Fluids Barriers CNS April 2023 PMID 37013549

Filter exchange imaging with crusher gradient modelling detects increased blood-brain barrier water permeability in response to mild lung infection.

Yolanda Ohene, William J Harris, Elizabeth Powell, Nina W Wycech, Katherine F Smethers, Samo Lasič, Kieron South, Graham Coutts, Andrew Sharp, Catherine B Lawrence, Hervé Boutin, Geoff J M Parker, Laura M Parkes, Ben R Dickie

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Peak: 7 in Apr 2023

across 2 sources since Apr 2023

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Apr 2023 – Jul 2023

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X / Twitter7 posts
YouTube1 videos

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What people are saying

Throughout these discussions, users highlight the innovative use of advanced MRI methods to detect BBB permeability changes caused by mild lung infections, with several emphasizing the potential for early diagnosis and disease prevention, using technical language and expressing curiosity about the methodology and implications.

AgreementModerate agreement

Most discussions acknowledge the significance of the findings, especially regarding the effects of mild infections on brain health.

InterestModerate interest

Participants show moderate curiosity, often referencing the use of advanced MRI techniques and their potential implications.

EngagementModerate engagement

Posts include technical descriptions of filter exchange imaging and its relevance, indicating a reasonable level of detailed engagement.

ImpactModerate impact

Discussions focus on the potential importance of detecting subtle BBB changes, hinting at meaningful implications for neurological disease understanding.

Abstract in brief

The study introduces an extended crusher-compensated exchange rate (CCXR) model for more accurately measuring water exchange across the blood-brain barrier (BBB) using filter exchange imaging (FEXI), especially in small animal models where traditional methods underestimate this rate.
Applying this new model to rats with lung infection by Streptococcus pneumoniae, researchers found a significant increase (~70%) in BBB water permeability during infection, which correlated with markers of vascular inflammation such as elevated von Willebrand factor and increased expression of aquaporin-4.
These findings suggest that mild peripheral infections can compromise BBB integrity, highlighting the potential role of BBB dysfunction in the early stages of brain diseases like dementia, and demonstrate the utility of advanced MRI techniques in detecting subtle changes in BBB permeability.

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Advanced MRI Technique Detects Blood-Brain Barrier Changes During Lung Infection

This video discusses a new MRI model for measuring water exchange across the blood-brain barrier, showing increased permeability during lung infection, which may indicate early brain disease processes.

Social RTCL TV · Jul 30, 2023 36 views

UCL Discovery

@ucl_discovery · X

Apr 18, 2023 · 2,521 followers View post →

thmonk

@thmonk_pf · X

Apr 9, 2023 · 1 share · 1,634 followers View post →

thmonk

@thmonk_pf · X

Apr 6, 2023 · 1 share · 1,634 followers View post →

bicismrm

@bicismrm · X

RT @y_ohene: My latest work detecting the effect of infection on the blood-brain barrier using MRI has just been published!

Apr 3, 2023 · 5 shares · 515 followers View post →

Olivia A Jones

@ooliviajones · X

RT @y_ohene: My latest work detecting the effect of infection on the blood-brain barrier using MRI has just been published!

Apr 3, 2023 · 5 shares · 260 followers View post →

Ben Dickie

@dickie_ben · X

RT @y_ohene: My latest work detecting the effect of infection on the blood-brain barrier using MRI has just been published!

Apr 3, 2023 · 5 shares · 179 followers View post →

Dr YO

@y_ohene · X

My latest work detecting the effect of infection on the blood-brain barrier using MRI has just been published!

Apr 3, 2023 · 30 likes · 5 shares · 1,663 followers View post →

Filter exchange imaging with crusher gradient modelling detects increased blood-brain barrier water permeability in response to mild lung infection.

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Abstract in brief

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Advanced MRI Technique Detects Blood-Brain Barrier Changes During Lung Infection