Publications by authors named "Anna Bisbe"

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High resistance barrier and prophylactic protection in preclinical models of SARS-CoV-2 with two siRNA combination.
Yesseinia I Anglero-Rodriguez, Florian A Lempp, Megha Subramanian, James McIninch, Mark K Schlegel, Anna Bisbe

Nucleic Acids Res· January 2025

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Shorter Is Better: The α-(l)-Threofuranosyl Nucleic Acid Modification Improves Stability, Potency, Safety, and Ago2 Binding and Mitigates Off-Target Effects of Small Interfering RNAs.
Shigeo Matsuda, Saikat Bala, Jen-Yu Liao, Dhrubajyoti Datta, Atsushi Mikami, Anna Bisbe

J Am Chem Soc· September 2023

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RNAi-mediated rheostat for dynamic control of AAV-delivered transgenes.
Megha Subramanian, James McIninch, Ivan Zlatev, Mark K Schlegel, Charalambos Kaittanis, Anna Bisbe

Nat Commun· April 2023

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Metabolically Stable Anomeric Linkages Containing GalNAc-siRNA Conjugates: An Interplay among ASGPR, Glycosidase, and RISC Pathways.
Pachamuthu Kandasamy, Shohei Mori, Shigeo Matsuda, Namrata Erande, Dhrubajyoti Datta, Anna Bisbe

J Med Chem· February 2023

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Role of a "Magic" Methyl: 2'-Deoxy-2'-α-F-2'-β--methyl Pyrimidine Nucleotides Modulate RNA Interference Activity through Synergy with 5'-Phosphate Mimics and Mitigation of Off-Target Effects.
Dale C Guenther, Shohei Mori, Shigeo Matsuda, Jason A Gilbert, Jennifer L S Willoughby, Anna Bisbe

J Am Chem Soc· August 2022

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Chirality matters: stereo-defined phosphorothioate linkages at the termini of small interfering RNAs improve pharmacology in vivo.
Hartmut Jahns, Nate Taneja, Jennifer L S Willoughby, Masaaki Akabane-Nakata, Christopher R Brown, Anna Bisbe

Nucleic Acids Res· February 2022

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Small circular interfering RNAs (sciRNAs) as a potent therapeutic platform for gene-silencing.
Hartmut Jahns, Rohan Degaonkar, Peter Podbevsek, Swati Gupta, Anna Bisbe

Nucleic Acids Res· October 2021

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Discovery of a novel deaminated metabolite of a single-stranded oligonucleotide by mass spectrometry.
Jing Li, Ju Liu, Jennifer Enders, Michael Arciprete, Chris Tran, Anna Bisbe

Bioanalysis· November 2019

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Structural basis for the synergy of 4'- and 2'-modifications on siRNA nuclease resistance, thermal stability and RNAi activity.
Joel M Harp, Dale C Guenther, Anna Bisbe, Lydia Perkins, Shigeo Matsuda

Nucleic Acids Res· September 2018

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4'-C-Methoxy-2'-deoxy-2'-fluoro Modified Ribonucleotides Improve Metabolic Stability and Elicit Efficient RNAi-Mediated Gene Silencing.
Elise Malek-Adamian, Dale C Guenther, Shigeo Matsuda, Saúl Martínez-Montero, Ivan Zlatev, Anna Bisbe

J Am Chem Soc· October 2017

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Chirality Dependent Potency Enhancement and Structural Impact of Glycol Nucleic Acid Modification on siRNA.
Mark K Schlegel, Donald J Foster, Alexander V Kel'in, Ivan Zlatev, Anna Bisbe

J Am Chem Soc· June 2017

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Structural Basis of Duplex Thermodynamic Stability and Enhanced Nuclease Resistance of 5'-C-Methyl Pyrimidine-Modified Oligonucleotides.
Alexander V Kel'in, Ivan Zlatev, Joel Harp, Muthusamy Jayaraman, Anna Bisbe

J Org Chem· March 2016

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