Give it a rest: a systematic review with Bayesian meta-analysis on the effect of inter-set rest interval duration on muscle hypertrophy.

Alec Singer, Milo Wolf, Leonardo Generoso, Elizabeth Arias, Kenneth Delcastillo, Edwin Echevarria, Amaris Martinez, Patroklos Androulakis Korakakis, Martin C Refalo, Paul A Swinton, Brad J Schoenfeld

August 2024 Front Sports Act Living

Synopsis of Social media discussions

The discussions reflect a balanced view, with many posts discussing how the review supports shorter rest periods for hypertrophy, using phrases like 'modest negative effect' and 'more gains,' which convey both support and nuance. Additionally, some posts emphasize the complexity of the topic, indicating thoughtful engagement and recognition of practical implications.

A
Agreement
 Moderate agreement

Most discussions acknowledge the findings, especially that shorter rest times may slightly hinder hypertrophy, showing general support.

I
Interest
 Moderate level of interest

Posts show moderate interest, with some focusing on practical recommendations and individualization, indicating active engagement but not extreme curiosity.

E
Engagement
 Moderate level of engagement

Participants reference specific research details, such as rest durations and effects on muscle growth, reflecting meaningful engagement.

I
Impact
 Moderate level of impact

The social discussions highlight how the review could influence training practices and future research directions, indicating a moderate impact.

Social Mentions

YouTube

2 Videos

Twitter

76 Posts

News

6 Articles

Reddit

2 Posts

Metrics

Video Views

33,479

Total Likes

633

Extended Reach

389,835

Social Features

86

Timeline: Posts about article

Top Social Media Posts

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  • FungibleEther
    @FungibleEther (Twitter)

    @DeanTTraining While I agree, this is a meta analysis of the literature. So they are pointing towards lower rest times across many studies. Granted we need to take in ecological validity, but it is a pretty strong finding. https://t.co/Y5lcJWzo9L
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    June 5, 2025

    1

  • FungibleEther
    @FungibleEther (Twitter)

    @DeanTTraining This is a really complicated topic and a recent meta analysis shows that rest times really depend on many factors and may be individualized event to muscle groups. I am curious to see how the research unfolds in this area. https://t.co/Y5lcJWyQkd
    view full post

    May 17, 2025

    1

  • ユウキ/トレーナー×理学療法士×肉焼店長
    @xqkk5s5FxE89350 (Twitter)


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    May 2, 2025

  • Dr. Grayson Wickham
    @drgraysonDPT (Twitter)

    [9/9] Rest duration between lifts references: https://t.co/e3cBKasfVx https://t.co/jrWh3x9sLh https://t.co/XCAmWhk9Xm https://t.co/XddZFjtDRw? https://t.co/XddZFjtDRw? https://t.co/2ujHRzx1a9 https://t.co/8kvxcyYnq2
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    February 18, 2025

  • Brad Schoenfeld, PhD
    @BradSchoenfeld (Twitter)

    @ActivateGlutes @adamcvscott @Guadango @jake_tuura @MarkBennett07 Actually, very short rest periods (~1 min or less) appear to blunt hypertrophy https://t.co/jJYNaiEDVe
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    December 27, 2024

    5

  • Haresh Suppiah
    @hareshsuppiah (Twitter)


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    October 24, 2024

  • Héctor Hernández
    @hectorhernzfit (Twitter)

    Referencia: https://t.co/hcDMa88bo0
    view full post

    September 15, 2024

    2

  • Tiger Resilience LLC
    @Tigeresilience (Twitter)

    RT @tiga_style: How long should you rest during training? It depends on your goal. For muscle growth, resting at least 60 seconds works b…
    view full post

    September 10, 2024

    1

  • Michael Tiger
    @tiga_style (Twitter)

    How long should you rest during training? It depends on your goal. For muscle growth, resting at least 60 seconds works best. Personally, I use a timer as a guide, but I always listen to my body—resting just enough to properly execute the next set. https://t.co/pLvm1NxKy1
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    September 10, 2024

    3

    1

  • 比嘉一雄/筋肉まわりの全て/ヒガトレ®︎/AI 筋トレマシン Higatrec®
    @Higa_Kazuo (Twitter)

    休息時間の長さが筋肥大に与える影響は限定的。 60秒は休んだ方がよさそうだが、120秒以上はほぼ変わらない。 https://t.co/DNUKLrBSRH
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    September 2, 2024

    1

  • Danilo Amorim
    @danilonutripers (Twitter)

    RT @tecoughlin: Reference: https://t.co/rSMlGQWZu2
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    August 27, 2024

    1

  • Tom Coughlin
    @tecoughlin (Twitter)

    Reference: https://t.co/rSMlGQWZu2
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    August 26, 2024

    3

    1

  • ivanpinzon
    @ivanpin81236291 (Twitter)

    RT @DanielBerglind: Systematic review: More rest between set = more gains
    view full post

    August 23, 2024

    15

  • Slawomir
    @Slawomi18369321 (Twitter)

    RT @DanielBerglind: Systematic review: More rest between set = more gains
    view full post

    August 23, 2024

    15

  • Kinetic Impact
    @KineticImpactRP (Twitter)

    RT @DanielBerglind: Systematic review: More rest between set = more gains
    view full post

    August 23, 2024

    15

  • Gabriel Pérez
    @gperez441 (Twitter)

    RT @DanielBerglind: Systematic review: More rest between set = more gains
    view full post

    August 22, 2024

    15

  • Carlos Alberto
    @CarlosAbertoVM (Twitter)

    RT @DanielBerglind: Systematic review: More rest between set = more gains
    view full post

    August 22, 2024

    15

  • Joe Collins
    @JD_Collins7 (Twitter)

    RT @DanielBerglind: Systematic review: More rest between set = more gains
    view full post

    August 22, 2024

    15

  • Koushik
    @koushikphysio (Twitter)

    RT @DanielBerglind: Systematic review: More rest between set = more gains
    view full post

    August 22, 2024

    15

  • Adrián De la Rosa G.
    @AdrianDeGonz (Twitter)

    RT @DanielBerglind: Systematic review: More rest between set = more gains
    view full post

    August 22, 2024

    15

  • Anan
    @Anan83174H (Twitter)

    RT @DanielBerglind: Systematic review: More rest between set = more gains
    view full post

    August 22, 2024

    15

  • Ideefixe - Ιντεφίξ
    @idefix_ideefixe (Twitter)

    RT @DanielBerglind: Systematic review: More rest between set = more gains
    view full post

    August 22, 2024

    15

  • Liza Stathokostas, PhD
    @ActiveAgingJnx (Twitter)

    Review provides new direction for inter-set rest interval duration for muscle hypertrophy. Hypertrophy can be achieved across wide spectrum of rest interval w/ small benefit to employing longer vs. shorter inter-set rest intervals. https://t.co/GxCsIrFAso
    view full post

    August 22, 2024

    1

  • Mind Your Science!
    @MindYourSci (Twitter)

    RT @DanielBerglind: Systematic review: More rest between set = more gains
    view full post

    August 22, 2024

    15

  • Fundación Iberoamericana de Nutrición
    @FinutOrg (Twitter)

    RT @DanielBerglind: Systematic review: More rest between set = more gains
    view full post

    August 22, 2024

    15

  • Bensther DF
    @BenstherDf (Twitter)

    RT @DanielBerglind: Systematic review: More rest between set = more gains
    view full post

    August 22, 2024

    15

  • Daniel Berglind, PhD
    @DanielBerglind (Twitter)

    Systematic review: More rest between set = more gains
    view full post

    August 22, 2024

    67

    15

  • s_vahid hosseini
    @s_vahidhosseini (Twitter)

    Is it time to reconsider the prescribed rest duration between sets for muscle hypertrophy? @BradSchoenfeld https://t.co/1uy7Me9DYh
    view full post

    August 21, 2024

  • Ale Moraes
    @AleHartley (Twitter)

    https://t.co/ZUvFbZF1UF
    view full post

    August 15, 2024

  • Frontiers - Sports and Active Living
    @FrontSportsAL (Twitter)

    New Research: Give it a rest: a systematic review with Bayesian meta-analysis on the effect of inter-set rest interval duration on muscle hypertrophy https://t.co/ivTp5hWr0O #FrontiersIn #SportsActiveLiving
    view full post

    August 14, 2024

  • Nick Krontiris
    @nick_krontiris (Twitter)

    Give it a rest: a systematic review with Bayesian meta-analysis on the effect of inter-set rest interval duration on muscle hypertrophy (open access) https://t.co/WMyl87KEK0
    view full post

    August 14, 2024

    2

  • Ilustre Kefas
    @Esperanza_Mex (Twitter)

    RT @BradSchoenfeld: Our meta-analysis on the effect of rest intervals on hypertrophy officially pubbed. Modest negative effect with very sh…
    view full post

    August 10, 2024

    45

  • Mind Your Science!
    @MindYourSci (Twitter)

    RT @BradSchoenfeld: Our meta-analysis on the effect of rest intervals on hypertrophy officially pubbed. Modest negative effect with very sh…
    view full post

    August 5, 2024

    45

  • José Antonio Benítez Muñoz
    @jabenitezm4 (Twitter)

    RT @BradSchoenfeld: Our meta-analysis on the effect of rest intervals on hypertrophy officially pubbed. Modest negative effect with very sh…
    view full post

    August 5, 2024

    45

  • Mahito L'apostolos
    @OMaMihai (Twitter)

    RT @BradSchoenfeld: Our meta-analysis on the effect of rest intervals on hypertrophy officially pubbed. Modest negative effect with very sh…
    view full post

    August 4, 2024

    45

  • Raúl Celdrán
    @NTSAcademia (Twitter)

    RT @BradSchoenfeld: Our meta-analysis on the effect of rest intervals on hypertrophy officially pubbed. Modest negative effect with very sh…
    view full post

    August 4, 2024

    45

  • Footnotes of History
    @curious_ledger (Twitter)

    RT @BradSchoenfeld: Our meta-analysis on the effect of rest intervals on hypertrophy officially pubbed. Modest negative effect with very sh…
    view full post

    August 4, 2024

    45

  • PA
    @perfathletix (Twitter)

    RT @BradSchoenfeld: Our meta-analysis on the effect of rest intervals on hypertrophy officially pubbed. Modest negative effect with very sh…
    view full post

    August 3, 2024

    45

  • Carrie Mullin Innes
    @scorenutrition (Twitter)

    RT @BradSchoenfeld: Our meta-analysis on the effect of rest intervals on hypertrophy officially pubbed. Modest negative effect with very sh…
    view full post

    August 3, 2024

    45

  • Incremental_Logic
    @Incrementallog1 (Twitter)

    RT @BradSchoenfeld: Our meta-analysis on the effect of rest intervals on hypertrophy officially pubbed. Modest negative effect with very sh…
    view full post

    August 3, 2024

    45

  • John Kenneth
    @walkinginparis (Twitter)

    RT @BradSchoenfeld: Our meta-analysis on the effect of rest intervals on hypertrophy officially pubbed. Modest negative effect with very sh…
    view full post

    August 3, 2024

    45

  • William Amaral
    @_sempreguica (Twitter)

    RT @BradSchoenfeld: Our meta-analysis on the effect of rest intervals on hypertrophy officially pubbed. Modest negative effect with very sh…
    view full post

    August 3, 2024

    45

  • Rosalie Brown
    @rosaliebrownfit (Twitter)

    RT @BradSchoenfeld: Our meta-analysis on the effect of rest intervals on hypertrophy officially pubbed. Modest negative effect with very sh…
    view full post

    August 3, 2024

    45

  • s_vahid hosseini
    @s_vahidhosseini (Twitter)

    RT @BradSchoenfeld: Our meta-analysis on the effect of rest intervals on hypertrophy officially pubbed. Modest negative effect with very sh…
    view full post

    August 3, 2024

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  • Thomas [Everyone is Satoshi. Except CSW]
    @zoogydoogy (Twitter)

    RT @BradSchoenfeld: Our meta-analysis on the effect of rest intervals on hypertrophy officially pubbed. Modest negative effect with very sh…
    view full post

    August 3, 2024

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  • Kristopher Mendes de Souza
    @KristopherDoc (Twitter)

    RT @BradSchoenfeld: Our meta-analysis on the effect of rest intervals on hypertrophy officially pubbed. Modest negative effect with very sh…
    view full post

    August 3, 2024

    45

  • Camille Goddard
    @camillegoddard (Twitter)

    RT @BradSchoenfeld: Our meta-analysis on the effect of rest intervals on hypertrophy officially pubbed. Modest negative effect with very sh…
    view full post

    August 3, 2024

    45

  • Argón
    @metilargon (Twitter)

    RT @BradSchoenfeld: Our meta-analysis on the effect of rest intervals on hypertrophy officially pubbed. Modest negative effect with very sh…
    view full post

    August 3, 2024

    45

  • Roger Hilfiker
    @RogerHilfiker (Twitter)

    RT @BradSchoenfeld: Our meta-analysis on the effect of rest intervals on hypertrophy officially pubbed. Modest negative effect with very sh…
    view full post

    August 3, 2024

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  • Rodney Kennedy
    @Rodn3yK3nn3dy (Twitter)

    RT @BradSchoenfeld: Our meta-analysis on the effect of rest intervals on hypertrophy officially pubbed. Modest negative effect with very sh…
    view full post

    August 3, 2024

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  • Dr. Michael Sagner, MD
    @DrMichaelSagner (Twitter)

    RT @BradSchoenfeld: Our meta-analysis on the effect of rest intervals on hypertrophy officially pubbed. Modest negative effect with very sh…
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    August 3, 2024

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  • Oliver Faude
    @OliverFaude (Twitter)

    RT @BradSchoenfeld: Our meta-analysis on the effect of rest intervals on hypertrophy officially pubbed. Modest negative effect with very sh…
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    August 3, 2024

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  • Pantelis Αngelides
    @pantangelides (Twitter)

    RT @BradSchoenfeld: Our meta-analysis on the effect of rest intervals on hypertrophy officially pubbed. Modest negative effect with very sh…
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    August 3, 2024

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  • Tío Terrón
    @AriesTerron (Twitter)

    RT @BradSchoenfeld: Our meta-analysis on the effect of rest intervals on hypertrophy officially pubbed. Modest negative effect with very sh…
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    August 3, 2024

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  • gio de biase
    @gio1974db (Twitter)

    RT @BradSchoenfeld: Our meta-analysis on the effect of rest intervals on hypertrophy officially pubbed. Modest negative effect with very sh…
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    August 3, 2024

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  • Rx Readmore Livemore
    @SopitaSirirata1 (Twitter)

    RT @BradSchoenfeld: Our meta-analysis on the effect of rest intervals on hypertrophy officially pubbed. Modest negative effect with very sh…
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    August 3, 2024

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  • Thryve | Stress & Wellness
    @ReallyThryve (Twitter)

    RT @BradSchoenfeld: Our meta-analysis on the effect of rest intervals on hypertrophy officially pubbed. Modest negative effect with very sh…
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    August 3, 2024

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  • Mean & Lean Fitness
    @MeanLeanFitness (Twitter)

    RT @BradSchoenfeld: Our meta-analysis on the effect of rest intervals on hypertrophy officially pubbed. Modest negative effect with very sh…
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    August 3, 2024

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  • Prof. Nasser Alzerwi
    @NAlzerwi (Twitter)

    RT @BradSchoenfeld: Our meta-analysis on the effect of rest intervals on hypertrophy officially pubbed. Modest negative effect with very sh…
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    August 2, 2024

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  • Jay Bert
    @bert695 (Twitter)

    RT @BradSchoenfeld: Our meta-analysis on the effect of rest intervals on hypertrophy officially pubbed. Modest negative effect with very sh…
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    August 2, 2024

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  • MarcoAntonioMedeiros
    @professormarcoa (Twitter)

    RT @BradSchoenfeld: Our meta-analysis on the effect of rest intervals on hypertrophy officially pubbed. Modest negative effect with very sh…
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    August 2, 2024

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  • Raul
    @RaulM06 (Twitter)

    RT @BradSchoenfeld: Our meta-analysis on the effect of rest intervals on hypertrophy officially pubbed. Modest negative effect with very sh…
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    August 2, 2024

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  • Zack
    @keychupkicap (Twitter)

    RT @BradSchoenfeld: Our meta-analysis on the effect of rest intervals on hypertrophy officially pubbed. Modest negative effect with very sh…
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    August 2, 2024

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  • Leonardo Amorim, MSc
    @leonardo_amr (Twitter)

    RT @BradSchoenfeld: Our meta-analysis on the effect of rest intervals on hypertrophy officially pubbed. Modest negative effect with very sh…
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    August 2, 2024

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  • Daniel Godeassi
    @dangodeassi (Twitter)

    RT @BradSchoenfeld: Our meta-analysis on the effect of rest intervals on hypertrophy officially pubbed. Modest negative effect with very sh…
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    August 2, 2024

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  • Dr Paul Swinton
    @PaulSwinton9 (Twitter)

    RT @BradSchoenfeld: Our meta-analysis on the effect of rest intervals on hypertrophy officially pubbed. Modest negative effect with very sh…
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    August 2, 2024

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  • Wil Martínez, entrenador
    @Wilentrenador (Twitter)

    RT @BradSchoenfeld: Our meta-analysis on the effect of rest intervals on hypertrophy officially pubbed. Modest negative effect with very sh…
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    August 2, 2024

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  • Jeff A ⚜️
    @JeffA000 (Twitter)

    RT @BradSchoenfeld: Our meta-analysis on the effect of rest intervals on hypertrophy officially pubbed. Modest negative effect with very sh…
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    August 2, 2024

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  • Mikey
    @GaintrustMikey (Twitter)

    RT @BradSchoenfeld: Our meta-analysis on the effect of rest intervals on hypertrophy officially pubbed. Modest negative effect with very sh…
    view full post

    August 2, 2024

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  • -
    @AlanMG__ (Twitter)

    RT @BradSchoenfeld: Our meta-analysis on the effect of rest intervals on hypertrophy officially pubbed. Modest negative effect with very sh…
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    August 2, 2024

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  • Dr Chris Kirk
    @ChrisKirk_ASP (Twitter)

    RT @BradSchoenfeld: Our meta-analysis on the effect of rest intervals on hypertrophy officially pubbed. Modest negative effect with very sh…
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    August 2, 2024

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  • gx
    @Gxrawr (Twitter)

    RT @BradSchoenfeld: Our meta-analysis on the effect of rest intervals on hypertrophy officially pubbed. Modest negative effect with very sh…
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    August 2, 2024

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  • Brad Schoenfeld, PhD
    @BradSchoenfeld (Twitter)

    Our meta-analysis on the effect of rest intervals on hypertrophy officially pubbed. Modest negative effect with very short rest (~1 min); above 90 secs, no appreciable differences https://t.co/2kvEtTsAkT
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    August 2, 2024

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  • Nick Vardavas
    @vardavas (Twitter)

    1. Singer, Alec et al. (2024). Give it a Rest: A systematic review with Bayesian meta-analysis on the effect of inter-set rest interval duration on muscle hypertrophy. 10.51224/SRXIV.395.
    view full post

    June 12, 2024

  • Lorenzo S.Wayne
    @LorenzoSWayne (Twitter)

    Give it a Rest: a systematic review with Bayesian meta-analysis on the effect of inter-set rest interval duration on muscle hypertrophy
    view full post

    April 15, 2024

    1


  • @javierbutra (Twitter)

    Give it a Rest A systematic review with Bayesian meta-analysis on the effect of inter-set rest interval duration on muscle hypertrophy https://t.co/QtEb4u3n2a https://t.co/YOvgmIrh5k
    view full post

    April 15, 2024

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Abstract Synopsis

  • This systematic review and Bayesian meta-analysis examined how different rest interval durations between sets affect muscle growth, using data from studies that controlled most training variables and measured muscle gains in healthy adults.
  • The results showed some evidence that shorter rest periods (around 60 seconds) might promote slightly more muscle hypertrophy, especially in the arms and thighs, possibly due to reduced volume load, but differences were small and varied across studies.
  • Rest intervals longer than about 90 seconds did not show significant additional benefits, suggesting that extending rest beyond this point doesn't further enhance muscle growth, as the negative effects on training volume tend to stabilize.