Nat Rev Cardiol October 2024 PMID 38969749

The LDL cumulative exposure hypothesis: evidence and practical applications.

Brian A Ference, Eugene Braunwald, Alberico L Catapano

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Mentions

130

Peak: 95 in Jul 2024

across 7 sources since Jul 2024

Extended reach

641,307

potential audience

Total likes

7,272

Video views

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Mentions per month

Jul 2024 – Oct 2025

Where it's discussed

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AI synopsis

What people are saying

The discussions reflect strong agreement and interest, with examples such as praising the 'plaque-years' concept and mentioning practical strategies to lower LDL exposure; the tone is enthusiastic and forward-looking, emphasizing the potential for changing treatment approaches based on the new hypothesis.

AgreementModerate agreement

Most discussions support the idea that reducing LDL exposure is crucial to preventing cardiovascular disease.

InterestHigh interest

Posts demonstrate high interest by highlighting new concepts like 'plaque-years' and emphasizing the importance of LDL timing.

EngagementHigh engagement

Several posts actively share thoughts, like disagreeing with reactive approaches or emphasizing practical applications, showing deep engagement.

ImpactHigh impact

The discussions suggest that the concept may influence future research and clinical practices, indicating high potential impact.

Abstract in brief

* Keeping LDL cholesterol levels low reduces the number of LDL particles in arteries, which slows atherosclerosis progression and lowers lifetime ASCVD risk.
* The concept of LDL cumulative exposure, combining the amount and duration of LDL levels, serves as a unique risk marker for cardiovascular events and can guide strategies for ASCVD prevention in clinical practice.

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All mentions

Understanding LDL Cumulative Exposure and Atherosclerosis Risk

doctorpetrik · Sep 30, 2024 111,314 views

Understanding Atherosclerosis and LDL Cholesterol's Role

The accumulation of LDL and other lipoproteins in artery walls leads to atherosclerosis, increasing the risk of cardiovascular events. Keeping LDL cholesterol levels low is crucial for slowing progression and lowering…

doctorpetrik · Jan 11, 2025 64,416 views

ESC Dyslipidemia Guidelines - 2025 Update - Prof. Dr. François Mach, Geneva, Switzerland

MARKUS at HOMe · Oct 29, 2025 0 views

Heart News

@HearttNews · X

Keeping low levels of LDL-cholesterol over time reduces risk of heart disease. Cumulative LDL exposure is a unique biomarker for estimating heart attack risk. #HeartHealth #Cholesterol https://t.co/qQzx4aiZkn https://t.co/Ruj9WADKsZ

Jun 20, 2025 · 8 followers View post →

أخبار القلب

@A5barEl2alb · X

الحفاظ على مستويات منخفضة من الكوليسترول LDL على مر الزمن يقلل من خطر الإصابة بأمراض القلب. التعرض التراكمي لـ LDL هو علامة حيوية فريدة لتقدير خطر الإصابة بالنوبة القلبية. #صحة_القلب #الكوليسترول https://t.co/lsYAKqnOga https://t.co/Jtu9BlpKzi

Jun 20, 2025 · 1 followers View post →

Leticia Kawano-Dourado

@leticiakawano.bsky.social · Bluesky

1/ Are women aware of the #metabolichealth challenges during #menopause #perimenopause? In middle-aged women, APO-B & LDL rise—while they remain stable in men pubmed.ncbi.nlm.nih.gov/38969749/ This shift, along with increased inflammation, sleep loss accelerates cardiovascular risk +

Mar 3, 2025 · 6 likes · 4 shares View post →

Thanh Nha Thai, MD

@thaithanhnha.bsky.social · Bluesky

The LDL cumulative exposure hypothesis: evidence and practical applications. www.nature.com/articles/s41... @natrevcardiol.bsky.social #CardioSky #MedSky #Cardiology #LDL

Feb 14, 2025 · 1 like · 1 share View post →

drjasonmccloskey

@drjmccloskey · X

The LDL cumulative exposure hypothesis: evidence and practical applications | Nature Reviews Cardiology https://t.co/ZTm1XQl0nx

Jan 31, 2025 · 78 followers View post →

Raul Eduardo Reyes Toledo

@rauleduardore · X

RT @ZHeart11768530:

Oct 1, 2024 · 8 shares · 97 followers View post →

Lucrativo

@Lucrativo4 · X

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Sep 29, 2024 · 8 shares · 3 followers View post →

Victor Adrian

@adriaan00 · X

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د. مُفيد المطيري

@MofeedDr · X

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@crop6511 · X

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@sinta_gf · X

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The Heart

@ZHeart11768530 · X

Sep 28, 2024 · 17 likes · 8 shares · 32,843 followers View post →

Otavio Berwanger

@OtavioBerwanger · X

The LDL cumulative exposure hypothesis: evidence and practical applications https://t.co/ZMyMXlBRSE

Sep 28, 2024 · 3 likes · 1,176 followers View post →

Eugene Lucas, MD

@elucasmd · X

@drpablocorral Seems like the suggestion is to wait until the disease process begins/progresses, rather than being proactive. I respectfully disagree. Some data to support my position. https://t.co/R3OGKxiURO https://t.co/dHpypn5IVZ https://t.co/FZTWTBVUbP

Sep 26, 2024 · 7 likes · 512 followers View post →

M. Handayani

@cimutHandayani · X

RT @ZHeart11768530:

Sep 2, 2024 · 3 shares · 326 followers View post →

Sintayehu Abebe

@sinta_gf · X

RT @ZHeart11768530:

Sep 1, 2024 · 3 shares · 451 followers View post →

Abdulrahman Ahmed

@Abdulra03281419 · X

RT @ZHeart11768530:

Sep 1, 2024 · 3 shares · 283 followers View post →

The Heart

@ZHeart11768530 · X

Sep 1, 2024 · 11 likes · 3 shares · 32,843 followers View post →

Akl Fahed

@aklfahed · X

The LDL cumulative exposure hypothesis: evidence and practical applications | Nature Reviews Cardiology https://t.co/3r59iIp0xq

Aug 30, 2024 · 2 likes · 2,786 followers View post →

Joseph

@Joeas21 · X

RT @bengreenfield: Great research update on how plaque accumulates over time: https://t.co/KqhgjYhFz9... https://t.co/Qt3OTxSbNx

Jul 30, 2024 · 3 shares · 42 followers View post →

Mind Your Science!

@MindYourSci · X

RT @bengreenfield: Great research update on how plaque accumulates over time: https://t.co/KqhgjYhFz9... https://t.co/Qt3OTxSbNx

Jul 30, 2024 · 3 shares · 133 followers View post →

Daniel Fisk

@DanielFisk · X

RT @bengreenfield: Great research update on how plaque accumulates over time: https://t.co/KqhgjYhFz9... https://t.co/Qt3OTxSbNx

Jul 29, 2024 · 3 shares · 1,917 followers View post →

Ben Greenfield

@bengreenfield · X

Great research update on how plaque accumulates over time: https://t.co/KqhgjYhFz9... https://t.co/Qt3OTxSbNx

Jul 29, 2024 · 18 likes · 3 shares · 94,888 followers View post →

Dr Jainer Mendez

@JainerDr · X

RT @ValleAlfonso: Simply essential➡️importance of LDL exposure time

Jul 22, 2024 · 19 shares · 317 followers View post →

Alexandra de Paz

@AlexandradePaz8 · X

RT @ValleAlfonso: Simply essential➡️importance of LDL exposure time

Jul 22, 2024 · 19 shares · 92 followers View post →

JaviVal MD, PhD

@JaviVal1964 · X

RT @ValleAlfonso: Simply essential➡️importance of LDL exposure time

Jul 20, 2024 · 19 shares · 243 followers View post →

F.Yusufzai

@obsurfer84 · X

RT @agingdoc1: The LDL cumulative exposure hypothesis: evidence and practical applications "Cumulative exposure to LDL can be used as a th…

Jul 16, 2024 · 3 shares · 294 followers View post →

Mind Your Science!

@MindYourSci · X

RT @agingdoc1: The LDL cumulative exposure hypothesis: evidence and practical applications "Cumulative exposure to LDL can be used as a th…

Jul 16, 2024 · 3 shares · 133 followers View post →

まゆき会

@mayukikai · X

RT @agingdoc1: The LDL cumulative exposure hypothesis: evidence and practical applications "Cumulative exposure to LDL can be used as a th…

Jul 16, 2024 · 3 shares · 147 followers View post →

Agingdoc

@agingdoc1 · X

Jul 16, 2024 · 7 likes · 3 shares · 41,366 followers View post →

Dr. Mark Goldberger

@theheartdoc · X

RT @MohammedAlo: The LDL Cumulative Exposure Hypothesis: Evidence and Practical Applications Must Read New Review By Brian Ference, Eugene…

Jul 12, 2024 · 35 shares · 1,362 followers View post →

Dra Isabel Cardenas M

@DrIsaCardenas · X

RT @drpablocorral:

Jul 11, 2024 · 90 shares · 267 followers View post →

leroyvanderberg

@physiquecheck · X

RT @MohammedAlo: The LDL Cumulative Exposure Hypothesis: Evidence and Practical Applications Must Read New Review By Brian Ference, Eugene…

Jul 10, 2024 · 35 shares · 11 followers View post →

jorge gamboa

@jorgega62811906 · X

RT @drpablocorral:

Jul 10, 2024 · 90 shares · 65 followers View post →

P123

@P1231032850 · X

@SBakerMD Link https://t.co/XkK1wbTDPe

Jul 10, 2024 · 3,194 followers View post →

Adela Rodriguez

@adelarovega · X

RT @gustavendocrino: Revista Nature la hipotesis de la acumulacion de LDL en la ateroesclerosis. MAGNITUD/DURACION/FACTORES MAGNIFICADORES…

Jul 9, 2024 · 2 shares · 232 followers View post →

Victor Hernández

@VicHdez27 · X

RT @gustavendocrino: Revista Nature la hipotesis de la acumulacion de LDL en la ateroesclerosis. MAGNITUD/DURACION/FACTORES MAGNIFICADORES…

Jul 9, 2024 · 2 shares · 141 followers View post →

endocrinogustavoparra

@gustavendocrino · X

Revista Nature la hipotesis de la acumulacion de LDL en la ateroesclerosis. MAGNITUD/DURACION/FACTORES MAGNIFICADORES https://t.co/AuVLTRL9V6 https://t.co/uoc51eRgIl

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Gustavo Lopes

@GustavoLopesO · X

RT @drpablocorral:

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P123

@P1231032850 · X

https://t.co/XkK1wbTDPe

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Juan Carlos Obaya

@jcobaya69 · X

RT @ValleAlfonso: Simply essential➡️importance of LDL exposure time

Jul 9, 2024 · 19 shares · 856 followers View post →

Arizona Augie

@ArizonaAugie · X

RT @drpablocorral:

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rafaelportalupp

@rafaelportalup2 · X

RT @drpablocorral:

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Mind Your Science!

@MindYourSci · X

RT @drpablocorral:

Jul 9, 2024 · 90 shares · 133 followers View post →

ZackB

@zacharyberndsen · X

RT @MohammedAlo: The LDL Cumulative Exposure Hypothesis: Evidence and Practical Applications Must Read New Review By Brian Ference, Eugene…

Jul 9, 2024 · 35 shares · 274 followers View post →

Ian Smith

@IjsSmith · X

RT @drpablocorral:

Jul 9, 2024 · 90 shares · 728 followers View post →

Nicolas Renna, MD PhD ISHF FESC

@nicolasrennamd · X

RT @ValleAlfonso: Simply essential➡️importance of LDL exposure time

Jul 9, 2024 · 19 shares · 935 followers View post →

Kinetic Impact

@KineticImpactRP · X

RT @MohammedAlo: The LDL Cumulative Exposure Hypothesis: Evidence and Practical Applications Must Read New Review By Brian Ference, Eugene…

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Adrianpxx

@Adrianpxx1 · X

RT @ValleAlfonso: Simply essential➡️importance of LDL exposure time

Jul 9, 2024 · 19 shares · 67 followers View post →

Maria Bernarda Iriarte

@Mbiriarte2203 · X

RT @drpablocorral:

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BIMDG

@BIMDG · X

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Juan Rivera

@Juan_RiveraQ21 · X

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Nana Sarpong

@Nanasarpong01 · X

RT @MohammedAlo: The LDL Cumulative Exposure Hypothesis: Evidence and Practical Applications Must Read New Review By Brian Ference, Eugene…

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Mehmet B. Barutcugil

@barutcugil · X

RT @drpablocorral:

Jul 8, 2024 · 90 shares · 882 followers View post →

CardioAcademic

@CardioAcademic · X

RT @ValleAlfonso: Simply essential➡️importance of LDL exposure time

Jul 8, 2024 · 19 shares · 3,221 followers View post →

Mary

@maryconniey · X

RT @MohammedAlo: The LDL Cumulative Exposure Hypothesis: Evidence and Practical Applications Must Read New Review By Brian Ference, Eugene…

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Terry Simpson

@drterrysimpson · X

RT @drpablocorral:

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Anandita Kulkarni, MD FACC

@AKulkarniMD · X

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YO PEEP GAME!

@YDWYPG · X

RT @MohammedAlo: The LDL Cumulative Exposure Hypothesis: Evidence and Practical Applications Must Read New Review By Brian Ference, Eugene…

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Dr. NguyenTienDung - BachmaiStrokeCenter

@Drtiendung89 · X

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John Patrick Stein

@JPSwcpmc · X

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Miguel Turégano

@tureyedro · X

RT @ValleAlfonso: Simply essential➡️importance of LDL exposure time

Jul 8, 2024 · 19 shares · 812 followers View post →

Nathan Cantley

@NathanWPCantley · X

RT @drpablocorral:

Jul 8, 2024 · 90 shares · 1,179 followers View post →

Daniel Pita, MD

@danpita · X

RT @drpablocorral:

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Dr Alo, DO, FACC

@MohammedAlo · X

RT @MohammedAlo: The LDL Cumulative Exposure Hypothesis: Evidence and Practical Applications Must Read New Review By Brian Ference, Eugene…

Jul 8, 2024 · 35 shares · 12,682 followers View post →

Alfonso Valle

@ValleAlfonso · X

RT @ValleAlfonso: Simply essential➡️importance of LDL exposure time

Jul 8, 2024 · 19 shares · 21,709 followers View post →

Michelle Fisher

@michellefisherm · X

RT @MohammedAlo: The LDL Cumulative Exposure Hypothesis: Evidence and Practical Applications Must Read New Review By Brian Ference, Eugene…

Jul 8, 2024 · 35 shares · 25 followers View post →

Kamil Faridi MD MSc

@kfaridiMD · X

RT @MohammedAlo: The LDL Cumulative Exposure Hypothesis: Evidence and Practical Applications Must Read New Review By Brian Ference, Eugene…

Jul 8, 2024 · 35 shares · 647 followers View post →

Funcolehf

@funcolehf · X

RT @drpablocorral:

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Reuben Elovitz MD

@Concierge__MD · X

RT @drpablocorral:

Jul 8, 2024 · 90 shares · 253 followers View post →

Biswajit Majumder

@Biswaji83036474 · X

RT @JeremyFarrar: The LDL cumulative exposure hypothesis: evidence and practical applications https://t.co/WtnnHQhzY7

Jul 8, 2024 · 5 shares · 598 followers View post →

the paper link

@the_paper_link · X

Trend up+192: Ference BA, ..., Catapano AL (Nat Rev Cardiol) __The LDL cumulative exposure hypothesis: evidence and practical applications__ https://t.co/apqRLpu4cY

Jul 8, 2024 · 136 followers View post →

siri th

@AnneSirikul · X

RT @MohammedAlo: The LDL Cumulative Exposure Hypothesis: Evidence and Practical Applications Must Read New Review By Brian Ference, Eugene…

Jul 8, 2024 · 35 shares · 12 followers View post →

Nehal Elsayed

@NehalEl94728323 · X

RT @drpablocorral:

Jul 8, 2024 · 90 shares · 24 followers View post →

Cristobal Morales

@CristobMorales · X

RT @ValleAlfonso: Simply essential➡️importance of LDL exposure time

Jul 8, 2024 · 19 shares · 17,048 followers View post →

Carlos Alvarez

@CarlosAlvarezDM · X

RT @ValleAlfonso: Simply essential➡️importance of LDL exposure time

Jul 8, 2024 · 19 shares · 662 followers View post →

Equity & Health

@equitylist · X

RT @GlobalPHObserv: The LDL cumulative exposure hypothesis: evidence and practical applications | Nature Reviews Cardiology https://t.co/Ie…

Jul 8, 2024 · 3 shares · 28,893 followers View post →

Dr Anastasia Mihailidou FAHA FCSANZ FESC

@AnastasiaSMihai · X

RT @ValleAlfonso: Simply essential➡️importance of LDL exposure time

Jul 8, 2024 · 19 shares · 19,289 followers View post →

Lucia Ruggiero EALR

@luciaruggiero · X

RT @GlobalPHObserv: The LDL cumulative exposure hypothesis: evidence and practical applications | Nature Reviews Cardiology https://t.co/Ie…

Jul 8, 2024 · 3 shares · 1,028 followers View post →

Raul Villar

@DrRaulvillar · X

RT @MohammedAlo: The LDL Cumulative Exposure Hypothesis: Evidence and Practical Applications Must Read New Review By Brian Ference, Eugene…

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Joey

@Joey41754402 · X

RT @drpablocorral:

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Dr. Shashank Joshi

@AskDrShashank · X

RT @ValleAlfonso: Simply essential➡️importance of LDL exposure time

Jul 8, 2024 · 19 shares · 32,515 followers View post →

Nelson murillo

@nemurillob · X

RT @ValleAlfonso: Simply essential➡️importance of LDL exposure time

Jul 8, 2024 · 19 shares · 247 followers View post →

Chih-Yao Hsu

@reclast · X

RT @MohammedAlo: The LDL Cumulative Exposure Hypothesis: Evidence and Practical Applications Must Read New Review By Brian Ference, Eugene…

Jul 8, 2024 · 35 shares · 19 followers View post →

Chema Fernandez

@chemachir · X

RT @ValleAlfonso: Simply essential➡️importance of LDL exposure time

Jul 8, 2024 · 19 shares · 3,835 followers View post →

Jamie Wang

@jamiewang1228 · X

RT @ValleAlfonso: Simply essential➡️importance of LDL exposure time

Jul 8, 2024 · 19 shares · 9 followers View post →

Alfonso Valle

@ValleAlfonso · X

Simply essential➡️importance of LDL exposure time

Jul 8, 2024 · 48 likes · 19 shares · 21,709 followers View post →

Bhopender Thakur

@TheBhupiThakur · X

RT @MohammedAlo: The LDL Cumulative Exposure Hypothesis: Evidence and Practical Applications Must Read New Review By Brian Ference, Eugene…

Jul 8, 2024 · 35 shares · 1,365 followers View post →

Tushar Mehta

@EcoDocTush · X

RT @MohammedAlo: The LDL Cumulative Exposure Hypothesis: Evidence and Practical Applications Must Read New Review By Brian Ference, Eugene…

Jul 8, 2024 · 35 shares · 581 followers View post →

Culture of Health Eq

@CofHEQ · X

RT @GlobalPHObserv: The LDL cumulative exposure hypothesis: evidence and practical applications | Nature Reviews Cardiology https://t.co/Ie…

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Rx Readmore Livemore

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@DrBeat019 · X

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Manuela Băbuș

@manuelababus · X

RT @drpablocorral:

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Luke Pilling

@lcpilling · X

Love this concept of "plaque-years" - so intuitive! Reducing cumulative exposure to LDL reduces the buildup of lipoproteins trapped in the artery wall, slowing progression of atherosclerosis, & reducing risk of cardiovascular events @NatRevCardiol https://t.co/Jc3qTAVwgC https://t.co/5oxaV0R8iO

Jul 8, 2024 · 2 likes · 982 followers View post →

Fish

@FishYFaith321 · X

RT @drpablocorral:

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Alper Aydın (Dietitian )

@aydinnalper · X

RT @MohammedAlo: The LDL Cumulative Exposure Hypothesis: Evidence and Practical Applications Must Read New Review By Brian Ference, Eugene…

Jul 8, 2024 · 35 shares · 1,422 followers View post →

Slawomir

@Slawomi18369321 · X

RT @drpablocorral:

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@SofiaVi185 · X

RT @MohammedAlo: The LDL Cumulative Exposure Hypothesis: Evidence and Practical Applications Must Read New Review By Brian Ference, Eugene…

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Ekkapong Roothumnong

@EkkapongR · X

RT @MohammedAlo: The LDL Cumulative Exposure Hypothesis: Evidence and Practical Applications Must Read New Review By Brian Ference, Eugene…

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Ander Ernaga

@AnderErnaga · X

RT @drpablocorral:

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@WilhelmBeermann · X

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Dr. Gennadi Glinsky, MD, Ph.D.

@gglinskii · X

The LDL cumulative exposure hypothesis: evidence and practical applications https://t.co/i1im5atvWb

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@jrst09 · X

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Lucia Ruggiero

@lruggiero.bsky.social · Bluesky

The LDL cumulative exposure hypothesis: evidence and practical applications | Nature Reviews Cardiology www.nature.com/articles/s41...

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Global Health Observ

@GlobalPHObserv · X

The LDL cumulative exposure hypothesis: evidence and practical applications | Nature Reviews Cardiology https://t.co/IedE12cEVk

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The LDL cumulative exposure hypothesis: evidence and practical applications.

Mentions per month

Where it's discussed

What people are saying

Abstract in brief

Top posts

All mentions

Understanding LDL Cumulative Exposure and Atherosclerosis Risk

Understanding Atherosclerosis and LDL Cholesterol's Role

ESC Dyslipidemia Guidelines - 2025 Update - Prof. Dr. François Mach, Geneva, Switzerland