stop progression of SARS-CoV-2. UF…

May 17, 2022 · 81 shares · 125 followers View post →

Jo Kuehn - 昆周瑟芬

@jo_kuehn · X

RT @BeateJaegerMD: We should consider the use of unfractionated heparin (UFH) as a preventive measure to stop progression of SARS-CoV-2. UF…

May 11, 2022 · 81 shares · 726 followers View post →

leer

@AnnaN91477067 · X

RT @BeateJaegerMD: We should consider the use of unfractionated heparin (UFH) as a preventive measure to stop progression of SARS-CoV-2. UF…

May 11, 2022 · 81 shares · 163 followers View post →

charlos

@loscharlos · X

RT @BeateJaegerMD: We should consider the use of unfractionated heparin (UFH) as a preventive measure to stop progression of SARS-CoV-2. UF…

May 10, 2022 · 81 shares · 26,424 followers View post →

Shannon

@RHlobbyist · X

RT @BeateJaegerMD: We should consider the use of unfractionated heparin (UFH) as a preventive measure to stop progression of SARS-CoV-2. UF…

May 8, 2022 · 81 shares · 1,387 followers View post →

Concerned Citizen

@bearonwings · X

RT @BeateJaegerMD: We should consider the use of unfractionated heparin (UFH) as a preventive measure to stop progression of SARS-CoV-2. UF…

May 8, 2022 · 81 shares · 704 followers View post →

CaliforniaHeartBavariaHome

@lgoshen · X

RT @BeateJaegerMD: We should consider the use of unfractionated heparin (UFH) as a preventive measure to stop progression of SARS-CoV-2. UF…

May 7, 2022 · 81 shares · 5,261 followers View post →

ICUGasDoc

@IcuGasDr · X

RT @BeateJaegerMD: We should consider the use of unfractionated heparin (UFH) as a preventive measure to stop progression of SARS-CoV-2. UF…

May 6, 2022 · 81 shares · 445 followers View post →

lateafternoon_k

@lateafternoon_k · X

RT @BeateJaegerMD: We should consider the use of unfractionated heparin (UFH) as a preventive measure to stop progression of SARS-CoV-2. UF…

May 2, 2022 · 81 shares · 556 followers View post →

Meri Perkins

@mlperk1 · X

Unfractionated heparin inhibits live wild type SARS-CoV-2 cell infectivity at therapeutically relevant concentratio… https://t.co/PWHqmYjihR

Apr 6, 2022 · 1,294 followers View post →

plague rat

@x3r0gx4 · X

RT @BeateJaegerMD: We should consider the use of unfractionated heparin (UFH) as a preventive measure to stop progression of SARS-CoV-2. UF…

Mar 30, 2022 · 81 shares · 6,883 followers View post →

Jane Marple

@Arianrhod11 · X

RT @BeateJaegerMD: We should consider the use of unfractionated heparin (UFH) as a preventive measure to stop progression of SARS-CoV-2. UF…

Mar 24, 2022 · 81 shares · 3,550 followers View post →

anarosah

@anarosahj · X

RT @BeateJaegerMD: We should consider the use of unfractionated heparin (UFH) as a preventive measure to stop progression of SARS-CoV-2. UF…

Mar 22, 2022 · 81 shares · 359 followers View post →

Carbonara - #ME/CFS #ChronicallyIgnored

@BettinafightsME · X

RT @BeateJaegerMD: We should consider the use of unfractionated heparin (UFH) as a preventive measure to stop progression of SARS-CoV-2. UF…

Mar 22, 2022 · 81 shares · 1,611 followers View post →

Jacquesenboit

@jacquesenboit · X

RT @BeateJaegerMD: We should consider the use of unfractionated heparin (UFH) as a preventive measure to stop progression of SARS-CoV-2. UF…

Mar 21, 2022 · 81 shares · 640 followers View post →

NickyP

@montnicole · X

RT @BeateJaegerMD: We should consider the use of unfractionated heparin (UFH) as a preventive measure to stop progression of SARS-CoV-2. UF…

Mar 20, 2022 · 81 shares · 1,534 followers View post →

Regina

@regina_anita_ · X

RT @BeateJaegerMD: We should consider the use of unfractionated heparin (UFH) as a preventive measure to stop progression of SARS-CoV-2. UF…

Mar 20, 2022 · 81 shares · 375 followers View post →

Just Here For The News

@ktho641521 · X

RT @BeateJaegerMD: We should consider the use of unfractionated heparin (UFH) as a preventive measure to stop progression of SARS-CoV-2. UF…

Mar 20, 2022 · 81 shares · 2,119 followers View post →

Inpi

@Inpi · X

RT @BeateJaegerMD: We should consider the use of unfractionated heparin (UFH) as a preventive measure to stop progression of SARS-CoV-2. UF…

Mar 20, 2022 · 81 shares · 1,838 followers View post →

Agata

@Agata32424303 · X

RT @BeateJaegerMD: We should consider the use of unfractionated heparin (UFH) as a preventive measure to stop progression of SARS-CoV-2. UF…

Mar 20, 2022 · 81 shares · 188 followers View post →

Mau and ME

@_Mau_ME · X

RT @BeateJaegerMD: We should consider the use of unfractionated heparin (UFH) as a preventive measure to stop progression of SARS-CoV-2. UF…

Mar 20, 2022 · 81 shares · 234 followers View post →

Ekhi

@Ekhi_sasienGain · X

RT @BeateJaegerMD: We should consider the use of unfractionated heparin (UFH) as a preventive measure to stop progression of SARS-CoV-2. UF…

Mar 20, 2022 · 81 shares · 566 followers View post →

ettie de jonge #zorgbetervoorME #verzekerMe

@epkedj · X

RT @BeateJaegerMD: We should consider the use of unfractionated heparin (UFH) as a preventive measure to stop progression of SARS-CoV-2. UF…

Mar 20, 2022 · 81 shares · 445 followers View post →

Marlene Robin

@TheVitalClub · X

RT @BeateJaegerMD: We should consider the use of unfractionated heparin (UFH) as a preventive measure to stop progression of SARS-CoV-2. UF…

Mar 20, 2022 · 81 shares · 594 followers View post →

Shep de Beenham

@YRUnotlistening · X

RT @BeateJaegerMD: We should consider the use of unfractionated heparin (UFH) as a preventive measure to stop progression of SARS-CoV-2. UF…

Mar 20, 2022 · 81 shares · 807 followers View post →

球拔

@ballbama · X

RT @BeateJaegerMD: We should consider the use of unfractionated heparin (UFH) as a preventive measure to stop progression of SARS-CoV-2. UF…

Mar 19, 2022 · 81 shares · 158 followers View post →

Derek Morgan

@DerekMorgan2020 · X

RT @BeateJaegerMD: We should consider the use of unfractionated heparin (UFH) as a preventive measure to stop progression of SARS-CoV-2. UF…

Mar 19, 2022 · 81 shares · 344 followers View post →

Mary-Jane Kohler MT(ASCP)

@TruthAbout_ME2 · X

RT @BeateJaegerMD: We should consider the use of unfractionated heparin (UFH) as a preventive measure to stop progression of SARS-CoV-2. UF…

Mar 19, 2022 · 81 shares · 2,818 followers View post →

phil oliver

@oliver_phil · X

RT @BeateJaegerMD: We should consider the use of unfractionated heparin (UFH) as a preventive measure to stop progression of SARS-CoV-2. UF…

Mar 19, 2022 · 81 shares · 3,282 followers View post →

Donna Chesner

@YerbaDonna · X

RT @BeateJaegerMD: We should consider the use of unfractionated heparin (UFH) as a preventive measure to stop progression of SARS-CoV-2. UF…

Mar 19, 2022 · 81 shares · 313 followers View post →

tiana.loret

@tia_loret · X

RT @BeateJaegerMD: We should consider the use of unfractionated heparin (UFH) as a preventive measure to stop progression of SARS-CoV-2. UF…

Mar 19, 2022 · 81 shares · 805 followers View post →

Moonpussy

@Moonpussy_ · X

RT @BeateJaegerMD: We should consider the use of unfractionated heparin (UFH) as a preventive measure to stop progression of SARS-CoV-2. UF…

Mar 19, 2022 · 81 shares · 27 followers View post →

MatthewJ#SafeEdForAll #FBPE #Wearamask

@MatthewJJenkins · X

RT @BeateJaegerMD: We should consider the use of unfractionated heparin (UFH) as a preventive measure to stop progression of SARS-CoV-2. UF…

Mar 19, 2022 · 81 shares · 1,957 followers View post →

Hannah Davis

@ahandvanish · X

RT @BeateJaegerMD: We should consider the use of unfractionated heparin (UFH) as a preventive measure to stop progression of SARS-CoV-2. UF…

Mar 19, 2022 · 81 shares · 56,023 followers View post →

BlueDotVet

@vet_dot · X

RT @BeateJaegerMD: We should consider the use of unfractionated heparin (UFH) as a preventive measure to stop progression of SARS-CoV-2. UF…

Mar 19, 2022 · 81 shares · 1,933 followers View post →

#RespiratorsWork #AirborneProtections

@flowermusickids · X

RT @BeateJaegerMD: We should consider the use of unfractionated heparin (UFH) as a preventive measure to stop progression of SARS-CoV-2. UF…

Mar 19, 2022 · 81 shares · 4,638 followers View post →

Abraham

@AbrahamAubry · X

RT @BeateJaegerMD: We should consider the use of unfractionated heparin (UFH) as a preventive measure to stop progression of SARS-CoV-2. UF…

Mar 19, 2022 · 81 shares · 2,152 followers View post →

Dr. Nina Kreddig | MCAS-Beratung

@mastzellenhilfe · X

RT @BeateJaegerMD: We should consider the use of unfractionated heparin (UFH) as a preventive measure to stop progression of SARS-CoV-2. UF…

Mar 19, 2022 · 81 shares · 1,223 followers View post →

Cindy

@lmay4528 · X

RT @BeateJaegerMD: We should consider the use of unfractionated heparin (UFH) as a preventive measure to stop progression of SARS-CoV-2. UF…

Mar 19, 2022 · 81 shares · 97 followers View post →

Ana Calber

@amcalber · X

RT @BeateJaegerMD: We should consider the use of unfractionated heparin (UFH) as a preventive measure to stop progression of SARS-CoV-2. UF…

Mar 19, 2022 · 81 shares · 2,268 followers View post →

Rene Sugar

@renesugar · X

RT @BeateJaegerMD: We should consider the use of unfractionated heparin (UFH) as a preventive measure to stop progression of SARS-CoV-2. UF…

Mar 19, 2022 · 81 shares · 3,970 followers View post →

lateafternoon_k

@lateafternoon_k · X

RT @BeateJaegerMD: We should consider the use of unfractionated heparin (UFH) as a preventive measure to stop progression of SARS-CoV-2. UF…

Mar 19, 2022 · 81 shares · 556 followers View post →

Erlend Bleken

@vitemer · X

RT @BeateJaegerMD: We should consider the use of unfractionated heparin (UFH) as a preventive measure to stop progression of SARS-CoV-2. UF…

Mar 19, 2022 · 81 shares · 383 followers View post →

Boo-trino Lab

@PutrinoLab · X

RT @BeateJaegerMD: We should consider the use of unfractionated heparin (UFH) as a preventive measure to stop progression of SARS-CoV-2. UF…

Mar 19, 2022 · 81 shares · 35,936 followers View post →

Peter Just

@Ttgg355g · X

RT @BeateJaegerMD: We should consider the use of unfractionated heparin (UFH) as a preventive measure to stop progression of SARS-CoV-2. UF…

Mar 19, 2022 · 81 shares · 22 followers View post →

Fuzzylogic5 ♒️

@Fuzzylogic5 · X

RT @BeateJaegerMD: We should consider the use of unfractionated heparin (UFH) as a preventive measure to stop progression of SARS-CoV-2. UF…

Mar 19, 2022 · 81 shares · 519 followers View post →

Dr. Beate Jaeger, MD

@BeateJaegerMD · X

Mar 19, 2022 · 272 likes · 81 shares · 6,373 followers View post →

Charles Whalley

@cwhalleypub · X

RT @BritPharmSoc: From E Bülbring's 'Observations on the isolated phrenic nerve diaphragm preparation of the rat' to 'Unfractionated hepari…

Dec 13, 2021 · 1 share · 809 followers View post →

British Pharmacological Society

@BritPharmSoc · X

Dec 10, 2021 · 1 like · 1 share · 12,888 followers View post →

James Kerwin

@JamesKerwin9 · X

Unfractionated heparin inhibits live wild type SARS-CoV-2 cell infectivity at therapeutically relevant concentrations #COVID19 #heparin #LMWH #nebulised #SARSCoV2 #UFH https://t.co/gsVVByqPc3

Mar 31, 2021 · 143 followers View post →

Wiley Clinical Health

@WileyHealth · X

This @BrJPharmacol study strongly supports further clinical investigation of nebulised unfractionated #heparin as a potential treatment for patients with #COVID19. Read the #OpenAccess article here: https://t.co/Wdzz1SfN5L @BritPharmSoc https://t.co/DWbsxqKz1f

Mar 18, 2021 · 1 like · 2 shares · 11,918 followers View post →

Miguel Ángel Sogorb

@MASogorb · X

Un anticoagulante común para impedir la infección por SARS-CoV2? https://t.co/2WXlFJyO6o Más información: Unfractionated heparin inhibits live wild type SARS‐CoV‐2 cell infectivity at therapeutically relevant concentrations https://t.co/1U7lJ00PAj

Feb 13, 2021 · 158 followers View post →

Dr Erini Abdelmessih

@EriniMessih · X

BPS Publications https://t.co/tQgjfckDFL

Feb 8, 2021 · 1 like · 32 followers View post →

Wiley Clinical Health

@WileyHealth · X

Feb 6, 2021 · 6 likes · 4 shares · 11,918 followers View post →

Antonio

@pecoraroanto · X

#UnfractionatedHeparin inhibits live wild type SARS-CoV-2 cell infectivity at therapeutically relevant concentrations #COVID19; #LMWH; #SARSCoV2; #UFH; #heparin https://t.co/RbFb3I23XE

Feb 1, 2021 · 55 followers View post →

د.علي الشهري

@alishehri1400 · X

RT @alishehri1400: #فيروس_كورونا #صوت_الصيدلي #جديد_الطب

Unfractionated heparin inhibits live wild type SARS-CoV-2 cell infectivity at therapeutically relevant concentrations.

Mentions per month

Where it's discussed

What people are saying

Abstract in brief

Top posts

All mentions

Heparin's Antiviral Effect Against SARS-CoV-2 Infection

Heparin's Role in Reducing SARS-CoV-2 Infectivity