Publications by authors named "Adam Orr"

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Mitochondrial complex III-derived ROS amplify immunometabolic changes in astrocytes and promote dementia pathology.
Daniel Barnett, Till S Zimmer, Caroline Booraem, Fernando Palaguachi, Samantha M Meadows, Anna G Orr, Adam L Orr

Nat Metab· November 2025

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Identifying Links between Alzheimer's Disease and Type 2 Diabetes through Proteomics.
Tong N Chen, Adam L Orr, Anna G Orr, Nathaniel M Vacanti

J Proteome Res· August 2025

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Neuroimmune signaling mediates astrocytic nucleocytoplasmic disruptions and stress granule formation associated with TDP-43 pathology.
Constance Zhou, Evelyn J Hardin, Till S Zimmer, Stephanie Jackvony, Daniel Barnett, Adam L Orr, Anna G Orr

Neurobiol Dis· July 2025

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Mitochondrial complex III-derived ROS amplify immunometabolic changes in astrocytes and promote dementia pathology.
Daniel Barnett, Till S Zimmer, Caroline Booraem, Fernando Palaguachi, Samantha M Meadows, Anna G Orr, Adam L Orr

bioRxiv· August 2024

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Hippocampal astrocytes induce sex-dimorphic effects on memory.
Samantha M Meadows, Fernando Palaguachi, Minwoo Wendy Jang, Avital Licht-Murava, Daniel Barnett, Adam L Orr, Anna G Orr

Cell Rep· June 2024

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Astrocytes in selective vulnerability to neurodegenerative disease.
Till S Zimmer, Adam L Orr, Anna G Orr

Trends Neurosci· April 2024

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Systems-level analyses dissociate genetic regulators of reactive oxygen species and energy production.
Neal K Bennett, Megan Lee, Adam L Orr, Ken Nakamura

Proc Natl Acad Sci U S A· January 2024

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Systems-level analyses dissociate genetic regulators of reactive oxygen species and energy production.
Neal K Bennett, Megan Lee, Adam L Orr, Ken Nakamura

bioRxiv· October 2023

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Quantitative Proteomic Analysis Reveals apoE4-Dependent Phosphorylation of the Actin-Regulating Protein VASP.
Zeynep Cakir, Samuel J Lord, Yuan Zhou, Gwendolyn M Jang, Benjamin J Polacco, Adam L Orr

Mol Cell Proteomics· May 2023

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Astrocytic TDP-43 dysregulation impairs memory by modulating antiviral pathways and interferon-inducible chemokines.
Avital Licht-Murava, Samantha M Meadows, Fernando Palaguachi, Soomin C Song, Stephanie Jackvony, Adam L Orr, Anna G Orr

Sci Adv· April 2023

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Rib Fracture Mortality: Are There Clues in the Core?
Kathrine A Kelly-Schuette, Anthony Prentice, Adam Orr, Anna Levine, Allison Zarnke

J Surg Res· December 2021

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Pituitary sellar spine in a pediatric patient with diabetes insipidus.
Adam Orr, Chi Braunreiter, Christel Keefe, Matthew Christy, Bradford W Betz

Clin Imaging· January 2021

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Neuronal Apolipoprotein E4 Expression Results in Proteome-Wide Alterations and Compromises Bioenergetic Capacity by Disrupting Mitochondrial Function.
Adam L Orr, Chaeyoung Kim, David Jimenez-Morales, Billy W Newton, Jeffrey R Johnson

J Alzheimers Dis· August 2020

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A phylogenomic approach reveals a low somatic mutation rate in a long-lived plant.
Adam J Orr, Amanda Padovan, David Kainer, Carsten Külheim, Lindell Bromham

Proc Biol Sci· March 2020

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The use of site-specific suppressors to measure the relative contributions of different mitochondrial sites to skeletal muscle superoxide and hydrogen peroxide production.
Renata L S Goncalves, Mark A Watson, Hoi-Shan Wong, Adam L Orr, Martin D Brand

Redox Biol· January 2020

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To be or not to be pink(1): contradictory findings in an animal model for Parkinson's disease.
Ria de Haas, Lisa C M W Heltzel, Denise Tax, Petra van den Broek, Hilbert Steenbreker, Adam L Orr

Brain Commun· September 2019

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Plate-Based Measurement of Superoxide and Hydrogen Peroxide Production by Isolated Mitochondria.
Hoi-Shan Wong, Pierre-Axel Monternier, Adam L Orr, Martin D Brand

Methods Mol Biol· February 2019

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Loss of α-Synuclein Does Not Affect Mitochondrial Bioenergetics in Rodent Neurons.
Divya Pathak, Amandine Berthet, Jacob T Bendor, Katharine Yu, Rhyomi C Sellnow, Adam L Orr

eNeuro· March 2018

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Long-term oral kinetin does not protect against α-synuclein-induced neurodegeneration in rodent models of Parkinson's disease.
Adam L Orr, Florentine U Rutaganira, Daniel de Roulet, Eric J Huang, Nicholas T Hertz

Neurochem Int· October 2017

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Ancient genes establish stress-induced mutation as a hallmark of cancer.
Luis Cisneros, Kimberly J Bussey, Adam J Orr, Milica Miočević, Charles H Lineweaver

PLoS One· September 2017

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Suppressors of Superoxide-HO Production at Site I of Mitochondrial Complex I Protect against Stem Cell Hyperplasia and Ischemia-Reperfusion Injury.
Martin D Brand, Renata L S Goncalves, Adam L Orr, Leonardo Vargas, Akos A Gerencser

Cell Metab· October 2016

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Suppressors of superoxide production from mitochondrial complex III.
Adam L Orr, Leonardo Vargas, Carolina N Turk, Janine E Baaten, Jason T Matzen

Nat Chem Biol· November 2015

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The NHLBI-sponsored Consortium for preclinicAl assESsment of cARdioprotective therapies (CAESAR): a new paradigm for rigorous, accurate, and reproducible evaluation of putative infarct-sparing interventions in mice, rabbits, and pigs.
Steven P Jones, Xian-Liang Tang, Yiru Guo, Charles Steenbergen, David J Lefer, Adam Orr

Circ Res· February 2015

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Novel inhibitors of mitochondrial sn-glycerol 3-phosphate dehydrogenase.
Adam L Orr, Deepthi Ashok, Melissa R Sarantos, Ryan Ng, Tong Shi

PLoS One· January 2015

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Production of superoxide/H2O2 by dihydroorotate dehydrogenase in rat skeletal muscle mitochondria.
Martin Hey-Mogensen, Renata L S Goncalves, Adam L Orr, Martin D Brand

Free Radic Biol Med· July 2014

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