Transposon aficionados and physician friends will see that this video has some inaccuracies. But for those who’d like some Saturday morning cartoons …there’s also entertainment and delight to be had in this primer on our field and recent work: https://t.co/7kqGpBNCfy
LINE-1 expression in cancer correlates with p53 mutation, copy number alteration, and S phase checkpoint.
Mentions
Extended reach
Total likes
Video views
Mentions per month
Feb 2022 – Jun 2024Where it's discussed
-
X / Twitter30 posts
-
YouTube1 videos
AI synopsis
What people are saying
Discussions emphasize the importance of the publication, with some explicitly noting that understanding LINE-1 activity could lead to novel cancer detection approaches, as highlighted in comments about ultrasensitive detection and its potential to detect half of all cancers. The tone varies from enthusiastic praise to critical reflections, illustrating a general interest in the implications of the research while acknowledging its foundational nature.
Most discussions acknowledge the significance of the published research, with some even praising its potential impact on cancer detection and understanding, as seen in comments supporting the importance of LINE-1 activity in cancer genomics.
The posts demonstrate high curiosity, especially when highlighting breakthroughs like ultrasensitive detection methods and linking molecular mechanisms to cancer diagnostics, reflecting enthusiasm and relevance.
Several messages reference the research's implications, question details like protein naming, and connect the findings to broader contexts such as vaccine development and cancer detection tools, indicating moderate deep engagement.
While some posts hint at the profound potential of the work to influence future cancer detection and understanding, most perceive it as an important but preliminary step, contributing to an overall moderate impact perception.
Abstract in brief
- LINE1 retrotransposons are typically suppressed in normal somatic tissues but become active in many cancers, where their activity is linked to mutations in the p53 gene and changes in copy number.
- In cancers, increased LINE1 activity can cause DNA damage, such as double-strand breaks, and help induce replication stress, which disrupts normal DNA copying processes during cell division.
- Data analysis from various cancer types shows a consistent relationship between LINE1 activity and enhanced DNA replication stress responses, particularly activating the S phase checkpoint pathway, implying LINE1 directly contributes to genomic instability in tumors.]
Top posts
Most liked on X and Blueskyhttps://t.co/2NUeefEIZX Really cool video on LINE-1 and our work on ultrasensitive detection of Orf1p. I love their description of the total lack of creativity in naming the LINE-1 proteins. Orf1=“Protein McProtein Face”. https://t.co/ucfZvlhiI1
Congratulations to our CGC collaborator @MckerrowWilson and the publication of their work on @PNASNews! The tools and data are available on the @genomicscloud! #bioinformatics #Transposons #cloudcomputing #cancerresearch https://t.co/b0Omw3GaZH
Check out @MckerrowWilson publication @PNASNews suggesting that "LINE-1 expression in cancer correlates with p53 mutation, copy number alteration, and S phase checkpoint" Thanks for the opportunity to contribute! @KathleenHBurns https://t.co/sB5xSIFzOI https://t.co/RScrFN5EgH
https://t.co/C2rGkzSCp9 ゲノムはLINE-1(L1) retrotransposon反復copyをcode DNA一本鎖切断,新L1 DNA copy逆転写で複製 乳癌,卵巣癌,子宮内膜癌,結腸癌L1はp53変異,CNA(copy数変化)相関 子宮内膜癌でS期checkpoint経路がL1発現のDNA損傷応答経路 L1がDNA損傷,複製stress⬆️→
@MarkRainycity here is the report: https://t.co/ofko7a7Udo
All mentions
Detecting Cancer Early Through LINE1 Retrotransposon Activity
Cancer detection may improve through LINE1 retrotransposon activity, which increases in many tumors and is linked to p53 mutations and genomic instability. LINE1 activity can cause DNA damage and replication stress…
https://t.co/C2rGkzSCp9 ゲノムはLINE-1(L1) retrotransposon反復copyをcode DNA一本鎖切断,新L1 DNA copy逆転写で複製 乳癌,卵巣癌,子宮内膜癌,結腸癌L1はp53変異,CNA(copy数変化)相関 子宮内膜癌でS期checkpoint経路がL1発現のDNA損傷応答経路 L1がDNA損傷,複製stress⬆️→
RT @DrMartyTaylor: https://t.co/2NUeefEIZX Really cool video on LINE-1 and our work on ultrasensitive detection of Orf1p. I love their desc…
https://t.co/nZ4vAa7nrl
science is WOKE !!! This Simple Test Could Detect Half of All Cancers https://t.co/YjUSo0lEPC via @YouTube ......... UKRAINE SONG maybe https://t.co/6L7uAgMUDF…… .......... ARM #UKRAINE NOW- V V #democracy #VVMrJOE
RT @DrMartyTaylor: https://t.co/2NUeefEIZX Really cool video on LINE-1 and our work on ultrasensitive detection of Orf1p. I love their desc…
RT @DrMartyTaylor: https://t.co/2NUeefEIZX Really cool video on LINE-1 and our work on ultrasensitive detection of Orf1p. I love their desc…
https://t.co/2NUeefEIZX Really cool video on LINE-1 and our work on ultrasensitive detection of Orf1p. I love their description of the total lack of creativity in naming the LINE-1 proteins. Orf1=“Protein McProtein Face”. https://t.co/ucfZvlhiI1
This Simple Test Could Detect Half of All Cancers https://t.co/OwORNWlhxx via @YouTube
@MarkRainycity here is the report: https://t.co/ofko7a7Udo
This Simple Test Could Detect Half of All Cancers https://t.co/FZtl9kN4c6 via @YouTube
https://t.co/vMZYSMzs6e
This Simple Test Could Detect Half of All Cancers https://t.co/hRQhDfinLO via @YouTube
https://t.co/nZ4vAa7nrl
RT @KathleenHBurns: Transposon aficionados and physician friends will see that this video has some inaccuracies. But for those who’d like s…
Transposon aficionados and physician friends will see that this video has some inaccuracies. But for those who’d like some Saturday morning cartoons …there’s also entertainment and delight to be had in this primer on our field and recent work: https://t.co/7kqGpBNCfy
@hankgreen @SciShowTangents @SciShow @ScienceNews @ScienceChannel Wait though did scientists just also create the path to a vaccine to protect against cancer?! #Science #cancer #CancerResearch This Simple Test Could Find Half of All Cancers https://t.co/WB6A8LXKGW via @YouTube
This Simple Test Could Find Half of All Cancers https://t.co/jZNJIiKQPE via @YouTube
This Simple Test Could Find Half of All Cancers https://t.co/wcYbNeqyQ7 via @YouTube
This Simple Test Could Find Half of All Cancers https://t.co/xQXSy6YXsy via @YouTube
This Simple Test Could Find Half of All Cancers https://t.co/c5QchwZcCM via @YouTube
SciShow https://t.co/EuQSETCG98
@DavidLMayhew @crabb_vicki @jennabgreen @dr_jon_l @Jikkyleaks @Doctor_Eric_B @gorskon @CaulfieldTim @medicamentarii @MakisMD @DrCanuckMD @DrJacobsRad @19joho @DrEricDing Oh no? https://t.co/jg7oUoatkW
Check out @MckerrowWilson publication @PNASNews suggesting that "LINE-1 expression in cancer correlates with p53 mutation, copy number alteration, and S phase checkpoint" Thanks for the opportunity to contribute! @KathleenHBurns https://t.co/sB5xSIFzOI https://t.co/RScrFN5EgH
RT @genomicscloud: Congratulations to our CGC collaborator @MckerrowWilson and the publication of their work on @PNASNews! The tools and da…
RT @genomicscloud: Congratulations to our CGC collaborator @MckerrowWilson and the publication of their work on @PNASNews! The tools and da…
RT @genomicscloud: Congratulations to our CGC collaborator @MckerrowWilson and the publication of their work on @PNASNews! The tools and da…
Congratulations to our CGC collaborator @MckerrowWilson and the publication of their work on @PNASNews! The tools and data are available on the @genomicscloud! #bioinformatics #Transposons #cloudcomputing #cancerresearch https://t.co/b0Omw3GaZH
LINE-1 expression in cancer correlates with p53 mutation, copy number alteration, and S phase checkpoint https://t.co/6jRcfnwSZO
LINE-1 expression in cancer correlates with p53 mutation, copy number alteration, and S phase... - https://t.co/L4L4je40km #ScholarAlerts
LINE-1 expression in cancer correlates with p53 mutation, copy number alteration, and S ... https://t.co/FHmx1RZvdQ