The group's discussions are characterized by enthusiastic support, with posts praising the development of synthetic phosphorylation circuits and proposing applications like targeted cell therapy. Words like 'excited', 'great work', and phrases such as 'design rules for engineering' reveal a tone of admiration and anticipation, indicating a community that values the scientific advances and their potential real-world impacts.
AgreementModerate agreement
Most discussions express support and enthusiasm for the research, emphasizing its innovative aspects and potential applications.
InterestHigh interest
The discussions demonstrate a high level of curiosity and engagement with the topic, often highlighting specific advancements and implications.
EngagementHigh engagement
Posts reference detailed aspects of the research, such as design rules and potential for cell therapy, indicating deep involvement.
ImpactModerate impact
The excitement about the research's transformative potential suggests it could significantly influence future biomedical engineering efforts, though some acknowledge it's early-stage.
Abstract in brief
This research focuses on creating artificial phosphorylation networks in human cells using modular protein parts, allowing precise control over cellular responses to environmental signals.
The engineered circuits can be connected to cell surface receptors for rapid detection of external signals and can influence gene expression to control cell behavior.
The approach was applied to develop cytokine controllers that can detect and suppress activated T cells, demonstrating potential for customizable biosensing and therapeutic uses.]
Really excited to share this synthetic phosphorylation piece out @ScienceMagazine. We present design rules for engineering synthetic phosphorylation circuits and its application in engineering cell therapy.
https://t.co/QZLNqELc4e
Jan 2, 2025 · 169 likes · 35 shares · 861 followersView post →
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ShorterLab
@ShorterLab · X
Engineering synthetic phosphorylation signaling networks in human cells | Science https://t.co/8pJ9FWaQE9
Jan 2, 2025 · 70 likes · 18 shares · 12,241 followersView post →
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The first issue of 2025 includes fascinating #syntheticbiology work showing engineering synthetic phosphorylation signaling networks in human cells @science.org
Let us keep making discoveries and innovations, showing the power of science for a better world!
Excited to see @BashorLab's work in @ScienceMagazine! This paper presents a framework for engineering synthetic phosphorylation signaling networks in human cells, enabling fast, reversible, dynamic responses and paving the way for next-gen biosensors and smart cell therapy! https://t.co/ft1912vPek
Engineering synthetic phosphorylation signaling networks in human cells
“in human T cells, such a circuit could sense tumor necrosis factor–α and maintain controlled cytokine secretion”
www.science.org/doi/10.1126/...
Engineering synthetic phosphorylation signaling networks in human cells
“in human T cells, such a circuit could sense tumor necrosis factor–α and maintain controlled cytokine secretion”
https://t.co/9D1LooTi5p
Jan 2, 2025 · 2 likes · 18,656 followersView post →
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AngryPhDstudent❗️❗️❗️
@ONNESHA092 · X
RT @idmjky: Really excited to share this synthetic phosphorylation piece out @ScienceMagazine. We present design rules for engineering synt…
Jan 2, 2025 · 35 shares · 196 followersView post →
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Tomasz Grzywa, MD, PhD
@drtomaszgrzywa · X
RT @idmjky: Really excited to share this synthetic phosphorylation piece out @ScienceMagazine. We present design rules for engineering synt…
Jan 2, 2025 · 35 shares · 382 followersView post →
SL
Stéphane Lemaire
@SLemaire75 · X
Engineering synthetic phosphorylation signaling networks in human cells | Science https://t.co/sCKUipOBQ1
Jan 2, 2025 · 6 likes · 2 shares · 894 followersView post →
HS
Hugo Almarza Salazar
@HugoAlmarza · X
RT @ShorterLab: Engineering synthetic phosphorylation signaling networks in human cells | Science https://t.co/8pJ9FWaQE9
Jan 2, 2025 · 18 shares · 6,919 followersView post →
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dpu29
@dpu29 · X
RT @idmjky: Really excited to share this synthetic phosphorylation piece out @ScienceMagazine. We present design rules for engineering synt…
RT @Moon_Synth_Bio: Great work by @BashorLab in @ScienceMagazine
https://t.co/UilQz6mGy4
Jan 2, 2025 · 4 shares · 1,492 followersView post →
SM
Shinsuke Segawa (Maitotoxin)
@MaitotoxicPhD · X
RT @Moon_Synth_Bio: Great work by @BashorLab in @ScienceMagazine
https://t.co/UilQz6mGy4
Jan 2, 2025 · 4 shares · 1,127 followersView post →
TM
Tae Seok Moon
@Moon_Synth_Bio · X
Great work by @BashorLab in @ScienceMagazine
https://t.co/UilQz6mGy4
Jan 2, 2025 · 15 likes · 4 shares · 6,792 followersView post →
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Siliang Li
@SiliangLi3 · X
RT @idmjky: Really excited to share this synthetic phosphorylation piece out @ScienceMagazine. We present design rules for engineering synt…
Jan 2, 2025 · 35 shares · 267 followersView post →
JG
Jonathan Gootenberg
@jgooten · X
RT @idmjky: Really excited to share this synthetic phosphorylation piece out @ScienceMagazine. We present design rules for engineering synt…
Jan 2, 2025 · 35 shares · 5,220 followersView post →
MD
Margaret S. Cheung Ph.D.
@MARGARETSCHEUNG · X
RT @ShorterLab: Engineering synthetic phosphorylation signaling networks in human cells | Science https://t.co/8pJ9FWaQE9
Jan 2, 2025 · 18 shares · 897 followersView post →
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a
@ayanosatoh · X
RT @ShorterLab: Engineering synthetic phosphorylation signaling networks in human cells | Science https://t.co/8pJ9FWaQE9
Jan 2, 2025 · 18 shares · 624 followersView post →
KJ
Kaiyi Jiang
@idmjky · X
Really excited to share this synthetic phosphorylation piece out @ScienceMagazine. We present design rules for engineering synthetic phosphorylation circuits and its application in engineering cell therapy.
https://t.co/QZLNqELc4e
Jan 2, 2025 · 169 likes · 35 shares · 861 followersView post →
KD
Kyle G Daniels
@ScienceKyle · X
RT @ShorterLab: Engineering synthetic phosphorylation signaling networks in human cells | Science https://t.co/8pJ9FWaQE9
Jan 2, 2025 · 18 shares · 2,468 followersView post →
FM
Frank Paul Mora
@InTime_49 · X
RT @ShorterLab: Engineering synthetic phosphorylation signaling networks in human cells | Science https://t.co/8pJ9FWaQE9
Jan 2, 2025 · 18 shares · 429 followersView post →
AE
Ahmed Ezat
@AhmedAdelEzat · X
RT @ShorterLab: Engineering synthetic phosphorylation signaling networks in human cells | Science https://t.co/8pJ9FWaQE9
science.org/doi/10.1126/science.adm8485 and NSF GRFP award 1842494 (A.J.W.). Author contributions: available in the manuscript or supplementary materials ...
Engineering synthetic phosphorylation signaling networks in human ...
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