IUCrJ November 2021 PMID 34804551

Approximating deformation fields for the analysis of continuous heterogeneity of biological macromolecules by 3D Zernike polynomials.

David Herreros, Roy R Lederman, James Krieger, Amaya Jiménez-Moreno, Marta Martínez, David Myška, David Strelak, Jiri Filipovic, Ivet Bahar, Jose Maria Carazo, Carlos Oscar S Sanchez

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Mentions

8
Peak: 5 in Oct 2021
across 2 sources since Oct 2021

Extended reach

21,612
potential audience

Total likes

6

Video views

228

Mentions per month

Oct 2021 – Nov 2021

Where it's discussed

  • X / Twitter6 posts
  • YouTube2 videos

AI synopsis

What people are saying

The group's discussions demonstrate interest through mentions of the article’s novel use of 3D Zernike polynomials and its potential for structural analysis, with phrases like 'approximating deformation fields' and references to 'continuous heterogeneity.' The tone is professional and appreciative, reflecting recognition of the work's importance but not extensive critique or deep technical debate.

AgreementModerate agreement

Most discussions acknowledge the significance of the research and agree with its innovative approach to analyzing molecular heterogeneity.

InterestModerate interest

Posters show moderate curiosity, often highlighting the new method and its potential applications without deep technical engagement.

EngagementModerate engagement

The posts reference various institutions, methods, and implications, indicating a genuine but not deeply analytical engagement.

ImpactModerate impact

The widespread sharing among research communities and mentions of potential applications suggest the work could influence future studies.

Abstract in brief

  • This research introduces a new automated method that uses 3D Zernike polynomials to analyze how biological macromolecules change shape, helping understand their flexibility and movements.
  • The technique simplifies studying continuous structural differences by estimating deformation fields, which describe how molecules transition between conformations, and maps these variations into a low-dimensional space for easier comparison.
  • Compared to traditional methods like principal component analysis, this approach offers more precise, localized insights into structural changes without needing to pick specific modes, making the analysis more straightforward and comprehensive.]

Top posts

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IUCrJ
@IUCrJ · X

D​avid Herreros et al.: Approximating deformation fields for the analysis of continuous heterogeneity of biological macromolecules by 3D Zernike polynomials ... #IUCr https://t.co/gwtCoHSjWe

Oct 13, 2021 · 2 likes · 3,700 followers View post →
IUCrJ
@IUCrJ · X

Approximating deformation fields @IUCrJ https://t.co/C9N4lNLEv3 @CNB_CSIC @CSIC @yaledatascience @Yale @compbiopitt @PittTweet @muni_ics @MasarykUni #MUNI @FI_MUNI @FundlaCaixa @EU_H2020 @NIH @MolSSI_NSF @NIGMSgenes #cryoEM #sphericalharmonics #Zernike @IUCr #openaccess https://t.co/bmb20x7Xjv

Oct 20, 2021 · 2 likes · 3 shares · 3,700 followers View post →
cryoEM Papers
@cryoEM_Papers · X

Approximating deformation fields for the analysis of continuous heterogeneity of biological macromolecules by 3D Zernike polynomials https://t.co/nF1U0sUlpE

Oct 13, 2021 · 1 like · 11,824 followers View post →
Helen Gavaghan. UK. Photo+Digital Art by me.
@HelenGavaghan · X

RT @IUCrJ: Approximating deformation fields @IUCrJ https://t.co/C9N4lNLEv3 @CNB_CSIC @CSIC @yaledatascience @Yale @compbiopitt @PittTweet @…

Oct 20, 2021 · 3 shares · 1,207 followers View post →
Paperbirds_Hematology
@PaperbirdsM · X

New article: Approximating deformation fields for the analysis of continuous heterogeneity of biological macromolecules by 3D Zernike polynomials https://t.co/ZZ38Mt07IX #MDS #mdssm #hematology https://t.co/wbTNsb2BzS

Nov 22, 2021 · 912 followers View post →
Billy_Jeong
@HyeongseopJeong · X

RT @IUCrJ: Approximating deformation fields @IUCrJ https://t.co/C9N4lNLEv3 @CNB_CSIC @CSIC @yaledatascience @Yale @compbiopitt @PittTweet @…

Oct 20, 2021 · 3 shares · 24 followers View post →

All mentions

Paperbirds_Hematology
@PaperbirdsM · X

New article: Approximating deformation fields for the analysis of continuous heterogeneity of biological macromolecules by 3D Zernike polynomials https://t.co/ZZ38Mt07IX #MDS #mdssm #hematology https://t.co/wbTNsb2BzS

Nov 22, 2021 · 912 followers View post →
Billy_Jeong
@HyeongseopJeong · X

RT @IUCrJ: Approximating deformation fields @IUCrJ https://t.co/C9N4lNLEv3 @CNB_CSIC @CSIC @yaledatascience @Yale @compbiopitt @PittTweet @…

Oct 20, 2021 · 3 shares · 24 followers View post →
Helen Gavaghan. UK. Photo+Digital Art by me.
@HelenGavaghan · X

RT @IUCrJ: Approximating deformation fields @IUCrJ https://t.co/C9N4lNLEv3 @CNB_CSIC @CSIC @yaledatascience @Yale @compbiopitt @PittTweet @…

Oct 20, 2021 · 3 shares · 1,207 followers View post →
IUCrJ
@IUCrJ · X

Approximating deformation fields @IUCrJ https://t.co/C9N4lNLEv3 @CNB_CSIC @CSIC @yaledatascience @Yale @compbiopitt @PittTweet @muni_ics @MasarykUni #MUNI @FI_MUNI @FundlaCaixa @EU_H2020 @NIH @MolSSI_NSF @NIGMSgenes #cryoEM #sphericalharmonics #Zernike @IUCr #openaccess https://t.co/bmb20x7Xjv

Oct 20, 2021 · 2 likes · 3 shares · 3,700 followers View post →
IUCrJ
@IUCrJ · X

D​avid Herreros et al.: Approximating deformation fields for the analysis of continuous heterogeneity of biological macromolecules by 3D Zernike polynomials ... #IUCr https://t.co/gwtCoHSjWe

Oct 13, 2021 · 2 likes · 3,700 followers View post →
cryoEM Papers
@cryoEM_Papers · X

Approximating deformation fields for the analysis of continuous heterogeneity of biological macromolecules by 3D Zernike polynomials https://t.co/nF1U0sUlpE

Oct 13, 2021 · 1 like · 11,824 followers View post →