July 2022 PMID 35786873

Deoxytrifluoromethylation of Alcohols.

Nicholas E Intermaggio, Agustin Millet, Dali L Davis, David W C MacMillan

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Peak: 47 in Jul 2022

across 2 sources since Jan 2019

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1,133

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28,290

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Jan 2019 – Jul 2024

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What people are saying

The discussions highlight specific aspects of the publication, with users referencing innovative methods like 'deoxygenative trifluoromethylation' and noting the significance of the research in drug development. The use of phrases such as 'game-changing technique' and 'must-read for chemists' reflects excitement and underscores the perceived potential impact of this new methodology on the field.

AgreementModerate agreement

Most discussions express a positive view towards the method introduced in the publication.

InterestHigh interest

There is a strong level of curiosity shown by multiple mentions and inquiries regarding the method and its potential applications.

EngagementModerate engagement

Some discussions touch on specific aspects of the methodology, but overall engagement is moderate.

ImpactHigh impact

Participants believe that this research could significantly enhance the efficiency of drug development.

Abstract in brief

Deoxy-functionalization of alcohols, like deoxyfluorination, is crucial in modern medicine for incorporating fluorine into drug molecules.
The trifluoromethyl (CF) group is gaining popularity among medicinal chemists for its ability to enhance the effectiveness of small-molecule drugs.
This report introduces a new method using copper metallaphotoredox to directly perform deoxytrifluoromethylation of alcohols, activating them with benzoxazolium salts for C(sp)-CF bond formation.

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Advancements in Organic Synthesis: Key Papers from June 2022

In this video, I discuss five important papers in organic synthesis that were published in June 2022. The trifluoromethyl group is highlighted for its impact on small-molecule drugs, showcasing a new method for…

That Chemist · Jul 22, 2022 17,622 views

Advancements in Deoxy-Fluorination and Trifluoromethylation

This video discusses essential strategies in deoxyfluorination and deoxytrifluoromethylation, critical for drug development in modern medicine. Highlighting key papers, we explore how these reactions enhance the…

That Chemist · Jul 20, 2024 10,668 views

テフラン@Aセメは頑張る

@tefurane · X

RT @_M26Pershing: 内容あんま覚えてないけどアルコールを-CF3に置換するためにエグいことやってる https://t.co/GdvZ8Pvu6y

May 21, 2023 · 1 share · 882 followers View post →

_M26Pershing

@_M26Pershing · X

内容あんま覚えてないけどアルコールを-CF3に置換するためにエグいことやってる https://t.co/GdvZ8Pvu6y

May 21, 2023 · 7 likes · 1 share · 2,161 followers View post →

Dr. Vishal Agrawal

@best_vishu · X

RT @MacMillan_Lab: Have an alcohol fragment but want the trifluoromethyl analog? Check out our method for deoxygenative trifluoromethylatio…

Nov 24, 2022 · 10 shares · 380 followers View post →

Dr. Ashish Kumar Sahoo

@AKS_tutu1 · X

RT @MacMillan_Lab: Have an alcohol fragment but want the trifluoromethyl analog? Check out our method for deoxygenative trifluoromethylatio…

Aug 6, 2022 · 10 shares · 160 followers View post →

Wenqi Xu

@xu_wenqi · X

RT @MacMillan_Lab: Have an alcohol fragment but want the trifluoromethyl analog? Check out our method for deoxygenative trifluoromethylatio…

Aug 5, 2022 · 10 shares · 131 followers View post →

xxy

@xxy07255392 · X

RT @MacMillan_Lab: Have an alcohol fragment but want the trifluoromethyl analog? Check out our method for deoxygenative trifluoromethylatio…

Aug 4, 2022 · 10 shares · 264 followers View post →

Andy McNally

@AndyMcNally367 · X

RT @MacMillan_Lab: Have an alcohol fragment but want the trifluoromethyl analog? Check out our method for deoxygenative trifluoromethylatio…

Aug 4, 2022 · 10 shares · 1,274 followers View post →

J. Am. Chem. Soc.

@J_A_C_S · X

RT @MacMillan_Lab: Have an alcohol fragment but want the trifluoromethyl analog? Check out our method for deoxygenative trifluoromethylatio…

Aug 4, 2022 · 10 shares · 186,602 followers View post →

Stephen A. Boyd, Ph.D.

@StephenABoydPh1 · X

RT @MacMillan_Lab: Have an alcohol fragment but want the trifluoromethyl analog? Check out our method for deoxygenative trifluoromethylatio…

Aug 3, 2022 · 10 shares · 3,104 followers View post →

Dr. Mourad Daoubi Khamlichi

@MouradDaoubi · X

RT @MacMillan_Lab: Have an alcohol fragment but want the trifluoromethyl analog? Check out our method for deoxygenative trifluoromethylatio…

Aug 3, 2022 · 10 shares · 549 followers View post →

MacMillan Group

@MacMillan_Lab · X

Aug 3, 2022 · 162 likes · 10 shares · 22,491 followers View post →

~Laboratory Analyst.

@JrChelimo · X

RT @ChemistryNews: Just Published: Deoxytrifluoromethylation of Alcohols https://t.co/jR8IP7kPXp

Jul 10, 2022 · 7 shares · 1,533 followers View post →

nor

@noriji0 · X

Deoxytrifluoromethylation of Alcohols https://t.co/SAlUkokgc0 #nor論文

Jul 10, 2022 · 828 followers View post →

Hiroshige OGAWA

@hiroshige_ogawa · X

RT @J_A_C_S: Deoxytrifluoromethylation of Alcohols @PrincetonChem @Princeton @Merck @TotalSyntheses #Deoxytrifluoromethylation #Alcohols #P…

Jul 7, 2022 · 8 shares · 259 followers View post →

J. Am. Chem. Soc.

@J_A_C_S · X

RT @TotalSynthesis: Deoxytrifluoromethylation of Alcohols by Nicholas E. Intermaggio, Agustin Millet, Dali L. Davis, and David W. C. MacMil…

Jul 6, 2022 · 26 shares · 186,602 followers View post →

Flow and/or Glow Papers

@chem_flow · X

RT @J_A_C_S: Deoxytrifluoromethylation of Alcohols @PrincetonChem @Princeton @Merck @TotalSyntheses #Deoxytrifluoromethylation #Alcohols #P…

Jul 6, 2022 · 8 shares · 931 followers View post →

Abhijit Sau

@ASau_Chem · X

RT @J_A_C_S: Deoxytrifluoromethylation of Alcohols @PrincetonChem @Princeton @Merck @TotalSyntheses #Deoxytrifluoromethylation #Alcohols #P…

Jul 6, 2022 · 8 shares · 505 followers View post →

xxy

@xxy07255392 · X

RT @J_A_C_S: Deoxytrifluoromethylation of Alcohols @PrincetonChem @Princeton @Merck @TotalSyntheses #Deoxytrifluoromethylation #Alcohols #P…

Jul 6, 2022 · 8 shares · 264 followers View post →

Wei Li

@WeiLilab · X

RT @J_A_C_S: Deoxytrifluoromethylation of Alcohols @PrincetonChem @Princeton @Merck @TotalSyntheses #Deoxytrifluoromethylation #Alcohols #P…

Jul 6, 2022 · 8 shares · 359 followers View post →

CatalysisBOT

@CatalysisBOT · X

RT @J_A_C_S: Deoxytrifluoromethylation of Alcohols @PrincetonChem @Princeton @Merck @TotalSyntheses #Deoxytrifluoromethylation #Alcohols #P…

Jul 6, 2022 · 8 shares · 52 followers View post →

Based Hatter

@BasedHatter · X

RT @isciverse: Online NOW | @J_A_C_S Deoxytrifluoromethylation of Alcohols @isciverse #Chemistry #ChemTwitter #scicomm #news #Technology…

Jul 6, 2022 · 3 shares · 4,511 followers View post →

J. Am. Chem. Soc.

@J_A_C_S · X

RT @isciverse: Online NOW | @J_A_C_S Deoxytrifluoromethylation of Alcohols @isciverse #Chemistry #ChemTwitter #scicomm #news #Technology…

Jul 6, 2022 · 3 shares · 186,602 followers View post →

Khanh M. N. An (光絃之明)

@2xYS_MG_ · X

RT @J_A_C_S: Deoxytrifluoromethylation of Alcohols @PrincetonChem @Princeton @Merck @TotalSyntheses #Deoxytrifluoromethylation #Alcohols #P…

Jul 6, 2022 · 8 shares · 205 followers View post →

Iaroshenko Viktor

@Iaroshenko108 · X

RT @J_A_C_S: Deoxytrifluoromethylation of Alcohols @PrincetonChem @Princeton @Merck @TotalSyntheses #Deoxytrifluoromethylation #Alcohols #P…

Jul 6, 2022 · 8 shares · 1,509 followers View post →

J. Am. Chem. Soc.

@J_A_C_S · X

Deoxytrifluoromethylation of Alcohols @PrincetonChem @Princeton @Merck @TotalSyntheses #Deoxytrifluoromethylation #Alcohols #Photoredox #Catalysis @dmac68 @MacMillan_Lab https://t.co/ZdfRzZrVZX

Jul 6, 2022 · 47 likes · 8 shares · 186,602 followers View post →

Iaroshenko Viktor

@Iaroshenko108 · X

RT @ChemistryNews: Just Published: Deoxytrifluoromethylation of Alcohols https://t.co/jR8IP7kPXp

Jul 6, 2022 · 7 shares · 1,509 followers View post →

ma de

@maadevaa · X

RT @TotalSynthesis: Deoxytrifluoromethylation of Alcohols by Nicholas E. Intermaggio, Agustin Millet, Dali L. Davis, and David W. C. MacMil…

Jul 6, 2022 · 26 shares · 26 followers View post →

Princeton Chemistry

@PrincetonChem · X

RT @TotalSynthesis: Deoxytrifluoromethylation of Alcohols by Nicholas E. Intermaggio, Agustin Millet, Dali L. Davis, and David W. C. MacMil…

Jul 6, 2022 · 26 shares · 10,982 followers View post →

Dr.Anjani Kumar (Jaiswal)

@anjanee09094684 · X

RT @TotalSynthesis: Deoxytrifluoromethylation of Alcohols by Nicholas E. Intermaggio, Agustin Millet, Dali L. Davis, and David W. C. MacMil…

Jul 6, 2022 · 26 shares · 152 followers View post →

Lorineest

@Lorineest1 · X

RT @TotalSynthesis: Deoxytrifluoromethylation of Alcohols by Nicholas E. Intermaggio, Agustin Millet, Dali L. Davis, and David W. C. MacMil…

Jul 6, 2022 · 26 shares · 22 followers View post →

Sesamin 4649

@beebeebee231 · X

RT @TotalSynthesis: Deoxytrifluoromethylation of Alcohols by Nicholas E. Intermaggio, Agustin Millet, Dali L. Davis, and David W. C. MacMil…

Jul 6, 2022 · 26 shares · 119 followers View post →

Tehshik Yoon

@TehshikYoon · X

RT @TotalSynthesis: Deoxytrifluoromethylation of Alcohols by Nicholas E. Intermaggio, Agustin Millet, Dali L. Davis, and David W. C. MacMil…

Jul 6, 2022 · 26 shares · 13,748 followers View post →

ScienceStop

@B0tSci · X

RT @isciverse: Online NOW | @J_A_C_S Deoxytrifluoromethylation of Alcohols @isciverse #Chemistry #ChemTwitter #scicomm #news #Technology…

Jul 6, 2022 · 3 shares · 4,071 followers View post →

Top Science

@isciverse · X

Jul 6, 2022 · 21 likes · 3 shares · 40,407 followers View post →

Schrödinger's Cat

@13_moles · X

RT @TotalSynthesis: Deoxytrifluoromethylation of Alcohols by Nicholas E. Intermaggio, Agustin Millet, Dali L. Davis, and David W. C. MacMil…

Jul 6, 2022 · 26 shares · 459 followers View post →

@cat.

@kawagoe88868476 · X

RT @TotalSynthesis: Deoxytrifluoromethylation of Alcohols by Nicholas E. Intermaggio, Agustin Millet, Dali L. Davis, and David W. C. MacMil…

Jul 5, 2022 · 26 shares · 26 followers View post →

VTKTwit

@VTKTwit · X

RT @TotalSynthesis: Deoxytrifluoromethylation of Alcohols by Nicholas E. Intermaggio, Agustin Millet, Dali L. Davis, and David W. C. MacMil…

Jul 5, 2022 · 26 shares · 53 followers View post →

Hiroshige OGAWA

@hiroshige_ogawa · X

RT @TotalSynthesis: Deoxytrifluoromethylation of Alcohols by Nicholas E. Intermaggio, Agustin Millet, Dali L. Davis, and David W. C. MacMil…

Jul 5, 2022 · 26 shares · 259 followers View post →

Khanh M. N. An (光絃之明)

@2xYS_MG_ · X

RT @ChemistryNews: Just Published: Deoxytrifluoromethylation of Alcohols https://t.co/jR8IP7kPXp

Jul 5, 2022 · 7 shares · 205 followers View post →

Khanh M. N. An (光絃之明)

@2xYS_MG_ · X

RT @TotalSynthesis: Deoxytrifluoromethylation of Alcohols by Nicholas E. Intermaggio, Agustin Millet, Dali L. Davis, and David W. C. MacMil…

Jul 5, 2022 · 26 shares · 205 followers View post →

_M26Pershing

@_M26Pershing · X

RT @TotalSynthesis: Deoxytrifluoromethylation of Alcohols by Nicholas E. Intermaggio, Agustin Millet, Dali L. Davis, and David W. C. MacMil…

Jul 5, 2022 · 26 shares · 2,161 followers View post →

Lieu Ngoc Thien

@LieuNgocThien1 · X

RT @TotalSynthesis: Deoxytrifluoromethylation of Alcohols by Nicholas E. Intermaggio, Agustin Millet, Dali L. Davis, and David W. C. MacMil…

Jul 5, 2022 · 26 shares · 7 followers View post →

Sammy

@ManasyeErlangga · X

RT @TotalSynthesis: Deoxytrifluoromethylation of Alcohols by Nicholas E. Intermaggio, Agustin Millet, Dali L. Davis, and David W. C. MacMil…

Jul 5, 2022 · 26 shares · 17 followers View post →

Anthony Saucedo

@AtsauSaucedo · X

RT @TotalSynthesis: Deoxytrifluoromethylation of Alcohols by Nicholas E. Intermaggio, Agustin Millet, Dali L. Davis, and David W. C. MacMil…

Jul 5, 2022 · 26 shares · 245 followers View post →

xxy

@xxy07255392 · X

RT @ChemistryNews: Just Published: Deoxytrifluoromethylation of Alcohols https://t.co/jR8IP7kPXp

Jul 5, 2022 · 7 shares · 264 followers View post →

xxy

@xxy07255392 · X

RT @TotalSynthesis: Deoxytrifluoromethylation of Alcohols by Nicholas E. Intermaggio, Agustin Millet, Dali L. Davis, and David W. C. MacMil…

Jul 5, 2022 · 26 shares · 264 followers View post →

Víctor H. Uc

@vicuc30 · X

RT @TotalSynthesis: Deoxytrifluoromethylation of Alcohols by Nicholas E. Intermaggio, Agustin Millet, Dali L. Davis, and David W. C. MacMil…

Jul 5, 2022 · 26 shares · 790 followers View post →

Maurice Médebielle

@FLUORrismo · X

RT @TotalSynthesis: Deoxytrifluoromethylation of Alcohols by Nicholas E. Intermaggio, Agustin Millet, Dali L. Davis, and David W. C. MacMil…

Jul 5, 2022 · 26 shares · 1,384 followers View post →

Michael Heilmann

@dieserheilmann · X

RT @TotalSynthesis: Deoxytrifluoromethylation of Alcohols by Nicholas E. Intermaggio, Agustin Millet, Dali L. Davis, and David W. C. MacMil…

Jul 5, 2022 · 26 shares · 193 followers View post →

Rubén Miguélez

@MorenRmm · X

RT @TotalSynthesis: Deoxytrifluoromethylation of Alcohols by Nicholas E. Intermaggio, Agustin Millet, Dali L. Davis, and David W. C. MacMil…

Jul 5, 2022 · 26 shares · 598 followers View post →

Maurice Médebielle

@FLUORrismo · X

RT @ChemistryNews: Just Published: Deoxytrifluoromethylation of Alcohols https://t.co/jR8IP7kPXp

Jul 5, 2022 · 7 shares · 1,384 followers View post →

ENMANUEL ECHAVARRIA

@lluberes7 · X

RT @TotalSynthesis: Deoxytrifluoromethylation of Alcohols by Nicholas E. Intermaggio, Agustin Millet, Dali L. Davis, and David W. C. MacMil…

Jul 5, 2022 · 26 shares · 236 followers View post →

HEMANT ALONE

@AloneHemant · X

RT @TotalSynthesis: Deoxytrifluoromethylation of Alcohols by Nicholas E. Intermaggio, Agustin Millet, Dali L. Davis, and David W. C. MacMil…

Jul 5, 2022 · 26 shares · 312 followers View post →

Total Synthesis

@TotalSynthesis · X

Jul 5, 2022 · 130 likes · 26 shares · 17,447 followers View post →

junwu

@junwu54104779 · X

RT @ChemistryNews: Just Published: Deoxytrifluoromethylation of Alcohols https://t.co/jR8IP7kPXp

Jul 5, 2022 · 7 shares · 212 followers View post →

alọyinlẹ̀pọ́n.

@ezekielprince1 · X

RT @ChemistryNews: Just Published: Deoxytrifluoromethylation of Alcohols https://t.co/jR8IP7kPXp

Jul 5, 2022 · 7 shares · 690 followers View post →

Chemistry News

@ChemistryNews · X

Just Published: Deoxytrifluoromethylation of Alcohols https://t.co/jR8IP7kPXp

Jul 5, 2022 · 42 likes · 7 shares · 517,935 followers View post →

Drug Discovery and Synthesis Highlights

@TotalSyntheses · X

Catalytic One-Step Deoxytrifluoromethylation of Alcohols from @Altmaniacs group. https://t.co/LBeGj2MYvA https://t.co/TuiOxts4Jw

Mar 6, 2019 · 15 likes · 7,385 followers View post →

J Org Chem/Org Lett

@JOC_OL · X

RT @DrTSCarter: A new bench-stable reagent for installing benzyllic and allylic CF3's Catalytic One-Step Deoxytrifluoromethylation of Alco…

Jan 30, 2019 · 1 share · 53,379 followers View post →

Tom Carter

@DrTSCarter · X

Jan 30, 2019 · 22 likes · 1 share · 713 followers View post →

Scientific Update

@SciUp · X

Catalytic One-Step Deoxytrifluoromethylation of Alcohols https://t.co/ld8CW254EM

Jan 27, 2019 · 1 like · 2,220 followers View post →

有機化学を学ぶ人

@yuukiwomanabu · X

いい反応だけど第一級水酸基のみか。二級アルコールも基質に使えればいいのだけれど。 #学ぶの論文紹介 Catalytic One-Step Deoxytrifluoromethylation of Alcohols https://t.co/GpKentTEI5

Jan 26, 2019 · 3 likes · 6,602 followers View post →

Deoxytrifluoromethylation of Alcohols.

Mentions per month

Where it's discussed

What people are saying

Abstract in brief

Top posts

All mentions

Advancements in Organic Synthesis: Key Papers from June 2022

Advancements in Deoxy-Fluorination and Trifluoromethylation