March 2021 PMID 33758256

Selective time-dependent changes in activity and cell-specific gene expression in human postmortem brain.

Fabien Dachet, James B Brown, Tibor Valyi-Nagy, Kunwar D Narayan, Anna Serafini, Nathan Boley, Thomas R Gingeras, Susan E Celniker, Gayatry Mohapatra, Jeffrey A Loeb

Mentions

178
Peak: 16 in Mar 2021
across 6 sources since Mar 2021

Extended reach

365,661
potential audience

Total likes

309

Video views

10,797

Mentions per month

Mar 2021 – May 2024

Where it's discussed

  • News120 articles
  • X / Twitter27 posts
  • Blogs17 articles
  • Facebook8 posts
  • YouTube4 videos
  • Reddit2 posts

AI synopsis

What people are saying

Discussions frequently focus on the intriguing aspect of genes that become more active after death, such as 'zombie genes', and the remarkable changes in glial cells—terms like 'grow' and 'enlarge' convey active cellular transformations. The tone varies from fascination to academic analysis, with phrases like 'amazing genes' and 'we should follow their expression' highlighting perceived significance, while some posts simply share headlines, indicating moderate engagement.

AgreementModerate agreement

Most discussions acknowledge the importance of the findings, with some expressing fascination by calling the genes 'amazing' and emphasizing the dynamic cellular changes observed postmortem.

InterestHigh interest

Posts demonstrate high curiosity, with multiple tweets highlighting key aspects like 'zombie genes' and the impact on understanding brain activity after death, indicating active engagement.

EngagementHigh engagement

Several discussions delve into the specifics, such as the increase in glial cell activity and the implications for neuropsychiatric research, showing deep analysis of the article’s content.

ImpactModerate impact

While some discussions see the research as highly impactful ('we should follow their expression'), others consider it interesting but not revolutionary, reflecting a moderate perception of its influence.

Abstract in brief

  • The study compares gene expression and tissue structure in fresh human brain tissue immediately after removal versus postmortem samples, revealing that fresh tissue has a distinct transcriptional profile.
  • Within hours after tissue removal, there is a rapid decrease in neuronal activity-related genes, while genes associated with glial cells (like astrocytes and microglia) increase, indicating dynamic cellular changes over time.
  • These findings highlight the importance of considering time-dependent changes in gene expression and cell activity when analyzing postmortem brain samples for neuropsychiatric research.]

Top posts

Most liked on X and Bluesky
B i y o t e k n o l o j i
@Biyoteknolojitr · X

Illinois Üniversitesi'nin yeni araştırmasına göre, insan beynindeki bazı hücreler ölümden sonra aktivitelerini artırıyor ve devasa boyutlara ulaşıyor.

Mar 26, 2021 · 5 likes · 1 share · 2,835 followers View post →
Wafik S. El-Deiry, MD, PhD, FACP
@weldeiry · X

Selective time-dependent changes in activity and cell-specific gene expression in human postmortem brain | Scientific Reports https://t.co/jGfCU2uXx0

Mar 24, 2021 · 4 likes · 1 share · 18,136 followers View post →
Società Italiana di Gerontologia e Geriatria
@GeriSocITA · X

Selective time-dependent changes in activity and cell-specific gene expression in human postmortem brain https://t.co/qWsQR9F2hT

Mar 26, 2021 · 4 likes · 722 followers View post →
Scientific Reports
@SciReports · X

Selective time-dependent changes in activity and cell-specific gene expression in human postmortem brain #Neurologicaldisorders https://t.co/LCYxlIl3IA

Apr 15, 2021 · 3 likes · 1 share · 124,561 followers View post →
Andres F. Cardona
@AndresFCardonaZ · X

Selective time-dependent changes in activity and cell-specific gene expression in human postmortem brain - Amazing genes, we should follow their expression in immortalized and quiescent tumor cells https://t.co/DTOJ94fZoe

Mar 24, 2021 · 3 likes · 8,815 followers View post →
Researching the Brain
@Brain_Database · X

Selective time-dependent changes in activity and cell-specific gene expression in human postmortem brain https://t.co/WGZl5Pkyio

Mar 23, 2021 · 2 likes · 1 share · 1,037 followers View post →

All mentions

George Dawson
@dawso007 · X

Dachet, F., Brown, J.B., Valyi-Nagy, T. et al. Selective time-dependent changes in activity and cell-specific gene expression in human postmortem brain. Sci Rep 11, 6078 (2021). https://t.co/jWuiuDZ3tS

May 14, 2021 · 1 like · 7,819 followers View post →
Miguel Ángel Sogorb
@MASogorb · X

Genes que se vuelven más activos tras la muerte y células que crecen mucho en el difunto https://t.co/WtVUN2qNis Más información: Selective time-dependent changes in activity and cell-specific gene expression in human postmortem brain https://t.co/8vXsgZYAH6

Apr 17, 2021 · 158 followers View post →
Dr Khalid
@rauf_khalid · X

RT @SciReports: Selective time-dependent changes in activity and cell-specific gene expression in human postmortem brain #Neurologicaldisor…

Apr 15, 2021 · 1 share · 2,486 followers View post →
Scientific Reports
@SciReports · X

Selective time-dependent changes in activity and cell-specific gene expression in human postmortem brain #Neurologicaldisorders https://t.co/LCYxlIl3IA

Apr 15, 2021 · 3 likes · 1 share · 124,561 followers View post →
pebbleone
@THEIALX · X

RT @LifeboatHQ: Selective time-dependent changes in activity and cell-specific gene expression in human postmortem brain https://t.co/SEw0I…

Apr 7, 2021 · 1 share · 7,678 followers View post →
Lifeboat Foundation
@LifeboatHQ · X

Selective time-dependent changes in activity and cell-specific gene expression in human postmortem brain https://t.co/SEw0IqSRar

Apr 7, 2021 · 1 share · 31,618 followers View post →
Gonzalo Córdova
@Gcordovas · X

RT @SciReports: Selective time-dependent changes in activity and cell-specific gene expression in human postmortem brain #Neurologicaldisor…

Apr 4, 2021 · 3 shares · 2,060 followers View post →
Springer Cell Bio
@SpringerCellBio · X

RT @SciReports: Selective time-dependent changes in activity and cell-specific gene expression in human postmortem brain #Neurologicaldisor…

Apr 4, 2021 · 3 shares · 2,788 followers View post →
-callmecitra
@callmecitra1 · X

RT @SciReports: Selective time-dependent changes in activity and cell-specific gene expression in human postmortem brain #Neurologicaldisor…

Apr 4, 2021 · 3 shares · 45 followers View post →
Scientific Reports
@SciReports · X

Selective time-dependent changes in activity and cell-specific gene expression in human postmortem brain #Neurologicaldisorders https://t.co/LCYxlIl3IA

Apr 4, 2021 · 3 shares · 124,561 followers View post →
Pooja
@pm_girl · X

#Selective time-dependent changes in activity and cell-specific gene expression in human postmortem brain https://t.co/HaADAjeNVR #science

Apr 4, 2021 · 2,072 followers View post →
Diego Forero MD, PhD
@daforerog · X

Selective time-dependent changes in activity and cell-specific gene expression in human postmortem brain https://t.co/s2EjLQn98Y

Mar 31, 2021 · 1,596 followers View post →
Eridan
@ArgoHydra8 · X

Selective time-dependent changes in activity and cell-specific gene expression in human postmortem brain @nresearchnews https://t.co/kJpPrGEDOO

Mar 29, 2021 · 2 likes · 706 followers View post →
helyx
@helyxscience · X

Researchers at the University of Illinois investigated how "zombie genes" that increase in activity after someone dies, causing glial cells to enlarge post-mortem. Source: Selective time-dependent changes in activity and cell-specific gene expression in… https://t.co/YjUJ70YI1i https://t.co/RgkyOSLn1V

Mar 29, 2021 · 46 followers View post →
Gac Ciencia Forense
@GacetaCienForen · X

Selective time-dependent changes in activity and cell-specific gene expression in human postmortem brain - https://t.co/Fzs4txC8vX

Mar 29, 2021 · 1,520 followers View post →
Şeyma Aydın
@seymaydin94 · X

RT @Biyoteknolojitr: Illinois Üniversitesi'nin yeni araştırmasına göre, insan beynindeki bazı hücreler ölümden sonra aktivitelerini artırıy…

Mar 27, 2021 · 1 share · 77 followers View post →
Società Italiana di Gerontologia e Geriatria
@GeriSocITA · X

Selective time-dependent changes in activity and cell-specific gene expression in human postmortem brain https://t.co/qWsQR9F2hT

Mar 26, 2021 · 4 likes · 722 followers View post →
B i y o t e k n o l o j i
@Biyoteknolojitr · X

Illinois Üniversitesi'nin yeni araştırmasına göre, insan beynindeki bazı hücreler ölümden sonra aktivitelerini artırıyor ve devasa boyutlara ulaşıyor.

Mar 26, 2021 · 5 likes · 1 share · 2,835 followers View post →
The Aegean Society
@aegeansociety · X

Çalışma, “Selective time-dependent changes in activity and cell-specific gene expression in human postmortem brain” başlığı ile 23 Mart 2021 tarihinde Scientific Reports'da yayınlandı. https://t.co/XoK8mY6WyS

Mar 25, 2021 · 462 followers View post →
Rina Saltman
@rinatie_ceo · X

Selective time-dependent changes in activity and cell-specific gene expression in human postmortem brain | Scientific Reports https://t.co/SFzHXfcQYU

Mar 25, 2021 · 3,560 followers View post →
Andres F. Cardona
@AndresFCardonaZ · X

Selective time-dependent changes in activity and cell-specific gene expression in human postmortem brain - Amazing genes, we should follow their expression in immortalized and quiescent tumor cells https://t.co/DTOJ94fZoe

Mar 24, 2021 · 3 likes · 8,815 followers View post →
Dr Cara Croft
@Cara_Croft · X

RT @Discovery_Brain: Selective time-dependent changes in activity and cell-specific gene expression in human postmortem brain https://t.co/…

Mar 24, 2021 · 1 share · 2,524 followers View post →
Selda Abyar
@AbyarSelda · X

RT @weldeiry: Selective time-dependent changes in activity and cell-specific gene expression in human postmortem brain | Scientific Reports…

Mar 24, 2021 · 1 share · 1,779 followers View post →
Wafik S. El-Deiry, MD, PhD, FACP
@weldeiry · X

Selective time-dependent changes in activity and cell-specific gene expression in human postmortem brain | Scientific Reports https://t.co/jGfCU2uXx0

Mar 24, 2021 · 4 likes · 1 share · 18,136 followers View post →
Paul McCullough
@ThePostsynaptic · X

Selective time-dependent changes in activity and cell-specific gene expression in human postmortem brain https://t.co/9K1jdOhUti https://t.co/jAWEDLrd42

Mar 24, 2021 · 2,591 followers View post →
Ordo Fraterna Fibonacci
@OrdoFibonacci · X

Selective time-dependent changes in activity and cell-specific gene expression in human postmortem brain https://t.co/rKCTqyUf5g

Mar 23, 2021 · 2,569 followers View post →
Researching the Brain
@Brain_Database · X

Selective time-dependent changes in activity and cell-specific gene expression in human postmortem brain https://t.co/WGZl5Pkyio

Mar 23, 2021 · 2 likes · 1 share · 1,037 followers View post →