Selective time-dependent changes in activity and cell-specific gene expression in human postmortem brain.

Fabien Dachet, James B Brown, Tibor Valyi-Nagy, Kunwar D Narayan, Anna Serafini, Nathan Boley, Thomas R Gingeras, Susan E Celniker, Gayatry Mohapatra, Jeffrey A Loeb

March 2021

Synopsis of Social media discussions

Discussions frequently focus on the intriguing aspect of genes that become more active after death, such as 'zombie genes', and the remarkable changes in glial cells—terms like 'grow' and 'enlarge' convey active cellular transformations. The tone varies from fascination to academic analysis, with phrases like 'amazing genes' and 'we should follow their expression' highlighting perceived significance, while some posts simply share headlines, indicating moderate engagement.

A
Agreement
 Moderate agreement

Most discussions acknowledge the importance of the findings, with some expressing fascination by calling the genes 'amazing' and emphasizing the dynamic cellular changes observed postmortem.

I
Interest
 High level of interest

Posts demonstrate high curiosity, with multiple tweets highlighting key aspects like 'zombie genes' and the impact on understanding brain activity after death, indicating active engagement.

E
Engagement
 High engagement

Several discussions delve into the specifics, such as the increase in glial cell activity and the implications for neuropsychiatric research, showing deep analysis of the article’s content.

I
Impact
 Moderate level of impact

While some discussions see the research as highly impactful ('we should follow their expression'), others consider it interesting but not revolutionary, reflecting a moderate perception of its influence.

Social Mentions

YouTube

4 Videos

Facebook

8 Posts

Twitter

27 Posts

Blogs

17 Articles

News

120 Articles

Reddit

2 Posts

Metrics

Video Views

10,797

Total Likes

309

Extended Reach

365,661

Social Features

178

Timeline: Posts about article

Top Social Media Posts

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  • George Dawson
    @dawso007 (Twitter)

    Dachet, F., Brown, J.B., Valyi-Nagy, T. et al. Selective time-dependent changes in activity and cell-specific gene expression in human postmortem brain. Sci Rep 11, 6078 (2021). https://t.co/jWuiuDZ3tS
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    May 14, 2021

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  • Miguel Ángel Sogorb
    @MASogorb (Twitter)

    Genes que se vuelven más activos tras la muerte y células que crecen mucho en el difunto https://t.co/WtVUN2qNis Más información: Selective time-dependent changes in activity and cell-specific gene expression in human postmortem brain https://t.co/8vXsgZYAH6
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    April 17, 2021

  • Dr Khalid
    @rauf_khalid (Twitter)

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    @THEIALX (Twitter)

    RT @LifeboatHQ: Selective time-dependent changes in activity and cell-specific gene expression in human postmortem brain https://t.co/SEw0I…
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    April 7, 2021

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  • Lifeboat Foundation
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  • Gonzalo Córdova
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    RT @SciReports: Selective time-dependent changes in activity and cell-specific gene expression in human postmortem brain #Neurologicaldisor…
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    @SpringerCellBio (Twitter)

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  • -callmecitra
    @callmecitra1 (Twitter)

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  • Scientific Reports
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    Selective time-dependent changes in activity and cell-specific gene expression in human postmortem brain #Neurologicaldisorders https://t.co/LCYxlIl3IA
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    #Selective time-dependent changes in activity and cell-specific gene expression in human postmortem brain https://t.co/HaADAjeNVR #science
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    @daforerog (Twitter)

    Selective time-dependent changes in activity and cell-specific gene expression in human postmortem brain https://t.co/s2EjLQn98Y
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    March 31, 2021

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    @ArgoHydra8 (Twitter)

    Selective time-dependent changes in activity and cell-specific gene expression in human postmortem brain @nresearchnews https://t.co/kJpPrGEDOO
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    March 29, 2021

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  • helyx
    @helyxscience (Twitter)

    Researchers at the University of Illinois investigated how "zombie genes" that increase in activity after someone dies, causing glial cells to enlarge post-mortem. Source: Selective time-dependent changes in activity and cell-specific gene expression in… https://t.co/YjUJ70YI1i https://t.co/RgkyOSLn1V
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  • Gac Ciencia Forense
    @GacetaCienForen (Twitter)

    Selective time-dependent changes in activity and cell-specific gene expression in human postmortem brain - https://t.co/Fzs4txC8vX
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    March 29, 2021

  • Şeyma Aydın
    @seymaydin94 (Twitter)

    RT @Biyoteknolojitr: Illinois Üniversitesi'nin yeni araştırmasına göre, insan beynindeki bazı hücreler ölümden sonra aktivitelerini artırıy…
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    March 27, 2021

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  • Società Italiana di Gerontologia e Geriatria
    @GeriSocITA (Twitter)

    Selective time-dependent changes in activity and cell-specific gene expression in human postmortem brain https://t.co/qWsQR9F2hT
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    March 26, 2021

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  • B i y o t e k n o l o j i
    @Biyoteknolojitr (Twitter)

    Illinois Üniversitesi'nin yeni araştırmasına göre, insan beynindeki bazı hücreler ölümden sonra aktivitelerini artırıyor ve devasa boyutlara ulaşıyor.
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    March 26, 2021

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  • The Aegean Society
    @aegeansociety (Twitter)

    Çalışma, “Selective time-dependent changes in activity and cell-specific gene expression in human postmortem brain” başlığı ile 23 Mart 2021 tarihinde Scientific Reports'da yayınlandı. https://t.co/XoK8mY6WyS
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  • Andres F. Cardona
    @AndresFCardonaZ (Twitter)

    Selective time-dependent changes in activity and cell-specific gene expression in human postmortem brain - Amazing genes, we should follow their expression in immortalized and quiescent tumor cells https://t.co/DTOJ94fZoe
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    March 24, 2021

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  • Dr Cara Croft
    @Cara_Croft (Twitter)

    RT @Discovery_Brain: Selective time-dependent changes in activity and cell-specific gene expression in human postmortem brain https://t.co/…
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    March 24, 2021

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  • Selda Abyar
    @AbyarSelda (Twitter)

    RT @weldeiry: Selective time-dependent changes in activity and cell-specific gene expression in human postmortem brain | Scientific Reports…
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    March 24, 2021

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  • Wafik S. El-Deiry, MD, PhD, FACP
    @weldeiry (Twitter)

    Selective time-dependent changes in activity and cell-specific gene expression in human postmortem brain | Scientific Reports https://t.co/jGfCU2uXx0
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    March 24, 2021

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  • Paul McCullough
    @ThePostsynaptic (Twitter)

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    @OrdoFibonacci (Twitter)

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    @Brain_Database (Twitter)

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Abstract Synopsis

  • The study compares gene expression and tissue structure in fresh human brain tissue immediately after removal versus postmortem samples, revealing that fresh tissue has a distinct transcriptional profile.
  • Within hours after tissue removal, there is a rapid decrease in neuronal activity-related genes, while genes associated with glial cells (like astrocytes and microglia) increase, indicating dynamic cellular changes over time.
  • These findings highlight the importance of considering time-dependent changes in gene expression and cell activity when analyzing postmortem brain samples for neuropsychiatric research.]