Publications by authors named "Adrian Israelson"

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Muscle-derived miR-126 regulates TDP-43 axonal local synthesis and NMJ integrity in ALS models.
Ariel Ionescu, Lior Ankol, Anand Ganapathy Subramaniam, Topaz Altman, Iddo Magen, Adrian Israelson

Nat Neurosci· November 2025

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Translational challenges in amyotrophic lateral sclerosis therapy with macrophage migration inhibitory factor.
Leenor Alfahel, Aleksandar Rajkovic, Adrian Israelson

Neural Regen Res· September 2025

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Protocol for handling and using SOD1 mice for amyotrophic lateral sclerosis pre-clinical studies.
Leenor Alfahel, Aleksandar Rajkovic, Adrian Israelson

STAR Protoc· December 2024

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VDAC1: A Key Player in the Mitochondrial Landscape of Neurodegeneration.
Shirel Argueti-Ostrovsky, Shir Barel, Joy Kahn, Adrian Israelson

Biomolecules· December 2024

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Targeting low levels of MIF expression as a potential therapeutic strategy for ALS.
Leenor Alfahel, Thomas Gschwendtberger, Velina Kozareva, Laura Dumas, Rachel Gibbs, Adrian Israelson

Cell Rep Med· May 2024

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CD4 T-cell aging exacerbates neuroinflammation in a late-onset mouse model of amyotrophic lateral sclerosis.
Shir Zaccai, Anna Nemirovsky, Livnat Lerner, Leenor Alfahel, Ekaterina Eremenko, Adrian Israelson

J Neuroinflammation· January 2024

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Blocking an epitope of misfolded SOD1 ameliorates disease phenotype in a model of amyotrophic lateral sclerosis.
Shamchal Bakavayev, Alexandra Stavsky, Shirel Argueti-Ostrovsky, Galit Yehezkel, Yael Fridmann-Sirkis, Adrian Israelson

Brain· November 2023

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Intracellular spatially-targeted chemical chaperones increase native state stability of mutant SOD1 barrel.
Sara S Ribeiro, David Gnutt, Salome Azoulay-Ginsburg, Zamira Fetahaj, Ella Spurlock, Adrian Israelson

Biol Chem· September 2023

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Therapeutic Potential of Phytocannabinoid Cannabigerol for Multiple Sclerosis: Modulation of Microglial Activation In Vitro and In Vivo.
Sigal Fleisher-Berkovich, Yvonne Ventura, Maya Amoyal, Arik Dahan, Valeria Feinshtein, Adrian Israelson

Biomolecules· February 2023

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Targeting the Mitochondrial Protein VDAC1 as a Potential Therapeutic Strategy in ALS.
Anna Shteinfer-Kuzmine, Shirel Argueti-Ostrovsky, Marcel F Leyton-Jaimes, Uttpal Anand, Salah Abu-Hamad, Adrian Israelson

Int J Mol Sci· September 2022

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4-Phenylbutyric Acid (4-PBA) Derivatives Prevent SOD1 Amyloid Aggregation In Vitro with No Effect on Disease Progression in SOD1-ALS Mice.
Leenor Alfahel, Shirel Argueti-Ostrovsky, Shir Barel, Mahmood Ali Saleh, Joy Kahn, Adrian Israelson

Int J Mol Sci· August 2022

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MIF homolog d-dopachrome tautomerase (D-DT/MIF-2) does not inhibit accumulation and toxicity of misfolded SOD1.
Amina Alaskarov, Shir Barel, Shamchal Bakavayev, Joy Kahn, Adrian Israelson

Sci Rep· June 2022

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Early upregulation of cytosolic phospholipase Aα in motor neurons is induced by misfolded SOD1 in a mouse model of amyotrophic lateral sclerosis.
Yafa Fetfet Malada Edelstein, Yulia Solomonov, Nurit Hadad, Leenor Alfahel, Adrian Israelson

J Neuroinflammation· November 2021

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All Roads Lead to Rome: Different Molecular Players Converge to Common Toxic Pathways in Neurodegeneration.
Shirel Argueti-Ostrovsky, Leenor Alfahel, Joy Kahn, Adrian Israelson

Cells· September 2021

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Exposure of β6/β7-Loop in Zn/Cu Superoxide Dismutase (SOD1) Is Coupled to Metal Loss and Is Transiently Reversible During Misfolding.
Shamchal Bakavayev, Shirel Argueti, Nachiyappan Venkatachalam, Galit Yehezkel, Alexandra Stavsky, Adrian Israelson

ACS Chem Neurosci· January 2021

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Empty mesoporous silica particles significantly delay disease progression and extend survival in a mouse model of ALS.
Marcel F Leyton-Jaimes, Patrik Ivert, Jan Hoeber, Yilin Han, Adam Feiler, Adrian Israelson

Sci Rep· November 2020

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Potential roles of gut microbiome and metabolites in modulating ALS in mice.
Eran Blacher, Stavros Bashiardes, Hagit Shapiro, Daphna Rothschild, Uria Mor, Adrian Israelson

Nature· August 2019

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A VDAC1-Derived N-Terminal Peptide Inhibits Mutant SOD1-VDAC1 Interactions and Toxicity in the SOD1 Model of ALS.
Anna Shteinfer-Kuzmine, Shirel Argueti, Rajeev Gupta, Neta Shvil, Salah Abu-Hamad, Adrian Israelson

Front Cell Neurosci· August 2019

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AAV2/9-mediated overexpression of MIF inhibits SOD1 misfolding, delays disease onset, and extends survival in mouse models of ALS.
Marcel F Leyton-Jaimes, Joy Kahn, Adrian Israelson

Proc Natl Acad Sci U S A· July 2019

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Cu/Zn-superoxide dismutase and wild-type like fALS SOD1 mutants produce cytotoxic quantities of HO via cysteine-dependent redox short-circuit.
Shamchal Bakavayev, Nimrod Chetrit, Tatiana Zvagelsky, Rasha Mansour, Maria Vyazmensky, Adrian Israelson

Sci Rep· July 2019

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Macrophage migration inhibitory factor: A multifaceted cytokine implicated in multiple neurological diseases.
Marcel F Leyton-Jaimes, Joy Kahn, Adrian Israelson

Exp Neurol· March 2018

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MIF inhibits the formation and toxicity of misfolded SOD1 amyloid aggregates: implications for familial ALS.
Neta Shvil, Victor Banerjee, Guy Zoltsman, Tom Shani, Joy Kahn, Adrian Israelson

Cell Death Dis· January 2018

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Misfolded SOD1 Accumulation and Mitochondrial Association Contribute to the Selective Vulnerability of Motor Neurons in Familial ALS: Correlation to Human Disease.
Salah Abu-Hamad, Joy Kahn, Marcel F Leyton-Jaimes, Jonathan Rosenblatt, Adrian Israelson

ACS Chem Neurosci· October 2017

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Assay to Measure Nucleocytoplasmic Transport in Real Time within Motor Neuron-like NSC-34 Cells.
Tom Shani, Moshe Levy, Adrian Israelson

J Vis Exp· May 2017

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Endogenous macrophage migration inhibitory factor reduces the accumulation and toxicity of misfolded SOD1 in a mouse model of ALS.
Marcel F Leyton-Jaimes, Clara Benaim, Salah Abu-Hamad, Joy Kahn, Amos Guetta, Adrian Israelson

Proc Natl Acad Sci U S A· September 2016

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