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Neuron July 2025 PMID 40381615

Distinct systemic impacts of Aβ42 and Tau revealed by whole-organism snRNA-seq.

Ye-Jin Park, Tzu-Chiao Lu, Tyler Jackson, Lindsey D Goodman, Lindsey Ran, Jiaye Chen, Chung-Yi Liang, Erin Harrison, Christina Ko, Xi Chen, Baiping Wang, Ao-Lin Hsu, Elizabeth Ochoa, Kevin F Bieniek, Shinya Yamamoto

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Mentions

59
Peak: 18 in May 2025
across 6 sources since May 2025

Extended reach

695,721
potential audience

Total likes

89

Video views

35

Mentions per month

May 2025 – Jul 2025

Where it's discussed

  • X / Twitter25 posts
  • News23 articles
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  • YouTube2 videos
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  • Bluesky1 posts

AI synopsis

What people are saying

Discussions reflect high interest and perceived importance through phrases like 'new understanding' and '#science', while some posts express enthusiasm about its implications for treatment and research, showing a deep engagement with the topic and recognizing the study's broad impact in the field of neurodegeneration and systemic effects.

AgreementModerate

Most discussions acknowledge the significance of the research, emphasizing the distinct impacts of Aβ42 and Tau, and some highlight its relevance to understanding Alzheimer's disease.

InterestHigh

The posts show high interest, with many describing the study as groundbreaking or important for advancing knowledge about neurodegeneration.

EngagementModerate

Posts demonstrate moderate to deep engagement by mentioning specific aspects like systemic impacts, the method used, and cross-species findings, indicating thoughtful consideration.

ImpactHigh

The overall sentiment suggests that users view this research as potentially transformative, with words such as 'understanding' and 'breakthrough' highlighting its significance.

Abstract in brief

  • Research on Alzheimer's disease (AD) using Drosophila (fruit flies) created an AD Fly Cell Atlas (AD-FCA) that maps how AD impacts various tissues throughout the body.
  • Aβ42 primarily disrupts the nervous system, particularly sensory neurons, while Tau is linked to accelerated aging in peripheral tissues.
  • The study uncovers a specific neuronal cluster with high lactate dehydrogenase (LDH) expression, which is also found in mice and humans with AD, indicating a common defect in fat metabolism across species and enhancing understanding of brain-body interactions in neurodegeneration.
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ShorterLab
@ShorterLab · X

Distinct systemic impacts of Aβ42 and Tau revealed by whole-organism snRNA-seq: Neuron https://t.co/M61dAyr7TX

Jul 9, 2025 · 32 likes · 8 shares · 12,042 followers View post →
Neuron
@NeuroCellPress · X

Online now: Distinct systemic impacts of Aβ42 and Tau revealed by whole-organism snRNA-seq https://t.co/I4ddVM9emc https://t.co/oORRPl2jbt

May 16, 2025 · 22 likes · 4 shares · 146,837 followers View post →
ShorterLab
@ShorterLab · X

Distinct systemic impacts of Aβ42 and Tau revealed by whole-organism snRNA-seq: Neuron https://t.co/M61dAyrFJv

May 21, 2025 · 15 likes · 5 shares · 12,042 followers View post →
Neuroscience News
@NeuroscienceNew · X

“Distinct systemic impacts of Aβ42 and Tau revealed by whole-organism snRNA-seq” by Hongjie Li et al. Neuron https://t.co/kHdShDosgq

May 17, 2025 · 14 likes · 2 shares · 505,458 followers View post →
Ventura's Lab
@PPMC_UAB · X

Distinct systemic impacts of Aβ42 and Tau revealed by whole-organism snRNA-seq: Neuron https://t.co/K4UxM5VyXT

May 26, 2025 · 3 likes · 2,174 followers View post →
Ventura's Lab
@PPMC_UAB · X

Distinct systemic impacts of Aβ42 and Tau revealed by whole-organism snRNA-seq: Neuron https://t.co/K4UxM5VyXT

Jul 11, 2025 · 2 likes · 2,174 followers View post →

All mentions

Ventura's Lab
@PPMC_UAB · X

Distinct systemic impacts of Aβ42 and Tau revealed by whole-organism snRNA-seq: Neuron https://t.co/K4UxM5VyXT

Jul 11, 2025 · 2 likes · 2,174 followers View post →
Charles Jourdan Reyes, Ph.D.
@reyes_jourdan · X

RT @ShorterLab: Distinct systemic impacts of Aβ42 and Tau revealed by whole-organism snRNA-seq: Neuron https://t.co/M61dAyr7TX

Jul 10, 2025 · 8 shares · 625 followers View post →
Hugo Almarza Salazar
@HugoAlmarza · X

RT @ShorterLab: Distinct systemic impacts of Aβ42 and Tau revealed by whole-organism snRNA-seq: Neuron https://t.co/M61dAyr7TX

Jul 10, 2025 · 8 shares · 6,825 followers View post →
nike
@wot_mikey · X

RT @ShorterLab: Distinct systemic impacts of Aβ42 and Tau revealed by whole-organism snRNA-seq: Neuron https://t.co/M61dAyr7TX

Jul 9, 2025 · 8 shares · 469 followers View post →
David Mawutor Donkor
@DavidMawutor01 · X

RT @ShorterLab: Distinct systemic impacts of Aβ42 and Tau revealed by whole-organism snRNA-seq: Neuron https://t.co/M61dAyr7TX

Jul 9, 2025 · 8 shares · 160 followers View post →
Xiaojing Sui
@Xiaojing_Sui · X

RT @ShorterLab: Distinct systemic impacts of Aβ42 and Tau revealed by whole-organism snRNA-seq: Neuron https://t.co/M61dAyr7TX

Jul 9, 2025 · 8 shares · 453 followers View post →
Ahmed Ezat
@AhmedAdelEzat · X

RT @ShorterLab: Distinct systemic impacts of Aβ42 and Tau revealed by whole-organism snRNA-seq: Neuron https://t.co/M61dAyr7TX

Jul 9, 2025 · 8 shares · 86 followers View post →
ShorterLab
@ShorterLab · X

Distinct systemic impacts of Aβ42 and Tau revealed by whole-organism snRNA-seq: Neuron https://t.co/M61dAyr7TX

Jul 9, 2025 · 32 likes · 8 shares · 12,042 followers View post →
Raquel
@raquelrita88 · X

The science of dementia will only truly advance when it finally reconnects the brain to the body. The reductionist "brain-body" reasoning needs to go! https://t.co/Zjd3ZsgXWH

Jun 5, 2025 · 93 followers View post →
yo_ful
@Yoshifull1 · X

RT @NeuroCellPress: Online now: Distinct systemic impacts of Aβ42 and Tau revealed by whole-organism snRNA-seq https://t.co/I4ddVM9emc htt…

May 28, 2025 · 4 shares · 17 followers View post →
Ventura's Lab
@PPMC_UAB · X

Distinct systemic impacts of Aβ42 and Tau revealed by whole-organism snRNA-seq: Neuron https://t.co/K4UxM5VyXT

May 26, 2025 · 3 likes · 2,174 followers View post →
Nicholas Sweeney
@NickSweeney23 · X

RT @ShorterLab: Distinct systemic impacts of Aβ42 and Tau revealed by whole-organism snRNA-seq: Neuron https://t.co/M61dAyrFJv

May 22, 2025 · 5 shares · 19 followers View post →
Pritam Mukherjee
@PritamM__ · X

RT @ShorterLab: Distinct systemic impacts of Aβ42 and Tau revealed by whole-organism snRNA-seq: Neuron https://t.co/M61dAyrFJv

May 22, 2025 · 5 shares · 368 followers View post →
Xiaojing Sui
@Xiaojing_Sui · X

RT @ShorterLab: Distinct systemic impacts of Aβ42 and Tau revealed by whole-organism snRNA-seq: Neuron https://t.co/M61dAyrFJv

May 22, 2025 · 5 shares · 453 followers View post →
ShorterLab
@ShorterLab · X

Distinct systemic impacts of Aβ42 and Tau revealed by whole-organism snRNA-seq: Neuron https://t.co/M61dAyrFJv

May 21, 2025 · 15 likes · 5 shares · 12,042 followers View post →
Life Science Journal Content
@lsn_jc · X

Distinct systemic impacts of Aβ42 and Tau revealed by whole-organism snRNA-seq #science #publication #research #journal https://t.co/v4GKSSNVIy

May 19, 2025 · 265 followers View post →
Rostyslav Pulsar
@LvivPulsar · X

RT @NeuroscienceNew: “Distinct systemic impacts of Aβ42 and Tau revealed by whole-organism snRNA-seq” by Hongjie Li et al. Neuron https://…

May 19, 2025 · 2 shares · 235 followers View post →
Hongjie Li
@HongjieLi5 · X

RT @IcahnCMIN: Working w/ laboratory fruit fly, researchers Ye-Jin Park, Hugo Bellen, @HongjieLi5, et al. provide new understanding of how…

May 18, 2025 · 1 share · 1,132 followers View post →
CMIN
@IcahnCMIN · X

Working w/ laboratory fruit fly, researchers Ye-Jin Park, Hugo Bellen, @HongjieLi5, et al. provide new understanding of how #AlzheimersDisease affects different tissues across entire body. @NeuroCellPress https://t.co/zeyYq0ca5D Overview @NeuroscienceNew https://t.co/qghIPMMP9M

May 18, 2025 · 1 like · 1 share · 851 followers View post →
fly paper broadcast
@fly-broadcast.bsky.social · Bluesky

Distinct systemic impacts of Aβ42 and Tau revealed by whole-organism snRNA-seq #Drosophila

May 18, 2025 View post →
Gisela
@GiselaParraG · X

RT @NeuroCellPress: Online now: Distinct systemic impacts of Aβ42 and Tau revealed by whole-organism snRNA-seq https://t.co/I4ddVM9emc htt…

May 18, 2025 · 4 shares · 46 followers View post →
GhostsofHistorysPast
@Ghostof1896 · X

RT @NeuroscienceNew: “Distinct systemic impacts of Aβ42 and Tau revealed by whole-organism snRNA-seq” by Hongjie Li et al. Neuron https://…

May 17, 2025 · 2 shares · 2,534 followers View post →
Neuroscience News
@NeuroscienceNew · X

“Distinct systemic impacts of Aβ42 and Tau revealed by whole-organism snRNA-seq” by Hongjie Li et al. Neuron https://t.co/kHdShDosgq

May 17, 2025 · 14 likes · 2 shares · 505,458 followers View post →
Tzu-Chiao Lu
@TzuChiaoLu · X

RT @NeuroCellPress: Online now: Distinct systemic impacts of Aβ42 and Tau revealed by whole-organism snRNA-seq https://t.co/I4ddVM9emc htt…

May 16, 2025 · 4 shares · 105 followers View post →
Ye-Jin Park
@YeJin_YeahGene · X

RT @NeuroCellPress: Online now: Distinct systemic impacts of Aβ42 and Tau revealed by whole-organism snRNA-seq https://t.co/I4ddVM9emc htt…

May 16, 2025 · 4 shares · 16 followers View post →
Neuron
@NeuroCellPress · X

Online now: Distinct systemic impacts of Aβ42 and Tau revealed by whole-organism snRNA-seq https://t.co/I4ddVM9emc https://t.co/oORRPl2jbt

May 16, 2025 · 22 likes · 4 shares · 146,837 followers View post →