Publications by authors named "Adam Castoreno"

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Modified unlocked nucleic acid (MUNA) mitigates off-target effects of small interfering RNAs.
Shohei Mori, Dhrubajyoti Datta, Lydia Perkins, Michelle Jung, Lauren Blair Woods, Adam Castoreno

Nucleic Acids Res· September 2025

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Improving the potency prediction for chemically modified siRNAs through insights from molecular modeling of individual sequence positions.
Evgenii Kliuchnikov, Farkhad Maksudov, Jeffrey Zuber, Sarah Hyde, Adam Castoreno

Mol Ther Nucleic Acids· March 2025

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Expanding Conjugate Space of RNAi Therapeutics: Ligand at the 3' End of the Antisense Strand Achieves Uncompromised In Vivo Potency and Efficacy and Reveals Interactions with the Argonaute-2 PAZ Domain.
Rajat S Das, Dhrubajyoti Datta, Christopher R Brown, Jason A Gilbert, Amy Chan, Adam Castoreno

J Med Chem· February 2025

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In vivo expansion of gene-targeted hepatocytes through transient inhibition of an essential gene.
Marco De Giorgi, So Hyun Park, Adam Castoreno, Mingming Cao, Ayrea Hurley

Sci Transl Med· February 2025

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High resistance barrier and prophylactic protection in preclinical models of SARS-CoV-2 with two siRNA combination.
Yesseinia I Anglero-Rodriguez, Florian A Lempp, Megha Subramanian, James McIninch, Mark K Schlegel, Adam B Castoreno

Nucleic Acids Res· January 2025

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Evaluating the oral delivery of GalNAc-conjugated siRNAs in rodents and non-human primates.
Mikyung Yu, June Qin, Xiumin Liu, Diane Ramsden, Brian Williams, Adam Castoreno

Nucleic Acids Res· June 2024

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Shorter Is Better: The α-(l)-Threofuranosyl Nucleic Acid Modification Improves Stability, Potency, Safety, and Ago2 Binding and Mitigates Off-Target Effects of Small Interfering RNAs.
Shigeo Matsuda, Saikat Bala, Jen-Yu Liao, Dhrubajyoti Datta, Atsushi Mikami, Adam Castoreno

J Am Chem Soc· September 2023

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expansion of gene-targeted hepatocytes through transient inhibition of an essential gene.
Marco De Giorgi, So Hyun Park, Adam Castoreno, Mingming Cao, Ayrea Hurley

bioRxiv· July 2023

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RNAi-mediated rheostat for dynamic control of AAV-delivered transgenes.
Megha Subramanian, James McIninch, Ivan Zlatev, Mark K Schlegel, Charalambos Kaittanis, Adam B Castoreno

Nat Commun· April 2023

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Expanding RNAi therapeutics to extrahepatic tissues with lipophilic conjugates.
Kirk M Brown, Jayaprakash K Nair, Maja M Janas, Yesseinia I Anglero-Rodriguez, Lan T H Dang, Adam Castoreno

Nat Biotechnol· October 2022

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From bench to bedside: Improving the clinical safety of GalNAc-siRNA conjugates using seed-pairing destabilization.
Mark K Schlegel, Maja M Janas, Yongfeng Jiang, Joseph D Barry, Wendell Davis, Adam Castoreno

Nucleic Acids Res· July 2022

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Overcoming GNA/RNA base-pairing limitations using isonucleotides improves the pharmacodynamic activity of ESC+ GalNAc-siRNAs.
Mark K Schlegel, Shigeo Matsuda, Christopher R Brown, Joel M Harp, Joseph D Barry, Adam Castoreno

Nucleic Acids Res· November 2021

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Small circular interfering RNAs (sciRNAs) as a potent therapeutic platform for gene-silencing.
Hartmut Jahns, Rohan Degaonkar, Peter Podbevsek, Swati Gupta, Anna Bisbe, Adam Castoreno

Nucleic Acids Res· October 2021

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LDL-Cholesterol Reduction by ANGPTL3 Inhibition in Mice Is Dependent on Endothelial Lipase.
Liya Wu, Mangala M Soundarapandian, Adam B Castoreno, John S Millar, Daniel J Rader

Circ Res· September 2020

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Chimeric siRNAs with chemically modified pentofuranose and hexopyranose nucleotides: altritol-nucleotide (ANA) containing GalNAc-siRNA conjugates: in vitro and in vivo RNAi activity and resistance to 5'-exonuclease.
Pawan Kumar, Rohan Degaonkar, Dale C Guenther, Mikhail Abramov, Guy Schepers, Adam Castoreno

Nucleic Acids Res· May 2020

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An investigational RNAi therapeutic targeting Factor XII (ALN-F12) for the treatment of hereditary angioedema.
Jingxuan Liu, June Qin, Anna Borodovsky, Timothy Racie, Adam Castoreno

RNA· February 2019

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Reversal of siRNA-mediated gene silencing in vivo.
Ivan Zlatev, Adam Castoreno, Christopher R Brown, June Qin, Scott Waldron

Nat Biotechnol· July 2018

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Selection of GalNAc-conjugated siRNAs with limited off-target-driven rat hepatotoxicity.
Maja M Janas, Mark K Schlegel, Carole E Harbison, Vedat O Yilmaz, Yongfeng Jiang, Adam Castoreno

Nat Commun· February 2018

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Autophagy Inhibition Dysregulates TBK1 Signaling and Promotes Pancreatic Inflammation.
Shenghong Yang, Yu Imamura, Russell W Jenkins, Israel Cañadas, Shunsuke Kitajima, Adam Castoreno

Cancer Immunol Res· June 2016

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Small-molecule enhancers of autophagy modulate cellular disease phenotypes suggested by human genetics.
Szu-Yu Kuo, Adam B Castoreno, Leslie N Aldrich, Kara G Lassen, Gautam Goel

Proc Natl Acad Sci U S A· August 2015

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Discovery of a Small-Molecule Probe for V-ATPase Function.
Leslie N Aldrich, Szu-Yu Kuo, Adam B Castoreno, Gautam Goel, Petric Kuballa

J Am Chem Soc· April 2015

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Atg16l1 is required for autophagy in intestinal epithelial cells and protection of mice from Salmonella infection.
Kara L Conway, Petric Kuballa, Joo-Hye Song, Khushbu K Patel, Adam B Castoreno

Gastroenterology· December 2013

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Selective modulation of autophagy, innate immunity, and adaptive immunity by small molecules.
Stanley Y Shaw, Khoa Tran, Adam B Castoreno, Joanna M Peloquin, Kara G Lassen

ACS Chem Biol· December 2013

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Small molecule probes of cellular pathways and networks.
Adam B Castoreno, Ulrike S Eggert

ACS Chem Biol· January 2011

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