Publications by authors named "Aaron Fullerton"

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The OASIS Consortium: integrating multi-omics technologies to transform chemical safety assessment.
David Rouquié, Andreas Bender, Jaime Cheah, Christine E Crute, Deidre Dalmas, Aaron Fullerton

Toxicol Sci· December 2025

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Autologous Organoid-T Cell Co-Culture Platform for Modeling of Immune-Mediated Drug-Induced Liver Injury.
Fadoua El Abdellaoui Soussi, Michael Brusilovsky, Emma Buck, W Clark Bacon, Sina Dadgar, Aaron Fullerton

Adv Sci (Weinh)· November 2025

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Analysis of Multiplexed Flow Cytometric Assays and Toxicogenomic Signatures for Genotoxicity Prediction: A Model Performance and Case Study Approach.
Tomás Lagunas, Fjodor Melnikov, Gabby Cole, Steve Niu, Estefania Esparza, Aaron Fullerton

Environ Mol Mutagen· August 2025

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Elucidating Molecular Mechanisms of Drug-Induced Hepatotoxicity of Lapatinib.
Qinying Yu, Li Ma, Leah M Norona, Peter S Dragovich, Jianshuang Wang, Aaron Fullerton

J Med Chem· August 2025

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Projecting individualized probabilities of lifetime all-cancer risk.
Neel M Butala, Noor Al-Hammadi, Asiri Ediriwickrema, Jaime L Schneider, Aaron Fullerton

medRxiv· July 2025

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The differentiation state of small intestinal organoid models influences prediction of drug-induced toxicity.
Jessica A Klein, Julia D Heidmann, Tomomi Kiyota, Aaron Fullerton, Kimberly A Homan

Front Cell Dev Biol· January 2025

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Towards in vitro models for reducing or replacing the use of animals in drug testing.
David M Stresser, Anna K Kopec, Philip Hewitt, Rhiannon N Hardwick, Terry R Van Vleet, Aaron Fullerton

Nat Biomed Eng· August 2024

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Complexmodels positioned for impact to drug testing in pharma: a review.
Serah Kang, Eugene C Chen, Helen Cifuentes, Julia Y Co, Gabrielle Cole, Aaron M Fullerton

Biofabrication· August 2024

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Discovery of TRPA1 Antagonist : Derisking Preclinical Toxicity and Aldehyde Oxidase Metabolism with a Potential First-in-Class Therapy for Respiratory Disease.
Jack A Terrett, Justin Q Ly, Paula Katavolos, Catrin Hasselgren, Steven Laing, Aaron Fullerton

J Med Chem· March 2024

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A BCMA/CD16A bispecific innate cell engager for the treatment of multiple myeloma.
Satoko Kakiuchi-Kiyota, Thorsten Ross, Heidi Ackerly Wallweber, James R Kiefer, Melissa M Schutten, Aaron Fullerton

Leukemia· April 2022

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Perspectives on the evaluation and adoption of complex in vitro models in drug development: Workshop with the FDA and the pharmaceutical industry (IQ MPS Affiliate).
Szczepan W Baran, Paul C Brown, Andreas R Baudy, Suzanne C Fitzpatrick, Christopher Frantz, Aaron Fullerton

ALTEX· April 2022

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Antibody-Mediated Delivery of Chimeric BRD4 Degraders. Part 2: Improvement of In Vitro Antiproliferation Activity and In Vivo Antitumor Efficacy.
Peter S Dragovich, Thomas H Pillow, Robert A Blake, Jack D Sadowsky, Emel Adaligil, Aaron Fullerton

J Med Chem· March 2021

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In vitro assessment of farnesoid X receptor antagonism to predict drug-induced liver injury risk.
Leah M Norona, Aaron Fullerton, Chris Lawson, Leslie Leung, Jochen Brumm

Arch Toxicol· September 2020

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An in vitro quantitative systems pharmacology approach for deconvolving mechanisms of drug-induced, multilineage cytopenias.
Jennifer L Wilson, Dan Lu, Nick Corr, Aaron Fullerton, James Lu

PLoS Comput Biol· July 2020

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Application of microphysiological systems in biopharmaceutical research and development.
Norman C Peterson, Prathap Kumar Mahalingaiah, Aaron Fullerton, Matteo Di Piazza

Lab Chip· February 2020

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General Principles for the Validation of Proarrhythmia Risk Prediction Models: An Extension of the CiPA In Silico Strategy.
Zhihua Li, Gary R Mirams, Takashi Yoshinaga, Bradley J Ridder, Xiaomei Han, Aaron Fullerton

Clin Pharmacol Ther· January 2020

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Sequential azacitidine and lenalidomide for patients with relapsed and refractory acute myeloid leukemia: Clinical results and predictive modeling using computational analysis.
Brett Stevens, Amanda Winters, Jonathan A Gutman, Aaron Fullerton, Gregory Hemenway

Leuk Res· June 2019

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Proof of Concept for an Automated Image Analysis Method to Quantify Rat Bone Marrow Hematopoietic Lineages on H&E Sections.
Cleopatra Kozlowski, Aaron Fullerton, Gary Cain, Paula Katavolos, Joseph Bravo

Toxicol Pathol· April 2018

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Safety Lead Optimization and Candidate Identification: Integrating New Technologies into Decision-Making.
Donna M Dambach, Dinah Misner, Mathew Brock, Aaron Fullerton, William Proctor

Chem Res Toxicol· April 2016

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Drug-induced allergic hepatitis develops in mice when myeloid-derived suppressor cells are depleted prior to halothane treatment.
Mala Chakraborty, Aaron M Fullerton, Kenrick Semple, Lynette S Chea, William R Proctor

Hepatology· August 2015

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Trovafloxacin-induced replication stress sensitizes HepG2 cells to tumor necrosis factor-alpha-induced cytotoxicity mediated by extracellular signal-regulated kinase and ataxia telangiectasia and Rad3-related.
Kevin M Beggs, Ashley R Maiuri, Aaron M Fullerton, Kyle L Poulsen, Anna B Breier

Toxicology· May 2015

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Thymic stromal lymphopoietin and interleukin-4 mediate the pathogenesis of halothane-induced liver injury in mice.
William R Proctor, Mala Chakraborty, Aaron M Fullerton, Midhun C Korrapati, Pauline M Ryan

Hepatology· November 2014

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Molecular mechanisms of hepatocellular apoptosis induced by trovafloxacin-tumor necrosis factor-alpha interaction.
Kevin M Beggs, Aaron M Fullerton, Kazuhisa Miyakawa, Patricia E Ganey, Robert A Roth

Toxicol Sci· January 2014

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Pretreatment with TCDD exacerbates liver injury from Concanavalin A: critical role for NK cells.
Aaron M Fullerton, Robert A Roth, Patricia E Ganey

Toxicol Sci· November 2013

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2,3,7,8-TCDD enhances the sensitivity of mice to concanavalin A immune-mediated liver injury.
Aaron M Fullerton, Robert A Roth, Patricia E Ganey

Toxicol Appl Pharmacol· January 2013

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