From @NatureComms - Skin basal cell carcinomas assemble a pro-tumorigenic spatially organized and self-propagating Trem2+ myeloid niche https://t.co/7NGiypgol8 #bwfcams
Skin basal cell carcinomas assemble a pro-tumorigenic spatially organized and self-propagating Trem2+ myeloid niche.
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May 2023 – Aug 2023Where it's discussed
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The discussions demonstrate a balanced perspective, with some posters emphasizing the potential therapeutic implications, such as targeting the Trem2+ myeloid cells, by using words like 'self-propagating' and 'microenvironment', which showcase the importance of understanding this tumor niche, while others maintain a focus on the basic science. The overall tone reflects a mixture of curiosity and recognition of the research's significance.
Most discussions acknowledge the significance of the study in understanding tumor microenvironments, indicating general agreement with its findings.
The discussions show moderate curiosity, with some posters highlighting the novelty of the pro-tumorigenic niche while others briefly mention the research without deep analysis.
Participants reference specific details like the role of Trem2+ myeloid cells and the self-sustaining nature of the niche, reflecting a fair level of engagement.
There is a consensus that these findings could influence future cancer treatments, implying a perceived high impact.
Abstract in brief
- Skin basal cell carcinomas create a specialized environment called a TREM2 myeloid niche that promotes tumor growth and can self-sustain over time.
- Within this tumor environment, a unique type of macrophage called SCAMs supports tumor cell proliferation through specific signaling pathways, independent of traditional immune suppression mechanisms.
- The study shows that the tumor can actively influence immune cells, inducing their differentiation and proliferation quickly, which offers new potential strategies for combination cancer therapies targeting these microenvironmental interactions.]
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Most liked on X and BlueskySkin basal cell carcinomas assemble a pro-tumorigenic spatially organized and self-propagating Trem2+ myeloid niche https://t.co/00LEdaEWxt https://t.co/bg5oWBQ4LT
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Pro-tumorigenic Microenvironment in Skin Basal Cell Carcinomas Revealed
Skin basal cell carcinomas develop a specialized TREM2 myeloid niche that promotes tumor growth and sustains itself. The environment involves unique macrophages supporting proliferation through specific pathways…
From @NatureComms - Skin basal cell carcinomas assemble a pro-tumorigenic spatially organized and self-propagating Trem2+ myeloid niche https://t.co/7NGiypgol8 #bwfcams
Skin basal cell carcinomas assemble a pro-tumorigenic spatially organized and self-propagating Trem2+ myeloid niche https://t.co/00LEdaEWxt https://t.co/bg5oWBQ4LT