Publications by authors named "Sabine Sewing"

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Considerations in the Preclinical Assessment of the Safety of Antisense Oligonucleotides.
Aurélie Goyenvalle, Cecilia Jimenez-Mallebrera, Willeke van Roon, Sabine Sewing, Arthur M Krieg

Nucleic Acid Ther· January 2023

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Investigating discovery strategies and pharmacological properties of stereodefined phosphorodithioate LNA gapmers.
Jörg Duschmalé, Adrian Schäublin, Erik Funder, Steffen Schmidt, Łukasz J Kiełpiński, Sabine Sewing

Mol Ther Nucleic Acids· September 2022

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Safety, Tissue Distribution, and Metabolism of LNA-Containing Antisense Oligonucleotides in Rats.
Fernando Romero-Palomo, Matthias Festag, Barbara Lenz, Simone Schadt, Andreas Brink, Sabine Sewing

Toxicol Pathol· August 2021

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Evaluation of bovine milk extracellular vesicles for the delivery of locked nucleic acid antisense oligonucleotides.
Philip Grossen, Michaela Portmann, Erich Koller, Martina Duschmalé, Tanja Minz, Sabine Sewing

Eur J Pharm Biopharm· January 2021

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Combining In Vivo and Organotypic In Vitro Approaches to Assess the Human Relevance of Basimglurant (RG7090), a Potential CAR Activator.
Ramona Nudischer, Kasper Renggli, Cristina Bertinetti-Lapatki, Jean-Christophe Hoflack, Nicholas Flint, Sabine Sewing

Toxicol Sci· August 2020

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Refining LNA safety profile by controlling phosphorothioate stereochemistry.
Erik Daa Funder, Nanna Albæk, Annie Moisan, Sabine Sewing, Troels Koch

PLoS One· August 2020

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In Vitro Assessment of the Hepatotoxicity Potential of Therapeutic Oligonucleotides.
Sabine Sewing, Tanja Minz, Franziska Boess

Methods Mol Biol· April 2020

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GalNAc Conjugation Attenuates the Cytotoxicity of Antisense Oligonucleotide Drugs in Renal Tubular Cells.
Sabine Sewing, Marcel Gubler, Régine Gérard, Blandine Avignon, Yasmin Mueller

Mol Ther Nucleic Acids· March 2019

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Assessing single-stranded oligonucleotide drug-induced effects in vitro reveals key risk factors for thrombocytopenia.
Sabine Sewing, Adrian B Roth, Michael Winter, Andreas Dieckmann, Cristina Bertinetti-Lapatki

PLoS One· November 2017

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Establishment of a Predictive In Vitro Assay for Assessment of the Hepatotoxic Potential of Oligonucleotide Drugs.
Sabine Sewing, Franziska Boess, Annie Moisan, Cristina Bertinetti-Lapatki, Tanja Minz

PLoS One· July 2017

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Inhibition of EGF Uptake by Nephrotoxic Antisense Drugs In Vitro and Implications for Preclinical Safety Profiling.
Annie Moisan, Marcel Gubler, Jitao David Zhang, Yann Tessier, Kamille Dumong Erichsen, Sabine Sewing

Mol Ther Nucleic Acids· March 2017

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Incretin-like effects of small molecule trace amine-associated receptor 1 agonists.
Susanne Raab, Haiyan Wang, Sabine Uhles, Nadine Cole, Ruben Alvarez-Sanchez, Sabine Sewing

Mol Metab· January 2016

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A Transcriptome-Led Exploration of Molecular Mechanisms Regulating Somatostatin-Producing D-Cells in the Gastric Epithelium.
Alice Adriaenssens, Brian Yee Hong Lam, Lawrence Billing, Katie Skeffington, Sabine Sewing

Endocrinology· November 2015

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Discovery and optimisation of 1-hydroxyimino-3,3-diphenylpropanes, a new class of orally active GPBAR1 (TGR5) agonists.
Henrietta Dehmlow, Rubén Alvarez Sánchez, Stephan Bachmann, Caterina Bissantz, Fritz Bliss, Sabine Sewing

Bioorg Med Chem Lett· August 2013

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Taspoglutide, an analog of human glucagon-like Peptide-1 with enhanced stability and in vivo potency.
Elena Sebokova, Andreas D Christ, Haiyan Wang, Sabine Sewing, Jesse Z Dong

Endocrinology· June 2010

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Fibroblast growth factor-21 improves pancreatic beta-cell function and survival by activation of extracellular signal-regulated kinase 1/2 and Akt signaling pathways.
Wolf Wente, Alexander M Efanov, Martin Brenner, Alexei Kharitonenkov, Anja Köster, Sabine Sewing

Diabetes· September 2006

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Sterol regulatory element-binding protein 1 mediates liver X receptor-beta-induced increases in insulin secretion and insulin messenger ribonucleic acid levels.
Heike Zitzer, Wolf Wente, Martin B Brenner, Sabine Sewing, Karsten Buschard

Endocrinology· August 2006

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A novel glucokinase activator modulates pancreatic islet and hepatocyte function.
Alexander M Efanov, David G Barrett, Martin B Brenner, Stephen L Briggs, Annie Delaunois, Sabine Sewing

Endocrinology· September 2005

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Glucagon stimulates exocytosis in mouse and rat pancreatic alpha-cells by binding to glucagon receptors.
Xiaosong Ma, Yang Zhang, Jesper Gromada, Sabine Sewing, Per-Olof Berggren

Mol Endocrinol· January 2005

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Liver X receptor activation stimulates insulin secretion via modulation of glucose and lipid metabolism in pancreatic beta-cells.
Alexander M Efanov, Sabine Sewing, Krister Bokvist, Jesper Gromada

Diabetes· December 2004

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GABAB receptor activation inhibits exocytosis in rat pancreatic beta-cells by G-protein-dependent activation of calcineurin.
Matthias Braun, Anna Wendt, Karsten Buschard, Albert Salehi, Sabine Sewing

J Physiol· September 2004

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Glucose inhibition of glucagon secretion from rat alpha-cells is mediated by GABA released from neighboring beta-cells.
Anna Wendt, Bryndis Birnir, Karsten Buschard, Jesper Gromada, Albert Salehi, Sabine Sewing

Diabetes· April 2004

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SUR1 regulates PKA-independent cAMP-induced granule priming in mouse pancreatic B-cells.
Lena Eliasson, Xiaosong Ma, Erik Renström, Sebastian Barg, Per-Olof Berggren, Sabine Sewing

J Gen Physiol· March 2003

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Inhibition of Kv2.1 voltage-dependent K+ channels in pancreatic beta-cells enhances glucose-dependent insulin secretion.
Patrick E MacDonald, Sabine Sewing, Jianli Wang, Jamie W Joseph, Simon R Smukler

J Biol Chem· November 2002

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