bioRxiv April 2025 PMID 39990504

Impact of protein degradation and cell growth on mammalian proteomes.

Andrew Leduc, Shanshan Zheng, Purvi Saxena, Nikolai Slavov

Full text PDF Download social card

Mentions

Peak: 6 in Aug 2025

across 2 sources since Mar 2025

Extended reach

96,612

potential audience

Total likes

Video views

1,002

Mentions per month

Mar 2025 – Aug 2025

Where it's discussed

X / Twitter9 posts
YouTube2 videos

AI synopsis

What people are saying

The discussions highlight the importance of protein interactions and degradation, with mentions of protein complexes and their role in abundance regulation, using language that reflects a general interest but not profound enthusiasm or disagreement about the study's implications.

AgreementNeither agree nor disagree

The discussions acknowledge key findings like protein interactions and degradation as important factors, but lack strong consensus or disagreement.

InterestModerate interest

Posts show some curiosity, especially around protein complexes and degradation, though the overall engagement is modest.

EngagementModerate engagement

Participants touch on various aspects of the research, indicating a basic level of engagement without deep analysis.

ImpactModerate impact

The discussions recognize the significance of proteomic regulation, but do not explicitly convey a sense of transformative impact.

Abstract in brief

The study shows that cell growth and protein degradation significantly influence the concentration of proteins in cells, with growth-dependent dilution explaining around 40% of changes in protein levels under different conditions.
Protein degradation rates vary widely between different forms of the same protein, especially in the brain, and can account for up to 50% of protein level differences in slowly growing cells.
These findings suggest that understanding protein degradation and cell growth is crucial for explaining how protein levels are regulated across various cell types and tissues, especially in slow-growing cells like those in the brain.]

Read the full abstract

All mentions

Single Cell Quantification of Gene Expression in Mammalian Tissue

This presentation discusses how cell growth and protein degradation influence protein levels in mammalian tissues, highlighting the importance of these factors in gene expression regulation across different cell types…

Nikolai Slavov · Jun 10, 2025 530 views

Advancements in Single-Cell Proteomics Research

This presentation by Prof. Nikolai Slavov explores technological and biological advancements in single-cell proteomics, focusing on the implications of protein variation for biological functions. Conducted at…

Nikolai Slavov · Jul 16, 2025 473 views

Pavlos Msaouel

@PavlosMsaouel · X