Overall, discussions reflect a balanced curiosity and cautiousness, with several posts emphasizing the molecular mechanism of molnupiravir and expressing concern over its mutagenic potential. Words like 'mutagenesis,' 'risk,' and references to scientific articles demonstrate an analytical tone, while questions about safety and efficacy point to active engagement on the topic's significance.
AgreementNeither agree nor disagree
The discussions show mixed opinions, with some recognizing the scientific findings while others express skepticism or concern about mutagenicity and safety.
InterestModerate interest
Participants demonstrate moderate curiosity, mainly focused on understanding the mechanism and implications of mutagenesis described in the publication.
EngagementModerate engagement
Comments reference detailed mechanisms, cite scientific studies, and question the safety, indicating a relatively deeper engagement with the research.
ImpactModerate impact
Many discussions highlight the importance of understanding the drug's mechanism, signaling some influence on public and scientific discourse regarding antiviral strategies.
Abstract in brief
Molnupiravir is a drug in phase III trials that fights COVID-19 by increasing mutations in the virus's RNA, which hampers its ability to replicate.
It works by mimicking the building blocks used by the viral RNA polymerase enzyme, specifically mimicking NHC triphosphate, leading to errors in the viral RNA sequence.
The drug causes the viral polymerase to incorporate incorrect bases (G or A), forming stable pairs that result in mutated viral RNA, which helps explain its broad effectiveness against different viruses.]
Mechanism of molnupiravir-induced SARS-CoV-2 mutagenesis
Excellent paper summarizing the very interesting proposed mechanism of action @NatureSMB https://t.co/omXcQdqt0x
Oct 1, 2021 · 103 likes · 35 shares · 403,947 followersView post →
叢創
叢雲くすり (創薬ちゃん)
@souyakuchan · X
Molnupirabir のウイルス RNA 変異原性メカニズムについての elucidation が最近 詳しめに進んでいた。
JBC: Molnupiravir promotes SARS-CoV-2 mutagenesis via the RNA template https://t.co/o5ZeRygdg3
NSMB: Mechanism of molnupiravir-induced SARS-CoV-2 mutagenesis https://t.co/fUjK4IwpsL
Oct 2, 2021 · 21 likes · 11 shares · 10,227 followersView post →
Jan 10, 2022 · 21 likes · 4 shares · 9,491 followersView post →
KR
Keith Robison
@OmicsOmicsBlog · X
Molnupiravir acts by generating G->A transitions - will overuse and poor dosing compliance lead to new resistance?
https://t.co/Od45XFqhaq
Oct 2, 2021 · 8 likes · 10,012 followersView post →
AG
Antibiotic Steward Bassam Ghanem
@ABsteward · X
Oct 1, 2021 · 7 likes · 1 share · 60,014 followersView post →
HF
Hironori Funabiki
@HironoriFunabi1 · X
Molnupiriavir does not inhibit the viral RNA-dependent RNA polymerase (RdRp), but introduces transition mutations by letting RdRp incorporate molnupiravir as a mimetic of C (and less frequently that of U). 2/
https://t.co/53ZGCW6o2o
https://t.co/GdKEZifFsb https://t.co/cTfzUILnYf
Oct 2, 2021 · 5 likes · 9,712 followersView post →
This video discusses the mechanism of remdesivir as a delayed translocation inhibitor of SARS-CoV-2 replication. It references key studies addressing the antiviral properties of remdesivir and its effectiveness against…
Molnupiravir is a Phase III drug that reduces COVID-19 hospitalization and death by inducing mutations in viral RNA, disrupting replication. It mimics viral RNA building blocks, causing errors that hamper the virus's…
I’m not happy being right. Paxlovid does nothing and gov spent billions on it. Molnupiravir is mutagenic. Not my words. https://t.co/F4ro7eJUJU https://t.co/o3QmThuVWf https://t.co/MoHcxcORid
Jan 10, 2022 · 21 likes · 4 shares · 9,491 followersView post →
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#RespiratorsWork #AirborneProtections
@flowermusickids · X
@PresumptuousBug @fitterhappierAJ This is the reference about mutagenesis, nothing to do with vaccines whatsoever. https://t.co/giaJfQdrON
On this note, there’ll be other antivirals without this issue. I think Pfizer has one in the pipeline.
@Gatorba86262202 @TulsiGabbard Kabinger, F., Stiller, C., Schmitzová, J. et al. Mechanism of molnupiravir-induced SARS-CoV-2 mutagenesis. Nat Struct Mol Biol 28, 740–746 (2021). https://t.co/wIpjDJx495
Its definetly a risk in this type of antiviral that should be explored more before release.
@FaheemYounus Molnupiravir works via inhibiting rna dependent rna polymerase, same as Ivermectin. Peer reviewed papers linked for reference.
https://t.co/FVsxSoOhs3
https://t.co/f3WeqeH8jM
@Thom_Hartmann The Nature article
"Mechanism of molnupiravir-induced SARS-CoV-2 mutagenesis", explicitly describes the mutagenesis of molnupiravir. Question: How could it be so specific that it only acts on the viral RNA-dependent RNA polymerase? Molnupiravir is a rather simple molecule: https://t.co/LiA0K7xxZo
@Victor05095953 @LaVeritaWeb È il meccanismo di funzionamento. Chiaramente bisogna capire il rischio di effetti indesiderati dovuti a questo meccanismo, le preoccupazioni ci sono
https://t.co/LBLSzdnUgi
@DrJuv2 "Molnupiravir increases the frequency of viral RNA mutations and impairs SARS-CoV-2 replication in animal models and in humans". And still under test III and not yet approved.
But gess what happens when you mutate a virus?
You guessed it, VARIANTS
https://t.co/39FfAebsga
RT @PeterHotez: Mechanism of molnupiravir-induced SARS-CoV-2 mutagenesis
Excellent paper summarizing the very interesting proposed mechan…
Oct 2, 2021 · 35 shares · 478 followersView post →
CS
Chris Street
@ChrisGStreet · X
RT @PeterHotez: Mechanism of molnupiravir-induced SARS-CoV-2 mutagenesis
Excellent paper summarizing the very interesting proposed mechan…
Oct 2, 2021 · 35 shares · 620 followersView post →
KR
Keith Robison
@OmicsOmicsBlog · X
Molnupiravir acts by generating G->A transitions - will overuse and poor dosing compliance lead to new resistance?
https://t.co/Od45XFqhaq
Oct 2, 2021 · 8 likes · 10,012 followersView post →
ZK
z_kvae
@z_kvae · X
RT @PeterHotez: Mechanism of molnupiravir-induced SARS-CoV-2 mutagenesis
Excellent paper summarizing the very interesting proposed mechan…
Oct 2, 2021 · 35 shares · 531 followersView post →
HF
Hironori Funabiki
@HironoriFunabi1 · X
Molnupiriavir does not inhibit the viral RNA-dependent RNA polymerase (RdRp), but introduces transition mutations by letting RdRp incorporate molnupiravir as a mimetic of C (and less frequently that of U). 2/
https://t.co/53ZGCW6o2o
https://t.co/GdKEZifFsb https://t.co/cTfzUILnYf
Oct 2, 2021 · 5 likes · 9,712 followersView post →
RT @PeterHotez: Mechanism of molnupiravir-induced SARS-CoV-2 mutagenesis
Excellent paper summarizing the very interesting proposed mechan…
Oct 1, 2021 · 35 shares · 2,585 followersView post →
I
ijefff
@ijefff · X
RT @PeterHotez: Mechanism of molnupiravir-induced SARS-CoV-2 mutagenesis
Excellent paper summarizing the very interesting proposed mechan…
Oct 1, 2021 · 35 shares · 1,252 followersView post →
IA
Ivonne Torres-Atencio
@negrita73bn · X
RT @PeterHotez: Mechanism of molnupiravir-induced SARS-CoV-2 mutagenesis
Excellent paper summarizing the very interesting proposed mechan…
Oct 1, 2021 · 35 shares · 2,379 followersView post →
MS
M Sabadach
@SabadachM · X
RT @PeterHotez: Mechanism of molnupiravir-induced SARS-CoV-2 mutagenesis
Excellent paper summarizing the very interesting proposed mechan…
Oct 1, 2021 · 35 shares · 151 followersView post →
K
kitzeyes
@kitzeyes · X
RT @PeterHotez: Mechanism of molnupiravir-induced SARS-CoV-2 mutagenesis
Excellent paper summarizing the very interesting proposed mechan…
Oct 1, 2021 · 35 shares · 557 followersView post →
V
VOTELIKEYOURDAUGHTERSLIFEDEPENDSONITBECAUSEITDOES
@Suzecat52 · X
RT @PeterHotez: Mechanism of molnupiravir-induced SARS-CoV-2 mutagenesis
Excellent paper summarizing the very interesting proposed mechan…
Oct 1, 2021 · 35 shares · 3,924 followersView post →
AC
Anna Davidson | OzSAGE | #CovidisAirborne
@PMGPSC · X
RT @PeterHotez: Mechanism of molnupiravir-induced SARS-CoV-2 mutagenesis
Excellent paper summarizing the very interesting proposed mechan…
Oct 1, 2021 · 35 shares · 8,989 followersView post →
PH
Prof Peter Hotez MD PhD DSc(hon)
@PeterHotez · X
Mechanism of molnupiravir-induced SARS-CoV-2 mutagenesis
Excellent paper summarizing the very interesting proposed mechanism of action @NatureSMB https://t.co/omXcQdqt0x
Oct 1, 2021 · 103 likes · 35 shares · 403,947 followersView post →
KS
KC Martin-Stone
@KCMartinStone · X
@yodaberg How it works at the molecular level:
https://t.co/DcdfKxOLcO
What could possibly go wrong? Mechanism of molnupiravir-induced SARS-CoV-2 mutagenesis | Nature Structural & Molecular Biology. https://t.co/I6aLjxfzhi
And, for those wanting to do the learnings:
Kabinger, Florian, et al ‘Mechanism of Molnupiravir-Induced SARS-CoV-2 Mutagenesis’. Nature Structural & Molecular Biology 28, no. 9 (September 2021): 740–46. https://doi.org/10.1038/s41594-021-00651-0.
@denomeme Here is an extract of an abstract of another paper
https://t.co/GX8VtS80nl:
When the pandemic began, molnupiravir was in pre-clinical development for the treatment of seasonal influenza. As COVID-19 spread, the timeline for the development program was moved forward significantly
MK-4482 $MRK Mercks investigational oral antiviral agent currently being studied in a ph3 trial for treatment of non-hospitalized patients with confirmed COVID-19:
"Mechanism of #molnupiravir-induced SARS-CoV-2 mutagenesis" https://t.co/SaKIXyVQ1Q #covid19 $AVIR
Mechanism of #molnupiravir-induced #SARSCoV2 mutagenesis
» https://t.co/14iy0XlVP2
Molecular mechanisms of #coronavirus drug candidate Molnupiravir unraveled. The antiviral agent incorporates RNA-like building blocks into the genome of the virus. https://t.co/bBRk82svHD
RT @torusengoku: molnupiravir、メカニズムも構造も調べられていた
Mechanism of molnupiravir-induced SARS-CoV-2 mutagenesis
https://t.co/Yd4Z2Co80z https://t.c…
Aug 12, 2021 · 3 shares · 248 followersView post →
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without416
@without416 · X
RT @torusengoku: molnupiravir、メカニズムも構造も調べられていた
Mechanism of molnupiravir-induced SARS-CoV-2 mutagenesis
https://t.co/Yd4Z2Co80z https://t.c…
Aug 12, 2021 · 3 shares · 773 followersView post →
T
torusengoku
@torusengoku · X
molnupiravir、メカニズムも構造も調べられていた
Mechanism of molnupiravir-induced SARS-CoV-2 mutagenesis
https://t.co/Yd4Z2Co80z https://t.co/5RCqDUWNpx
Aug 12, 2021 · 4 likes · 3 shares · 3,078 followersView post →
SS
SIMple*shh
@SIMple_shh · X
Mechanism of molnupiravir-induced SARS-CoV-2 mutagenesis | Nature Structural & Molecular Biology @chrismartenson What do you make of this ‘new’ drug currently under phase 3 trials? https://t.co/O9NSajeedU
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