bioRxiv October 2025 PMID 39253435

Alternate RNA decoding results in stable and abundant proteins in mammals.

Shira Tsour, Rainer Machne, Andrew Leduc, Simon Widmer, Eunice Koo, Jeremy Guez, Konrad Karczewski, Nikolai Slavov

Mentions

34
Peak: 16 in Aug 2024
across 5 sources since Aug 2024

Extended reach

122,012
potential audience

Total likes

137

Video views

4,328

Mentions per month

Aug 2024 – Oct 2025

Where it's discussed

  • X / Twitter23 posts
  • Bluesky4 posts
  • YouTube3 videos
  • Reddit2 posts
  • Blogs2 articles

AI synopsis

What people are saying

The group's evaluations show genuine interest through mentions of the research's implications for mammalian protein diversity and disease, supported by supportive language like 'surprisingly' and references to mechanisms like codon-anticodon mismatches, which foster a sense of importance. Engagement is deepened by references to academic defenses and mechanisms, emphasizing the research’s significance and potential influence on the field.

AgreementModerate agreement

Most discussions recognize and support the significance of the research findings, emphasizing the novelty of stable, abundant proteins resulting from alternative RNA decoding.

InterestHigh interest

Participants demonstrate high curiosity, sharing multiple posts about the research, attending dissertation defenses, and highlighting detailed mechanisms and implications.

EngagementModerate engagement

The discussions include references to specific mechanisms, such as protein stability and RNA modifications, and mention upcoming academic presentations, indicating active involvement.

ImpactModerate impact

The conversations suggest these findings could potentially influence understanding of protein diversity and disease mechanisms, reflecting a perceived moderate to high impact.

Abstract in brief

  • Amino acid substitutions from alternate translation can significantly impact protein stability and function, with a study analyzing over 1,000 human samples revealing 60,024 high-confidence substitutions across various proteins.
  • The analysis found that recoded proteins, which differ from standard genetic codes, are more common for hundreds of proteins, and are linked to conditions like neurodegeneration, with certain substitutions showing tissue-specific patterns.
  • These findings highlight how the abundance of alternative translations contributes to diversity in mammalian proteins, influencing protein stability and associations with tissue-specific functions and diseases.

Top posts

Most liked on X and Bluesky
Slavov Laboratory
@slavovLab · X

On Tue, we shared results from 2 projects: 1. Alternate RNA decoding results in stable and abundant proteins in mammals https://t.co/gyIhKSLp7G 2. Proteome asymmetry in mouse and human embryos before fate specification https://t.co/ukCFQ5c4aX Synopsis: https://t.co/JDn0OLvde6

Aug 30, 2024 · 31 likes · 6 shares · 2,836 followers View post →
Slavov Laboratory
@slavovLab · X

Next week, @shiri_tsour and @_AndrewLeduc will be defending their dissertations ! They will present research from: https://t.co/dObDKJ85EJ https://t.co/gyIhKSKRi8 https://t.co/hpnd38VDE1 https://t.co/7nqZfGAsZ7 and more

Sep 10, 2024 · 16 likes · 1 share · 2,836 followers View post →
Albert Vilella
@AlbertVilella · X

Alternate RNA decoding results in stable and abundant proteins in mammals https://t.co/b1b8OEPgfB

Aug 27, 2024 · 7 likes · 1 share · 23,785 followers View post →
Ribosome Papers
@ribosome_papers · X

bioRxiv: Alternate RNA decoding results in stable and abundant proteins in mammals https://t.co/PPt3mOVnOU

Aug 26, 2024 · 4 likes · 2,932 followers View post →
Zeynep Baharoglu
@BaharogluZeynep · X

"Mechanisms contributing to substitution abundance include protein stability, codon frequency, codon-anticodon mismatches, and RNA modifications" Alternate RNA decoding results in stable and abundant proteins in mammals https://t.co/B69iVmCICg

Sep 7, 2024 · 2 likes · 1,014 followers View post →
Milo B. Fasken, Ph.D. (he/him)
@MiloFasken · X

Alternate #RNA #decoding results in stable and abundant #proteins in mammals | bioRxiv https://t.co/mWr9bVQqG1

Sep 7, 2024 · 2 likes · 1,011 followers View post →

All mentions

Slavov Laboratory
@slavovlab.bsky.social · Bluesky

Preprint: Alternate RNA decoding results in stable and abundant proteins in mammals www.biorxiv.org/content/10.1...

Oct 25, 2025 · 1 like View post →
Manoj Mayogi Mishra
@mayogisense · X

RT @gglinskii: Alternate RNA decoding results in stable and abundant proteins in mammals https://t.co/akSLDxfOAD

Oct 23, 2024 · 1 share · 573 followers View post →
Dr. Gennadi Glinsky, MD, Ph.D.
@gglinskii · X

Alternate RNA decoding results in stable and abundant proteins in mammals https://t.co/akSLDxfOAD

Oct 23, 2024 · 1 like · 1 share · 2,061 followers View post →
Supurmario basler
@SupurmarioH · X

RT @slavovLab: On Tue, we shared results from 2 projects: 1. Alternate RNA decoding results in stable and abundant proteins in mammals htt…

Oct 12, 2024 · 6 shares · 36 followers View post →
Mandragore ⛩️
@mandragore.bsky.social · Bluesky

➡️ #Alternate #RNA #decoding #results in stable and abundant #proteins in mammals www.biorxiv.org/content/10.1... 1) …Surprisingly, the products of alternative translation are more abundant than their canonical counterparts

Sep 18, 2024 · 1 share View post →
Prof. Nikolai Slavov
@slavov_n · X

RT @slavovLab: Next week, @shiri_tsour and @_AndrewLeduc will be defending their dissertations ! They will present research from: https:…

Sep 10, 2024 · 1 share · 20,009 followers View post →
Slavov Laboratory
@slavovLab · X

Next week, @shiri_tsour and @_AndrewLeduc will be defending their dissertations ! They will present research from: https://t.co/dObDKJ85EJ https://t.co/gyIhKSKRi8 https://t.co/hpnd38VDE1 https://t.co/7nqZfGAsZ7 and more

Sep 10, 2024 · 16 likes · 1 share · 2,836 followers View post →
Javier Santoyo
@jsantoyo · X

Alternate RNA decoding results in stable and abundant proteins in mammals. #AlternativeRNAdecoding #Translation #AlternateProteins @biorxivpreprint https://t.co/BVResalgEG

Sep 8, 2024 · 1 like · 6,086 followers View post →
PZM Diagnostics
@PZMLLC · X

Alternate RNA decoding results in stable and abundant proteins in mammals | bioRxiv https://t.co/SMDG0MXHnE

Sep 8, 2024 · 1,955 followers View post →
M
@micmicmic1 · X

Alternate RNA decoding results in stable and abundant proteins in mammals | bioRxiv https://t.co/N5q4zBp1f3

Sep 8, 2024 · 1,620 followers View post →
Milo B. Fasken, Ph.D. (he/him)
@MiloFasken · X

Alternate #RNA #decoding results in stable and abundant #proteins in mammals | bioRxiv https://t.co/mWr9bVQqG1

Sep 7, 2024 · 2 likes · 1,011 followers View post →
Zeynep Baharoglu
@BaharogluZeynep · X

"Mechanisms contributing to substitution abundance include protein stability, codon frequency, codon-anticodon mismatches, and RNA modifications" Alternate RNA decoding results in stable and abundant proteins in mammals https://t.co/B69iVmCICg

Sep 7, 2024 · 2 likes · 1,014 followers View post →
Victor Zegarra
@zegarrv · X

RT @slavovLab: On Tue, we shared results from 2 projects: 1. Alternate RNA decoding results in stable and abundant proteins in mammals htt…

Aug 31, 2024 · 6 shares · 411 followers View post →
Saubhik Som
@SaubhikSom · X

RT @slavovLab: On Tue, we shared results from 2 projects: 1. Alternate RNA decoding results in stable and abundant proteins in mammals htt…

Aug 31, 2024 · 6 shares · 69 followers View post →
IntoWild
@euvlook · X

RT @slavovLab: On Tue, we shared results from 2 projects: 1. Alternate RNA decoding results in stable and abundant proteins in mammals htt…

Aug 30, 2024 · 6 shares · 78 followers View post →
Simon
@Kinker_0 · X

RT @slavovLab: On Tue, we shared results from 2 projects: 1. Alternate RNA decoding results in stable and abundant proteins in mammals htt…

Aug 30, 2024 · 6 shares · 127 followers View post →
Prof. Nikolai Slavov
@slavov_n · X

RT @slavovLab: On Tue, we shared results from 2 projects: 1. Alternate RNA decoding results in stable and abundant proteins in mammals htt…

Aug 30, 2024 · 6 shares · 20,009 followers View post →
Slavov Laboratory
@slavovLab · X

On Tue, we shared results from 2 projects: 1. Alternate RNA decoding results in stable and abundant proteins in mammals https://t.co/gyIhKSLp7G 2. Proteome asymmetry in mouse and human embryos before fate specification https://t.co/ukCFQ5c4aX Synopsis: https://t.co/JDn0OLvde6

Aug 30, 2024 · 31 likes · 6 shares · 2,836 followers View post →
Eamon McAndrew
@eamon_mcandrew · X

RT @AlbertVilella: Alternate RNA decoding results in stable and abundant proteins in mammals https://t.co/b1b8OEPgfB

Aug 27, 2024 · 1 share · 642 followers View post →
Albert Vilella
@AlbertVilella · X

Alternate RNA decoding results in stable and abundant proteins in mammals https://t.co/b1b8OEPgfB

Aug 27, 2024 · 7 likes · 1 share · 23,785 followers View post →
Harry Pantazopoulos
@HarryPantazopo1 · X

Alternate RNA decoding results in stable and abundant proteins in mammals https://t.co/a6HmU1K9PA

Aug 27, 2024 · 1 like · 174 followers View post →
Biology+AI Daily
@BiologyAIDaily · X

Alternate RNA decoding results in stable and abundant proteins in mammals @slavov_n @slavovLab @_AndrewLeduc @SimonDWidmer

Aug 27, 2024 · 1 like · 14,388 followers View post →
Biology+AI Daily
@BiologyAIDaily · X

Alternate RNA decoding results in stable and abundant proteins in mammals @slavov_n @slavovLab @_AndrewLeduc @SimonDWidmer

Aug 27, 2024 · 1 like · 14,388 followers View post →
Ribosome Papers
@ribosome_papers · X

bioRxiv: Alternate RNA decoding results in stable and abundant proteins in mammals https://t.co/PPt3mOVnOU

Aug 26, 2024 · 4 likes · 2,932 followers View post →
bioRxivpreprint
@biorxivpreprint.bsky.social · Bluesky

Alternate RNA decoding results in stable and abundant proteins in mammals https://www.biorxiv.org/content/10.1101/2024.08.26.609665v1

Aug 26, 2024 · 2 likes View post →
bioRxiv Molecular Biology
@biorxiv-molbio.bsky.social · Bluesky

Alternate RNA decoding results in stable and abundant proteins in mammals https://www.biorxiv.org/content/10.1101/2024.08.26.609665v1

Aug 26, 2024 View post →
bioRxiv Molecular Biology
@biorxiv_molbio · X

Alternate RNA decoding results in stable and abundant proteins in mammals https://t.co/qxjVCUUnw0 #biorxiv_molbio

Aug 26, 2024 · 547 followers View post →