PLoS Pathog May 2023 PMID 37146066

CpG dinucleotide enrichment in the influenza A virus genome as a live attenuated vaccine development strategy.

Colin P Sharp, Beth H Thompson, Tessa J Nash, Ola Diebold, Rute M Pinto, Luke Thorley, Yao-Tang Lin, Samantha Sives, Helen Wise, Sara Clohisey Hendry, Finn Grey, Lonneke Vervelde, Peter Simmonds, Paul Digard, Eleanor R Gaunt

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Mentions

Peak: 29 in May 2023

across 5 sources since Nov 2022

Extended reach

131,624

potential audience

Total likes

107

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Mentions per month

Nov 2022 – Jan 2024

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X / Twitter39 posts
News2 articles
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Bluesky1 posts
YouTube1 videos

AI synopsis

What people are saying

The collective discussions express strong agreement with the research's promise, highlighted by mentions of its utility and success in animal models, while words like 'demonstrate', 'utility', and 'potential' reinforce the positive tone. Most comments show genuine interest and delve into the possible implications for vaccine creation, reflected in phrases like 'a journey exploring' and 'new strategies,' which also indicate active engagement. The emphasis on practical applications and innovative techniques underscores the perceived high impact of the findings.

AgreementModerate agreement

Most discussions support the potential of CpG enrichment as a promising vaccine strategy, with phrases like 'demonstrate utility' and 'potential' indicating agreement.

InterestHigh interest

The overall tone shows high curiosity about the research, with comments highlighting the innovative approach and its implications, reflecting strong interest.

EngagementModerate engagement

Posts mention specific findings and applications, such as efficiency in vaccine production systems and immune response, demonstrating active and thoughtful engagement.

ImpactHigh impact

Listings of the article as a 'latest paper' and mentions of potential 'game-changing' applications suggest that users see significant impact in this research for vaccine development.

Abstract in brief

Synonymous recoding of RNA viruses can produce safer vaccines, but it often reduces growth, which can be improved by enriching the virus with CpG dinucleotides.
Removing the cellular protein ZAP, which recognizes CpGs, can restore the virus's ability to multiply, allowing for the creation of a potent vaccine strain.
In tests with a modified influenza A virus, high CpG content led to strong immune protection in mice, showing that these viruses remain stable and effective, especially in vaccine production systems like MDCK cells and hens' eggs.

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All mentions

Enhancing Influenza A Vaccine Development with CpG Enrichment Strategies

This video discusses how CpG dinucleotide enrichment in influenza A virus enhances vaccine safety and efficacy by stabilizing the virus and inducing strong immune protection, demonstrating potential for improved live…

Social RTCL TV · Sep 10, 2023 75 views

Rowan Durrant

@RowanGDurrant · X

This study looks at whether an influenza A virus that has been synonymously recoded to have higher CpG content can be used as an effective live attenuated vaccine, and be produced in large enough quantities to be useful: https://t.co/tsVyvkzTIL (2/4)

Jan 31, 2024 · 516 followers View post →

Guty Schnauzer

@guty2370 · X

RT @PLOSPathogens: In this recent study, researchers discuss CpG dinucleotide enrichment in the influenza A virus genome as a live attenuat…

Dec 28, 2023 · 6 shares · 3,658 followers View post →

Saubashya Sur, PhD

@SaubashyaSur · X

RT @PLOSPathogens: In this recent study, researchers discuss CpG dinucleotide enrichment in the influenza A virus genome as a live attenuat…

Dec 12, 2023 · 6 shares · 768 followers View post →

Dr. Kevin HUANG

@lasergene · X

RT @PLOSPathogens: In this recent study, researchers discuss CpG dinucleotide enrichment in the influenza A virus genome as a live attenuat…

Dec 12, 2023 · 6 shares · 8 followers View post →

Christoph Grunau

@GrunauChristoph · X

RT @PLOSPathogens: In this recent study, researchers discuss CpG dinucleotide enrichment in the influenza A virus genome as a live attenuat…

Dec 12, 2023 · 6 shares · 315 followers View post →

Rowan Durrant

@RowanGDurrant · X

RT @PLOSPathogens: In this recent study, researchers discuss CpG dinucleotide enrichment in the influenza A virus genome as a live attenuat…

Dec 12, 2023 · 6 shares · 516 followers View post →

PLOS Pathogens

@PLOSPathogens · X

Dec 12, 2023 · 13 likes · 6 shares · 32,166 followers View post →

Saubashya Sur, PhD

@SaubashyaSur · X

RT @PLOSPathogens: In this recent study, researchers discuss CpG dinucleotide enrichment in the influenza A virus genome as a live attenuat…

Nov 14, 2023 · 2 shares · 768 followers View post →

PLOS Pathogens

@PLOSPathogens · X

Nov 13, 2023 · 7 likes · 2 shares · 32,166 followers View post →

Edinburgh Infectious Diseases

@edin_EID · X

Jun 2, 2023 · 7,050 followers View post →

Ed Rybicki

@edrybicki.bsky.social · Bluesky

CpG dinucleotide enrichment in the influenza A virus genome as a live attenuated vaccine development strategy | @scoopit

May 15, 2023 View post →

Ed Rybicki

@edrybicki · X

CpG dinucleotide enrichment in the influenza A virus genome as a live attenuated vaccine development strategy | @scoopit https://t.co/OTT2Tw7ntH

May 15, 2023 · 2 likes · 4,385 followers View post →

Spyros Lytras

@SpyrosLytras · X