Engineering synthetic phosphorylation signaling networks in human cells.

Xiaoyu Yang, Jason W Rocks, Kaiyi Jiang, Andrew J Walters, Kshitij Rai, Jing Liu, Jason Nguyen, Scott D Olson, Pankaj Mehta, James J Collins, Nichole M Daringer, Caleb J Bashor

January 2025 Science

Synopsis of Social media discussions

The group's discussions are characterized by enthusiastic support, with posts praising the development of synthetic phosphorylation circuits and proposing applications like targeted cell therapy. Words like 'excited', 'great work', and phrases such as 'design rules for engineering' reveal a tone of admiration and anticipation, indicating a community that values the scientific advances and their potential real-world impacts.

A
Agreement
 Moderate agreement

Most discussions express support and enthusiasm for the research, emphasizing its innovative aspects and potential applications.

I
Interest
 High level of interest

The discussions demonstrate a high level of curiosity and engagement with the topic, often highlighting specific advancements and implications.

E
Engagement
 High engagement

Posts reference detailed aspects of the research, such as design rules and potential for cell therapy, indicating deep involvement.

I
Impact
 Moderate level of impact

The excitement about the research's transformative potential suggests it could significantly influence future biomedical engineering efforts, though some acknowledge it's early-stage.

Social Mentions

YouTube

2 Videos

Bluesky

5 Posts

Twitter

98 Posts

Instagram

5 Posts

Blogs

2 Articles

News

20 Articles

Reddit

1 Posts

Metrics

Video Views

1,331

Total Likes

503

Extended Reach

4,907,891

Social Features

133

Timeline: Posts about article

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  • Dawn
    @DawnC1235 (Twitter)

    Engineering synthetic phosphorylation signaling networks in human cells | Science https://t.co/VZDIlm4jav
    view full post

    April 25, 2025

  • Shicheng Guo
    @shihcheng.bsky.social (Bluesky)


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    April 9, 2025

    2

  • Elegen
    @ElegenBio (Twitter)

    [3/3] Engineering the molecular circuits of smart cells takes repeated #DBTL iterations. Look to #EnfiniaDNA to expedite your DBTL workflows and optimize designs faster. @ScienceMagazine READ: https://t.co/L23VcO7pza #bioengineering #DNA @ElegenBio #DNAinnovation
    view full post

    February 21, 2025

  • American Elements
    @AmericanElement (Twitter)

    Rice University bioengineers develop construction kit for building custom sense-and-respond circuits in human cells https://t.co/SufyPJavF9
    view full post

    February 17, 2025

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  • Biological Design Center, Boston University
    @BioDesignCenter (Twitter)

    RT @MoKhalilLab:
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    January 8, 2025

    4

  • Kilachand Center, Boston University
    @KilachandCenter (Twitter)

    RT @MoKhalilLab:
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    January 8, 2025

    4

  • Hantao Gu
    @GuHantao (Twitter)

    《科学》 ：科学家在人类细胞中建立“智能电路” https://t.co/lVQdZbkHpf Science ： shtmEngineering synthetic phosphorylation signaling networks in human cells https://t.co/ktWvGQjslz
    view full post

    January 8, 2025

  • Rahul K
    @theresearch.bsky.social (Bluesky)

    5/5 biomed.news/bims-enlima/... The first issue of 2025 includes fascinating #syntheticbiology work showing engineering synthetic phosphorylation signaling networks in human cells @science.org Let us keep making discoveries and innovations, showing the power of science for a better world!
    view full post

    January 8, 2025

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  • 花鳥風月
    @kachofugetsujp (Twitter)

    RT @XX62: ヒト細胞内に人工リン酸化シグナルネットワーク構築 ヒトT細胞で この回路がTNFαを感知 制御されたサイトカイン分泌がが可能 必要な物質を 必要な場所に 必要な時に 必要な量 配送 知性 『Engineering synthetic phosphor…
    view full post

    January 5, 2025

    1

  • Xiaoyu Yang
    @XiaoyuYang6 (Twitter)

    RT @Chikara3254: Engineering synthetic phosphorylation signaling networks in human cells https://t.co/s3rRedGhIH 細胞内のシグナル伝達ではリン酸化がスイッチになること…
    view full post

    January 5, 2025

    1

  • Takumi Karasawa
    @Takumik_biology (Twitter)

    論文紹介 92日目 この論文では、既存のタンパク質のドメインなどを組み合わせることで新たにキナーゼなどを作り、それらを用いてヒトの細胞で機能するリン酸化ネットワークを設計し、実証も行っています。 実際に外部刺激に応答し、遺伝子発現やリン酸化を制御できています！ https://t.co/NnItvzkTns
    view full post

    January 5, 2025

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  • Chikara Mizukoshi 水越周良
    @Chikara3254 (Twitter)

    Engineering synthetic phosphorylation signaling networks in human cells https://t.co/s3rRedGhIH 細胞内のシグナル伝達ではリン酸化がスイッチになることがよくある。このシグナル　回路自体を細胞内に導入。人工的なキナーゼ、基質、SH2ドメイン、フォスファターゼをプラスミドで導入。
    view full post

    January 4, 2025

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  • Pierre Ber
    @Pierre018 (Twitter)

    RT @ShorterLab: Engineering synthetic phosphorylation signaling networks in human cells | Science https://t.co/8pJ9FWaQE9
    view full post

    January 4, 2025

    18

  • Andres Nejamkin
    @andres_nej (Twitter)

    Wow! Engineering synthetic phosphorylation signaling networks in human cells | Science https://t.co/rhUSfeT3Ie
    view full post

    January 4, 2025

    1

  • Yoshihisa Okazaki
    @XX62 (Twitter)

    ヒト細胞内に人工リン酸化シグナルネットワーク構築 ヒトT細胞で この回路がTNFαを感知 制御されたサイトカイン分泌がが可能 必要な物質を 必要な場所に 必要な時に 必要な量 配送 知性 『Engineering synthetic phosphorylation signaling networks in human cells』 Science 2 Jan 2025 https://t.co/oWPmSnWodK
    view full post

    January 4, 2025

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    1

  • Xbox
    @Xbox1_1 (Twitter)

    RT @idmjky: Really excited to share this synthetic phosphorylation piece out @ScienceMagazine. We present design rules for engineering synt…
    view full post

    January 4, 2025

    35

  • Sara Obeid
    @catstarssara (Twitter)

    RT @MoKhalilLab:
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    January 4, 2025

    4

  • Sudripta Das
    @DasSudript19120 (Twitter)

    RT @idmjky: Really excited to share this synthetic phosphorylation piece out @ScienceMagazine. We present design rules for engineering synt…
    view full post

    January 4, 2025

    35

  • Bioecomatics
    @bioecomatic (Twitter)

    RT @idmjky: Really excited to share this synthetic phosphorylation piece out @ScienceMagazine. We present design rules for engineering synt…
    view full post

    January 4, 2025

    35

  • さすらいの研究者（さすせん）
    @PI_in_abroad (Twitter)

    RT @jyasuda1: よくわかっていないが、ヒトT細胞の機能を、TNF-αによって制御可能なタンパク質リン酸化カスケード（キナーゼから基質である機能分子まで）を人為的にデザイン、稼働させることに成功したという論文のようだ。Science誌。 https://t.co/VR…
    view full post

    January 3, 2025

    6

  • Xiaoyu Yang
    @XiaoyuYang6 (Twitter)

    RT @iPatho1: ヒト細胞内で、さまざまなタンパク質ドメインを組み合わせて、キナーゼ、基質、リン酸化依存性の相互作用ドメインを設計し、外部からのシグナルを感知・増幅して導入遺伝子の発現を活性化する合成回路を人工的に作り上げた論文がScience誌に発表されました。 ht…
    view full post

    January 3, 2025

    3

  • Xiaoyu Yang
    @XiaoyuYang6 (Twitter)

    RT @jyasuda1: よくわかっていないが、ヒトT細胞の機能を、TNF-αによって制御可能なタンパク質リン酸化カスケード（キナーゼから基質である機能分子まで）を人為的にデザイン、稼働させることに成功したという論文のようだ。Science誌。 https://t.co/VR…
    view full post

    January 3, 2025

    6

  • Arun Thiruvalluvan
    @AThiruvalluvan (Twitter)

    RT @ShorterLab: Engineering synthetic phosphorylation signaling networks in human cells | Science https://t.co/8pJ9FWaQE9
    view full post

    January 3, 2025

    18

  • DHprotein
    @DHprotein (Twitter)

    RT @idmjky: Really excited to share this synthetic phosphorylation piece out @ScienceMagazine. We present design rules for engineering synt…
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    January 3, 2025

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  • DHprotein
    @DHprotein (Twitter)

    https://t.co/jk9XU3aIUt
    view full post

    January 3, 2025

  • Wei Roc Song
    @WeiRocSong (Twitter)

    RT @ShorterLab: Engineering synthetic phosphorylation signaling networks in human cells | Science https://t.co/8pJ9FWaQE9
    view full post

    January 3, 2025

    18

  • Jing Liu ("Vicky")
    @Jing_V_Liu (Twitter)

    Excited to see @BashorLab's work in @ScienceMagazine! This paper presents a framework for engineering synthetic phosphorylation signaling networks in human cells, enabling fast, reversible, dynamic responses and paving the way for next-gen biosensors and smart cell therapy! https://t.co/ft1912vPek
    view full post

    January 3, 2025

    3

  • Nathan Zhou
    @91_naynay (Twitter)

    RT @idmjky: Really excited to share this synthetic phosphorylation piece out @ScienceMagazine. We present design rules for engineering synt…
    view full post

    January 3, 2025

    35

  • Banana Pepper
    @Cortcort_93 (Twitter)

    RT @idmjky: Really excited to share this synthetic phosphorylation piece out @ScienceMagazine. We present design rules for engineering synt…
    view full post

    January 3, 2025

    35

  • Murcent
    @murcent (Twitter)

    RT @idmjky: Really excited to share this synthetic phosphorylation piece out @ScienceMagazine. We present design rules for engineering synt…
    view full post

    January 3, 2025

    35

  • Dæmon
    @Sniper137_ (Twitter)

    RT @idmjky: Really excited to share this synthetic phosphorylation piece out @ScienceMagazine. We present design rules for engineering synt…
    view full post

    January 3, 2025

    35

  • Science Magazine
    @ScienceMagazine (Twitter)

    RT @idmjky: Really excited to share this synthetic phosphorylation piece out @ScienceMagazine. We present design rules for engineering synt…
    view full post

    January 3, 2025

    35

  • 以羅利亚
    @inoriaaaa (Twitter)

    RT @ShorterLab: Engineering synthetic phosphorylation signaling networks in human cells | Science https://t.co/8pJ9FWaQE9
    view full post

    January 3, 2025

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  • Krai Andrey
    @back4ffff (Twitter)

    RT @ShorterLab: Engineering synthetic phosphorylation signaling networks in human cells | Science https://t.co/8pJ9FWaQE9
    view full post

    January 3, 2025

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  • Raymond
    @raymzyu (Twitter)

    RT @ShorterLab: Engineering synthetic phosphorylation signaling networks in human cells | Science https://t.co/8pJ9FWaQE9
    view full post

    January 3, 2025

    18

  • Danve Castroverde
    @DanveC (Twitter)

    RT @idmjky: Really excited to share this synthetic phosphorylation piece out @ScienceMagazine. We present design rules for engineering synt…
    view full post

    January 3, 2025

    35

  • SNZK
    @shinopp (Twitter)

    RT @jyasuda1: よくわかっていないが、ヒトT細胞の機能を、TNF-αによって制御可能なタンパク質リン酸化カスケード（キナーゼから基質である機能分子まで）を人為的にデザイン、稼働させることに成功したという論文のようだ。Science誌。 https://t.co/VR…
    view full post

    January 3, 2025

    6

  • Jason Lequyer
    @LequyerJason (Twitter)

    RT @idmjky: Really excited to share this synthetic phosphorylation piece out @ScienceMagazine. We present design rules for engineering synt…
    view full post

    January 3, 2025

    35

  • usshy
    @masa_ushio (Twitter)

    RT @jyasuda1: よくわかっていないが、ヒトT細胞の機能を、TNF-αによって制御可能なタンパク質リン酸化カスケード（キナーゼから基質である機能分子まで）を人為的にデザイン、稼働させることに成功したという論文のようだ。Science誌。 https://t.co/VR…
    view full post

    January 3, 2025

    6

  • Timofey Lebedev
    @Timofey_LTD (Twitter)

    RT @ShorterLab: Engineering synthetic phosphorylation signaling networks in human cells | Science https://t.co/8pJ9FWaQE9
    view full post

    January 3, 2025

    18

  • Chris Carter
    @fintechcyb (Twitter)

    RT @SLemaire75: Engineering synthetic phosphorylation signaling networks in human cells | Science https://t.co/sCKUipOBQ1
    view full post

    January 3, 2025

    2

  • Jason Yim ✈️ NeurIPS 2025
    @json_yim (Twitter)

    RT @idmjky: Really excited to share this synthetic phosphorylation piece out @ScienceMagazine. We present design rules for engineering synt…
    view full post

    January 3, 2025

    35

  • まる
    @standardtherap (Twitter)

    RT @jyasuda1: よくわかっていないが、ヒトT細胞の機能を、TNF-αによって制御可能なタンパク質リン酸化カスケード（キナーゼから基質である機能分子まで）を人為的にデザイン、稼働させることに成功したという論文のようだ。Science誌。 https://t.co/VR…
    view full post

    January 3, 2025

    6

  • Olivier Borkowski
    @O_Borkowski (Twitter)

    RT @SLemaire75: Engineering synthetic phosphorylation signaling networks in human cells | Science https://t.co/sCKUipOBQ1
    view full post

    January 3, 2025

    2

  • 綿¹⁰⁰%
    @LSRFortessa_X20 (Twitter)

    RT @jyasuda1: よくわかっていないが、ヒトT細胞の機能を、TNF-αによって制御可能なタンパク質リン酸化カスケード（キナーゼから基質である機能分子まで）を人為的にデザイン、稼働させることに成功したという論文のようだ。Science誌。 https://t.co/VR…
    view full post

    January 3, 2025

    6

  • Ｊｕｎ　Ｙａｓｕｄａ
    @jyasuda1 (Twitter)

    よくわかっていないが、ヒトT細胞の機能を、TNF-αによって制御可能なタンパク質リン酸化カスケード（キナーゼから基質である機能分子まで）を人為的にデザイン、稼働させることに成功したという論文のようだ。Science誌。 https://t.co/VRTdP3HTAs
    view full post

    January 3, 2025

    55

    6

  • Walid Zahra
    @SciFi_Genetics (Twitter)

    RT @ShorterLab: Engineering synthetic phosphorylation signaling networks in human cells | Science https://t.co/8pJ9FWaQE9
    view full post

    January 3, 2025

    18

  • maroon
    @cat_maroon (Twitter)

    RT @idmjky: Really excited to share this synthetic phosphorylation piece out @ScienceMagazine. We present design rules for engineering synt…
    view full post

    January 3, 2025

    35

  • Yuta Aoki, D.Sc.
    @YutaMAoki (Twitter)

    RT @idmjky: Really excited to share this synthetic phosphorylation piece out @ScienceMagazine. We present design rules for engineering synt…
    view full post

    January 3, 2025

    35

  • Leo Liu
    @leonardliu88 (Twitter)

    RT @idmjky: Really excited to share this synthetic phosphorylation piece out @ScienceMagazine. We present design rules for engineering synt…
    view full post

    January 3, 2025

    35

  • IntoWild
    @euvlook (Twitter)

    RT @idmjky: Really excited to share this synthetic phosphorylation piece out @ScienceMagazine. We present design rules for engineering synt…
    view full post

    January 3, 2025

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  • Indranil Singh
    @cancer_curious (Twitter)

    RT @idmjky: Really excited to share this synthetic phosphorylation piece out @ScienceMagazine. We present design rules for engineering synt…
    view full post

    January 3, 2025

    35

  • Tyler Inskeep (they/them)
    @trinskeep (Twitter)

    RT @idmjky: Really excited to share this synthetic phosphorylation piece out @ScienceMagazine. We present design rules for engineering synt…
    view full post

    January 3, 2025

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  • Matt Jones
    @MattG_Jones (Twitter)

    RT @idmjky: Really excited to share this synthetic phosphorylation piece out @ScienceMagazine. We present design rules for engineering synt…
    view full post

    January 3, 2025

    35

  • Naveen Jain
    @uffdaALLberries (Twitter)

    RT @idmjky: Really excited to share this synthetic phosphorylation piece out @ScienceMagazine. We present design rules for engineering synt…
    view full post

    January 2, 2025

    35

  • Manish Kushwaha @manishmicrobe.bsky.social
    @manishmicrobe (Twitter)

    RT @Moon_Synth_Bio: Great work by @BashorLab in @ScienceMagazine https://t.co/UilQz6mGy4
    view full post

    January 2, 2025

    4

  • Daniel S.
    @asecretcrow (Twitter)

    RT @idmjky: Really excited to share this synthetic phosphorylation piece out @ScienceMagazine. We present design rules for engineering synt…
    view full post

    January 2, 2025

    35

  • Lavanya Karinje
    @LavanyaKarinje (Twitter)

    RT @idmjky: Really excited to share this synthetic phosphorylation piece out @ScienceMagazine. We present design rules for engineering synt…
    view full post

    January 2, 2025

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  • Wafik S. El-Deiry, MD, PhD, FACP
    @weldeiry.bsky.social (Bluesky)

    Engineering synthetic phosphorylation signaling networks in human cells “in human T cells, such a circuit could sense tumor necrosis factor–α and maintain controlled cytokine secretion” www.science.org/doi/10.1126/...
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    January 2, 2025

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  • Wafik S. El-Deiry, MD, PhD, FACP
    @weldeiry (Twitter)

    Engineering synthetic phosphorylation signaling networks in human cells “in human T cells, such a circuit could sense tumor necrosis factor–α and maintain controlled cytokine secretion” https://t.co/9D1LooTi5p
    view full post

    January 2, 2025

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  • AngryPhDstudent❗️❗️❗️
    @ONNESHA092 (Twitter)

    RT @idmjky: Really excited to share this synthetic phosphorylation piece out @ScienceMagazine. We present design rules for engineering synt…
    view full post

    January 2, 2025

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  • Tomasz Grzywa, MD, PhD
    @drtomaszgrzywa (Twitter)

    RT @idmjky: Really excited to share this synthetic phosphorylation piece out @ScienceMagazine. We present design rules for engineering synt…
    view full post

    January 2, 2025

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  • Stéphane Lemaire
    @SLemaire75 (Twitter)

    Engineering synthetic phosphorylation signaling networks in human cells | Science https://t.co/sCKUipOBQ1
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    January 2, 2025

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  • Hugo Almarza Salazar
    @HugoAlmarza (Twitter)

    RT @ShorterLab: Engineering synthetic phosphorylation signaling networks in human cells | Science https://t.co/8pJ9FWaQE9
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    January 2, 2025

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  • dpu29
    @dpu29 (Twitter)

    RT @idmjky: Really excited to share this synthetic phosphorylation piece out @ScienceMagazine. We present design rules for engineering synt…
    view full post

    January 2, 2025

    35

  • Xiaoyu Yang
    @XiaoyuYang6 (Twitter)

    RT @MoKhalilLab:
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    January 2, 2025

    4

  • Waggoner Lab
    @LabWaggoner (Twitter)

    RT @ShorterLab: Engineering synthetic phosphorylation signaling networks in human cells | Science https://t.co/8pJ9FWaQE9
    view full post

    January 2, 2025

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  • Dr. Geo (Michel Geovanni Santiago-Martínez, PhD)
    @GeoSantiagoM (Twitter)

    RT @ShorterLab: Engineering synthetic phosphorylation signaling networks in human cells | Science https://t.co/8pJ9FWaQE9
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    January 2, 2025

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  • Mo Khalil
    @MoKhalilLab (Twitter)


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  • Mukshud
    @Mukshud (Twitter)

    RT @idmjky: Really excited to share this synthetic phosphorylation piece out @ScienceMagazine. We present design rules for engineering synt…
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    January 2, 2025

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  • Ahmed Abogosh
    @AhmedAbogosh (Twitter)

    RT @idmjky: Really excited to share this synthetic phosphorylation piece out @ScienceMagazine. We present design rules for engineering synt…
    view full post

    January 2, 2025

    35

  • サグリオ
    @sagurio24 (Twitter)

    RT @iPatho1: ヒト細胞内で、さまざまなタンパク質ドメインを組み合わせて、キナーゼ、基質、リン酸化依存性の相互作用ドメインを設計し、外部からのシグナルを感知・増幅して導入遺伝子の発現を活性化する合成回路を人工的に作り上げた論文がScience誌に発表されました。 ht…
    view full post

    January 2, 2025

    3

  • Meg T (she/her/hers)
    @megthescientist (Twitter)

    RT @idmjky: Really excited to share this synthetic phosphorylation piece out @ScienceMagazine. We present design rules for engineering synt…
    view full post

    January 2, 2025

    35

  • 谷口研究室（北海道大学医学部 統合病理学教室）
    @iPatho1 (Twitter)

    ヒト細胞内で、さまざまなタンパク質ドメインを組み合わせて、キナーゼ、基質、リン酸化依存性の相互作用ドメインを設計し、外部からのシグナルを感知・増幅して導入遺伝子の発現を活性化する合成回路を人工的に作り上げた論文がScience誌に発表されました。 https://t.co/tXzUO8UaOC
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    January 2, 2025

    19

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  • priya joseph
    @ayirpelle (Twitter)

    RT @idmjky: Really excited to share this synthetic phosphorylation piece out @ScienceMagazine. We present design rules for engineering synt…
    view full post

    January 2, 2025

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  • priya joseph
    @ayirpelle (Twitter)

    RT @ShorterLab: Engineering synthetic phosphorylation signaling networks in human cells | Science https://t.co/8pJ9FWaQE9
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    January 2, 2025

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  • Rio Sugimura
    @rio_sugimura (Twitter)

    RT @idmjky: Really excited to share this synthetic phosphorylation piece out @ScienceMagazine. We present design rules for engineering synt…
    view full post

    January 2, 2025

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  • Rio Sugimura
    @rio_sugimura (Twitter)

    RT @Moon_Synth_Bio: Great work by @BashorLab in @ScienceMagazine https://t.co/UilQz6mGy4
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    January 2, 2025

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  • Qi Tang
    @QiTang18 (Twitter)

    RT @idmjky: Really excited to share this synthetic phosphorylation piece out @ScienceMagazine. We present design rules for engineering synt…
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    January 2, 2025

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  • adeliebiology
    @adeliebiology (Twitter)

    RT @idmjky: Really excited to share this synthetic phosphorylation piece out @ScienceMagazine. We present design rules for engineering synt…
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    January 2, 2025

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  • Steve Kay
    @DrSteveKay (Twitter)

    RT @Moon_Synth_Bio: Great work by @BashorLab in @ScienceMagazine https://t.co/UilQz6mGy4
    view full post

    January 2, 2025

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  • Shinsuke Segawa (Maitotoxin)
    @MaitotoxicPhD (Twitter)

    RT @Moon_Synth_Bio: Great work by @BashorLab in @ScienceMagazine https://t.co/UilQz6mGy4
    view full post

    January 2, 2025

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  • Tae Seok Moon
    @Moon_Synth_Bio (Twitter)

    Great work by @BashorLab in @ScienceMagazine https://t.co/UilQz6mGy4
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    January 2, 2025

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  • Siliang Li
    @SiliangLi3 (Twitter)

    RT @idmjky: Really excited to share this synthetic phosphorylation piece out @ScienceMagazine. We present design rules for engineering synt…
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    January 2, 2025

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  • Jonathan Gootenberg
    @jgooten (Twitter)

    RT @idmjky: Really excited to share this synthetic phosphorylation piece out @ScienceMagazine. We present design rules for engineering synt…
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Abstract Synopsis

  • This research focuses on creating artificial phosphorylation networks in human cells using modular protein parts, allowing precise control over cellular responses to environmental signals.
  • The engineered circuits can be connected to cell surface receptors for rapid detection of external signals and can influence gene expression to control cell behavior.
  • The approach was applied to develop cytokine controllers that can detect and suppress activated T cells, demonstrating potential for customizable biosensing and therapeutic uses.]