Increasing the throughput of sensitive proteomics by plexDIA.

Jason Derks, Andrew Leduc, Georg Wallmann, R Gray Huffman, Matthew Willetts, Saad Khan, Harrison Specht, Markus Ralser, Vadim Demichev, Nikolai Slavov

January 2023

Synopsis of Social media discussions

Overall, the discussions reflect a high level of enthusiasm and support, with examples such as the mention of plexDIA increasing proteomics throughput and references to presentations by notable researchers like Prof. Slavov. The tone is technical yet optimistic, emphasizing the transformative potential of this framework for sensitive proteomics and single-cell analysis.

A
Agreement
 Strong agreement

Most discussions express strong support for the publication, highlighting its significance and potential to advance proteomics technology.

I
Interest
 High level of interest

The majority of discussions demonstrate high interest, with references to detailed techniques and enthusiasm for the framework's benefits.

E
Engagement
 High engagement

Users engage deeply by referencing specific methods like plexDIA, mentioning related presentations, and asking reflective questions about the field's progress.

I
Impact
 High level of impact

Many discussions imply that the study could revolutionize proteomics, especially for small samples, increasing throughput and detection capabilities in single-cell analysis.

Social Mentions

YouTube

12 Videos

Twitter

99 Posts

Blogs

5 Articles

News

3 Articles

Metrics

Video Views

11,556

Total Likes

428

Extended Reach

626,996

Social Features

119

Timeline: Posts about article

Top Social Media Posts

Posts referencing the article

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Advances in Single-Cell Proteomics Using Mass Spectrometry Techniques

This lecture introduces single-cell proteomics by mass spectrometry, highlighting plexDIA's high-throughput multiplexing capabilities for small samples, enabling detailed protein analysis in individual human cells.

Nikolai Slavov

November 30, 2022

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Advancements in Single-Cell Protein Analysis Using Mass Spectrometry

Advancements in Single-Cell Protein Analysis Using Mass Spectrometry

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Nikolai Slavov

October 9, 2022

1,761 views

Single-cell Mass Spectrometry Proteomics Data Acquisition and Analysis Techniques

Single-cell Mass Spectrometry Proteomics Data Acquisition and Analysis Techniques

Workshop on single-cell mass spectrometry proteomic data acquisition using plexDIA and timsTOF, with initial interpretation via QuantQC, held at SCP2024. Focuses on improving data quality by minimizing protein leakage artifacts across cell types.

Nikolai Slavov

July 30, 2024

1,302 views

Advancements in Single-Cell Proteomics with plexDIA Technology

Advancements in Single-Cell Proteomics with plexDIA Technology

Exploring new methodologies for sensitive protein analysis in single cells, focusing on plexDIA's framework that enhances throughput, accuracy, and proteome coverage for low sample amounts.

Nikolai Slavov

December 17, 2022

1,134 views

Advances in Single-Molecule Proteomics for Detailed Cell Analysis

Advances in Single-Molecule Proteomics for Detailed Cell Analysis

New methods in single-molecule protein detection are improving how scientists analyze proteins at a very detailed level, allowing for more thorough study of individual cells. These advances aim to increase detection sensitivity, enabling scalable analysis of the human proteome.

Nikolai Slavov

July 14, 2022

1,074 views

Advancements in Single-Cell Proteomics with plexDIA Technology

Advancements in Single-Cell Proteomics with plexDIA Technology

Prof. Nikolai Slavov discusses plexDIA, a new method boosting throughput and proteome coverage in single-cell proteomics through multiplexing, enabling detailed analysis of proteins in individual human cells.

Nikolai Slavov

July 14, 2022

1,074 views

Proteomics Insights: Single-Cell Variation and Molecular Mechanisms

Proteomics Insights: Single-Cell Variation and Molecular Mechanisms

This presentation explores proteome variation at the single-cell level and the underlying molecular mechanisms. It discusses progress in proteomics, analyzing over 1000 human samples, revealing significant amino acid substitutions impacting protein stability, abundance, and tissue-specificity in mammals.

Nikolai Slavov

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1,056 views

Enhancing Single-Cell Proteomics with Trapped Ion Mobility Technology

Enhancing Single-Cell Proteomics with Trapped Ion Mobility Technology

This presentation discusses trapped ion mobility's benefits for single-cell proteomics, enabling higher throughput and improved accuracy. It highlights the plexDIA framework that integrates multiplexing to analyze small samples efficiently.

Nikolai Slavov

July 7, 2023

603 views

Regulators of Protein Transport Revealed by Single-Nucleus Proteomics

Regulators of Protein Transport Revealed by Single-Nucleus Proteomics

Presentation by Dr. Jason Derks at SCP2024 discussing how singlenucleus proteomics identifies regulators of protein transport, leveraging multiplexed analysis to enhance proteome coverage and accuracy in small samples, including single human cells.

Nikolai Slavov

July 13, 2024

552 views

Enhancing Protein Analysis with plexDIA and MaxQuant

Enhancing Protein Analysis with plexDIA and MaxQuant

This presentation by Prof. Juergen Cox at the 7th Single Cell Proteomics Conference discusses sensitive and accurate plexDIA techniques using MaxQuant. The talk highlights recent advancements in library-based and library-free data-independent acquisition proteomics.

Nikolai Slavov

July 24, 2024

386 views

Advancements in Single-Cell Proteomics with plexDIA Methodology

Advancements in Single-Cell Proteomics with plexDIA Methodology

The video discusses advancements in single-cell proteomics using mass spectrometry focusing on overcoming current limitations. plexDIA is highlighted as a framework for increasing throughput and sensitivity, significantly improving data accuracy in proteomics analysis.

Nikolai Slavov

November 22, 2025

65 views

Enhancing Single-Cell Proteomics: Techniques and Data Interpretation

Enhancing Single-Cell Proteomics: Techniques and Data Interpretation

Parallel Squared Technology Institute

April 1, 2025

48 views

  • Prof. Nikolai Slavov
    @slavov_n (Twitter)

    Making the larger is challenging, but we may be able to host more workshops. We recorded the last one, so at least we can share a recording on YouTube. https://t.co/gqJUlhAI3e
    view full post

    October 5, 2024

  • Raymond
    @raymzyu (Twitter)

    RT @slavov_n: Sampling a sufficient number of protein molecules to cover the huge dynamic ranges of the proteome is a common challenge. ◼️…
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    September 23, 2024

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  • COVID -19
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    RT @slavov_n: Sampling a sufficient number of protein molecules to cover the huge dynamic ranges of the proteome is a common challenge. ◼️…
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    September 23, 2024

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  • Patrick Reeves
    @pmreeves (Twitter)

    RT @slavov_n: Sampling a sufficient number of protein molecules to cover the huge dynamic ranges of the proteome is a common challenge. ◼️…
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    September 22, 2024

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  • Junhao (Hao) Wen
    @JunhaoWen (Twitter)

    RT @slavov_n: Sampling a sufficient number of protein molecules to cover the huge dynamic ranges of the proteome is a common challenge. ◼️…
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    September 22, 2024

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  • JC Stanford
    @JCDarnestown (Twitter)

    RT @slavov_n: Sampling a sufficient number of protein molecules to cover the huge dynamic ranges of the proteome is a common challenge. ◼️…
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    September 22, 2024

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  • priya joseph
    @ayirpelle (Twitter)

    RT @slavov_n: Sampling a sufficient number of protein molecules to cover the huge dynamic ranges of the proteome is a common challenge. ◼️…
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    September 22, 2024

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  • Bowen Wang
    @NU_JEANSS (Twitter)

    RT @slavov_n: Sampling a sufficient number of protein molecules to cover the huge dynamic ranges of the proteome is a common challenge. ◼️…
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    September 22, 2024

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    @walko_lab (Twitter)

    RT @slavov_n: Sampling a sufficient number of protein molecules to cover the huge dynamic ranges of the proteome is a common challenge. ◼️…
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    September 22, 2024

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  • Michelle Fitzmaurice
    @DrMFitzmaurice (Twitter)

    RT @slavov_n: Sampling a sufficient number of protein molecules to cover the huge dynamic ranges of the proteome is a common challenge. ◼️…
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    September 22, 2024

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  • Rob Townley
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    RT @slavov_n: Sampling a sufficient number of protein molecules to cover the huge dynamic ranges of the proteome is a common challenge. ◼️…
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    September 22, 2024

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  • Proteomics CZ
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    RT @slavov_n: Sampling a sufficient number of protein molecules to cover the huge dynamic ranges of the proteome is a common challenge. ◼️…
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    September 22, 2024

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  • Prof. Nikolai Slavov
    @slavov_n (Twitter)

    Sampling a sufficient number of protein molecules to cover the huge dynamic ranges of the proteome is a common challenge. ◼️ All proteomic technologies face it. Below are our thoughts on how to overcome it
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    September 22, 2024

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  • Sushmita Roy @sroyyors.bsky.social,genomic.social
    @sroyyors (Twitter)

    RT @ParallelSqTech: A recording of our @SCP_meeting workshop is up on YouTube: Data acquisition and initial interpretation for single-cell…
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    July 31, 2024

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  • Prof. Nikolai Slavov
    @slavov_n (Twitter)

    RT @ParallelSqTech: A recording of our @SCP_meeting workshop is up on YouTube: Data acquisition and initial interpretation for single-cell…
    view full post

    July 31, 2024

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  • Parallel Squared Technology Institute (PTI)
    @ParallelSqTech (Twitter)

    A recording of our @SCP_meeting workshop is up on YouTube: Data acquisition and initial interpretation for single-cell proteomics by mass spectrometry. Thanks to @_AndrewLeduc and team for leading it! https://t.co/OwiKrmkIYe
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    July 30, 2024

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  • Parallel Squared Technology Institute (PTI)
    @ParallelSqTech (Twitter)

    RT @SCP_meeting: The talk by Dr. Jason Derks (@_JasonDerks) at #SCP2024 is on YouTube: Single-nucleus proteomics identifies regulators o…
    view full post

    July 25, 2024

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  • Single-Cell Proteomics Conference
    @SCP_meeting (Twitter)

    Sensitive and accurate plexDIA with @maxquant A presentation by Prof. Juergen Cox (@TheCoxLab) at #SCP2024 https://t.co/9jpjyPqHfG
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    July 24, 2024

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  • Single-Cell Proteomics Conference
    @SCP_meeting (Twitter)

    RT @slavovLab: Single-molecule proteomics can greatly benefit from separation. A talk from @SCP_meeting: https://t.co/BQTRXMc60G https://t…
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    July 21, 2024

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  • Slavov Laboratory
    @slavovLab (Twitter)

    RT @SCP_meeting: The talk by Dr. Jason Derks (@_JasonDerks) at #SCP2024 is on YouTube: Single-nucleus proteomics identifies regulators o…
    view full post

    July 14, 2024

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  • Single-Cell Proteomics Conference
    @SCP_meeting (Twitter)

    The talk by Dr. Jason Derks (@_JasonDerks) at #SCP2024 is on YouTube: Single-nucleus proteomics identifies regulators of protein transport. Preprint: https://t.co/2IJYEIs6f1 Talk: https://t.co/I8qqVFyvjG
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    July 14, 2024

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  • Helen Gavaghan. UK. Photo+Digital Art by me.
    @HelenGavaghan (Twitter)

    RT @slavovLab: Single-molecule proteomics can greatly benefit from separation. A talk from @SCP_meeting: https://t.co/BQTRXMc60G https://t…
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    July 8, 2024

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  • Thanadol Sutantiwanichkul
    @PhdThanadol (Twitter)

    RT @slavovLab: Single-molecule proteomics can greatly benefit from separation. A talk from @SCP_meeting: https://t.co/BQTRXMc60G https://t…
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    June 11, 2024

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  • Lili
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    RT @slavovLab: Single-molecule proteomics can greatly benefit from separation. A talk from @SCP_meeting: https://t.co/BQTRXMc60G https://t…
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    June 9, 2024

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  • Prof. Nikolai Slavov
    @slavov_n (Twitter)

    RT @slavovLab: Single-molecule proteomics can greatly benefit from separation. A talk from @SCP_meeting: https://t.co/BQTRXMc60G https://t…
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    June 8, 2024

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  • Slavov Laboratory
    @slavovLab (Twitter)

    Single-molecule proteomics can greatly benefit from separation. A talk from @SCP_meeting: https://t.co/BQTRXMc60G https://t.co/yjktRumYtZ
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    June 8, 2024

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  • Prof. Nikolai Slavov
    @slavov_n (Twitter)

    Here is my reflection on it in 2022, asking a question: ◼️ Could we have started 10 years earlier ? https://t.co/5WrIRLNSdt https://t.co/Mgdk2ClF1m
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    January 21, 2024

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  • Single-Cell Proteomics Conference
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    The talk by Dr. Matthew Willetts at #SCP2023 is on YouTube: The benefits of trapped ion mobility for single-cell proteomics https://t.co/VM9srMknWi
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    July 8, 2023

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    RT @slavov_n: We discussed these issues at @SCP_meeting last year: https://t.co/lhwLbEljki
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    March 11, 2023

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  • Ana B Villaseñor-Altamirano
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    RT @slavov_n: We discussed these issues at @SCP_meeting last year: https://t.co/lhwLbEljki
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    March 11, 2023

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  • Prof. Nikolai Slavov
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    We discussed these issues at @SCP_meeting last year: https://t.co/lhwLbEljki
    view full post

    March 10, 2023

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  • Made in Earth
    @MadeInEarthLK (Twitter)

    Increasing the throughput of sensitive proteomics by plexDIA https://t.co/9NpAZMYEXo
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    September 18, 2022

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    @BioDecoded (Twitter)

    Increasing the throughput of sensitive proteomics by plexDIA | Nature Biotechnology https://t.co/DNWXWlU1h2 #proteomics
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    September 15, 2022

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  • Fat Cat
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    Increasing the throughput of sensitive proteomics by plexDIA https://t.co/9y0ioItRvy
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    August 14, 2022

  • Taco Jesse
    @TJesse62 (Twitter)

    RT @slavov_n: We focussed on: ◼️ What is the number of protein molecules that single-molecule proteomics methods need to count to achieve…
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    August 3, 2022

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    @DreamingOfPomeg (Twitter)

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    August 2, 2022

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  • Prof. Nikolai Slavov
    @slavov_n (Twitter)

    We focussed on: ◼️ What is the number of protein molecules that single-molecule proteomics methods need to count to achieve comprehensive proteome coverage ? ◼️ What strategies may reduce this number ? We briefly discussed these Qs at @SCP_meeting https://t.co/lhwLbEkLuK
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    August 2, 2022

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    @RalserLab (Twitter)

    RT @ScienceinBoston: A @NatureBiotech paper from @_JasonDerks and a team in the @SlavovLab introduces a framework called plexDIA that incre…
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    August 1, 2022

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    @metricausa (Twitter)

    RT @ScienceinBoston: A @NatureBiotech paper from @_JasonDerks and a team in the @SlavovLab introduces a framework called plexDIA that incre…
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    August 1, 2022

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    @KawataKentaro (Twitter)

    RT @NatureBiotech: Increasing the throughput of sensitive proteomics by plexDIA https://t.co/CZA27dr3Iw https://t.co/RFgnGECg2V
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    August 1, 2022

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    @BinfoTrends (Twitter)

    RT @ScienceinBoston: A @NatureBiotech paper from @_JasonDerks and a team in the @SlavovLab introduces a framework called plexDIA that incre…
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    August 1, 2022

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  • Slavov Laboratory
    @slavovLab (Twitter)

    RT @ScienceinBoston: A @NatureBiotech paper from @_JasonDerks and a team in the @SlavovLab introduces a framework called plexDIA that incre…
    view full post

    August 1, 2022

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  • Science in Boston
    @ScienceinBoston (Twitter)

    A @NatureBiotech paper from @_JasonDerks and a team in the @SlavovLab introduces a framework called plexDIA that increases the throughput of sensitive #proteomics by simultaneously multiplexing the analysis of peptides and samples. @slavov_n ❔ Q&A: https://t.co/mrpWMDw62a https://t.co/nxNGHL5gZ5
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    August 1, 2022

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  • Rodrigo Nunes Cal
    @CalZole (Twitter)

    RT @NatureBiotech: Increasing the throughput of sensitive proteomics by plexDIA https://t.co/CZA27dr3Iw https://t.co/RFgnGECg2V
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    July 23, 2022

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  • Pastel BioScience
    @PastelBio (Twitter)

    Increasing the throughput of sensitive proteomics by plexDIA | https://t.co/Fw9umPRN1u #proteomics https://t.co/4lwvW7f2nJ
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    July 21, 2022

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  • Alvaro
    @AlvaroCountry (Twitter)

    RT @NatureBiotech: Increasing the throughput of sensitive proteomics by plexDIA https://t.co/CZA27dr3Iw https://t.co/RFgnGECg2V
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    July 21, 2022

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  • Miryan Sánchez
    @mimasaji1 (Twitter)

    RT @CDProteomics: Increasing the throughput of sensitive proteomics by plexDIA Proteomics of small sample sizes using data-independent acqu…
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    July 20, 2022

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  • Creative Proteomics
    @CDProteomics (Twitter)

    Increasing the throughput of sensitive proteomics by plexDIA Proteomics of small sample sizes using data-independent acquisition methods achieves higher throughput with multiplexing. https://t.co/whQZ6kBfiW
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    July 20, 2022

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    @CalZole (Twitter)

    RT @NatureBiotech: Increasing the throughput of sensitive proteomics by plexDIA https://t.co/CZA27dr3Iw https://t.co/RFgnGECg2V
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    RT @NatureBiotech: Increasing the throughput of sensitive proteomics by plexDIA https://t.co/CZA27dr3Iw https://t.co/RFgnGECg2V
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  • Single Cell Media
    @SingleCellMedia (Twitter)

    RT @SCP_meeting: Exploring functional protein covariation across single cells A presentation by Prof. Slavov (@slavov_n) at the 5th single…
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    July 16, 2022

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  • Single-Cell Proteomics Conference
    @SCP_meeting (Twitter)

    Exploring functional protein covariation across single cells A presentation by Prof. Slavov (@slavov_n) at the 5th single-cell proteomics conference #SCP2022. https://t.co/5O00FqDcWL
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    July 16, 2022

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    RT @SCP_meeting: Overcoming the dynamic-range challenge of the human proteome A presentation by Prof. Nikolai Slavov (@slavov_n) at the 5t…
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    Overcoming the dynamic-range challenge of the human proteome A presentation by Prof. Nikolai Slavov (@slavov_n) at the 5th single-cell proteomics conference #SCP2022. https://t.co/umHpoNt9gV
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  • Previn Naicker
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    RT @StoyanStoychev1: Please join us for EMERGE Ep 8 with @_JasonDerks from the @slavovLab: "Increasing the throughput of sensitive proteomi…
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    RT @StoyanStoychev1: Please join us for EMERGE Ep 8 with @_JasonDerks from the @slavovLab: "Increasing the throughput of sensitive proteomi…
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  • Stoyan Stoychev
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    Please join us for EMERGE Ep 8 with @_JasonDerks from the @slavovLab: "Increasing the throughput of sensitive proteomics by plexDIA" (27 April 17:00 CET, 11:00am EDT) - *|https://t.co/hAmZ5uozpa|* https://t.co/qkuxOqDELJ
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    RT @_JasonDerks: I'm very excited to share the work we've done @slavovLab in collaboration with @DemichevLab! Increasing the throughput of…
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Abstract Synopsis

  • Current mass spectrometry methods excel in high-throughput proteomics for large samples but struggle with low sample amounts, limiting depth and throughput.
  • Researchers developed plexDIA, a new framework that enables simultaneous multiplexing of peptide and sample analysis, significantly boosting throughput without sacrificing proteome coverage or accuracy.
  • plexDIA's use of three-plex non-isobaric mass tags allows for the quantification of more protein ratios in small samples, achieving impressive data completeness and enabling detailed analysis of proteins in single human cells.