Trends Mol Med July 2021 PMID 34030963

Impact of the Natural Compound Urolithin A on Health, Disease, and Aging.

Davide D'Amico, Pénélope A Andreux, Pamela Valdés, Anurag Singh, Chris Rinsch, Johan Auwerx

Mentions

93
Peak: 16 in Aug 2021
across 6 sources since May 2021

Extended reach

503,181
potential audience

Total likes

3,862

Video views

145,217

Mentions per month

May 2021 – Oct 2025

Where it's discussed

  • X / Twitter42 posts
  • News38 articles
  • Facebook4 posts
  • Blogs4 articles
  • Reddit3 posts
  • YouTube2 videos

AI synopsis

What people are saying

Several discussions underscore the promising nature of Urolithin A, with users using phrases like 'this might be one to watch' and referencing recent reviews to emphasize its potential. The tone remains optimistic but cautious, reflecting both excitement about new research and acknowledgment of ongoing investigations, supported by words like 'positive impact' and mentions of related benefits such as inflammation reduction and mitochondrial health.

AgreementModerate agreement

Most discussions express positive acknowledgment of the article's findings, with some emphasizing its potential benefits. For example, several posts mention the 'positive impact' of Urolithin A on health and aging, indicating general agreement or optimist

InterestHigh interest

Posts show high curiosity, frequently referencing the compound’s benefits and potential. Words like 'interesting', 'watch', and mentions of ongoing studies demonstrate active engagement and enthusiasm.

EngagementModerate engagement

Comments range from simple affirmations to references of related research or safety concerns. Some users discuss mechanisms like mitophagy and inflammation reduction, reflecting a moderate level of deep engagement.

ImpactModerate impact

While the discussions highlight potential health benefits and scientific promise, most posts tentatively suggest that Urolithin A could impact aging and disease management significantly, though conclusive claims seem limited at this stage.

Abstract in brief

  • Urolithin A (UA) is a natural compound produced by gut bacteria when digesting certain polyphenols found in foods like pomegranates, berries, and nuts, and has been studied for its effects on aging and disease.
  • Preclinical and recent clinical studies suggest that UA improves cellular health by promoting mitophagy (the removal of damaged mitochondria), boosting mitochondrial function, and reducing harmful inflammation, which may protect against age-related conditions in muscles, brains, joints, and other organs.
  • Research indicates that UA could become a promising nutritional intervention for healthier aging in humans, with ongoing studies supporting its benefits particularly in elderly populations.

Top posts

Most liked on X and Bluesky
Julia B.
@JuliaB_fitness · X

@deNutrients @HealthyFellow @_atanas_ @_INPST @ScienceCommuni2 @elanaspantry @terrywahls @club_gut @DrPalmquist @wendylee21742 @UAEJE @IntoGolia @RobertsCtrInMed #UrolithinA (pomegrante etc) is becoming pretty interesting, nice recent review from @Auwerx_Lab et al: Impact of the Natural Compound Urolithin A on Health, Disease, and Aging. 2021 https://t.co/RCRySlLOSB https://t.co/KJdtWVNcbs

Aug 10, 2021 · 28 likes · 19 shares · 2,270 followers View post →
Agingdoc
@agingdoc1 · X

Impact of the Natural Compound Urolithin A on Health, Disease, and Aging https://t.co/thUMhRPn91 @TrendsMolecMed

Jun 12, 2021 · 16 likes · 3 shares · 41,916 followers View post →
CoCo Based
@CocoBased · X

@KissMyCarol Impact of the Natural Compound Urolithin A on Health, Disease, and Aging: Trends in Molecular Medicine https://t.co/Jv8Ue66zdc

Oct 5, 2025 · 8 likes · 3 shares · 2,381 followers View post →
Dr. Aviseka
@aviseka · X

ଡାଳିମ୍ବ — positive impact on your bowl, Urolithin A is a natural compound produced by gut bacteria from ingested ellagitannins and ellagic acid helps in excessive inflammatory response https://t.co/uUrS3ZQt6y https://t.co/rhH5PTVSqp

Nov 14, 2022 · 5 likes · 1 share · 2,456 followers View post →
Roberta Anding
@RobertaAnding · X

Impact of the Natural Compound Urolithin A on Health, Disease, and Aging - this might be one to watch https://t.co/dwsMW0AQ20

Jun 1, 2022 · 4 likes · 2 shares · 5,997 followers View post →
Random Doggy
@randomdogginess · X

@joshuamcclure @chydorina @ales_frost @remissionbiome There are many health benefits from urolithin, produced in the gut via breakdown of ellegic acid - found in many fruits esp pomegranate. This may not be directly part of the remissionbiome model though I think urolithin may have value there. https://t.co/faKbzHqL95

Mar 23, 2023 · 3 likes · 2,325 followers View post →

All mentions

Paul franks
@Paulfra07911928 · X

RT @CocoBased: @KissMyCarol Impact of the Natural Compound Urolithin A on Health, Disease, and Aging: Trends in Molecular Medicine https://…

Oct 5, 2025 · 3 shares · 6,077 followers View post →
Leo Stew
@leo_stew91295 · X

Impact of the Natural Compound Urolithin A on Health, Disease, and Aging: Trends in Molecular Medicine https://t.co/G3dbMQ1dM4

Oct 5, 2025 · 3,163 followers View post →
Marsha for TX
@Marshaens62 · X

RT @CocoBased: @KissMyCarol Impact of the Natural Compound Urolithin A on Health, Disease, and Aging: Trends in Molecular Medicine https://…

Oct 5, 2025 · 3 shares · 31,224 followers View post →
Turaluralura
@KittyWhiskers54 · X

RT @CocoBased: @KissMyCarol Impact of the Natural Compound Urolithin A on Health, Disease, and Aging: Trends in Molecular Medicine https://…

Oct 5, 2025 · 3 shares · 1,667 followers View post →
CoCo Based
@CocoBased · X

@KissMyCarol Impact of the Natural Compound Urolithin A on Health, Disease, and Aging: Trends in Molecular Medicine https://t.co/Jv8Ue66zdc

Oct 5, 2025 · 8 likes · 3 shares · 2,381 followers View post →
ENDALA klinika zdraví
@endalaclinic · X

Impact of the Natural Compound Urolithin A on Health, Disease, and Aging - ScienceDirect https://t.co/EvJvhbH7II

May 18, 2024 · 251 followers View post →
Pretty Goat
@pretty_goat77 · X

RT @JuliaB_fitness: @deNutrients @HealthyFellow @_atanas_ @_INPST @ScienceCommuni2 @elanaspantry @terrywahls @club_gut @DrPalmquist @wendyl…

May 11, 2024 · 19 shares · 2 followers View post →
キダケン****健康の日常
@kenkofufu · X

ウロリチンAって成分が体のミトコンドリア機能を改善することで疾患改善に寄与するってはーなーしー! #予防医療 #スーパーフード #ヘルスケア #アンチエイジング #抗老化 #ミトコンドリア https://t.co/ve4n3Q8pwv

May 8, 2024 · 1 like · 51 followers View post →
Raspberrygold.com
@Raspberrygold1 · X

RT @aviseka: ଡାଳିମ୍ବ — positive impact on your bowl, Urolithin A is a natural compound produced by gut bacteria from ingested ellagitanni…

Dec 14, 2023 · 1 share · 430 followers View post →
Yuji Marutani | The Exiled Emperor
@YujiMarutani · X

Impact of the Natural Compound Urolithin A on Health, Disease, and Aging https://t.co/mHxeiVUlil

Dec 1, 2023 · 1,571 followers View post →
Jennifer Depew, RD
@deNutrients · X

RT @JuliaB_fitness: @deNutrients @HealthyFellow @_atanas_ @_INPST @ScienceCommuni2 @elanaspantry @terrywahls @club_gut @DrPalmquist @wendyl…

Aug 27, 2023 · 19 shares · 28,516 followers View post →
Random Doggy
@randomdogginess · X

@joshuamcclure @chydorina @ales_frost @remissionbiome There are many health benefits from urolithin, produced in the gut via breakdown of ellegic acid - found in many fruits esp pomegranate. This may not be directly part of the remissionbiome model though I think urolithin may have value there. https://t.co/faKbzHqL95

Mar 23, 2023 · 3 likes · 2,325 followers View post →
DrRPalmquist
@DrPalmquist · X

RT @JuliaB_fitness: @deNutrients @HealthyFellow @_atanas_ @_INPST @ScienceCommuni2 @elanaspantry @terrywahls @club_gut @DrPalmquist @wendyl…

Feb 1, 2023 · 19 shares · 3,163 followers View post →
DrRPalmquist
@DrPalmquist · X

Impact of the Natural Compound Urolithin A on Health, Disease, and Aging - PubMed https://t.co/RDuiR8QIF1

Jan 17, 2023 · 3,163 followers View post →
Dr. Aviseka
@aviseka · X

ଡାଳିମ୍ବ — positive impact on your bowl, Urolithin A is a natural compound produced by gut bacteria from ingested ellagitannins and ellagic acid helps in excessive inflammatory response https://t.co/uUrS3ZQt6y https://t.co/rhH5PTVSqp

Nov 14, 2022 · 5 likes · 1 share · 2,456 followers View post →
Patrick R
@PatrickReck40 · X

Does anyone know how safe Urolithin A is for longtime use? Experimental models consistently show that UA increases mitophagy and mitochondrial function and blunts excessive inflammatory responses. #aging #Inflammation #muscle #mitochondria #urolithina https://t.co/jfAOtJG1xU

Nov 1, 2022 · 164 followers View post →
Urolithin A
@UrolithinA · X

RT @RobertaAnding: Impact of the Natural Compound Urolithin A on Health, Disease, and Aging - this might be one to watch https://t.co/dwsMW…

Jun 2, 2022 · 2 shares · 884 followers View post →
Areej Fatima
@DtAreejFatima · X

RT @RobertaAnding: Impact of the Natural Compound Urolithin A on Health, Disease, and Aging - this might be one to watch https://t.co/dwsMW…

Jun 1, 2022 · 2 shares · 20 followers View post →
Roberta Anding
@RobertaAnding · X

Impact of the Natural Compound Urolithin A on Health, Disease, and Aging - this might be one to watch https://t.co/dwsMW0AQ20

Jun 1, 2022 · 4 likes · 2 shares · 5,997 followers View post →
Gita Erta
@GitaErta · X

Impact of the Natural Compound Urolithin A on Health, Disease, and Agi... https://t.co/MnYYdqurEZ

Mar 22, 2022 · 17 followers View post →
luis hernan graffe
@hernangraffe · X

RT @agingdoc1: Impact of the Natural Compound Urolithin A on Health, Disease, and Aging https://t.co/thUMhRPn91 @TrendsMolecMed

Jan 24, 2022 · 3 shares · 3,153 followers View post →
Simon L
@SnupSnus · X

RT @agingdoc1: Impact of the Natural Compound Urolithin A on Health, Disease, and Aging https://t.co/thUMhRPn91 @TrendsMolecMed

Jan 22, 2022 · 3 shares · 1,715 followers View post →
Jennifer Depew, RD
@deNutrients · X

RT @JuliaB_fitness: @deNutrients @HealthyFellow @_atanas_ @_INPST @ScienceCommuni2 @elanaspantry @terrywahls @club_gut @DrPalmquist @wendyl…

Sep 6, 2021 · 19 shares · 28,516 followers View post →
k
@kaspernilsen · X

RT @JuliaB_fitness: @deNutrients @HealthyFellow @_atanas_ @_INPST @ScienceCommuni2 @elanaspantry @terrywahls @club_gut @DrPalmquist @wendyl…

Aug 22, 2021 · 19 shares · 274 followers View post →
m73fitness
@m73fitness · X

RT @JuliaB_fitness: @deNutrients @HealthyFellow @_atanas_ @_INPST @ScienceCommuni2 @elanaspantry @terrywahls @club_gut @DrPalmquist @wendyl…

Aug 19, 2021 · 19 shares · 169 followers View post →
Ole Marius Tidemann
@oltidema · X

RT @JuliaB_fitness: @deNutrients @HealthyFellow @_atanas_ @_INPST @ScienceCommuni2 @elanaspantry @terrywahls @club_gut @DrPalmquist @wendyl…

Aug 13, 2021 · 19 shares · 28 followers View post →
Trym Rogg
@RoggTrym · X

RT @JuliaB_fitness: @deNutrients @HealthyFellow @_atanas_ @_INPST @ScienceCommuni2 @elanaspantry @terrywahls @club_gut @DrPalmquist @wendyl…

Aug 11, 2021 · 19 shares · 94 followers View post →
Catalina Ramírez-Contreras
@cataramirezc · X

RT @JuliaB_fitness: @deNutrients @HealthyFellow @_atanas_ @_INPST @ScienceCommuni2 @elanaspantry @terrywahls @club_gut @DrPalmquist @wendyl…

Aug 10, 2021 · 19 shares · 446 followers View post →
wendylee
@wendylee21742 · X

RT @JuliaB_fitness: @deNutrients @HealthyFellow @_atanas_ @_INPST @ScienceCommuni2 @elanaspantry @terrywahls @club_gut @DrPalmquist @wendyl…

Aug 10, 2021 · 19 shares · 2,023 followers View post →
CHSeaton
@COSseaton · X

RT @JuliaB_fitness: @deNutrients @HealthyFellow @_atanas_ @_INPST @ScienceCommuni2 @elanaspantry @terrywahls @club_gut @DrPalmquist @wendyl…

Aug 10, 2021 · 19 shares · 5,930 followers View post →
Atanas G. Atanasov
@_atanas_ · X

RT @JuliaB_fitness: @deNutrients @HealthyFellow @_atanas_ @_INPST @ScienceCommuni2 @elanaspantry @terrywahls @club_gut @DrPalmquist @wendyl…

Aug 10, 2021 · 19 shares · 123,950 followers View post →
Julia B.
@JuliaB_fitness · X

RT @JuliaB_fitness: @deNutrients @HealthyFellow @_atanas_ @_INPST @ScienceCommuni2 @elanaspantry @terrywahls @club_gut @DrPalmquist @wendyl…

Aug 10, 2021 · 19 shares · 2,270 followers View post →
Science Communication
@ScienceCommuni2 · X

RT @JuliaB_fitness: @deNutrients @HealthyFellow @_atanas_ @_INPST @ScienceCommuni2 @elanaspantry @terrywahls @club_gut @DrPalmquist @wendyl…

Aug 10, 2021 · 19 shares · 2,880 followers View post →
International Natural Product Sciences Taskforce
@_INPST · X

RT @JuliaB_fitness: @deNutrients @HealthyFellow @_atanas_ @_INPST @ScienceCommuni2 @elanaspantry @terrywahls @club_gut @DrPalmquist @wendyl…

Aug 10, 2021 · 19 shares · 10,286 followers View post →
DrRPalmquist
@DrPalmquist · X

RT @JuliaB_fitness: @deNutrients @HealthyFellow @_atanas_ @_INPST @ScienceCommuni2 @elanaspantry @terrywahls @club_gut @DrPalmquist @wendyl…

Aug 10, 2021 · 19 shares · 3,163 followers View post →
The GUT CLUB
@club_gut · X

RT @JuliaB_fitness: @deNutrients @HealthyFellow @_atanas_ @_INPST @ScienceCommuni2 @elanaspantry @terrywahls @club_gut @DrPalmquist @wendyl…

Aug 10, 2021 · 19 shares · 2,341 followers View post →
John Greene
@Greene_Thoughts · X

RT @JuliaB_fitness: @deNutrients @HealthyFellow @_atanas_ @_INPST @ScienceCommuni2 @elanaspantry @terrywahls @club_gut @DrPalmquist @wendyl…

Aug 10, 2021 · 19 shares · 1,700 followers View post →
Jennifer Depew, RD
@deNutrients · X

RT @JuliaB_fitness: @deNutrients @HealthyFellow @_atanas_ @_INPST @ScienceCommuni2 @elanaspantry @terrywahls @club_gut @DrPalmquist @wendyl…

Aug 10, 2021 · 19 shares · 28,516 followers View post →
Julia B.
@JuliaB_fitness · X

@deNutrients @HealthyFellow @_atanas_ @_INPST @ScienceCommuni2 @elanaspantry @terrywahls @club_gut @DrPalmquist @wendylee21742 @UAEJE @IntoGolia @RobertsCtrInMed #UrolithinA (pomegrante etc) is becoming pretty interesting, nice recent review from @Auwerx_Lab et al: Impact of the Natural Compound Urolithin A on Health, Disease, and Aging. 2021 https://t.co/RCRySlLOSB https://t.co/KJdtWVNcbs

Aug 10, 2021 · 28 likes · 19 shares · 2,270 followers View post →
Agingdoc
@agingdoc1 · X

Impact of the Natural Compound Urolithin A on Health, Disease, and Aging https://t.co/thUMhRPn91 @TrendsMolecMed

Jun 12, 2021 · 16 likes · 3 shares · 41,916 followers View post →
Atsushi_Tanaka_PhD
@ATP_1976 · X

Impact of the Natural Compound Urolithin A on Health, Disease, and Agi... https://t.co/CPiICJSL3J

May 27, 2021 · 568 followers View post →
George Vlasuk
@GVlasuk · X

Interesting review-Impact of the Natural Compound Urolithin A on Health, Disease, and Aging https://t.co/4lgI2NgiLU

May 22, 2021 · 1,417 followers View post →