Publications by authors named "Simone Schadt"

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Metabolism of new drug modalities research advances - 2024 year in review.
Bin Ma, Upendra A Argikar, Luying Chen, Lionel Cheruzel, Sungjoon Cho, Simone Schadt

Drug Metab Rev· November 2025

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Metabolism of new drug modalities research advances - 2023 year in review.
Bin Ma, Upendra A Argikar, Lionel Cheruzel, Sungjoon Cho, Simon Hauri, Simone Schadt

Drug Metab Rev· August 2024

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The Importance of Tracking "Missing" Metabolites: How and Why?
Shuai Wang, T Eric Ballard, Lisa J Christopher, Robert S Foti, Chungang Gu, Simone Schadt

J Med Chem· December 2023

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Investigating discovery strategies and pharmacological properties of stereodefined phosphorodithioate LNA gapmers.
Jörg Duschmalé, Adrian Schäublin, Erik Funder, Steffen Schmidt, Łukasz J Kiełpiński, Simone Schadt

Mol Ther Nucleic Acids· September 2022

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Safety, Tissue Distribution, and Metabolism of LNA-Containing Antisense Oligonucleotides in Rats.
Fernando Romero-Palomo, Matthias Festag, Barbara Lenz, Simone Schadt, Andreas Brink

Toxicol Pathol· August 2021

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Combining In Vivo and Organotypic In Vitro Approaches to Assess the Human Relevance of Basimglurant (RG7090), a Potential CAR Activator.
Ramona Nudischer, Kasper Renggli, Cristina Bertinetti-Lapatki, Jean-Christophe Hoflack, Nicholas Flint, Simone Schadt

Toxicol Sci· August 2020

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Absolute Bioavailability of Vemurafenib in Patients With BRAF Mutation-Positive Malignancies.
Weijiang Zhang, Dawn Colburn, Brian Simmons, Zsuzsanna Papai, Enric Bertran, Simone Schadt

Clin Pharmacol Drug Dev· May 2020

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Studying the Biotransformation of Phosphorothioate-Containing Oligonucleotide Drugs by LC-MS.
Christophe Husser, Erich Koller, Andreas Brink, Simone Schadt

Methods Mol Biol· April 2020

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Genotoxicity Assessment of Drug Metabolites in the Context of MIST and Beyond.
Andreas Zeller, Alessandro Brigo, Andreas Brink, Melanie Guerard, Dieter Lang, Simone Schadt

Chem Res Toxicol· January 2020

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Are Biotransformation Studies of Therapeutic Proteins Needed? Scientific Considerations and Technical Challenges.
Simone Schadt, Simon Hauri, Filipe Lopes, Martin R Edelmann, Roland F Staack

Drug Metab Dispos· December 2019

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The In Vitro Biotransformation of the Fusion Protein Tetranectin-Apolipoprotein A1.
Simone Schadt, Christophe Husser, Roland F Staack, Aynur Ekiciler, Na Hong Qiu

Sci Rep· March 2019

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Advanced MALDI mass spectrometry imaging in pharmaceutical research and drug development.
Sandra Schulz, Michael Becker, M Reid Groseclose, Simone Schadt, Carsten Hopf

Curr Opin Biotechnol· February 2019

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Application of Imaging Techniques to Cases of Drug-Induced Crystal Nephropathy in Preclinical Studies.
Barbara Lenz, Andreas Brink, Monira Siam, Anne De Paepe, Simon Bassett, Simone Schadt

Toxicol Sci· June 2018

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A Decade in the MIST: Learnings from Investigations of Drug Metabolites in Drug Development under the "Metabolites in Safety Testing" Regulatory Guidance.
Simone Schadt, Bojan Bister, Swapan K Chowdhury, Christoph Funk, Cornelis E C A Hop

Drug Metab Dispos· June 2018

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Profiling of dalcetrapib metabolites in human plasma by accelerator mass spectrometry and investigation of the free phenothiol by derivatisation with methylacrylate.
Christophe Husser, Axel Pähler, Mark Seymour, Olaf Kuhlmann, Simone Schadt

J Pharm Biomed Anal· April 2018

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Identification of GalNAc-Conjugated Antisense Oligonucleotide Metabolites Using an Untargeted and Generic Approach Based on High Resolution Mass Spectrometry.
Christophe Husser, Andreas Brink, Manfred Zell, Martina B Müller, Erich Koller, Simone Schadt

Anal Chem· June 2017

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Minimizing the risk of chemically reactive metabolite formation of new drug candidates: implications for preclinical drug design.
Andreas Brink, Axel Pähler, Christoph Funk, Franz Schuler, Simone Schadt

Drug Discov Today· May 2017

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A double-tracer technique to characterize absorption, distribution, metabolism and excretion (ADME) of [C]-basimglurant and absolute bioavailability after oral administration and concomitant intravenous microdose administration of [C]-labeled basimglurant in humans.
Elena Guerini, Simone Schadt, Gerard Greig, Ruth Haas, Christophe Husser

Xenobiotica· February 2017

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Shedding light on minipig drug metabolism - elevated amide hydrolysis in vitro.
Russell Jones, Michaela Marschmann, Michael Keller, Na Hong Qiu, Stephen Fowler, Simone Schadt

Xenobiotica· December 2016

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In Vivo Biotransformation of the Fusion Protein Tetranectin-Apolipoprotein A1 Analyzed by Ligand-Binding Mass Spectrometry Combined with Quantitation by ELISA.
Manfred Zell, Christophe Husser, Roland F Staack, Gregor Jordan, Wolfgang F Richter, Simone Schadt

Anal Chem· December 2016

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A New Rapid In Vitro Assay for Assessing Reactivity of Acyl Glucuronides.
Sheng Zhong, Russell Jones, Wenzhe Lu, Simone Schadt, Giorgio Ottaviani

Drug Metab Dispos· November 2015

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Investigation of figopitant and its metabolites in rat tissue by combining whole-body autoradiography with liquid extraction surface analysis mass spectrometry.
Simone Schadt, Susanne Kallbach, Reinaldo Almeida, Jan Sandel

Drug Metab Dispos· March 2012

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Evaluation of relative LC/MS response of metabolites to parent drug in LC/nanospray ionization mass spectrometry: potential implications in MIST assessment.
Simone Schadt, Lin-Zhi Chen, Daniel Bischoff

J Mass Spectrom· December 2011

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Abyssomicin biosynthesis: formation of an unusual polyketide, antibiotic-feeding studies and genetic analysis.
Elvira M Gottardi, Joanna M Krawczyk, Hanna von Suchodoletz, Simone Schadt, Agnes Mühlenweg

Chembiochem· June 2011

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2-Amino-2-deoxyisochorismate is a key intermediate in Bacillus subtilis p-aminobenzoic acid biosynthesis.
Heiko S Schadt, Simone Schadt, Florian Oldach, Roderich D Süssmuth

J Am Chem Soc· March 2009

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