On Tue, we shared results from 2 projects: 1. Alternate RNA decoding results in stable and abundant proteins in mammals https://t.co/gyIhKSLp7G 2. Proteome asymmetry in mouse and human embryos before fate specification https://t.co/ukCFQ5c4aX Synopsis: https://t.co/JDn0OLvde6
Alternate RNA decoding results in stable and abundant proteins in mammals.
Mentions
Extended reach
Total likes
Video views
Mentions per month
Aug 2024 – Oct 2025Where it's discussed
-
X / Twitter23 posts
-
Bluesky4 posts
-
YouTube3 videos
-
Reddit2 posts
-
Blogs2 articles
AI synopsis
What people are saying
The group's evaluations show genuine interest through mentions of the research's implications for mammalian protein diversity and disease, supported by supportive language like 'surprisingly' and references to mechanisms like codon-anticodon mismatches, which foster a sense of importance. Engagement is deepened by references to academic defenses and mechanisms, emphasizing the research’s significance and potential influence on the field.
Most discussions recognize and support the significance of the research findings, emphasizing the novelty of stable, abundant proteins resulting from alternative RNA decoding.
Participants demonstrate high curiosity, sharing multiple posts about the research, attending dissertation defenses, and highlighting detailed mechanisms and implications.
The discussions include references to specific mechanisms, such as protein stability and RNA modifications, and mention upcoming academic presentations, indicating active involvement.
The conversations suggest these findings could potentially influence understanding of protein diversity and disease mechanisms, reflecting a perceived moderate to high impact.
Abstract in brief
- Amino acid substitutions from alternate translation can significantly impact protein stability and function, with a study analyzing over 1,000 human samples revealing 60,024 high-confidence substitutions across various proteins.
- The analysis found that recoded proteins, which differ from standard genetic codes, are more common for hundreds of proteins, and are linked to conditions like neurodegeneration, with certain substitutions showing tissue-specific patterns.
- These findings highlight how the abundance of alternative translations contributes to diversity in mammalian proteins, influencing protein stability and associations with tissue-specific functions and diseases.
Top posts
Most liked on X and BlueskyNext week, @shiri_tsour and @_AndrewLeduc will be defending their dissertations ! They will present research from: https://t.co/dObDKJ85EJ https://t.co/gyIhKSKRi8 https://t.co/hpnd38VDE1 https://t.co/7nqZfGAsZ7 and more
Alternate RNA decoding results in stable and abundant proteins in mammals https://t.co/b1b8OEPgfB
bioRxiv: Alternate RNA decoding results in stable and abundant proteins in mammals https://t.co/PPt3mOVnOU
"Mechanisms contributing to substitution abundance include protein stability, codon frequency, codon-anticodon mismatches, and RNA modifications" Alternate RNA decoding results in stable and abundant proteins in mammals https://t.co/B69iVmCICg
Alternate #RNA #decoding results in stable and abundant #proteins in mammals | bioRxiv https://t.co/mWr9bVQqG1
All mentions
Advances in Proteomics: RNA Decoding and Embryo Cell Fate
This presentation from May 2024 highlights progress in proteomics, focusing on two discoveries: stable, abundant proteins resulting from alternate RNA decoding, and proteome asymmetry in early embryos, enhancing our…
Proteomics Insights: Single-Cell Variation and Molecular Mechanisms
This presentation explores proteome variation at the single-cell level and the underlying molecular mechanisms. It discusses progress in proteomics, analyzing over 1000 human samples, revealing significant amino acid…
Advancements in Single-Cell Proteomics Research
This presentation by Prof. Nikolai Slavov explores technological and biological advancements in single-cell proteomics, focusing on the implications of protein variation for biological functions. Conducted at…
Preprint: Alternate RNA decoding results in stable and abundant proteins in mammals www.biorxiv.org/content/10.1...
RT @gglinskii: Alternate RNA decoding results in stable and abundant proteins in mammals https://t.co/akSLDxfOAD
Alternate RNA decoding results in stable and abundant proteins in mammals https://t.co/akSLDxfOAD
RT @slavovLab: On Tue, we shared results from 2 projects: 1. Alternate RNA decoding results in stable and abundant proteins in mammals htt…
➡️ #Alternate #RNA #decoding #results in stable and abundant #proteins in mammals www.biorxiv.org/content/10.1... 1) …Surprisingly, the products of alternative translation are more abundant than their canonical counterparts
RT @slavovLab: Next week, @shiri_tsour and @_AndrewLeduc will be defending their dissertations ! They will present research from: https:…
Next week, @shiri_tsour and @_AndrewLeduc will be defending their dissertations ! They will present research from: https://t.co/dObDKJ85EJ https://t.co/gyIhKSKRi8 https://t.co/hpnd38VDE1 https://t.co/7nqZfGAsZ7 and more
Alternate RNA decoding results in stable and abundant proteins in mammals. #AlternativeRNAdecoding #Translation #AlternateProteins @biorxivpreprint https://t.co/BVResalgEG
Alternate RNA decoding results in stable and abundant proteins in mammals | bioRxiv https://t.co/SMDG0MXHnE
Alternate RNA decoding results in stable and abundant proteins in mammals | bioRxiv https://t.co/N5q4zBp1f3
Alternate #RNA #decoding results in stable and abundant #proteins in mammals | bioRxiv https://t.co/mWr9bVQqG1
"Mechanisms contributing to substitution abundance include protein stability, codon frequency, codon-anticodon mismatches, and RNA modifications" Alternate RNA decoding results in stable and abundant proteins in mammals https://t.co/B69iVmCICg
RT @slavovLab: On Tue, we shared results from 2 projects: 1. Alternate RNA decoding results in stable and abundant proteins in mammals htt…
RT @slavovLab: On Tue, we shared results from 2 projects: 1. Alternate RNA decoding results in stable and abundant proteins in mammals htt…
RT @slavovLab: On Tue, we shared results from 2 projects: 1. Alternate RNA decoding results in stable and abundant proteins in mammals htt…
RT @slavovLab: On Tue, we shared results from 2 projects: 1. Alternate RNA decoding results in stable and abundant proteins in mammals htt…
RT @slavovLab: On Tue, we shared results from 2 projects: 1. Alternate RNA decoding results in stable and abundant proteins in mammals htt…
On Tue, we shared results from 2 projects: 1. Alternate RNA decoding results in stable and abundant proteins in mammals https://t.co/gyIhKSLp7G 2. Proteome asymmetry in mouse and human embryos before fate specification https://t.co/ukCFQ5c4aX Synopsis: https://t.co/JDn0OLvde6
RT @AlbertVilella: Alternate RNA decoding results in stable and abundant proteins in mammals https://t.co/b1b8OEPgfB
Alternate RNA decoding results in stable and abundant proteins in mammals https://t.co/b1b8OEPgfB
Alternate RNA decoding results in stable and abundant proteins in mammals https://t.co/a6HmU1K9PA
Alternate RNA decoding results in stable and abundant proteins in mammals @slavov_n @slavovLab @_AndrewLeduc @SimonDWidmer
Alternate RNA decoding results in stable and abundant proteins in mammals @slavov_n @slavovLab @_AndrewLeduc @SimonDWidmer
bioRxiv: Alternate RNA decoding results in stable and abundant proteins in mammals https://t.co/PPt3mOVnOU
Alternate RNA decoding results in stable and abundant proteins in mammals https://www.biorxiv.org/content/10.1101/2024.08.26.609665v1
Alternate RNA decoding results in stable and abundant proteins in mammals https://www.biorxiv.org/content/10.1101/2024.08.26.609665v1
Alternate RNA decoding results in stable and abundant proteins in mammals https://t.co/qxjVCUUnw0 #biorxiv_molbio