Filter exchange imaging with crusher gradient modelling detects increased blood-brain barrier water permeability in response to mild lung infection.

Yolanda Ohene, William J Harris, Elizabeth Powell, Nina W Wycech, Katherine F Smethers, Samo Lasič, Kieron South, Graham Coutts, Andrew Sharp, Catherine B Lawrence, Hervé Boutin, Geoff J M Parker, Laura M Parkes, Ben R Dickie

April 2023 Fluids Barriers CNS

Synopsis of Social media discussions

Throughout these discussions, users highlight the innovative use of advanced MRI methods to detect BBB permeability changes caused by mild lung infections, with several emphasizing the potential for early diagnosis and disease prevention, using technical language and expressing curiosity about the methodology and implications.

A
Agreement
 Moderate agreement

Most discussions acknowledge the significance of the findings, especially regarding the effects of mild infections on brain health.

I
Interest
 Moderate level of interest

Participants show moderate curiosity, often referencing the use of advanced MRI techniques and their potential implications.

E
Engagement
 Moderate level of engagement

Posts include technical descriptions of filter exchange imaging and its relevance, indicating a reasonable level of detailed engagement.

I
Impact
 Moderate level of impact

Discussions focus on the potential importance of detecting subtle BBB changes, hinting at meaningful implications for neurological disease understanding.

Social Mentions

YouTube

1 Videos

Twitter

7 Posts

Metrics

Video Views

36

Total Likes

30

Extended Reach

8,486

Social Features

8

Timeline: Posts about article

Top Social Media Posts

Posts referencing the article

Advanced MRI Technique Detects Blood-Brain Barrier Changes During Lung Infection

Advanced MRI Technique Detects Blood-Brain Barrier Changes During Lung Infection

This video discusses a new MRI model for measuring water exchange across the blood-brain barrier, showing increased permeability during lung infection, which may indicate early brain disease processes.

Social RTCL TV

July 30, 2023

36 views

  • UCL Discovery
    @ucl_discovery (Twitter)

    Open Access UCL Research: Filter exchange imaging with crusher gradient modelling detects increased blood–brain barrier water permeability in response to mild lung infection - UCL Discovery https://t.co/V3Gj8n1uud
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    April 18, 2023

  • thmonk
    @thmonk_pf (Twitter)

    RT @thmonk_pf: 丁度Fluids and Barriers of the CNSにはMPGで血管内の信号をfileringしてmixing timeの後に脳組織と血管内の水の交換量を測定するFilter-exchange imaging (FEXI)で全身炎症の水…
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    April 9, 2023

    1

  • thmonk
    @thmonk_pf (Twitter)

    丁度Fluids and Barriers of the CNSにはMPGで血管内の信号をfileringしてmixing timeの後に脳組織と血管内の水の交換量を測定するFilter-exchange imaging (FEXI)で全身炎症の水交換速度を定量AQP4の多寡と相関という報告も出ていました Open Access #FEXI #BBB #papers https://t.co/hucWaoQK5l https://t.co/9ee1yewowS
    view full post

    April 6, 2023

    1

  • bicismrm
    @bicismrm (Twitter)

    RT @y_ohene: My latest work detecting the effect of infection on the blood-brain barrier using MRI has just been published!
    view full post

    April 3, 2023

    5

  • Olivia A Jones
    @ooliviajones (Twitter)

    RT @y_ohene: My latest work detecting the effect of infection on the blood-brain barrier using MRI has just been published!
    view full post

    April 3, 2023

    5

  • Ben Dickie
    @dickie_ben (Twitter)

    RT @y_ohene: My latest work detecting the effect of infection on the blood-brain barrier using MRI has just been published!
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    April 3, 2023

    5

  • Dr YO
    @y_ohene (Twitter)

    My latest work detecting the effect of infection on the blood-brain barrier using MRI has just been published!
    view full post

    April 3, 2023

    30

    5

Abstract Synopsis

  • The study introduces an extended crusher-compensated exchange rate (CCXR) model for more accurately measuring water exchange across the blood-brain barrier (BBB) using filter exchange imaging (FEXI), especially in small animal models where traditional methods underestimate this rate.
  • Applying this new model to rats with lung infection by Streptococcus pneumoniae, researchers found a significant increase (~70%) in BBB water permeability during infection, which correlated with markers of vascular inflammation such as elevated von Willebrand factor and increased expression of aquaporin-4.
  • These findings suggest that mild peripheral infections can compromise BBB integrity, highlighting the potential role of BBB dysfunction in the early stages of brain diseases like dementia, and demonstrate the utility of advanced MRI techniques in detecting subtle changes in BBB permeability.