Nat Commun May 2023 PMID 37164949

Skin basal cell carcinomas assemble a pro-tumorigenic spatially organized and self-propagating Trem2+ myeloid niche.

Daniel Haensel, Bence Daniel, Sadhana Gaddam, Cory Pan, Tania Fabo, Jeremy Bjelajac, Anna R Jussila, Fernanda Gonzalez, Nancy Yanzhe Li, Yun Chen, JinChao Hou, Tiffany Patel, Sumaira Aasi, Ansuman T Satpathy, Anthony E Oro

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Mentions

3
Peak: 2 in May 2023
across 2 sources since May 2023

Extended reach

7,216
potential audience

Total likes

4

Video views

24

Mentions per month

May 2023 – Aug 2023

Where it's discussed

  • X / Twitter2 posts
  • YouTube1 videos

AI synopsis

What people are saying

The discussions demonstrate a balanced perspective, with some posters emphasizing the potential therapeutic implications, such as targeting the Trem2+ myeloid cells, by using words like 'self-propagating' and 'microenvironment', which showcase the importance of understanding this tumor niche, while others maintain a focus on the basic science. The overall tone reflects a mixture of curiosity and recognition of the research's significance.

AgreementModerate agreement

Most discussions acknowledge the significance of the study in understanding tumor microenvironments, indicating general agreement with its findings.

InterestModerate interest

The discussions show moderate curiosity, with some posters highlighting the novelty of the pro-tumorigenic niche while others briefly mention the research without deep analysis.

EngagementModerate engagement

Participants reference specific details like the role of Trem2+ myeloid cells and the self-sustaining nature of the niche, reflecting a fair level of engagement.

ImpactModerate impact

There is a consensus that these findings could influence future cancer treatments, implying a perceived high impact.

Abstract in brief

  • Skin basal cell carcinomas create a specialized environment called a TREM2 myeloid niche that promotes tumor growth and can self-sustain over time.
  • Within this tumor environment, a unique type of macrophage called SCAMs supports tumor cell proliferation through specific signaling pathways, independent of traditional immune suppression mechanisms.
  • The study shows that the tumor can actively influence immune cells, inducing their differentiation and proliferation quickly, which offers new potential strategies for combination cancer therapies targeting these microenvironmental interactions.]

Top posts

Most liked on X and Bluesky
BWFUND
@BWFUND · X

From @NatureComms - Skin basal cell carcinomas assemble a pro-tumorigenic spatially organized and self-propagating Trem2+ myeloid niche https://t.co/7NGiypgol8 #bwfcams

May 15, 2023 · 3 likes · 1 share · 7,118 followers View post →
minnlab_litbot
@MLitbot · X

Skin basal cell carcinomas assemble a pro-tumorigenic spatially organized and self-propagating Trem2+ myeloid niche https://t.co/00LEdaEWxt https://t.co/bg5oWBQ4LT

May 11, 2023 · 72 followers View post →

All mentions

BWFUND
@BWFUND · X

From @NatureComms - Skin basal cell carcinomas assemble a pro-tumorigenic spatially organized and self-propagating Trem2+ myeloid niche https://t.co/7NGiypgol8 #bwfcams

May 15, 2023 · 3 likes · 1 share · 7,118 followers View post →
minnlab_litbot
@MLitbot · X

Skin basal cell carcinomas assemble a pro-tumorigenic spatially organized and self-propagating Trem2+ myeloid niche https://t.co/00LEdaEWxt https://t.co/bg5oWBQ4LT

May 11, 2023 · 72 followers View post →