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J Immunother Precis Oncol May 2023 PMID 37214210

Translational Studies Using the MALT1 Inhibitor ()-Mepazine to Induce Treg Fragility and Potentiate Immune Checkpoint Therapy in Cancer.

Mauro Di Pilato, Yun Gao, Yi Sun, Amina Fu, Carina Grass, Thomas Seeholzer, Regina Feederle, Irina Mazo, Samuel W Kazer, Kevin Litchfield, Ulrich H von Andrian, Thorsten R Mempel, Russell W Jenkins, Daniel Krappmann, Peter Keller

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Mentions

22
Peak: 6 in Mar 2023
across 3 sources since Mar 2023

Extended reach

34,667
potential audience

Total likes

38

Video views

1,616

Mentions per month

Mar 2023 – Mar 2024

Where it's discussed

  • X / Twitter20 posts
  • YouTube1 videos
  • News1 articles

AI synopsis

What people are saying

The posts demonstrate strong interest through phrases like 'great job' and 'stay tuned,' reflecting excitement about clinical progress, and show moderate engagement by referencing specific scientific concepts and ongoing trials, indicating the research's potential influence on cancer immunotherapy.

AgreementModerate agreement

Most discussions are positive and supportive of the research, emphasizing its potential benefits and promising results.

InterestHigh interest

Posts express high interest, highlighting the novel approach and clinical applications related to Treg fragility and immunotherapy.

EngagementModerate engagement

There is some depth in engagement, with references to ongoing clinical trials, methods, and scientific details.

ImpactModerate impact

The discussions suggest that the research could influence future treatments, but some posts are more enthusiastic than analytical.

Abstract in brief

  • Regulatory T cells (Tregs) help maintain immune balance but can also hinder effective cancer treatments, making them a target for new therapies like the MALT1 inhibitor, ()-mepazine.
  • Preclinical studies showed that ()-mepazine has strong antitumor effects and works well in combination with anti-PD-1 therapy, specifically in tumor environments without affecting healthy Treg levels.
  • The promising results suggest that further clinical trials are warranted for ()-mepazine in treating patients with challenging tumor types, indicating a new potential approach to improve immunotherapy effectiveness.
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Top posts

Most liked on X and Bluesky
MauroDiPilato
@DiPilatoMauro · X

I am very happy to share our translational studies on Treg fragility. Mepazine works in patient-derived organotypic tumor spheroids! Great job of all team and our CEO Peter Keller! Clinical trials ongoing... Stay tuned! https://t.co/OFIJMuRUGp

Mar 3, 2023 · 9 likes · 1 share · 270 followers View post →
Helmholtz Munich | @HelmholtzMunich
@HelmholtzMunich · X

Apr 4, 2023 · 6 likes · 3 shares · 10,159 followers View post →
JIPO Editors
@JIPOEditors · X

New research article in #JIPO "Translational Studies Using the MALT1 Inhibitor (S)-Mepazine to Induce Treg Fragility and Potentiate Immune Checkpoint Therapy in Cancer" by Pilato et al. https://t.co/TFgAkV8Pl7 #MALT1 #Immunotherapy #Cancer https://t.co/rJxKhGByfO

Mar 20, 2023 · 6 likes · 2 shares · 816 followers View post →
JIPO Editors
@JIPOEditors · X

New research in #JIPO - Pilato and colleagues explain the role of #MALT1 inhibitor (S)-mepazine in #immunotherapy for #cancer. READ: https://t.co/TFgAkV8Pl7 LISTEN: https://t.co/BvMbhm2dBJ https://t.co/zrDnvzvnV0

Jun 21, 2023 · 4 likes · 3 shares · 816 followers View post →
JIPO Editors
@JIPOEditors · X

Top 3 most read #JIPO articles in 2023 were: 1. Alali & Saifo: https://t.co/DOQ79Op0Bj 2. Feustel & Falchook: https://t.co/4iz3LhbFe9 3. Di Pilato et al: https://t.co/TFgAkV8Pl7 #oncology #immunotherapy https://t.co/XlEz3ofG1e

Jan 4, 2024 · 2 likes · 816 followers View post →
JIPO Editors
@JIPOEditors · X

New research in #JIPO - Pilato and colleagues explain the role of #MALT1 inhibitor (S)-mepazine in #immunotherapy for #cancer. READ: https://t.co/TFgAkV8Pl7 LISTEN: https://t.co/NEzF8E2RJX https://t.co/u47GQjtfhn

May 22, 2023 · 2 likes · 1 share · 816 followers View post →

All mentions

Innovations Journals
@InnoJournals · X

RT @JIPOEditors: Review the most popular #JIPO articles of 2023! 1. Alali & Saifo: https://t.co/DOQ79Op0Bj 2. Di Pilato et al.: https://t.c…

Mar 19, 2024 · 1 share · 149 followers View post →
JIPO Editors
@JIPOEditors · X

Review the most popular #JIPO articles of 2023! 1. Alali & Saifo: https://t.co/DOQ79Op0Bj 2. Di Pilato et al.: https://t.co/TFgAkV8Pl7 3. Son et al.: https://t.co/FP1ZgfATgq https://t.co/zoamUlptid

Mar 14, 2024 · 2 likes · 1 share · 816 followers View post →
JIPO Editors
@JIPOEditors · X

Top 3 most read #JIPO articles in 2023 were: 1. Alali & Saifo: https://t.co/DOQ79Op0Bj 2. Feustel & Falchook: https://t.co/4iz3LhbFe9 3. Di Pilato et al: https://t.co/TFgAkV8Pl7 #oncology #immunotherapy https://t.co/XlEz3ofG1e

Jan 4, 2024 · 2 likes · 816 followers View post →
Deniz Can Guven
@DenizCanGuven1 · X

RT @JIPOEditors: New research in #JIPO - Pilato and colleagues explain the role of #MALT1 inhibitor (S)-mepazine in #immunotherapy for #can…

Jun 21, 2023 · 3 shares · 2,475 followers View post →
Mohamed Derbala, MD
@MDerbalaMD · X

RT @JIPOEditors: New research in #JIPO - Pilato and colleagues explain the role of #MALT1 inhibitor (S)-mepazine in #immunotherapy for #can…

Jun 21, 2023 · 3 shares · 403 followers View post →
Aysun Ş. Yıkılmaz
@aysunsenturk · X

RT @JIPOEditors: New research in #JIPO - Pilato and colleagues explain the role of #MALT1 inhibitor (S)-mepazine in #immunotherapy for #can…

Jun 21, 2023 · 3 shares · 280 followers View post →
JIPO Editors
@JIPOEditors · X

New research in #JIPO - Pilato and colleagues explain the role of #MALT1 inhibitor (S)-mepazine in #immunotherapy for #cancer. READ: https://t.co/TFgAkV8Pl7 LISTEN: https://t.co/BvMbhm2dBJ https://t.co/zrDnvzvnV0

Jun 21, 2023 · 4 likes · 3 shares · 816 followers View post →
Deniz Can Guven
@DenizCanGuven1 · X

RT @JIPOEditors: New research in #JIPO - Pilato and colleagues explain the role of #MALT1 inhibitor (S)-mepazine in #immunotherapy for #can…

May 22, 2023 · 1 share · 2,475 followers View post →
JIPO Editors
@JIPOEditors · X

New research in #JIPO - Pilato and colleagues explain the role of #MALT1 inhibitor (S)-mepazine in #immunotherapy for #cancer. READ: https://t.co/TFgAkV8Pl7 LISTEN: https://t.co/NEzF8E2RJX https://t.co/u47GQjtfhn

May 22, 2023 · 2 likes · 1 share · 816 followers View post →
Deniz Can Guven
@DenizCanGuven1 · X

RT @JIPOEditors: New research in #JIPO - Pilato and colleagues explain the role of #MALT1 inhibitor (S)-mepazine in #immunotherapy for #can…

Apr 19, 2023 · 2 shares · 2,475 followers View post →
CancerLinks 
@CancerLinks · X

RT @JIPOEditors: New research in #JIPO - Pilato and colleagues explain the role of #MALT1 inhibitor (S)-mepazine in #immunotherapy for #can…

Apr 19, 2023 · 2 shares · 97 followers View post →
JIPO Editors
@JIPOEditors · X

New research in #JIPO - Pilato and colleagues explain the role of #MALT1 inhibitor (S)-mepazine in #immunotherapy for #cancer. READ: https://t.co/TFgAkV8Pl7 LISTEN: https://t.co/XAv1Pbb5Ky https://t.co/gDT3QT2a5F

Apr 19, 2023 · 2 likes · 2 shares · 816 followers View post →
Heiko Lickert
@LickertHeiko · X

RT @HelmholtzMunich:

Apr 4, 2023 · 3 shares · 3,066 followers View post →
sciencenews
@Scieducation1 · X

RT @HelmholtzMunich:

Apr 4, 2023 · 3 shares · 5,134 followers View post →
Helmholtz Munich | @HelmholtzMunich
@HelmholtzMunich · X

Apr 4, 2023 · 6 likes · 3 shares · 10,159 followers View post →
Jibran Ahmed
@jibranahmed1 · X

RT @JIPOEditors: New research article in #JIPO "Translational Studies Using the MALT1 Inhibitor (S)-Mepazine to Induce Treg Fragility and P…

Mar 20, 2023 · 2 shares · 96 followers View post →
CancerLinks 
@CancerLinks · X

RT @JIPOEditors: New research article in #JIPO "Translational Studies Using the MALT1 Inhibitor (S)-Mepazine to Induce Treg Fragility and P…

Mar 20, 2023 · 2 shares · 97 followers View post →
JIPO Editors
@JIPOEditors · X

New research article in #JIPO "Translational Studies Using the MALT1 Inhibitor (S)-Mepazine to Induce Treg Fragility and Potentiate Immune Checkpoint Therapy in Cancer" by Pilato et al. https://t.co/TFgAkV8Pl7 #MALT1 #Immunotherapy #Cancer https://t.co/rJxKhGByfO

Mar 20, 2023 · 6 likes · 2 shares · 816 followers View post →
Mempel Lab
@MempelThorsten · X

RT @DiPilatoMauro: I am very happy to share our translational studies on Treg fragility. Mepazine works in patient-derived organotypic tumo…

Mar 4, 2023 · 1 share · 892 followers View post →
MauroDiPilato
@DiPilatoMauro · X

I am very happy to share our translational studies on Treg fragility. Mepazine works in patient-derived organotypic tumor spheroids! Great job of all team and our CEO Peter Keller! Clinical trials ongoing... Stay tuned! https://t.co/OFIJMuRUGp

Mar 3, 2023 · 9 likes · 1 share · 270 followers View post →
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