Publications by authors named "Adrian B Roth"

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iPSC-hepatocyte organoids as a novel platform to predict AAV gene therapy efficacy.
Estelle Berreur, Giacomo Lazzaroni, Cyrill Roth, Marco Zihlmann, Martina Stirn, Adrian B Roth

Mol Ther Methods Clin Dev· June 2025

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Human immunocompetent Organ-on-Chip platforms allow safety profiling of tumor-targeted T-cell bispecific antibodies.
S Jordan Kerns, Chaitra Belgur, Debora Petropolis, Marianne Kanellias, Riccardo Barrile, Adrian B Roth

Elife· August 2021

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Characterization of a long-term mouse primary liver 3D tissue model recapitulating innate-immune responses and drug-induced liver toxicity.
Ramona Nudischer, Kasper Renggli, Andreas Hierlemann, Adrian B Roth, Cristina Bertinetti-Lapatki

PLoS One· September 2020

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Neutrophilic infiltration in organ-on-a-chip model of tissue inflammation.
Nikolce Gjorevski, Blandine Avignon, Régine Gérard, Lauriane Cabon, Adrian B Roth

Lab Chip· September 2020

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Combining In Vivo and Organotypic In Vitro Approaches to Assess the Human Relevance of Basimglurant (RG7090), a Potential CAR Activator.
Ramona Nudischer, Kasper Renggli, Cristina Bertinetti-Lapatki, Jean-Christophe Hoflack, Nicholas Flint, Adrian B Roth

Toxicol Sci· August 2020

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Concurrent isolation of hepatic stem cells and hepatocytes from the human liver.
Serene M L Lee, Cristina Bertinetti-Lapatki, Tobias S Schiergens, Karl-Walter Jauch, Adrian B Roth

In Vitro Cell Dev Biol Anim· March 2020

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Are Biotransformation Studies of Therapeutic Proteins Needed? Scientific Considerations and Technical Challenges.
Simone Schadt, Simon Hauri, Filipe Lopes, Martin R Edelmann, Roland F Staack, Adrian B Roth

Drug Metab Dispos· December 2019

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Multi-organ system for the evaluation of efficacy and off-target toxicity of anticancer therapeutics.
Christopher W McAleer, Christopher J Long, Daniel Elbrecht, Trevor Sasserath, L Richard Bridges, Adrian B Roth

Sci Transl Med· June 2019

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Assessing single-stranded oligonucleotide drug-induced effects in vitro reveals key risk factors for thrombocytopenia.
Sabine Sewing, Adrian B Roth, Michael Winter, Andreas Dieckmann, Cristina Bertinetti-Lapatki, Andreas Rothfuss

PLoS One· November 2017

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Bioprinted 3D Primary Liver Tissues Allow Assessment of Organ-Level Response to Clinical Drug Induced Toxicity In Vitro.
Deborah G Nguyen, Juergen Funk, Justin B Robbins, Candace Crogan-Grundy, Sharon C Presnell, Adrian B Roth

PLoS One· July 2017

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Establishment of a Predictive In Vitro Assay for Assessment of the Hepatotoxic Potential of Oligonucleotide Drugs.
Sabine Sewing, Franziska Boess, Annie Moisan, Cristina Bertinetti-Lapatki, Tanja Minz, Adrian B Roth

PLoS One· July 2017

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Culture and Drug Profiling of Patient Derived Malignant Pleural Effusions for Personalized Cancer Medicine.
Christian Ruiz, Stefan Kustermann, Elina Pietilae, Tatjana Vlajnic, Betty Baschiera, Sacha I Rothschild, Adrian B Roth

PLoS One· July 2017

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Use of early phenotypic in vivo markers to assess human relevance of an unusual rodent non-genotoxic carcinogen in vitro.
Franziska Boess, Barbara Lenz, Juergen Funk, Urs Niederhauser, Simon Bassett, Adrian B Roth

Toxicology· March 2017

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Inhibition of EGF Uptake by Nephrotoxic Antisense Drugs In Vitro and Implications for Preclinical Safety Profiling.
Annie Moisan, Marcel Gubler, Jitao David Zhang, Yann Tessier, Kamille Dumong Erichsen, Adrian B Roth

Mol Ther Nucleic Acids· March 2017

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Key Challenges and Opportunities Associated with the Use of In Vitro Models to Detect Human DILI: Integrated Risk Assessment and Mitigation Plans.
Franck A Atienzar, Eric A Blomme, Minjun Chen, Philip Hewitt, J Gerry Kenna, Adrian B Roth

Biomed Res Int· September 2016

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Temporal Patterns of Novel Circulating Biomarkers in IL-2-mediated Vascular Injury in the Rat.
Natalie D Keirstead, Cristina Bertinetti-Lapatki, Denise Knapp, Mudher Albassam, Valerie Hughes, Adrian B Roth

Toxicol Pathol· October 2015

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