LINE-1 expression in cancer correlates with p53 mutation, copy number alteration, and S phase checkpoint.
Wilson McKerrow, Xuya Wang, Carlos Mendez-Dorantes, Paolo Mita, Song Cao, Mark Grivainis, Li Ding, John LaCava, Kathleen H Burns, Jef D Boeke, David Fenyö
February 2022 Proc Natl Acad Sci U S ASynopsis of Social media discussions
Discussions emphasize the importance of the publication, with some explicitly noting that understanding LINE-1 activity could lead to novel cancer detection approaches, as highlighted in comments about ultrasensitive detection and its potential to detect half of all cancers. The tone varies from enthusiastic praise to critical reflections, illustrating a general interest in the implications of the research while acknowledging its foundational nature.
Agreement
Moderate agreementMost discussions acknowledge the significance of the published research, with some even praising its potential impact on cancer detection and understanding, as seen in comments supporting the importance of LINE-1 activity in cancer genomics.
Interest
High level of interestThe posts demonstrate high curiosity, especially when highlighting breakthroughs like ultrasensitive detection methods and linking molecular mechanisms to cancer diagnostics, reflecting enthusiasm and relevance.
Engagement
Moderate level of engagementSeveral messages reference the research's implications, question details like protein naming, and connect the findings to broader contexts such as vaccine development and cancer detection tools, indicating moderate deep engagement.
Impact
Moderate level of impactWhile some posts hint at the profound potential of the work to influence future cancer detection and understanding, most perceive it as an important but preliminary step, contributing to an overall moderate impact perception.
Social Mentions
YouTube
1 Videos
30 Posts
Metrics
Video Views
343,542
Total Likes
14,644
Extended Reach
387,521
Social Features
31
Timeline: Posts about article
Top Social Media Posts
Kathleen Helen Burns
Transposon aficionados and physician friends will see that this video has some inaccuracies. But for those who’d like some Saturday morning cartoons …there’s also entertainment and delight to be had in this primer on our field and recent work: https://t.co/7kqGpBNCfy
view full post
Marty Taylor, MD PhD
https://t.co/2NUeefEIZX
Really cool video on LINE-1 and our work on ultrasensitive detection of Orf1p. I love their description of the total lack of creativity in naming the LINE-1 proteins. Orf1=“Protein McProtein Face”.
https://t.co/ucfZvlhiI1
view full post
CancerGenomicsCloud
Congratulations to our CGC collaborator @MckerrowWilson and the publication of their work on @PNASNews! The tools and data are available on the @genomicscloud! #bioinformatics #Transposons #cloudcomputing #cancerresearch https://t.co/b0Omw3GaZH
view full post
Carlos Mendez-Dorantes
Check out @MckerrowWilson publication @PNASNews suggesting that "LINE-1 expression in cancer correlates with p53 mutation, copy number alteration, and S phase checkpoint"
Thanks for the opportunity to contribute!
@KathleenHBurns
https://t.co/sB5xSIFzOI https://t.co/RScrFN5EgH
view full post
tune
https://t.co/C2rGkzSCp9
ゲノムはLINE-1(L1) retrotransposon反復copyをcode
DNA一本鎖切断,新L1 DNA copy逆転写で複製
乳癌,卵巣癌,子宮内膜癌,結腸癌L1はp53変異,CNA(copy数変化)相関
子宮内膜癌でS期checkpoint経路がL1発現のDNA損傷応答経路
L1がDNA損傷,複製stress⬆️→
view full post
Posts referencing the article
Detecting Cancer Early Through LINE1 Retrotransposon Activity
Cancer detection may improve through LINE1 retrotransposon activity, which increases in many tumors and is linked to p53 mutations and genomic instability. LINE1 activity can cause DNA damage and replication stress, disrupting normal cell division.
January 12, 2024
343,542 views
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https://t.co/C2rGkzSCp9 ゲノムはLINE-1(L1) retrotransposon反復copyをcode DNA一本鎖切断,新L1 DNA copy逆転写で複製 乳癌,卵巣癌,子宮内膜癌,結腸癌L1はp53変異,CNA(copy数変化)相関 子宮内膜癌でS期checkpoint経路がL1発現のDNA損傷応答経路 L1がDNA損傷,複製stress⬆️→
view full postJune 28, 2024
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Jennifer E. Fairman, CMI, FAMI
@fairmanstudios (Twitter)RT @DrMartyTaylor: https://t.co/2NUeefEIZX Really cool video on LINE-1 and our work on ultrasensitive detection of Orf1p. I love their desc…
view full postJanuary 29, 2024
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Corine
@FloatingIsland (Twitter)https://t.co/nZ4vAa7nrl
view full postJanuary 23, 2024
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Kay Ydill
@SirrK (Twitter)science is WOKE !!! This Simple Test Could Detect Half of All Cancers https://t.co/YjUSo0lEPC via @YouTube ......... UKRAINE SONG maybe https://t.co/6L7uAgMUDF…… .......... ARM #UKRAINE NOW- V V #democracy #VVMrJOE
view full postJanuary 18, 2024
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MGH Pathology
@MGHPathology (Twitter)RT @DrMartyTaylor: https://t.co/2NUeefEIZX Really cool video on LINE-1 and our work on ultrasensitive detection of Orf1p. I love their desc…
view full postJanuary 17, 2024
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Stephanie Gomez, PhD
@ScientistStephG (Twitter)RT @DrMartyTaylor: https://t.co/2NUeefEIZX Really cool video on LINE-1 and our work on ultrasensitive detection of Orf1p. I love their desc…
view full postJanuary 16, 2024
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Marty Taylor, MD PhD
@DrMartyTaylor (Twitter)https://t.co/2NUeefEIZX Really cool video on LINE-1 and our work on ultrasensitive detection of Orf1p. I love their description of the total lack of creativity in naming the LINE-1 proteins. Orf1=“Protein McProtein Face”. https://t.co/ucfZvlhiI1
view full postJanuary 15, 2024
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homer60
@homer604 (Twitter)This Simple Test Could Detect Half of All Cancers https://t.co/OwORNWlhxx via @YouTube
view full postJanuary 15, 2024
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Oniraptor™️
@0NlRAPTOR (Twitter)@MarkRainycity here is the report: https://t.co/ofko7a7Udo
view full postJanuary 14, 2024
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N. Petrenko
@npetrenko13 (Twitter)This Simple Test Could Detect Half of All Cancers https://t.co/FZtl9kN4c6 via @YouTube
view full postJanuary 14, 2024
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Rick
@g967665 (Twitter)https://t.co/vMZYSMzs6e
view full postJanuary 14, 2024
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Thomas R. Stevenson
@ThomasStevenson (Twitter)This Simple Test Could Detect Half of All Cancers https://t.co/hRQhDfinLO via @YouTube
view full postJanuary 13, 2024
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Corine
@FloatingIsland (Twitter)https://t.co/nZ4vAa7nrl
view full postJanuary 13, 2024
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Maja
@mc_haerle (Twitter)RT @KathleenHBurns: Transposon aficionados and physician friends will see that this video has some inaccuracies. But for those who’d like s…
view full postJanuary 13, 2024
1
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Kathleen Helen Burns
@KathleenHBurns (Twitter)Transposon aficionados and physician friends will see that this video has some inaccuracies. But for those who’d like some Saturday morning cartoons …there’s also entertainment and delight to be had in this primer on our field and recent work: https://t.co/7kqGpBNCfy
view full postJanuary 13, 2024
33
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@Jmayfield3 (Twitter)@hankgreen @SciShowTangents @SciShow @ScienceNews @ScienceChannel Wait though did scientists just also create the path to a vaccine to protect against cancer?! #Science #cancer #CancerResearch This Simple Test Could Find Half of All Cancers https://t.co/WB6A8LXKGW via @YouTube
view full postJanuary 12, 2024
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Ravenwood
@rawnwyd (Twitter)This Simple Test Could Find Half of All Cancers https://t.co/jZNJIiKQPE via @YouTube
view full postJanuary 12, 2024
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Grytulf Vankelhane
@Vankelhane (Twitter)This Simple Test Could Find Half of All Cancers https://t.co/wcYbNeqyQ7 via @YouTube
view full postJanuary 12, 2024
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kirsten houseknecht aka fabricdragon
@fabricdragon (Twitter)This Simple Test Could Find Half of All Cancers https://t.co/xQXSy6YXsy via @YouTube
view full postJanuary 12, 2024
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Hashim AbdusSamad
@MegaWubba89 (Twitter)This Simple Test Could Find Half of All Cancers https://t.co/c5QchwZcCM via @YouTube
view full postJanuary 12, 2024
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kodiakbear
@kodiakbear1969 (Twitter)SciShow https://t.co/EuQSETCG98
view full postJanuary 12, 2024
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Gzugouiten Grutelbitz
@Cailzmaster (Twitter)@DavidLMayhew @crabb_vicki @jennabgreen @dr_jon_l @Jikkyleaks @Doctor_Eric_B @gorskon @CaulfieldTim @medicamentarii @MakisMD @DrCanuckMD @DrJacobsRad @19joho @DrEricDing Oh no? https://t.co/jg7oUoatkW
view full postJune 20, 2023
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Carlos Mendez-Dorantes
@CarlosMendezPhD (Twitter)Check out @MckerrowWilson publication @PNASNews suggesting that "LINE-1 expression in cancer correlates with p53 mutation, copy number alteration, and S phase checkpoint" Thanks for the opportunity to contribute! @KathleenHBurns https://t.co/sB5xSIFzOI https://t.co/RScrFN5EgH
view full postMarch 7, 2022
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Jack DiGiovanna
@jack_digi (Twitter)RT @genomicscloud: Congratulations to our CGC collaborator @MckerrowWilson and the publication of their work on @PNASNews! The tools and da…
view full postMarch 7, 2022
4
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David Roberson
@David_Roberson (Twitter)RT @genomicscloud: Congratulations to our CGC collaborator @MckerrowWilson and the publication of their work on @PNASNews! The tools and da…
view full postMarch 7, 2022
4
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CompChemBio Bot
@CompChemBioBot (Twitter)RT @genomicscloud: Congratulations to our CGC collaborator @MckerrowWilson and the publication of their work on @PNASNews! The tools and da…
view full postMarch 7, 2022
4
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CancerGenomicsCloud
@genomicscloud (Twitter)Congratulations to our CGC collaborator @MckerrowWilson and the publication of their work on @PNASNews! The tools and data are available on the @genomicscloud! #bioinformatics #Transposons #cloudcomputing #cancerresearch https://t.co/b0Omw3GaZH
view full postMarch 7, 2022
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Farina M. Yusoff
@DrMYFarina (Twitter)LINE-1 expression in cancer correlates with p53 mutation, copy number alteration, and S phase checkpoint https://t.co/6jRcfnwSZO
view full postMarch 3, 2022
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Seiichi Mori
@seiichi_mori (Twitter)LINE-1 expression in cancer correlates with p53 mutation, copy number alteration, and S phase... - https://t.co/L4L4je40km #ScholarAlerts
view full postFebruary 19, 2022
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KidneyCancers.org (Pine Island Community Radio)
@kidneycancers (Twitter)LINE-1 expression in cancer correlates with p53 mutation, copy number alteration, and S ... https://t.co/FHmx1RZvdQ
view full postFebruary 16, 2022
Abstract Synopsis
- LINE1 retrotransposons are typically suppressed in normal somatic tissues but become active in many cancers, where their activity is linked to mutations in the p53 gene and changes in copy number.
- In cancers, increased LINE1 activity can cause DNA damage, such as double-strand breaks, and help induce replication stress, which disrupts normal DNA copying processes during cell division.
- Data analysis from various cancer types shows a consistent relationship between LINE1 activity and enhanced DNA replication stress responses, particularly activating the S phase checkpoint pathway, implying LINE1 directly contributes to genomic instability in tumors.]
tune
@keisuke4713 (Twitter)