Proc Natl Acad Sci U S A February 2022 PMID 35169076

LINE-1 expression in cancer correlates with p53 mutation, copy number alteration, and S phase checkpoint.

Wilson McKerrow, Xuya Wang, Carlos Mendez-Dorantes, Paolo Mita, Song Cao, Mark Grivainis, Li Ding, John LaCava, Kathleen H Burns, Jef D Boeke, David Fenyö

Mentions

31
Peak: 21 in Jan 2024
across 2 sources since Feb 2022

Extended reach

387,521
potential audience

Total likes

14,644

Video views

343,542

Mentions per month

Feb 2022 – Jun 2024

Where it's discussed

  • X / Twitter30 posts
  • YouTube1 videos

AI synopsis

What people are saying

Discussions emphasize the importance of the publication, with some explicitly noting that understanding LINE-1 activity could lead to novel cancer detection approaches, as highlighted in comments about ultrasensitive detection and its potential to detect half of all cancers. The tone varies from enthusiastic praise to critical reflections, illustrating a general interest in the implications of the research while acknowledging its foundational nature.

AgreementModerate agreement

Most discussions acknowledge the significance of the published research, with some even praising its potential impact on cancer detection and understanding, as seen in comments supporting the importance of LINE-1 activity in cancer genomics.

InterestHigh interest

The posts demonstrate high curiosity, especially when highlighting breakthroughs like ultrasensitive detection methods and linking molecular mechanisms to cancer diagnostics, reflecting enthusiasm and relevance.

EngagementModerate engagement

Several messages reference the research's implications, question details like protein naming, and connect the findings to broader contexts such as vaccine development and cancer detection tools, indicating moderate deep engagement.

ImpactModerate impact

While some posts hint at the profound potential of the work to influence future cancer detection and understanding, most perceive it as an important but preliminary step, contributing to an overall moderate impact perception.

Abstract in brief

  • LINE1 retrotransposons are typically suppressed in normal somatic tissues but become active in many cancers, where their activity is linked to mutations in the p53 gene and changes in copy number.
  • In cancers, increased LINE1 activity can cause DNA damage, such as double-strand breaks, and help induce replication stress, which disrupts normal DNA copying processes during cell division.
  • Data analysis from various cancer types shows a consistent relationship between LINE1 activity and enhanced DNA replication stress responses, particularly activating the S phase checkpoint pathway, implying LINE1 directly contributes to genomic instability in tumors.]

Top posts

Most liked on X and Bluesky
Kathleen Helen Burns
@KathleenHBurns · X

Transposon aficionados and physician friends will see that this video has some inaccuracies. But for those who’d like some Saturday morning cartoons …there’s also entertainment and delight to be had in this primer on our field and recent work: https://t.co/7kqGpBNCfy

Jan 13, 2024 · 33 likes · 1 share · 3,956 followers View post →
Marty Taylor, MD PhD
@DrMartyTaylor · X

https://t.co/2NUeefEIZX Really cool video on LINE-1 and our work on ultrasensitive detection of Orf1p. I love their description of the total lack of creativity in naming the LINE-1 proteins. Orf1=“Protein McProtein Face”. https://t.co/ucfZvlhiI1

Jan 15, 2024 · 13 likes · 3 shares · 352 followers View post →
CancerGenomicsCloud
@genomicscloud · X

Congratulations to our CGC collaborator @MckerrowWilson and the publication of their work on @PNASNews! The tools and data are available on the @genomicscloud! #bioinformatics #Transposons #cloudcomputing #cancerresearch https://t.co/b0Omw3GaZH

Mar 7, 2022 · 6 likes · 4 shares · 1,036 followers View post →
Carlos Mendez-Dorantes
@CarlosMendezPhD · X

Check out @MckerrowWilson publication @PNASNews suggesting that "LINE-1 expression in cancer correlates with p53 mutation, copy number alteration, and S phase checkpoint" Thanks for the opportunity to contribute! @KathleenHBurns https://t.co/sB5xSIFzOI https://t.co/RScrFN5EgH

Mar 7, 2022 · 2 likes · 754 followers View post →
tune
@keisuke4713 · X

https://t.co/C2rGkzSCp9 ゲノムはLINE-1(L1) retrotransposon反復copyをcode DNA一本鎖切断,新L1 DNA copy逆転写で複製 乳癌,卵巣癌,子宮内膜癌,結腸癌L1はp53変異,CNA(copy数変化)相関 子宮内膜癌でS期checkpoint経路がL1発現のDNA損傷応答経路 L1がDNA損傷,複製stress⬆️→

Jun 28, 2024 · 1 like · 3,735 followers View post →
Oniraptor™️
@0NlRAPTOR · X

@MarkRainycity here is the report: https://t.co/ofko7a7Udo

Jan 14, 2024 · 1 like · 1,419 followers View post →

All mentions

tune
@keisuke4713 · X

https://t.co/C2rGkzSCp9 ゲノムはLINE-1(L1) retrotransposon反復copyをcode DNA一本鎖切断,新L1 DNA copy逆転写で複製 乳癌,卵巣癌,子宮内膜癌,結腸癌L1はp53変異,CNA(copy数変化)相関 子宮内膜癌でS期checkpoint経路がL1発現のDNA損傷応答経路 L1がDNA損傷,複製stress⬆️→

Jun 28, 2024 · 1 like · 3,735 followers View post →
Jennifer E. Fairman, CMI, FAMI
@fairmanstudios · X

RT @DrMartyTaylor: https://t.co/2NUeefEIZX Really cool video on LINE-1 and our work on ultrasensitive detection of Orf1p. I love their desc…

Jan 29, 2024 · 3 shares · 1,647 followers View post →
Corine
@FloatingIsland · X

https://t.co/nZ4vAa7nrl

Jan 23, 2024 · 424 followers View post →
Kay Ydill
@SirrK · X

science is WOKE !!! This Simple Test Could Detect Half of All Cancers https://t.co/YjUSo0lEPC via @YouTube ......... UKRAINE SONG maybe https://t.co/6L7uAgMUDF…… .......... ARM #UKRAINE NOW- V V #democracy #VVMrJOE

Jan 18, 2024 · 1,692 followers View post →
MGH Pathology
@MGHPathology · X

RT @DrMartyTaylor: https://t.co/2NUeefEIZX Really cool video on LINE-1 and our work on ultrasensitive detection of Orf1p. I love their desc…

Jan 17, 2024 · 3 shares · 7,689 followers View post →
Stephanie Gomez, PhD
@ScientistStephG · X

RT @DrMartyTaylor: https://t.co/2NUeefEIZX Really cool video on LINE-1 and our work on ultrasensitive detection of Orf1p. I love their desc…

Jan 16, 2024 · 3 shares · 485 followers View post →
Marty Taylor, MD PhD
@DrMartyTaylor · X

https://t.co/2NUeefEIZX Really cool video on LINE-1 and our work on ultrasensitive detection of Orf1p. I love their description of the total lack of creativity in naming the LINE-1 proteins. Orf1=“Protein McProtein Face”. https://t.co/ucfZvlhiI1

Jan 15, 2024 · 13 likes · 3 shares · 352 followers View post →
homer60
@homer604 · X

This Simple Test Could Detect Half of All Cancers https://t.co/OwORNWlhxx via @YouTube

Jan 15, 2024 · 115 followers View post →
Oniraptor™️
@0NlRAPTOR · X

@MarkRainycity here is the report: https://t.co/ofko7a7Udo

Jan 14, 2024 · 1 like · 1,419 followers View post →
N. Petrenko
@npetrenko13 · X

This Simple Test Could Detect Half of All Cancers https://t.co/FZtl9kN4c6 via @YouTube

Jan 14, 2024 · 77 followers View post →
Rick
@g967665 · X

https://t.co/vMZYSMzs6e

Jan 14, 2024 · 7 followers View post →
Thomas R. Stevenson
@ThomasStevenson · X

This Simple Test Could Detect Half of All Cancers https://t.co/hRQhDfinLO via @YouTube

Jan 13, 2024 · 2,155 followers View post →
Corine
@FloatingIsland · X

https://t.co/nZ4vAa7nrl

Jan 13, 2024 · 424 followers View post →
Maja
@mc_haerle · X

RT @KathleenHBurns: Transposon aficionados and physician friends will see that this video has some inaccuracies. But for those who’d like s…

Jan 13, 2024 · 1 share · 142 followers View post →
Kathleen Helen Burns
@KathleenHBurns · X

Transposon aficionados and physician friends will see that this video has some inaccuracies. But for those who’d like some Saturday morning cartoons …there’s also entertainment and delight to be had in this primer on our field and recent work: https://t.co/7kqGpBNCfy

Jan 13, 2024 · 33 likes · 1 share · 3,956 followers View post →
Jmayfield3
@Jmayfield3 · X

@hankgreen @SciShowTangents @SciShow @ScienceNews @ScienceChannel Wait though did scientists just also create the path to a vaccine to protect against cancer?! #Science #cancer #CancerResearch This Simple Test Could Find Half of All Cancers https://t.co/WB6A8LXKGW via @YouTube

Jan 12, 2024 · 348 followers View post →
Ravenwood
@rawnwyd · X

This Simple Test Could Find Half of All Cancers https://t.co/jZNJIiKQPE via @YouTube

Jan 12, 2024 · 455 followers View post →
Grytulf Vankelhane
@Vankelhane · X

This Simple Test Could Find Half of All Cancers https://t.co/wcYbNeqyQ7 via @YouTube

Jan 12, 2024 · 3,689 followers View post →
kirsten houseknecht aka fabricdragon
@fabricdragon · X

This Simple Test Could Find Half of All Cancers https://t.co/xQXSy6YXsy via @YouTube

Jan 12, 2024 · 3,964 followers View post →
Hashim AbdusSamad
@MegaWubba89 · X

This Simple Test Could Find Half of All Cancers https://t.co/c5QchwZcCM via @YouTube

Jan 12, 2024 · 852 followers View post →
kodiakbear
@kodiakbear1969 · X

SciShow https://t.co/EuQSETCG98

Jan 12, 2024 · 98 followers View post →
Gzugouiten Grutelbitz
@Cailzmaster · X

@DavidLMayhew @crabb_vicki @jennabgreen @dr_jon_l @Jikkyleaks @Doctor_Eric_B @gorskon @CaulfieldTim @medicamentarii @MakisMD @DrCanuckMD @DrJacobsRad @19joho @DrEricDing Oh no? https://t.co/jg7oUoatkW

Jun 20, 2023 · 144 followers View post →
Carlos Mendez-Dorantes
@CarlosMendezPhD · X

Check out @MckerrowWilson publication @PNASNews suggesting that "LINE-1 expression in cancer correlates with p53 mutation, copy number alteration, and S phase checkpoint" Thanks for the opportunity to contribute! @KathleenHBurns https://t.co/sB5xSIFzOI https://t.co/RScrFN5EgH

Mar 7, 2022 · 2 likes · 754 followers View post →
Jack DiGiovanna
@jack_digi · X

RT @genomicscloud: Congratulations to our CGC collaborator @MckerrowWilson and the publication of their work on @PNASNews! The tools and da…

Mar 7, 2022 · 4 shares · 1,102 followers View post →
David Roberson
@David_Roberson · X

RT @genomicscloud: Congratulations to our CGC collaborator @MckerrowWilson and the publication of their work on @PNASNews! The tools and da…

Mar 7, 2022 · 4 shares · 169 followers View post →
CompChemBio Bot
@CompChemBioBot · X

RT @genomicscloud: Congratulations to our CGC collaborator @MckerrowWilson and the publication of their work on @PNASNews! The tools and da…

Mar 7, 2022 · 4 shares · 2,760 followers View post →
CancerGenomicsCloud
@genomicscloud · X

Congratulations to our CGC collaborator @MckerrowWilson and the publication of their work on @PNASNews! The tools and data are available on the @genomicscloud! #bioinformatics #Transposons #cloudcomputing #cancerresearch https://t.co/b0Omw3GaZH

Mar 7, 2022 · 6 likes · 4 shares · 1,036 followers View post →
Farina M. Yusoff
@DrMYFarina · X

LINE-1 expression in cancer correlates with p53 mutation, copy number alteration, and S phase checkpoint https://t.co/6jRcfnwSZO

Mar 3, 2022 · 197 followers View post →
Seiichi Mori
@seiichi_mori · X

LINE-1 expression in cancer correlates with p53 mutation, copy number alteration, and S phase... - https://t.co/L4L4je40km #ScholarAlerts

Feb 19, 2022 · 1 like · 313 followers View post →
KidneyCancers.org (Pine Island Community Radio)
@kidneycancers · X

LINE-1 expression in cancer correlates with p53 mutation, copy number alteration, and S ... https://t.co/FHmx1RZvdQ

Feb 16, 2022 · 3,719 followers View post →