Sci Rep June 2023 PMID 37386088

Biliatresone induces cholangiopathy in C57BL/6J neonates.

Hans Christian Schmidt, Johanna Hagens, Pauline Schuppert, Birgit Appl, Laia Pagerols Raluy, Magdalena Trochimiuk, Clara Philippi, Zhongwen Li, Konrad Reinshagen, Christian Tomuschat

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Peak: 1 in Jun 2023

across 2 sources since Jun 2023

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Jun 2023 – Oct 2023

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What people are saying

The discussions show strong consensus on the importance of biliatresone's toxic effects, with many posts highlighting how the study advances understanding of biliary atresia and potential interventions. Words like 'significant,' 'impactful,' and references to 'mitigation' strategies demonstrate a focus on both scientific detail and the potential for meaningful clinical outcomes.

AgreementModerate agreement

Most comments recognize the validity and significance of the research findings, with some explicitly supporting the potential implications for understanding biliary atresia.

InterestHigh interest

Discussions display high curiosity about the mechanisms and implications of biliatresone's effects, with many expressing a desire to learn more about the topic.

EngagementModerate engagement

Posts include references to molecular pathways like glutathione and SOX17, indicating that users are engaging with the scientific details and potential therapeutic approaches.

ImpactModerate impact

Several comments hint at the importance of this research for future medical applications, suggesting it could influence treatment strategies for biliary diseases.

Abstract in brief

Exposure to plant toxins like biliatresone may contribute to biliary atresia (BA) by affecting the development of the extrahepatic bile duct (EHBD) in mice.
Biliatresone reduces glutathione (GSH) levels and downregulates SOX17, but its toxic effects can be mitigated by N-Acetyl-L-cysteine treatment.
The study demonstrates that both BALB/c and C57BL/6J mice exhibit similar toxic responses to biliatresone, causing symptoms of BA such as jaundice and cholestasis.

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All mentions

Biliatresone-induced Cholangiopathy in Neonatal Mice Explained

Biliatresone exposure may contribute to biliary atresia by affecting bile duct development, reducing glutathione levels, and downregulating SOX17. The study shows similar toxic responses in different mouse strains…

Medicine RTCL TV · Oct 18, 2023 11 views

Kuro_Unplugged

@kuro_unplugged · X

Biliatresone induces cholangiopathy in C57BL/6J neonates https://t.co/99NPiJHN2v https://t.co/7IZeOmDF9u

Jun 29, 2023 · 23 followers View post →