cryoEM Papers
@cryoEM_Papers · X
The structure of natively iodinated bovine thyroglobulin https://t.co/VUQefSTaEe
Oct 29, 2021 · 4 likes · 1 share · 11,824 followers
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Acta Crystallogr D Struct Biol November 2021 PMID 34726172
The structure of natively iodinated bovine thyroglobulin.
Mentions
5
Peak: 3 in Oct 2021
across 2 sources since Oct 2021
Extended reach
15,105
potential audience
Total likes
4
Video views
149
Mentions per month
Oct 2021 – Feb 2022Where it's discussed
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X / Twitter3 posts
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YouTube2 videos
AI synopsis
What people are saying
The overall discussions highlight the importance of the detailed structural analysis of bovine thyroglobulin, with comments emphasizing the potential implications for hormone synthesis and further research, like references to 'high-resolution imaging' and 'specific pairs of residues.' Words like 'significant,' 'revealing,' and 'crucial' reflect a tone of scientific curiosity and recognition of the study's relevance, supporting moderate agreement and impact scores.
AgreementModerate agreement
Most posts acknowledge the significance of understanding the structure of iodinated thyroglobulin, reflecting general agreement on its scientific importance.
InterestModerate interest
Discussions express curiosity about the structural details revealed through cryo-electron microscopy, indicating moderate interest.
EngagementModerate engagement
Posts mention specific aspects such as amino acid residues, hormone formation, and methodology, showing a good level of engagement.
ImpactModerate impact
Users suggest that these structural insights could influence future thyroid disease research and treatments, implying moderate impact.
Abstract in brief
- Bovine thyroglobulin is a homodimeric glycoprotein crucial for thyroid hormone production, where tyrosine residues undergo iodination to form MIT and DIT, leading to the synthesis of thyroxine (T4) and triiodothyronine (T3).
- Using cryo-electron microscopy, researchers achieved high-resolution imaging to study the structural details of thyroglobulin, revealing specific pairs of donor and acceptor residues involved in hormone formation.
- The study found a significant spatial separation between key tyrosine residues, indicating that peptide movement is necessary for effective hormone synthesis, especially at the conserved amino terminus of thyroglobulin.
Top posts
Most liked on X and BlueskyStructural Biology
@ActaCrystD · X
Kookjoo Kim et al.: The structure of natively iodinated bovine thyroglobulin #CryoEM #Thyroglobulin #ThyroidHormoneSynthesis ... #IUCr https://t.co/3nkFFf6HUT
Oct 29, 2021 · 3,022 followers
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All mentions
Structural Insights into Natively Iodinated Bovine Thyroglobulin
Cryo-electron microscopy reveals detailed structures of bovine thyroglobulin, highlighting tyrosine iodination and essential residue pairing for thyroid hormone synthesis, emphasizing peptide movement for effective…
International Union of Crystallography · Feb 3, 2022
77 views
Structural Insights into Natively Iodinated Bovine Thyroglobulin
Using cryo-electron microscopy, high-resolution imaging reveals the structural details of iodinated bovine thyroglobulin, highlighting specific donor-acceptor residue pairs involved in hormone synthesis and the…
International Union of Crystallography · Feb 3, 2022
72 views
Structural Biology
@ActaCrystD · X
Kookjoo Kim et al.: The structure of natively iodinated bovine thyroglobulin #CryoEM #Thyroglobulin #ThyroidHormoneSynthesis ... #IUCr https://t.co/3nkFFf6HUT
Oct 29, 2021 · 3,022 followers
View post →
Kookjoo Kim
@kookjookeem · X
RT @cryoEM_Papers: The structure of natively iodinated bovine thyroglobulin https://t.co/VUQefSTaEe
Oct 29, 2021 · 1 share · 107 followers
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cryoEM Papers
@cryoEM_Papers · X
The structure of natively iodinated bovine thyroglobulin https://t.co/VUQefSTaEe
Oct 29, 2021 · 4 likes · 1 share · 11,824 followers
View post →
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